GREMLIN Database
FADH - 2,4-dienoyl-CoA reductase [NADPH]
UniProt: P42593 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12723
Length: 672 (627)
Sequences: 2548 (1701)
Seq/√Len: 67.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
382_A409_I4.5931.00
145_A201_A4.2621.00
405_A448_T3.9841.00
134_H183_Q3.8311.00
187_D190_N3.7961.00
328_R331_E3.7941.00
401_T444_K3.4771.00
500_I511_A3.2671.00
378_A403_F3.0951.00
46_E319_E3.0551.00
436_I443_L2.9181.00
115_V132_L2.9101.00
91_V98_I2.8931.00
10_L307_M2.8901.00
331_E438_V2.8551.00
149_Q205_R2.8481.00
298_D302_R2.7861.00
663_A667_R2.7821.00
99_A158_G2.7391.00
331_E435_M2.7171.00
274_R304_D2.6941.00
270_S299_I2.6671.00
435_M438_V2.6661.00
22_L307_M2.6401.00
376_N399_Q2.6221.00
646_L650_C2.5871.00
322_S326_S2.5521.00
78_A150_L2.5131.00
21_V321_L2.5111.00
132_L140_L2.5101.00
134_H137_I2.4461.00
389_F461_I2.4161.00
119_A131_E2.4061.00
168_L194_F2.3111.00
45_A94_E2.3011.00
213_I245_I2.2951.00
7_F325_Q2.2551.00
436_I441_V2.2541.00
38_E86_T2.2521.00
497_K520_S2.2401.00
403_F449_V2.2041.00
190_N193_R2.2021.00
132_L136_E2.1931.00
399_Q442_T2.1641.00
5_S301_S2.1551.00
378_A457_F2.1331.00
391_I395_A2.1171.00
152_R209_D2.1111.00
274_R278_G2.1101.00
584_L589_V2.1011.00
297_D300_L2.0861.00
130_H136_E2.0821.00
63_D143_N2.0681.00
169_I198_V2.0671.00
169_I195_A2.0561.00
45_A93_Q2.0531.00
486_D491_K2.0501.00
17_L53_A2.0431.00
374_K399_Q2.0411.00
192_M237_A2.0401.00
388_A391_I2.0311.00
371_A374_K2.0301.00
149_Q153_E2.0181.00
598_Q608_V2.0121.00
169_I194_F2.0111.00
654_M664_Q2.0001.00
459_E645_H1.9941.00
407_S446_N1.9831.00
161_V202_V1.9601.00
102_I147_C1.9451.00
142_D201_A1.9401.00
474_D599_K1.9351.00
239_E281_S1.9161.00
236_Q279_H1.8981.00
395_A435_M1.8971.00
382_A402_L1.8791.00
330_D434_R1.8761.00
184_W197_E1.8721.00
163_G214_Y1.8691.00
434_R438_V1.8671.00
11_D16_T1.8531.00
447_H453_Q1.8521.00
499_A618_V1.8511.00
598_Q613_T1.8451.00
592_I595_V1.8411.00
15_T97_K1.8381.00
401_T442_T1.8371.00
495_G619_D1.8351.00
391_I439_T1.8191.00
487_V494_V1.8171.00
92_H157_D1.8061.00
85_R89_E1.8041.00
176_R224_D1.7841.00
238_I243_A1.7791.00
471_P476_I1.7711.00
645_H668_L1.7691.00
482_L487_V1.7611.00
5_S8_A1.7511.00
499_A605_L1.7501.00
665_G669_A1.7481.00
478_H602_D1.7481.00
310_M313_P1.7441.00
49_R94_E1.7431.00
52_V314_F1.7391.00
138_L184_W1.7251.00
450_T453_Q1.7181.00
235_A280_V1.7141.00
145_A205_R1.7141.00
246_I282_L1.6971.00
41_A87_I1.6971.00
596_S608_V1.6910.99
633_L637_L1.6900.99
319_E322_S1.6790.99
603_D617_A1.6780.99
417_K426_Y1.6780.99
459_E643_T1.6730.99
322_S325_Q1.6680.99
326_S331_E1.6670.99
22_L285_V1.6670.99
261_A579_I1.6590.99
292_D320_L1.6570.99
173_L192_M1.6540.99
18_K96_G1.6500.99
403_F444_K1.6270.99
528_F532_W1.6240.99
239_E282_L1.6230.99
201_A204_E1.6100.99
152_R207_G1.6070.99
368_I392_N1.6050.99
590_K614_Q1.5810.99
138_L183_Q1.5740.99
173_L195_A1.5630.99
15_T211_I1.5620.99
651_D664_Q1.5520.99
601_D606_H1.5490.99
482_L492_A1.5430.99
444_K447_H1.5420.99
84_H156_Y1.5420.99
201_A205_R1.5390.99
387_L409_I1.5350.99
497_K619_D1.5190.99
5_S297_D1.5120.99
601_D604_G1.5040.99
482_L620_N1.5000.99
497_K617_A1.4950.99
528_F533_G1.4930.99
138_L201_A1.4880.99
134_H184_W1.4840.99
267_G295_V1.4790.99
46_E359_R1.4770.99
134_H138_L1.4770.99
286_T305_A1.4750.99
402_L409_I1.4690.99
138_L197_E1.4690.99
146_R150_L1.4680.99
275_K278_G1.4550.98
42_A364_T1.4480.98
45_A90_A1.4360.98
331_E434_R1.4310.98
299_I305_A1.4310.98
88_T156_Y1.4290.98
45_A49_R1.4170.98
378_A449_V1.4130.98
473_I600_I1.4110.98
432_Y436_I1.4050.98
599_K606_H1.4050.98
522_S592_I1.4040.98
392_N666_T1.4030.98
368_I666_T1.3990.98
403_F457_F1.3950.98
200_R241_A1.3950.98
377_L668_L1.3910.98
375_K459_E1.3860.98
14_F211_I1.3820.98
120_L129_P1.3800.98
232_V279_H1.3680.98
228_F275_K1.3610.98
434_R437_E1.3570.98
409_I443_L1.3520.98
409_I433_R1.3520.98
11_D14_F1.3430.97
528_F531_E1.3350.97
5_S300_L1.3350.97
387_L436_I1.3310.97
203_R212_I1.3290.97
81_I150_L1.3270.97
146_R205_R1.3180.97
635_Q638_I1.3170.97
122_A125_N1.3160.97
408_E433_R1.3160.97
245_I285_V1.3110.97
4_P297_D1.3060.97
176_R222_V1.3050.97
467_V630_N1.3010.97
377_L389_F1.2960.97
449_V453_Q1.2950.97
141_I184_W1.2950.97
527_G532_W1.2940.97
7_F324_A1.2920.97
389_F668_L1.2870.97
195_A214_Y1.2850.97
368_I371_A1.2830.97
595_V607_V1.2830.97
42_A45_A1.2820.97
435_M439_T1.2810.97
314_F321_L1.2800.97
378_A454_L1.2720.96
402_L441_V1.2660.96
133_S136_E1.2660.96
382_A404_D1.2660.96
152_R210_F1.2560.96
276_L284_L1.2560.96
18_K325_Q1.2500.96
38_E42_A1.2490.96
606_H613_T1.2470.96
120_L179_Q1.2400.96
527_G531_E1.2280.96
499_A525_I1.2280.96
233_E237_A1.2270.96
7_F321_L1.2260.96
193_R197_E1.2260.96
294_Q329_A1.2250.96
206_V210_F1.2240.96
23_M47_R1.2240.96
647_I665_G1.2220.95
290_I296_A1.2180.95
188_Y237_A1.2180.95
7_F21_V1.2160.95
189_R233_E1.2120.95
391_I435_M1.2110.95
480_K602_D1.2040.95
634_A638_I1.1970.95
371_A398_H1.1970.95
196_V241_A1.1960.95
98_I156_Y1.1960.95
392_N665_G1.1940.95
238_I246_I1.1940.95
267_G299_I1.1930.95
501_I625_A1.1910.95
142_D146_R1.1910.95
188_Y233_E1.1900.95
433_R437_E1.1880.95
14_F244_T1.1850.95
377_L393_A1.1840.95
24_G309_S1.1820.95
404_D449_V1.1800.95
3_Y329_A1.1790.95
476_I623_I1.1780.94
152_R206_V1.1780.94
99_A213_I1.1740.94
277_K306_D1.1700.94
116_A119_A1.1680.94
162_M165_E1.1650.94
515_S587_R1.1650.94
496_N519_E1.1630.94
188_Y192_M1.1620.94
409_I445_L1.1570.94
165_E249_G1.1570.94
15_T158_G1.1560.94
487_V492_A1.1470.94
89_E93_Q1.1460.94
451_A636_P1.1460.94
74_M80_Q1.1430.94
60_I100_L1.1420.94
380_V462_L1.1330.93
145_A204_E1.1270.93
395_A439_T1.1240.93
382_A387_L1.1240.93
299_I304_D1.1230.93
228_F232_V1.1220.93
634_A646_L1.1220.93
206_V212_I1.1210.93
604_G615_V1.1200.93
375_K398_H1.1150.93
63_D139_Q1.1150.93
609_I612_E1.1140.93
237_A240_A1.1140.93
515_S589_V1.1120.93
290_I299_I1.1120.93
608_V613_T1.1120.93
246_I280_V1.1100.93
275_K279_H1.0980.92
529_C533_G1.0950.92
132_L137_I1.0930.92
637_L640_S1.0920.92
232_V236_Q1.0900.92
388_A392_N1.0870.92
214_Y238_I1.0860.92
248_T276_L1.0860.92
75_L147_C1.0760.91
408_E414_N1.0730.91
51_G325_Q1.0730.91
345_Q659_R1.0650.91
46_E49_R1.0650.91
297_D301_S1.0650.91
22_L56_V1.0650.91
310_M320_L1.0630.91
65_T139_Q1.0620.91
211_I245_I1.0590.91
401_T457_F1.0570.91
289_R337_G1.0500.90
36_G83_H1.0450.90
50_H322_S1.0430.90
196_V200_R1.0420.90
44_Y55_I1.0400.90
131_E181_S1.0270.89
608_V611_G1.0260.89
202_V212_I1.0250.89
452_D455_Q1.0210.89
68_G105_T1.0190.89
607_V616_L1.0190.89
107_R171_E1.0140.89
32_E35_D1.0110.89
270_S304_D1.0100.88
382_A443_L1.0080.88
461_I668_L1.0060.88
214_Y243_A1.0040.88
218_M248_T1.0020.88
414_N417_K1.0000.88
601_D615_V0.9970.88
427_E430_R0.9930.88
270_S286_T0.9920.88
633_L636_P0.9910.88
17_L307_M0.9900.87
487_V491_K0.9870.87
158_G211_I0.9860.87
136_E139_Q0.9830.87
139_Q143_N0.9770.87
618_V621_V0.9760.87
88_T98_I0.9760.87
228_F279_H0.9760.87
15_T99_A0.9730.87
469_R628_E0.9700.86
145_A202_V0.9680.86
176_R223_E0.9680.86
24_G311_A0.9670.86
12_L211_I0.9650.86
422_K425_F0.9620.86
196_V243_A0.9610.86
481_V600_I0.9610.86
470_T483_S0.9560.86
525_I607_V0.9560.86
403_F447_H0.9530.85
316_A356_V0.9520.85
51_G322_S0.9510.85
527_G533_G0.9490.85
374_K398_H0.9480.85
239_E280_V0.9480.85
145_A149_Q0.9460.85
473_I476_I0.9460.85
576_T579_I0.9460.85
392_N396_R0.9450.85
137_I141_I0.9450.85
334_T430_R0.9450.85
56_V99_A0.9450.85
39_R351_V0.9410.85
529_C532_W0.9390.85
387_L402_L0.9370.84
285_V307_M0.9330.84
39_R365_K0.9330.84
146_R149_Q0.9310.84
101_Q160_E0.9290.84
315_L360_A0.9280.84
419_I422_K0.9260.84
488_L513_Y0.9260.84
235_A246_I0.9250.84
54_L95_G0.9230.84
163_G195_A0.9220.83
41_A90_A0.9210.83
392_N395_A0.9210.83
647_I668_L0.9210.83
389_F393_A0.9200.83
92_H97_K0.9200.83
584_L591_M0.9170.83
526_A529_C0.9170.83
192_M195_A0.9140.83
162_M249_G0.9130.83
192_M234_L0.9120.83
248_T273_T0.9120.83
470_T476_I0.9100.83
632_A636_P0.9090.83
294_Q298_D0.9080.82
333_N431_Y0.9080.82
483_S486_D0.9040.82
330_D438_V0.9020.82
90_A94_E0.9000.82
54_L99_A0.8990.82
49_R319_E0.8970.82
609_I614_Q0.8960.82
52_V321_L0.8960.82
512_M583_T0.8950.82
490_D493_P0.8940.82
606_H615_V0.8930.81
649_G653_A0.8910.81
647_I650_C0.8880.81
649_G655_E0.8860.81
18_K97_K0.8850.81
17_L54_L0.8840.81
192_M196_V0.8840.81
334_T427_E0.8840.81
495_G620_N0.8820.81
530_N533_G0.8800.80
649_G656_L0.8800.80
149_Q152_R0.8770.80
320_L324_A0.8760.80
140_L168_L0.8760.80
402_L442_T0.8750.80
187_D193_R0.8750.80
477_D481_V0.8730.80
462_L634_A0.8730.80
520_S590_K0.8710.80
486_D492_A0.8680.80
387_L443_L0.8670.79
64_L76_N0.8640.79
203_R206_V0.8630.79
516_Q587_R0.8620.79
387_L391_I0.8560.79
471_P623_I0.8560.79
142_D205_R0.8500.78
89_E92_H0.8480.78
57_S98_I0.8470.78
651_D654_M0.8470.78
184_W200_R0.8450.78
266_R424_E0.8420.77
377_L459_E0.8410.77
494_V620_N0.8400.77
18_K95_G0.8380.77
107_R166_G0.8370.77
577_G581_R0.8370.77
488_L510_T0.8370.77
415_I489_R0.8340.77
199_V241_A0.8340.77
631_R635_Q0.8290.76
388_A666_T0.8290.76
158_G213_I0.8280.76
436_I439_T0.8260.76
75_L80_Q0.8230.76
200_R204_E0.8220.76
164_S249_G0.8150.75
527_G530_N0.8150.75
334_T431_Y0.8150.75
482_L494_V0.8140.75
21_V52_V0.8140.75
525_I531_E0.8120.75
476_I600_I0.8120.75
3_Y294_Q0.8120.75
641_G644_V0.8100.75
196_V237_A0.8090.75
145_A198_V0.8080.74
334_T428_T0.8070.74
284_L287_T0.8040.74
436_I440_G0.8030.74
54_L97_K0.8020.74
344_D573_G0.7980.74
88_T154_A0.7960.73
25_S247_N0.7920.73
116_A120_L0.7910.73
115_V130_H0.7910.73
113_H130_H0.7900.73
394_A441_V0.7900.73
141_I145_A0.7900.73
480_K600_I0.7900.73
376_N401_T0.7880.73
490_D494_V0.7880.73
597_Y605_L0.7880.73
21_V320_L0.7850.72
78_A82_P0.7830.72
412_Q627_Q0.7830.72
243_A282_L0.7820.72
41_A45_A0.7810.72
398_H458_D0.7790.72
161_V199_V0.7790.72
30_L361_C0.7790.72
394_A439_T0.7790.72
116_A129_P0.7770.72
328_R434_R0.7770.72
261_A576_T0.7760.71
99_A211_I0.7750.71
655_E660_R0.7720.71
218_M276_L0.7710.71
274_R302_R0.7680.71
431_Y435_M0.7680.71
111_Q127_F0.7670.71
607_V614_Q0.7660.71
118_S131_E0.7650.70
50_H321_L0.7620.70
451_A454_L0.7600.70
6_L293_P0.7600.70
100_L151_A0.7590.70
213_I247_N0.7580.70
145_A206_V0.7580.70
81_I154_A0.7580.70
388_A665_G0.7560.69
278_G284_L0.7550.69
77_D80_Q0.7550.69
26_M311_A0.7540.69
229_A275_K0.7530.69
449_V454_L0.7510.69
428_T432_Y0.7490.69
130_H133_S0.7490.69
202_V205_R0.7480.69
141_I194_F0.7470.69
137_I193_R0.7470.69
141_I201_A0.7470.69
23_M26_M0.7450.68
480_K621_V0.7430.68
592_I614_Q0.7430.68
62_P102_I0.7410.68
320_L332_I0.7410.68
85_R88_T0.7400.68
429_L433_R0.7390.68
30_L39_R0.7380.68
199_V238_I0.7380.68
13_G208_N0.7370.68
362_H663_A0.7360.67
196_V238_I0.7340.67
326_S438_V0.7330.67
525_I528_F0.7330.67
115_V140_L0.7330.67
14_F209_D0.7320.67
271_W274_R0.7320.67
197_E200_R0.7260.66
513_Y517_P0.7260.66
403_F453_Q0.7240.66
640_S644_V0.7230.66
12_L244_T0.7200.66
8_A297_D0.7180.66
36_G40_L0.7180.66
7_F320_L0.7170.65
526_A531_E0.7160.65
454_L457_F0.7150.65
215_R247_N0.7150.65
276_L280_V0.7120.65
216_L235_A0.7110.65
26_M47_R0.7100.65
600_I605_L0.7100.65
379_V604_G0.7090.65
115_V136_E0.7090.65
448_T632_A0.7080.64
290_I310_M0.7080.64
424_E427_E0.7070.64
379_V400_V0.7070.64
36_G73_A0.7060.64
402_L445_L0.7060.64
404_D466_I0.7050.64
243_A246_I0.7050.64
88_T92_H0.7040.64
271_W304_D0.7040.64
323_K332_I0.7030.64
665_G668_L0.7030.64
379_V461_I0.7030.64
666_T670_L0.7000.64
232_V276_L0.7000.64
362_H365_K0.7000.64
107_R129_P0.6990.63
52_V55_I0.6970.63
359_R666_T0.6950.63
635_Q639_D0.6950.63
406_H446_N0.6950.63
75_L102_I0.6930.63
15_T245_I0.6930.63
216_L246_I0.6920.63
26_M315_L0.6910.63
85_R153_E0.6910.63
75_L151_A0.6890.62
614_Q617_A0.6890.62
486_D490_D0.6890.62
526_A532_W0.6870.62
291_N337_G0.6870.62
141_I198_V0.6860.62
247_N287_T0.6860.62
226_G231_T0.6850.62
305_A308_V0.6850.62
137_I184_W0.6830.62
195_A234_L0.6830.62
340_Q355_L0.6820.62
90_A93_Q0.6810.61
131_E179_Q0.6800.61
444_K449_V0.6800.61
78_A81_I0.6800.61
519_E620_N0.6800.61
138_L142_D0.6800.61
188_Y226_G0.6790.61
181_S190_N0.6790.61
289_R424_E0.6790.61
270_S295_V0.6780.61
28_T43_F0.6780.61
413_F428_T0.6760.61
77_D81_I0.6760.61
419_I509_D0.6750.61
333_N388_A0.6750.61
87_I91_V0.6740.61
138_L141_I0.6740.61
384_P387_L0.6740.61
147_C150_L0.6720.60
211_I244_T0.6720.60
165_E215_R0.6710.60
482_L622_V0.6710.60
292_D295_V0.6710.60
333_N428_T0.6710.60
459_E668_L0.6700.60
520_S523_Q0.6680.60
355_L656_L0.6680.60
525_I532_W0.6670.60
207_G210_F0.6660.60
324_A332_I0.6650.60
405_A451_A0.6640.59
419_I510_T0.6640.59
217_S220_D0.6640.59
198_V201_A0.6640.59
454_L462_L0.6630.59
299_I302_R0.6630.59
649_G652_V0.6620.59
28_T40_L0.6610.59
415_I490_D0.6610.59
183_Q190_N0.6610.59
158_G245_I0.6590.59
496_N520_S0.6580.59
418_Q491_K0.6580.59
203_R244_T0.6570.59
54_L96_G0.6570.59
13_G244_T0.6570.59
218_M273_T0.6560.59
17_L22_L0.6550.58
484_Y506_I0.6540.58
18_K94_E0.6540.58
73_A80_Q0.6540.58
240_A281_S0.6530.58
487_V622_V0.6530.58
134_H141_I0.6520.58
470_T623_I0.6520.58
491_K494_V0.6520.58
487_V510_T0.6500.58
40_L44_Y0.6500.58
449_V455_Q0.6480.58
97_K157_D0.6470.58
59_G103_L0.6470.58
70_E121_Q0.6470.58
8_A300_L0.6460.57
67_V111_Q0.6460.57
375_K458_D0.6460.57
502_G509_D0.6450.57
336_I355_L0.6440.57
232_V275_K0.6440.57
43_F47_R0.6440.57
430_R433_R0.6430.57
173_L226_G0.6430.57
637_L642_K0.6420.57
487_V490_D0.6410.57
117_P120_L0.6400.57
67_V71_G0.6400.57
78_A147_C0.6400.57
276_L279_H0.6390.57
49_R639_D0.6390.57
233_E236_Q0.6390.57
26_M502_G0.6390.57
78_A153_E0.6380.56
287_T309_S0.6380.56
525_I616_L0.6380.56
636_P641_G0.6360.56
23_M44_Y0.6350.56
114_L125_N0.6350.56
13_G203_R0.6340.56
78_A146_R0.6340.56
266_R427_E0.6340.56
38_E41_A0.6340.56
202_V206_V0.6320.56
426_Y430_R0.6320.56
351_V362_H0.6310.56
415_I485_L0.6310.56
393_A665_G0.6300.56
39_R364_T0.6300.56
218_M231_T0.6290.55
358_P391_I0.6280.55
412_Q485_L0.6270.55
107_R177_T0.6270.55
487_V514_L0.6270.55
413_F656_L0.6250.55
24_G247_N0.6250.55
107_R254_E0.6240.55
10_L17_L0.6240.55
278_G634_A0.6240.55
132_L168_L0.6230.55
293_P320_L0.6190.54
301_S450_T0.6190.54
318_A321_L0.6180.54
270_S305_A0.6170.54
391_I431_Y0.6150.54
186_G190_N0.6150.54
518_G523_Q0.6150.54
482_L493_P0.6140.54
203_R243_A0.6140.54
504_G626_G0.6140.54
153_E209_D0.6090.53
422_K509_D0.6090.53
165_E288_N0.6090.53
415_I488_L0.6090.53
293_P332_I0.6090.53
461_I647_I0.6080.53
221_L250_I0.6070.53
189_R237_A0.6070.53
277_K284_L0.6050.53
492_A620_N0.6050.53
60_I75_L0.6040.52
183_Q193_R0.6040.52
637_L641_G0.6030.52
218_M272_V0.6020.52
592_I616_L0.6020.52
366_M670_L0.6010.52
464_S650_C0.6000.52
636_P640_S0.5990.52
317_D332_I0.5990.52
324_A329_A0.5970.52
41_A86_T0.5970.52
488_L511_A0.5970.52
25_S101_Q0.5960.51
192_M233_E0.5960.51
359_R367_P0.5960.51
54_L92_H0.5960.51
388_A431_Y0.5960.51
313_P320_L0.5960.51
582_T586_S0.5940.51
343_L347_F0.5940.51
480_K616_L0.5930.51
203_R208_N0.5910.51
652_V655_E0.5910.51
377_L461_I0.5910.51
484_Y509_D0.5900.51
174_T220_D0.5900.51
367_P666_T0.5900.51
186_G191_R0.5900.51
55_I98_I0.5880.51
4_P324_A0.5870.50
117_P131_E0.5870.50
15_T18_K0.5870.50
478_H600_I0.5850.50
402_L436_I0.5850.50
428_T662_I0.5850.50
232_V278_G0.5840.50
23_M314_F0.5840.50
38_E44_Y0.5840.50
375_K645_H0.5840.50
451_A640_S0.5830.50
137_I195_A0.5830.50
22_L53_A0.5830.50
220_D226_G0.5820.50
317_D323_K0.5820.50
464_S630_N0.5820.50
7_F18_K0.5820.50
102_I144_F0.5810.50
321_L324_A0.5800.50
603_D615_V0.5800.50
509_D626_G0.5800.50
109_S114_L0.5790.49
271_W275_K0.5790.49
404_D485_L0.5790.49
202_V238_I0.5790.49
333_N435_M0.5780.49
148_A206_V0.5780.49
462_L636_P0.5770.49
292_D329_A0.5750.49
378_A456_A0.5750.49
142_D145_A0.5740.49
216_L231_T0.5740.49
99_A245_I0.5740.49
462_L643_T0.5740.49
76_N80_Q0.5730.49
600_I621_V0.5720.49
13_G211_I0.5700.48
502_G526_A0.5700.48
62_P144_F0.5700.48
634_A644_V0.5700.48
121_Q128_V0.5690.48
398_H669_A0.5680.48
388_A432_Y0.5680.48
388_A436_I0.5670.48
632_A637_L0.5670.48
404_D417_K0.5670.48
285_V309_S0.5660.48
3_Y297_D0.5660.48
218_M246_I0.5650.48
108_Y253_H0.5640.48
216_L226_G0.5630.48
11_D15_T0.5620.47
166_G253_H0.5620.47
6_L321_L0.5610.47
10_L13_G0.5610.47
483_S623_I0.5610.47
81_I153_E0.5600.47
86_T89_E0.5600.47
75_L100_L0.5590.47
422_K504_G0.5590.47
17_L97_K0.5590.47
508_F532_W0.5590.47
328_R438_V0.5580.47
525_I595_V0.5570.47
639_D642_K0.5560.47
68_G352_T0.5560.47
481_V623_I0.5560.47
194_F198_V0.5550.47
505_G509_D0.5540.46
282_L314_F0.5530.46
146_R153_E0.5530.46
177_T220_D0.5530.46
227_T230_E0.5530.46
235_A276_L0.5520.46
199_V243_A0.5520.46
396_R669_A0.5520.46
649_G654_M0.5520.46
270_S298_D0.5520.46
379_V402_L0.5520.46
474_D600_I0.5510.46
453_Q457_F0.5510.46
160_E213_I0.5500.46
322_S328_R0.5500.46
356_V428_T0.5500.46
144_F346_I0.5500.46
80_Q147_C0.5500.46
239_E283_P0.5480.46
634_A637_L0.5470.46
199_V212_I0.5470.46
402_L439_T0.5460.46
189_R193_R0.5460.46
24_G310_M0.5460.46
175_L224_D0.5460.46
368_I670_L0.5450.45
663_A666_T0.5450.45
98_I157_D0.5440.45
162_M288_N0.5440.45
629_P646_L0.5430.45
291_N424_E0.5430.45
525_I529_C0.5430.45
471_P600_I0.5420.45
372_V398_H0.5420.45
358_P392_N0.5420.45
605_L618_V0.5410.45
250_I269_F0.5410.45
230_E233_E0.5400.45
166_G254_E0.5400.45
65_T132_L0.5400.45
27_H162_M0.5400.45
27_H59_G0.5400.45
266_R295_V0.5400.45
65_T140_L0.5390.45
415_I665_G0.5390.45
75_L150_L0.5380.45
12_L15_T0.5380.45
478_H601_D0.5380.45
63_D140_L0.5380.45
507_G526_A0.5370.44
449_V644_V0.5370.44
162_M253_H0.5360.44
269_F289_R0.5350.44
68_G72_G0.5350.44
449_V457_F0.5340.44
480_K620_N0.5340.44
23_M167_Y0.5330.44
380_V449_V0.5320.44
28_T58_G0.5320.44
355_L412_Q0.5320.44
33_Y37_A0.5320.44
422_K502_G0.5320.44
382_A445_L0.5310.44
32_E36_G0.5310.44
33_Y36_G0.5300.44
198_V202_V0.5290.43
92_H98_I0.5280.43
133_S139_Q0.5270.43
50_H53_A0.5260.43
500_I515_S0.5260.43
461_I669_A0.5260.43
274_R277_K0.5260.43
212_I243_A0.5250.43
599_K615_V0.5250.43
314_F320_L0.5240.43
291_N427_E0.5230.43
334_T356_V0.5220.43
58_G352_T0.5220.43
220_D225_G0.5210.43
509_D624_C0.5200.42
228_F276_L0.5190.42
50_H314_F0.5190.42
245_I307_M0.5190.42
22_L54_L0.5190.42
494_V514_L0.5190.42
415_I510_T0.5190.42
270_S290_I0.5190.42
50_H318_A0.5180.42
102_I159_V0.5180.42
485_L627_Q0.5170.42
6_L296_A0.5170.42
352_T361_C0.5170.42
30_L360_A0.5170.42
3_Y293_P0.5160.42
597_Y607_V0.5150.42
592_I607_V0.5150.42
495_G519_E0.5150.42
73_A173_L0.5150.42
118_S172_F0.5140.42
107_R167_Y0.5140.42
136_E140_L0.5140.42
138_L200_R0.5130.42
333_N356_V0.5130.42
504_G509_D0.5130.42
340_Q353_S0.5120.42
287_T310_M0.5120.42
590_K617_A0.5120.42
216_L248_T0.5120.42
273_T286_T0.5110.41
163_G169_I0.5100.41
366_M666_T0.5100.41
391_I436_I0.5100.41
526_A593_P0.5100.41
56_V285_V0.5090.41
100_L156_Y0.5090.41
144_F169_I0.5090.41
640_S643_T0.5090.41
21_V324_A0.5080.41
37_A81_I0.5080.41
279_H284_L0.5070.41
370_P374_K0.5060.41
119_A129_P0.5050.41
117_P177_T0.5050.41
34_P37_A0.5040.41
439_T443_L0.5040.41
32_E39_R0.5030.40
376_N456_A0.5030.40
422_K626_G0.5030.40
460_T641_G0.5020.40
506_I624_C0.5020.40
18_K322_S0.5020.40
217_S249_G0.5020.40
527_G596_S0.5010.40
137_I227_T0.5010.40
25_S160_E0.5010.40
336_I356_V0.5010.40
420_P513_Y0.5010.40
631_R634_A0.5000.40
42_A46_E0.5000.40
354_C357_N0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ps9A 1 0.997 100 0.37 Contact Map
3k30A 2 0.933 100 0.374 Contact Map
1o94A 2 0.933 100 0.385 Contact Map
2hsaB 2 0.5179 100 0.606 Contact Map
4qnwA 1 0.5238 100 0.612 Contact Map
3l5aA 1 0.5253 100 0.612 Contact Map
4tmbA 2 0.5327 100 0.615 Contact Map
4gbuA 2 0.5327 100 0.615 Contact Map
4e2bA 1 0.503 100 0.616 Contact Map
3tjlA 2 0.5417 100 0.616 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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