FADH - ECOLI - GREMLIN Contacts

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FADH - 2,4-dienoyl-CoA reductase [NADPH]

UniProt:	P42593	Sequences: MSYPSLFAPLDLGFTTLKNRVLMGSMHTGLEEYPDGAERLAAFYAERARHGVALIVSGGIAPDLTGVGMEGGAMLNDASQIPHHRTITEAVHQEGGKIALQILHTGRYSYQPHLVAPSALQAPINRFVPHELSHEEILQLIDNFARCAQLAREAGYDGVEVMGSEGYLINEFLTLRTNQRSDQWGGDYRNRMRFAVEVVRAVRERVGNDFIIIYRLSMLDLVEDGGTFAETVELAQAIEAAGATIINTGIGWHEARIPTIATPVPRGAFSWVTRKLKGHVSLPLVTTNRINDPQVADDILSRGDADMVSMARPFLADAELLSKAQSGRADEINTCIGCNQACLDQIFVGKVTSCLVNPRACHETKMPILPAVQKKNLAVVGAGPAGLAFAINAAARGHQVTLFDAHSEIGGQFNIAKQIPGKEEFYETLRYYRRMIEVTGVTLKLNHTVTADQLQAFDETILASGIVPRTPPIDGIDHPKVLSYLDVLRDKAPVGNKVAIIGCGGIGFDTAMYLSQPGESTSQNIAGFCNEWGIDSSLQQAGGLSPQGMQIPRSPRQIVMLQRKASKPGQGLGKTTGWIHRTTLLSRGVKMIPGVSYQKIDDDGLHVVINGETQVLAVDNVVICAGQEPNRALAQPLIDSGKTVHLIGGCDVAMELDARRAIAQGTRLALEI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12723
Length:	672 (627)
Sequences:	2548 (1701)
Seq/√Len:	67.9

ECOLI - FADH
BACSU - YQIG
SULSO - Q97WT9 Q97X55

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
382_A	409_I	4.593	1.00
145_A	201_A	4.262	1.00
405_A	448_T	3.984	1.00
134_H	183_Q	3.831	1.00
187_D	190_N	3.796	1.00
328_R	331_E	3.794	1.00
401_T	444_K	3.477	1.00
500_I	511_A	3.267	1.00
378_A	403_F	3.095	1.00
46_E	319_E	3.055	1.00
436_I	443_L	2.918	1.00
115_V	132_L	2.910	1.00
91_V	98_I	2.893	1.00
10_L	307_M	2.890	1.00
331_E	438_V	2.855	1.00
149_Q	205_R	2.848	1.00
298_D	302_R	2.786	1.00
663_A	667_R	2.782	1.00
99_A	158_G	2.739	1.00
331_E	435_M	2.717	1.00
274_R	304_D	2.694	1.00
270_S	299_I	2.667	1.00
435_M	438_V	2.666	1.00
22_L	307_M	2.640	1.00
376_N	399_Q	2.622	1.00
646_L	650_C	2.587	1.00
322_S	326_S	2.552	1.00
78_A	150_L	2.513	1.00
21_V	321_L	2.511	1.00
132_L	140_L	2.510	1.00
134_H	137_I	2.446	1.00
389_F	461_I	2.416	1.00
119_A	131_E	2.406	1.00
168_L	194_F	2.311	1.00
45_A	94_E	2.301	1.00
213_I	245_I	2.295	1.00
7_F	325_Q	2.255	1.00
436_I	441_V	2.254	1.00
38_E	86_T	2.252	1.00
497_K	520_S	2.240	1.00
403_F	449_V	2.204	1.00
190_N	193_R	2.202	1.00
132_L	136_E	2.193	1.00
399_Q	442_T	2.164	1.00
5_S	301_S	2.155	1.00
378_A	457_F	2.133	1.00
391_I	395_A	2.117	1.00
152_R	209_D	2.111	1.00
274_R	278_G	2.110	1.00
584_L	589_V	2.101	1.00
297_D	300_L	2.086	1.00
130_H	136_E	2.082	1.00
63_D	143_N	2.068	1.00
169_I	198_V	2.067	1.00
169_I	195_A	2.056	1.00
45_A	93_Q	2.053	1.00
486_D	491_K	2.050	1.00
17_L	53_A	2.043	1.00
374_K	399_Q	2.041	1.00
192_M	237_A	2.040	1.00
388_A	391_I	2.031	1.00
371_A	374_K	2.030	1.00
149_Q	153_E	2.018	1.00
598_Q	608_V	2.012	1.00
169_I	194_F	2.011	1.00
654_M	664_Q	2.000	1.00
459_E	645_H	1.994	1.00
407_S	446_N	1.983	1.00
161_V	202_V	1.960	1.00
102_I	147_C	1.945	1.00
142_D	201_A	1.940	1.00
474_D	599_K	1.935	1.00
239_E	281_S	1.916	1.00
236_Q	279_H	1.898	1.00
395_A	435_M	1.897	1.00
382_A	402_L	1.879	1.00
330_D	434_R	1.876	1.00
184_W	197_E	1.872	1.00
163_G	214_Y	1.869	1.00
434_R	438_V	1.867	1.00
11_D	16_T	1.853	1.00
447_H	453_Q	1.852	1.00
499_A	618_V	1.851	1.00
598_Q	613_T	1.845	1.00
592_I	595_V	1.841	1.00
15_T	97_K	1.838	1.00
401_T	442_T	1.837	1.00
495_G	619_D	1.835	1.00
391_I	439_T	1.819	1.00
487_V	494_V	1.817	1.00
92_H	157_D	1.806	1.00
85_R	89_E	1.804	1.00
176_R	224_D	1.784	1.00
238_I	243_A	1.779	1.00
471_P	476_I	1.771	1.00
645_H	668_L	1.769	1.00
482_L	487_V	1.761	1.00
5_S	8_A	1.751	1.00
499_A	605_L	1.750	1.00
665_G	669_A	1.748	1.00
478_H	602_D	1.748	1.00
310_M	313_P	1.744	1.00
49_R	94_E	1.743	1.00
52_V	314_F	1.739	1.00
138_L	184_W	1.725	1.00
450_T	453_Q	1.718	1.00
235_A	280_V	1.714	1.00
145_A	205_R	1.714	1.00
246_I	282_L	1.697	1.00
41_A	87_I	1.697	1.00
596_S	608_V	1.691	0.99
633_L	637_L	1.690	0.99
319_E	322_S	1.679	0.99
603_D	617_A	1.678	0.99
417_K	426_Y	1.678	0.99
459_E	643_T	1.673	0.99
322_S	325_Q	1.668	0.99
326_S	331_E	1.667	0.99
22_L	285_V	1.667	0.99
261_A	579_I	1.659	0.99
292_D	320_L	1.657	0.99
173_L	192_M	1.654	0.99
18_K	96_G	1.650	0.99
403_F	444_K	1.627	0.99
528_F	532_W	1.624	0.99
239_E	282_L	1.623	0.99
201_A	204_E	1.610	0.99
152_R	207_G	1.607	0.99
368_I	392_N	1.605	0.99
590_K	614_Q	1.581	0.99
138_L	183_Q	1.574	0.99
173_L	195_A	1.563	0.99
15_T	211_I	1.562	0.99
651_D	664_Q	1.552	0.99
601_D	606_H	1.549	0.99
482_L	492_A	1.543	0.99
444_K	447_H	1.542	0.99
84_H	156_Y	1.542	0.99
201_A	205_R	1.539	0.99
387_L	409_I	1.535	0.99
497_K	619_D	1.519	0.99
5_S	297_D	1.512	0.99
601_D	604_G	1.504	0.99
482_L	620_N	1.500	0.99
497_K	617_A	1.495	0.99
528_F	533_G	1.493	0.99
138_L	201_A	1.488	0.99
134_H	184_W	1.484	0.99
267_G	295_V	1.479	0.99
46_E	359_R	1.477	0.99
134_H	138_L	1.477	0.99
286_T	305_A	1.475	0.99
402_L	409_I	1.469	0.99
138_L	197_E	1.469	0.99
146_R	150_L	1.468	0.99
275_K	278_G	1.455	0.98
42_A	364_T	1.448	0.98
45_A	90_A	1.436	0.98
331_E	434_R	1.431	0.98
299_I	305_A	1.431	0.98
88_T	156_Y	1.429	0.98
45_A	49_R	1.417	0.98
378_A	449_V	1.413	0.98
473_I	600_I	1.411	0.98
432_Y	436_I	1.405	0.98
599_K	606_H	1.405	0.98
522_S	592_I	1.404	0.98
392_N	666_T	1.403	0.98
368_I	666_T	1.399	0.98
403_F	457_F	1.395	0.98
200_R	241_A	1.395	0.98
377_L	668_L	1.391	0.98
375_K	459_E	1.386	0.98
14_F	211_I	1.382	0.98
120_L	129_P	1.380	0.98
232_V	279_H	1.368	0.98
228_F	275_K	1.361	0.98
434_R	437_E	1.357	0.98
409_I	443_L	1.352	0.98
409_I	433_R	1.352	0.98
11_D	14_F	1.343	0.97
528_F	531_E	1.335	0.97
5_S	300_L	1.335	0.97
387_L	436_I	1.331	0.97
203_R	212_I	1.329	0.97
81_I	150_L	1.327	0.97
146_R	205_R	1.318	0.97
635_Q	638_I	1.317	0.97
122_A	125_N	1.316	0.97
408_E	433_R	1.316	0.97
245_I	285_V	1.311	0.97
4_P	297_D	1.306	0.97
176_R	222_V	1.305	0.97
467_V	630_N	1.301	0.97
377_L	389_F	1.296	0.97
449_V	453_Q	1.295	0.97
141_I	184_W	1.295	0.97
527_G	532_W	1.294	0.97
7_F	324_A	1.292	0.97
389_F	668_L	1.287	0.97
195_A	214_Y	1.285	0.97
368_I	371_A	1.283	0.97
595_V	607_V	1.283	0.97
42_A	45_A	1.282	0.97
435_M	439_T	1.281	0.97
314_F	321_L	1.280	0.97
378_A	454_L	1.272	0.96
402_L	441_V	1.266	0.96
133_S	136_E	1.266	0.96
382_A	404_D	1.266	0.96
152_R	210_F	1.256	0.96
276_L	284_L	1.256	0.96
18_K	325_Q	1.250	0.96
38_E	42_A	1.249	0.96
606_H	613_T	1.247	0.96
120_L	179_Q	1.240	0.96
527_G	531_E	1.228	0.96
499_A	525_I	1.228	0.96
233_E	237_A	1.227	0.96
7_F	321_L	1.226	0.96
193_R	197_E	1.226	0.96
294_Q	329_A	1.225	0.96
206_V	210_F	1.224	0.96
23_M	47_R	1.224	0.96
647_I	665_G	1.222	0.95
290_I	296_A	1.218	0.95
188_Y	237_A	1.218	0.95
7_F	21_V	1.216	0.95
189_R	233_E	1.212	0.95
391_I	435_M	1.211	0.95
480_K	602_D	1.204	0.95
634_A	638_I	1.197	0.95
371_A	398_H	1.197	0.95
196_V	241_A	1.196	0.95
98_I	156_Y	1.196	0.95
392_N	665_G	1.194	0.95
238_I	246_I	1.194	0.95
267_G	299_I	1.193	0.95
501_I	625_A	1.191	0.95
142_D	146_R	1.191	0.95
188_Y	233_E	1.190	0.95
433_R	437_E	1.188	0.95
14_F	244_T	1.185	0.95
377_L	393_A	1.184	0.95
24_G	309_S	1.182	0.95
404_D	449_V	1.180	0.95
3_Y	329_A	1.179	0.95
476_I	623_I	1.178	0.94
152_R	206_V	1.178	0.94
99_A	213_I	1.174	0.94
277_K	306_D	1.170	0.94
116_A	119_A	1.168	0.94
162_M	165_E	1.165	0.94
515_S	587_R	1.165	0.94
496_N	519_E	1.163	0.94
188_Y	192_M	1.162	0.94
409_I	445_L	1.157	0.94
165_E	249_G	1.157	0.94
15_T	158_G	1.156	0.94
487_V	492_A	1.147	0.94
89_E	93_Q	1.146	0.94
451_A	636_P	1.146	0.94
74_M	80_Q	1.143	0.94
60_I	100_L	1.142	0.94
380_V	462_L	1.133	0.93
145_A	204_E	1.127	0.93
395_A	439_T	1.124	0.93
382_A	387_L	1.124	0.93
299_I	304_D	1.123	0.93
228_F	232_V	1.122	0.93
634_A	646_L	1.122	0.93
206_V	212_I	1.121	0.93
604_G	615_V	1.120	0.93
375_K	398_H	1.115	0.93
63_D	139_Q	1.115	0.93
609_I	612_E	1.114	0.93
237_A	240_A	1.114	0.93
515_S	589_V	1.112	0.93
290_I	299_I	1.112	0.93
608_V	613_T	1.112	0.93
246_I	280_V	1.110	0.93
275_K	279_H	1.098	0.92
529_C	533_G	1.095	0.92
132_L	137_I	1.093	0.92
637_L	640_S	1.092	0.92
232_V	236_Q	1.090	0.92
388_A	392_N	1.087	0.92
214_Y	238_I	1.086	0.92
248_T	276_L	1.086	0.92
75_L	147_C	1.076	0.91
408_E	414_N	1.073	0.91
51_G	325_Q	1.073	0.91
345_Q	659_R	1.065	0.91
46_E	49_R	1.065	0.91
297_D	301_S	1.065	0.91
22_L	56_V	1.065	0.91
310_M	320_L	1.063	0.91
65_T	139_Q	1.062	0.91
211_I	245_I	1.059	0.91
401_T	457_F	1.057	0.91
289_R	337_G	1.050	0.90
36_G	83_H	1.045	0.90
50_H	322_S	1.043	0.90
196_V	200_R	1.042	0.90
44_Y	55_I	1.040	0.90
131_E	181_S	1.027	0.89
608_V	611_G	1.026	0.89
202_V	212_I	1.025	0.89
452_D	455_Q	1.021	0.89
68_G	105_T	1.019	0.89
607_V	616_L	1.019	0.89
107_R	171_E	1.014	0.89
32_E	35_D	1.011	0.89
270_S	304_D	1.010	0.88
382_A	443_L	1.008	0.88
461_I	668_L	1.006	0.88
214_Y	243_A	1.004	0.88
218_M	248_T	1.002	0.88
414_N	417_K	1.000	0.88
601_D	615_V	0.997	0.88
427_E	430_R	0.993	0.88
270_S	286_T	0.992	0.88
633_L	636_P	0.991	0.88
17_L	307_M	0.990	0.87
487_V	491_K	0.987	0.87
158_G	211_I	0.986	0.87
136_E	139_Q	0.983	0.87
139_Q	143_N	0.977	0.87
618_V	621_V	0.976	0.87
88_T	98_I	0.976	0.87
228_F	279_H	0.976	0.87
15_T	99_A	0.973	0.87
469_R	628_E	0.970	0.86
145_A	202_V	0.968	0.86
176_R	223_E	0.968	0.86
24_G	311_A	0.967	0.86
12_L	211_I	0.965	0.86
422_K	425_F	0.962	0.86
196_V	243_A	0.961	0.86
481_V	600_I	0.961	0.86
470_T	483_S	0.956	0.86
525_I	607_V	0.956	0.86
403_F	447_H	0.953	0.85
316_A	356_V	0.952	0.85
51_G	322_S	0.951	0.85
527_G	533_G	0.949	0.85
374_K	398_H	0.948	0.85
239_E	280_V	0.948	0.85
145_A	149_Q	0.946	0.85
473_I	476_I	0.946	0.85
576_T	579_I	0.946	0.85
392_N	396_R	0.945	0.85
137_I	141_I	0.945	0.85
334_T	430_R	0.945	0.85
56_V	99_A	0.945	0.85
39_R	351_V	0.941	0.85
529_C	532_W	0.939	0.85
387_L	402_L	0.937	0.84
285_V	307_M	0.933	0.84
39_R	365_K	0.933	0.84
146_R	149_Q	0.931	0.84
101_Q	160_E	0.929	0.84
315_L	360_A	0.928	0.84
419_I	422_K	0.926	0.84
488_L	513_Y	0.926	0.84
235_A	246_I	0.925	0.84
54_L	95_G	0.923	0.84
163_G	195_A	0.922	0.83
41_A	90_A	0.921	0.83
392_N	395_A	0.921	0.83
647_I	668_L	0.921	0.83
389_F	393_A	0.920	0.83
92_H	97_K	0.920	0.83
584_L	591_M	0.917	0.83
526_A	529_C	0.917	0.83
192_M	195_A	0.914	0.83
162_M	249_G	0.913	0.83
192_M	234_L	0.912	0.83
248_T	273_T	0.912	0.83
470_T	476_I	0.910	0.83
632_A	636_P	0.909	0.83
294_Q	298_D	0.908	0.82
333_N	431_Y	0.908	0.82
483_S	486_D	0.904	0.82
330_D	438_V	0.902	0.82
90_A	94_E	0.900	0.82
54_L	99_A	0.899	0.82
49_R	319_E	0.897	0.82
609_I	614_Q	0.896	0.82
52_V	321_L	0.896	0.82
512_M	583_T	0.895	0.82
490_D	493_P	0.894	0.82
606_H	615_V	0.893	0.81
649_G	653_A	0.891	0.81
647_I	650_C	0.888	0.81
649_G	655_E	0.886	0.81
18_K	97_K	0.885	0.81
17_L	54_L	0.884	0.81
192_M	196_V	0.884	0.81
334_T	427_E	0.884	0.81
495_G	620_N	0.882	0.81
530_N	533_G	0.880	0.80
649_G	656_L	0.880	0.80
149_Q	152_R	0.877	0.80
320_L	324_A	0.876	0.80
140_L	168_L	0.876	0.80
402_L	442_T	0.875	0.80
187_D	193_R	0.875	0.80
477_D	481_V	0.873	0.80
462_L	634_A	0.873	0.80
520_S	590_K	0.871	0.80
486_D	492_A	0.868	0.80
387_L	443_L	0.867	0.79
64_L	76_N	0.864	0.79
203_R	206_V	0.863	0.79
516_Q	587_R	0.862	0.79
387_L	391_I	0.856	0.79
471_P	623_I	0.856	0.79
142_D	205_R	0.850	0.78
89_E	92_H	0.848	0.78
57_S	98_I	0.847	0.78
651_D	654_M	0.847	0.78
184_W	200_R	0.845	0.78
266_R	424_E	0.842	0.77
377_L	459_E	0.841	0.77
494_V	620_N	0.840	0.77
18_K	95_G	0.838	0.77
107_R	166_G	0.837	0.77
577_G	581_R	0.837	0.77
488_L	510_T	0.837	0.77
415_I	489_R	0.834	0.77
199_V	241_A	0.834	0.77
631_R	635_Q	0.829	0.76
388_A	666_T	0.829	0.76
158_G	213_I	0.828	0.76
436_I	439_T	0.826	0.76
75_L	80_Q	0.823	0.76
200_R	204_E	0.822	0.76
164_S	249_G	0.815	0.75
527_G	530_N	0.815	0.75
334_T	431_Y	0.815	0.75
482_L	494_V	0.814	0.75
21_V	52_V	0.814	0.75
525_I	531_E	0.812	0.75
476_I	600_I	0.812	0.75
3_Y	294_Q	0.812	0.75
641_G	644_V	0.810	0.75
196_V	237_A	0.809	0.75
145_A	198_V	0.808	0.74
334_T	428_T	0.807	0.74
284_L	287_T	0.804	0.74
436_I	440_G	0.803	0.74
54_L	97_K	0.802	0.74
344_D	573_G	0.798	0.74
88_T	154_A	0.796	0.73
25_S	247_N	0.792	0.73
116_A	120_L	0.791	0.73
115_V	130_H	0.791	0.73
113_H	130_H	0.790	0.73
394_A	441_V	0.790	0.73
141_I	145_A	0.790	0.73
480_K	600_I	0.790	0.73
376_N	401_T	0.788	0.73
490_D	494_V	0.788	0.73
597_Y	605_L	0.788	0.73
21_V	320_L	0.785	0.72
78_A	82_P	0.783	0.72
412_Q	627_Q	0.783	0.72
243_A	282_L	0.782	0.72
41_A	45_A	0.781	0.72
398_H	458_D	0.779	0.72
161_V	199_V	0.779	0.72
30_L	361_C	0.779	0.72
394_A	439_T	0.779	0.72
116_A	129_P	0.777	0.72
328_R	434_R	0.777	0.72
261_A	576_T	0.776	0.71
99_A	211_I	0.775	0.71
655_E	660_R	0.772	0.71
218_M	276_L	0.771	0.71
274_R	302_R	0.768	0.71
431_Y	435_M	0.768	0.71
111_Q	127_F	0.767	0.71
607_V	614_Q	0.766	0.71
118_S	131_E	0.765	0.70
50_H	321_L	0.762	0.70
451_A	454_L	0.760	0.70
6_L	293_P	0.760	0.70
100_L	151_A	0.759	0.70
213_I	247_N	0.758	0.70
145_A	206_V	0.758	0.70
81_I	154_A	0.758	0.70
388_A	665_G	0.756	0.69
278_G	284_L	0.755	0.69
77_D	80_Q	0.755	0.69
26_M	311_A	0.754	0.69
229_A	275_K	0.753	0.69
449_V	454_L	0.751	0.69
428_T	432_Y	0.749	0.69
130_H	133_S	0.749	0.69
202_V	205_R	0.748	0.69
141_I	194_F	0.747	0.69
137_I	193_R	0.747	0.69
141_I	201_A	0.747	0.69
23_M	26_M	0.745	0.68
480_K	621_V	0.743	0.68
592_I	614_Q	0.743	0.68
62_P	102_I	0.741	0.68
320_L	332_I	0.741	0.68
85_R	88_T	0.740	0.68
429_L	433_R	0.739	0.68
30_L	39_R	0.738	0.68
199_V	238_I	0.738	0.68
13_G	208_N	0.737	0.68
362_H	663_A	0.736	0.67
196_V	238_I	0.734	0.67
326_S	438_V	0.733	0.67
525_I	528_F	0.733	0.67
115_V	140_L	0.733	0.67
14_F	209_D	0.732	0.67
271_W	274_R	0.732	0.67
197_E	200_R	0.726	0.66
513_Y	517_P	0.726	0.66
403_F	453_Q	0.724	0.66
640_S	644_V	0.723	0.66
12_L	244_T	0.720	0.66
8_A	297_D	0.718	0.66
36_G	40_L	0.718	0.66
7_F	320_L	0.717	0.65
526_A	531_E	0.716	0.65
454_L	457_F	0.715	0.65
215_R	247_N	0.715	0.65
276_L	280_V	0.712	0.65
216_L	235_A	0.711	0.65
26_M	47_R	0.710	0.65
600_I	605_L	0.710	0.65
379_V	604_G	0.709	0.65
115_V	136_E	0.709	0.65
448_T	632_A	0.708	0.64
290_I	310_M	0.708	0.64
424_E	427_E	0.707	0.64
379_V	400_V	0.707	0.64
36_G	73_A	0.706	0.64
402_L	445_L	0.706	0.64
404_D	466_I	0.705	0.64
243_A	246_I	0.705	0.64
88_T	92_H	0.704	0.64
271_W	304_D	0.704	0.64
323_K	332_I	0.703	0.64
665_G	668_L	0.703	0.64
379_V	461_I	0.703	0.64
666_T	670_L	0.700	0.64
232_V	276_L	0.700	0.64
362_H	365_K	0.700	0.64
107_R	129_P	0.699	0.63
52_V	55_I	0.697	0.63
359_R	666_T	0.695	0.63
635_Q	639_D	0.695	0.63
406_H	446_N	0.695	0.63
75_L	102_I	0.693	0.63
15_T	245_I	0.693	0.63
216_L	246_I	0.692	0.63
26_M	315_L	0.691	0.63
85_R	153_E	0.691	0.63
75_L	151_A	0.689	0.62
614_Q	617_A	0.689	0.62
486_D	490_D	0.689	0.62
526_A	532_W	0.687	0.62
291_N	337_G	0.687	0.62
141_I	198_V	0.686	0.62
247_N	287_T	0.686	0.62
226_G	231_T	0.685	0.62
305_A	308_V	0.685	0.62
137_I	184_W	0.683	0.62
195_A	234_L	0.683	0.62
340_Q	355_L	0.682	0.62
90_A	93_Q	0.681	0.61
131_E	179_Q	0.680	0.61
444_K	449_V	0.680	0.61
78_A	81_I	0.680	0.61
519_E	620_N	0.680	0.61
138_L	142_D	0.680	0.61
188_Y	226_G	0.679	0.61
181_S	190_N	0.679	0.61
289_R	424_E	0.679	0.61
270_S	295_V	0.678	0.61
28_T	43_F	0.678	0.61
413_F	428_T	0.676	0.61
77_D	81_I	0.676	0.61
419_I	509_D	0.675	0.61
333_N	388_A	0.675	0.61
87_I	91_V	0.674	0.61
138_L	141_I	0.674	0.61
384_P	387_L	0.674	0.61
147_C	150_L	0.672	0.60
211_I	244_T	0.672	0.60
165_E	215_R	0.671	0.60
482_L	622_V	0.671	0.60
292_D	295_V	0.671	0.60
333_N	428_T	0.671	0.60
459_E	668_L	0.670	0.60
520_S	523_Q	0.668	0.60
355_L	656_L	0.668	0.60
525_I	532_W	0.667	0.60
207_G	210_F	0.666	0.60
324_A	332_I	0.665	0.60
405_A	451_A	0.664	0.59
419_I	510_T	0.664	0.59
217_S	220_D	0.664	0.59
198_V	201_A	0.664	0.59
454_L	462_L	0.663	0.59
299_I	302_R	0.663	0.59
649_G	652_V	0.662	0.59
28_T	40_L	0.661	0.59
415_I	490_D	0.661	0.59
183_Q	190_N	0.661	0.59
158_G	245_I	0.659	0.59
496_N	520_S	0.658	0.59
418_Q	491_K	0.658	0.59
203_R	244_T	0.657	0.59
54_L	96_G	0.657	0.59
13_G	244_T	0.657	0.59
218_M	273_T	0.656	0.59
17_L	22_L	0.655	0.58
484_Y	506_I	0.654	0.58
18_K	94_E	0.654	0.58
73_A	80_Q	0.654	0.58
240_A	281_S	0.653	0.58
487_V	622_V	0.653	0.58
134_H	141_I	0.652	0.58
470_T	623_I	0.652	0.58
491_K	494_V	0.652	0.58
487_V	510_T	0.650	0.58
40_L	44_Y	0.650	0.58
449_V	455_Q	0.648	0.58
97_K	157_D	0.647	0.58
59_G	103_L	0.647	0.58
70_E	121_Q	0.647	0.58
8_A	300_L	0.646	0.57
67_V	111_Q	0.646	0.57
375_K	458_D	0.646	0.57
502_G	509_D	0.645	0.57
336_I	355_L	0.644	0.57
232_V	275_K	0.644	0.57
43_F	47_R	0.644	0.57
430_R	433_R	0.643	0.57
173_L	226_G	0.643	0.57
637_L	642_K	0.642	0.57
487_V	490_D	0.641	0.57
117_P	120_L	0.640	0.57
67_V	71_G	0.640	0.57
78_A	147_C	0.640	0.57
276_L	279_H	0.639	0.57
49_R	639_D	0.639	0.57
233_E	236_Q	0.639	0.57
26_M	502_G	0.639	0.57
78_A	153_E	0.638	0.56
287_T	309_S	0.638	0.56
525_I	616_L	0.638	0.56
636_P	641_G	0.636	0.56
23_M	44_Y	0.635	0.56
114_L	125_N	0.635	0.56
13_G	203_R	0.634	0.56
78_A	146_R	0.634	0.56
266_R	427_E	0.634	0.56
38_E	41_A	0.634	0.56
202_V	206_V	0.632	0.56
426_Y	430_R	0.632	0.56
351_V	362_H	0.631	0.56
415_I	485_L	0.631	0.56
393_A	665_G	0.630	0.56
39_R	364_T	0.630	0.56
218_M	231_T	0.629	0.55
358_P	391_I	0.628	0.55
412_Q	485_L	0.627	0.55
107_R	177_T	0.627	0.55
487_V	514_L	0.627	0.55
413_F	656_L	0.625	0.55
24_G	247_N	0.625	0.55
107_R	254_E	0.624	0.55
10_L	17_L	0.624	0.55
278_G	634_A	0.624	0.55
132_L	168_L	0.623	0.55
293_P	320_L	0.619	0.54
301_S	450_T	0.619	0.54
318_A	321_L	0.618	0.54
270_S	305_A	0.617	0.54
391_I	431_Y	0.615	0.54
186_G	190_N	0.615	0.54
518_G	523_Q	0.615	0.54
482_L	493_P	0.614	0.54
203_R	243_A	0.614	0.54
504_G	626_G	0.614	0.54
153_E	209_D	0.609	0.53
422_K	509_D	0.609	0.53
165_E	288_N	0.609	0.53
415_I	488_L	0.609	0.53
293_P	332_I	0.609	0.53
461_I	647_I	0.608	0.53
221_L	250_I	0.607	0.53
189_R	237_A	0.607	0.53
277_K	284_L	0.605	0.53
492_A	620_N	0.605	0.53
60_I	75_L	0.604	0.52
183_Q	193_R	0.604	0.52
637_L	641_G	0.603	0.52
218_M	272_V	0.602	0.52
592_I	616_L	0.602	0.52
366_M	670_L	0.601	0.52
464_S	650_C	0.600	0.52
636_P	640_S	0.599	0.52
317_D	332_I	0.599	0.52
324_A	329_A	0.597	0.52
41_A	86_T	0.597	0.52
488_L	511_A	0.597	0.52
25_S	101_Q	0.596	0.51
192_M	233_E	0.596	0.51
359_R	367_P	0.596	0.51
54_L	92_H	0.596	0.51
388_A	431_Y	0.596	0.51
313_P	320_L	0.596	0.51
582_T	586_S	0.594	0.51
343_L	347_F	0.594	0.51
480_K	616_L	0.593	0.51
203_R	208_N	0.591	0.51
652_V	655_E	0.591	0.51
377_L	461_I	0.591	0.51
484_Y	509_D	0.590	0.51
174_T	220_D	0.590	0.51
367_P	666_T	0.590	0.51
186_G	191_R	0.590	0.51
55_I	98_I	0.588	0.51
4_P	324_A	0.587	0.50
117_P	131_E	0.587	0.50
15_T	18_K	0.587	0.50
478_H	600_I	0.585	0.50
402_L	436_I	0.585	0.50
428_T	662_I	0.585	0.50
232_V	278_G	0.584	0.50
23_M	314_F	0.584	0.50
38_E	44_Y	0.584	0.50
375_K	645_H	0.584	0.50
451_A	640_S	0.583	0.50
137_I	195_A	0.583	0.50
22_L	53_A	0.583	0.50
220_D	226_G	0.582	0.50
317_D	323_K	0.582	0.50
464_S	630_N	0.582	0.50
7_F	18_K	0.582	0.50
102_I	144_F	0.581	0.50
321_L	324_A	0.580	0.50
603_D	615_V	0.580	0.50
509_D	626_G	0.580	0.50
109_S	114_L	0.579	0.49
271_W	275_K	0.579	0.49
404_D	485_L	0.579	0.49
202_V	238_I	0.579	0.49
333_N	435_M	0.578	0.49
148_A	206_V	0.578	0.49
462_L	636_P	0.577	0.49
292_D	329_A	0.575	0.49
378_A	456_A	0.575	0.49
142_D	145_A	0.574	0.49
216_L	231_T	0.574	0.49
99_A	245_I	0.574	0.49
462_L	643_T	0.574	0.49
76_N	80_Q	0.573	0.49
600_I	621_V	0.572	0.49
13_G	211_I	0.570	0.48
502_G	526_A	0.570	0.48
62_P	144_F	0.570	0.48
634_A	644_V	0.570	0.48
121_Q	128_V	0.569	0.48
398_H	669_A	0.568	0.48
388_A	432_Y	0.568	0.48
388_A	436_I	0.567	0.48
632_A	637_L	0.567	0.48
404_D	417_K	0.567	0.48
285_V	309_S	0.566	0.48
3_Y	297_D	0.566	0.48
218_M	246_I	0.565	0.48
108_Y	253_H	0.564	0.48
216_L	226_G	0.563	0.48
11_D	15_T	0.562	0.47
166_G	253_H	0.562	0.47
6_L	321_L	0.561	0.47
10_L	13_G	0.561	0.47
483_S	623_I	0.561	0.47
81_I	153_E	0.560	0.47
86_T	89_E	0.560	0.47
75_L	100_L	0.559	0.47
422_K	504_G	0.559	0.47
17_L	97_K	0.559	0.47
508_F	532_W	0.559	0.47
328_R	438_V	0.558	0.47
525_I	595_V	0.557	0.47
639_D	642_K	0.556	0.47
68_G	352_T	0.556	0.47
481_V	623_I	0.556	0.47
194_F	198_V	0.555	0.47
505_G	509_D	0.554	0.46
282_L	314_F	0.553	0.46
146_R	153_E	0.553	0.46
177_T	220_D	0.553	0.46
227_T	230_E	0.553	0.46
235_A	276_L	0.552	0.46
199_V	243_A	0.552	0.46
396_R	669_A	0.552	0.46
649_G	654_M	0.552	0.46
270_S	298_D	0.552	0.46
379_V	402_L	0.552	0.46
474_D	600_I	0.551	0.46
453_Q	457_F	0.551	0.46
160_E	213_I	0.550	0.46
322_S	328_R	0.550	0.46
356_V	428_T	0.550	0.46
144_F	346_I	0.550	0.46
80_Q	147_C	0.550	0.46
239_E	283_P	0.548	0.46
634_A	637_L	0.547	0.46
199_V	212_I	0.547	0.46
402_L	439_T	0.546	0.46
189_R	193_R	0.546	0.46
24_G	310_M	0.546	0.46
175_L	224_D	0.546	0.46
368_I	670_L	0.545	0.45
663_A	666_T	0.545	0.45
98_I	157_D	0.544	0.45
162_M	288_N	0.544	0.45
629_P	646_L	0.543	0.45
291_N	424_E	0.543	0.45
525_I	529_C	0.543	0.45
471_P	600_I	0.542	0.45
372_V	398_H	0.542	0.45
358_P	392_N	0.542	0.45
605_L	618_V	0.541	0.45
250_I	269_F	0.541	0.45
230_E	233_E	0.540	0.45
166_G	254_E	0.540	0.45
65_T	132_L	0.540	0.45
27_H	162_M	0.540	0.45
27_H	59_G	0.540	0.45
266_R	295_V	0.540	0.45
65_T	140_L	0.539	0.45
415_I	665_G	0.539	0.45
75_L	150_L	0.538	0.45
12_L	15_T	0.538	0.45
478_H	601_D	0.538	0.45
63_D	140_L	0.538	0.45
507_G	526_A	0.537	0.44
449_V	644_V	0.537	0.44
162_M	253_H	0.536	0.44
269_F	289_R	0.535	0.44
68_G	72_G	0.535	0.44
449_V	457_F	0.534	0.44
480_K	620_N	0.534	0.44
23_M	167_Y	0.533	0.44
380_V	449_V	0.532	0.44
28_T	58_G	0.532	0.44
355_L	412_Q	0.532	0.44
33_Y	37_A	0.532	0.44
422_K	502_G	0.532	0.44
382_A	445_L	0.531	0.44
32_E	36_G	0.531	0.44
33_Y	36_G	0.530	0.44
198_V	202_V	0.529	0.43
92_H	98_I	0.528	0.43
133_S	139_Q	0.527	0.43
50_H	53_A	0.526	0.43
500_I	515_S	0.526	0.43
461_I	669_A	0.526	0.43
274_R	277_K	0.526	0.43
212_I	243_A	0.525	0.43
599_K	615_V	0.525	0.43
314_F	320_L	0.524	0.43
291_N	427_E	0.523	0.43
334_T	356_V	0.522	0.43
58_G	352_T	0.522	0.43
220_D	225_G	0.521	0.43
509_D	624_C	0.520	0.42
228_F	276_L	0.519	0.42
50_H	314_F	0.519	0.42
245_I	307_M	0.519	0.42
22_L	54_L	0.519	0.42
494_V	514_L	0.519	0.42
415_I	510_T	0.519	0.42
270_S	290_I	0.519	0.42
50_H	318_A	0.518	0.42
102_I	159_V	0.518	0.42
485_L	627_Q	0.517	0.42
6_L	296_A	0.517	0.42
352_T	361_C	0.517	0.42
30_L	360_A	0.517	0.42
3_Y	293_P	0.516	0.42
597_Y	607_V	0.515	0.42
592_I	607_V	0.515	0.42
495_G	519_E	0.515	0.42
73_A	173_L	0.515	0.42
118_S	172_F	0.514	0.42
107_R	167_Y	0.514	0.42
136_E	140_L	0.514	0.42
138_L	200_R	0.513	0.42
333_N	356_V	0.513	0.42
504_G	509_D	0.513	0.42
340_Q	353_S	0.512	0.42
287_T	310_M	0.512	0.42
590_K	617_A	0.512	0.42
216_L	248_T	0.512	0.42
273_T	286_T	0.511	0.41
163_G	169_I	0.510	0.41
366_M	666_T	0.510	0.41
391_I	436_I	0.510	0.41
526_A	593_P	0.510	0.41
56_V	285_V	0.509	0.41
100_L	156_Y	0.509	0.41
144_F	169_I	0.509	0.41
640_S	643_T	0.509	0.41
21_V	324_A	0.508	0.41
37_A	81_I	0.508	0.41
279_H	284_L	0.507	0.41
370_P	374_K	0.506	0.41
119_A	129_P	0.505	0.41
117_P	177_T	0.505	0.41
34_P	37_A	0.504	0.41
439_T	443_L	0.504	0.41
32_E	39_R	0.503	0.40
376_N	456_A	0.503	0.40
422_K	626_G	0.503	0.40
460_T	641_G	0.502	0.40
506_I	624_C	0.502	0.40
18_K	322_S	0.502	0.40
217_S	249_G	0.502	0.40
527_G	596_S	0.501	0.40
137_I	227_T	0.501	0.40
25_S	160_E	0.501	0.40
336_I	356_V	0.501	0.40
420_P	513_Y	0.501	0.40
631_R	634_A	0.500	0.40
42_A	46_E	0.500	0.40
354_C	357_N	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ps9A	1	0.997	100	0.37	Contact Map
3k30A	2	0.933	100	0.374	Contact Map
1o94A	2	0.933	100	0.385	Contact Map
2hsaB	2	0.5179	100	0.606	Contact Map
4qnwA	1	0.5238	100	0.612	Contact Map
3l5aA	1	0.5253	100	0.612	Contact Map
4tmbA	2	0.5327	100	0.615	Contact Map
4gbuA	2	0.5327	100	0.615	Contact Map
4e2bA	1	0.503	100	0.616	Contact Map
3tjlA	2	0.5417	100	0.616	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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