GREMLIN Database
YGJI - Inner membrane transporter YgjI
UniProt: P42590 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12720
Length: 477 (422)
Sequences: 24870 (16204)
Seq/√Len: 788.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_T341_F4.5281.00
323_K335_R4.4171.00
386_N390_K3.2031.00
326_E335_R3.1341.00
227_K231_K3.0331.00
10_G223_K2.8601.00
73_Y317_E2.8161.00
89_A314_E2.7661.00
222_V228_S2.7591.00
224_G227_K2.7461.00
47_T241_G2.7051.00
315_I325_V2.6351.00
171_A250_L2.6131.00
132_M345_I2.5991.00
378_L411_S2.5881.00
328_N334_A2.5781.00
15_L235_L2.4631.00
323_K326_E2.4551.00
169_L173_T2.3961.00
60_E388_R2.3861.00
220_N316_P2.3821.00
11_K235_L2.3811.00
221_D309_K2.2371.00
77_K85_A2.2341.00
408_I412_M2.1861.00
338_W342_L2.1591.00
11_K228_S2.1521.00
139_T337_A2.1501.00
312_F316_P2.1451.00
140_W144_N2.1321.00
14_L222_V2.1091.00
136_A345_I2.0831.00
147_K151_P2.0561.00
11_K15_L2.0511.00
143_T334_A2.0441.00
259_E276_Y2.0401.00
381_M410_V2.0311.00
80_L386_N2.0161.00
231_K235_L1.9651.00
10_G13_G1.9641.00
93_W340_Q1.9551.00
131_S348_M1.9551.00
57_I381_M1.9351.00
272_G275_A1.9341.00
324_T339_I1.9261.00
44_F48_I1.9081.00
77_K82_G1.8991.00
318_G322_K1.8911.00
132_M348_M1.8711.00
158_T162_L1.8641.00
448_G452_W1.8541.00
80_L382_L1.8161.00
13_G154_S1.8151.00
5_K327_L1.7841.00
442_G446_F1.7601.00
136_A341_F1.7511.00
328_N332_V1.7421.00
256_S259_E1.7371.00
234_I238_I1.7301.00
224_G228_S1.7161.00
76_V88_T1.7121.00
15_L239_F1.7041.00
181_P184_A1.6841.00
142_S301_L1.6611.00
43_F46_A1.6601.00
126_A129_I1.6481.00
162_L166_S1.6451.00
272_G276_Y1.6421.00
104_L300_L1.6421.00
100_F344_V1.6371.00
9_I13_G1.6121.00
135_F344_V1.5991.00
412_M416_I1.5951.00
143_T338_W1.5871.00
88_T379_F1.5851.00
111_A130_I1.5821.00
180_Q183_D1.5761.00
330_N334_A1.5731.00
446_F450_A1.5641.00
432_I435_I1.5641.00
450_A454_Y1.5631.00
18_T236_A1.5311.00
238_I242_V1.5311.00
275_A285_N1.5231.00
183_D186_T1.5161.00
40_A43_F1.5111.00
31_N35_L1.5091.00
125_V129_I1.5091.00
440_V444_V1.5071.00
81_G84_W1.5011.00
6_R331_G1.5001.00
218_Y305_A1.4941.00
224_G231_K1.4911.00
386_N389_A1.4911.00
48_I52_I1.4891.00
42_M201_V1.4861.00
180_Q184_A1.4631.00
444_V448_G1.4591.00
311_F336_A1.4571.00
449_F453_K1.4541.00
335_R339_I1.4491.00
107_V134_L1.4421.00
163_L291_V1.4351.00
135_F341_F1.4351.00
139_T338_W1.4351.00
322_K326_E1.4331.00
438_Y442_G1.4271.00
444_V447_L1.4231.00
76_V379_F1.4221.00
104_L135_F1.4191.00
445_I449_F1.4181.00
434_T437_F1.4181.00
275_A280_P1.4101.00
55_C237_G1.4011.00
144_N330_N1.3961.00
39_S43_F1.3951.00
182_A186_T1.3951.00
13_G150_G1.3811.00
307_P340_Q1.3781.00
172_G250_L1.3761.00
442_G445_I1.3711.00
382_L411_S1.3711.00
443_I447_L1.3661.00
312_F327_L1.3651.00
281_E287_F1.3631.00
80_L84_W1.3621.00
286_R290_L1.3491.00
382_L386_N1.3481.00
31_N39_S1.3441.00
308_V337_A1.3401.00
39_S42_M1.3321.00
65_N78_S1.3321.00
69_E220_N1.3281.00
322_K325_V1.3221.00
107_V293_F1.3201.00
181_P186_T1.3001.00
326_E334_A1.2991.00
416_I420_G1.2981.00
161_L165_L1.2951.00
54_F381_M1.2941.00
11_K231_K1.2881.00
436_I440_V1.2851.00
132_M136_A1.2831.00
38_A191_I1.2821.00
435_I444_V1.2781.00
225_G230_V1.2751.00
23_Y26_N1.2711.00
186_T189_A1.2701.00
79_S383_A1.2681.00
391_L394_L1.2421.00
55_C233_I1.2361.00
103_L299_S1.2281.00
175_L253_V1.2271.00
311_F320_F1.2241.00
68_S74_A1.2231.00
22_V240_I1.2201.00
5_K312_F1.2181.00
228_S231_K1.2141.00
74_A78_S1.2141.00
435_I438_Y1.2101.00
138_S300_L1.2091.00
9_I150_G1.2021.00
40_A44_F1.2001.00
48_I409_V1.1971.00
173_T178_G1.1961.00
447_L450_A1.1941.00
128_T132_M1.1931.00
168_I246_V1.1921.00
433_L437_F1.1911.00
56_L234_I1.1831.00
93_W311_F1.1761.00
242_V246_V1.1751.00
32_N39_S1.1601.00
268_Q272_G1.1601.00
18_T215_V1.1561.00
9_I14_L1.1491.00
49_F413_L1.1431.00
68_S78_S1.1401.00
64_L396_R1.1401.00
40_A249_V1.1371.00
171_A254_F1.1341.00
404_R408_I1.1341.00
167_Y171_A1.1321.00
46_A205_I1.1281.00
62_V75_W1.1251.00
58_I72_V1.1211.00
433_L436_I1.1201.00
257_S260_L1.1191.00
189_A192_P1.1161.00
14_L232_V1.1121.00
181_P185_I1.1111.00
141_V152_I1.1101.00
166_S170_L1.1041.00
179_V182_A1.1021.00
223_K228_S1.1001.00
327_L331_G1.0991.00
405_T408_I1.0881.00
446_F453_K1.0851.00
19_F239_F1.0791.00
385_L408_I1.0781.00
447_L451_W1.0731.00
415_A419_V1.0721.00
432_I436_I1.0711.00
437_F440_V1.0691.00
151_P155_V1.0671.00
12_F16_S1.0671.00
446_F452_W1.0641.00
187_V192_P1.0551.00
411_S415_A1.0531.00
186_T190_M1.0531.00
83_R453_K1.0511.00
335_R338_W1.0501.00
76_V84_W1.0501.00
152_I156_T1.0441.00
108_I130_I1.0431.00
8_T223_K1.0401.00
43_F50_Y1.0371.00
73_Y313_S1.0351.00
172_G176_V1.0331.00
41_P44_F1.0321.00
86_F90_Y1.0311.00
342_L346_P1.0291.00
184_A188_D1.0291.00
184_A187_V1.0271.00
378_L415_A1.0271.00
185_I189_A1.0231.00
316_P325_V1.0221.00
57_I407_I1.0221.00
17_L218_Y1.0211.00
64_L394_L1.0191.00
153_T301_L1.0181.00
278_G284_M1.0151.00
405_T409_V1.0141.00
129_I133_V1.0101.00
38_A198_F1.0001.00
392_D396_R0.9971.00
146_A305_A0.9961.00
133_V137_F0.9911.00
165_L169_L0.9861.00
139_T143_T0.9851.00
442_G447_L0.9781.00
210_G373_S0.9751.00
60_E63_S0.9751.00
187_V190_M0.9751.00
136_A140_W0.9691.00
402_S406_G0.9681.00
438_Y441_G0.9631.00
439_N443_I0.9631.00
143_T332_V0.9541.00
399_R402_S0.9491.00
432_I446_F0.9491.00
389_A392_D0.9471.00
111_A293_F0.9431.00
437_F441_G0.9401.00
441_G445_I0.9391.00
414_I417_F0.9381.00
19_F240_I0.9311.00
78_S391_L0.9311.00
186_T191_I0.9241.00
43_F48_I0.9231.00
143_T328_N0.9221.00
378_L382_L0.9211.00
180_Q185_I0.9191.00
63_S397_D0.9181.00
256_S276_Y0.9151.00
434_T446_F0.9041.00
32_N35_L0.9031.00
185_I188_D0.9011.00
156_T298_G0.8981.00
281_E284_M0.8961.00
274_A279_L0.8921.00
191_I195_N0.8911.00
183_D188_D0.8911.00
168_I250_L0.8911.00
102_S207_M0.8891.00
304_T341_F0.8861.00
431_N434_T0.8831.00
47_T209_A0.8831.00
8_T147_K0.8811.00
90_Y320_F0.8811.00
108_I131_S0.8801.00
161_L243_L0.8791.00
434_T438_Y0.8791.00
235_L239_F0.8761.00
137_F297_F0.8751.00
219_V229_F0.8741.00
77_K317_E0.8721.00
403_R407_I0.8711.00
263_T272_G0.8691.00
213_E217_V0.8671.00
324_T335_R0.8661.00
241_G245_S0.8571.00
24_S27_N0.8511.00
160_M295_A0.8491.00
419_V423_A0.8481.00
111_A115_F0.8471.00
403_R406_G0.8451.00
432_I438_Y0.8441.00
16_S154_S0.8391.00
200_G204_W0.8391.00
441_G444_V0.8381.00
138_S301_L0.8381.00
431_N435_I0.8351.00
13_G151_P0.8351.00
167_Y274_A0.8301.00
385_L407_I0.8261.00
102_S366_I0.8251.00
393_H396_R0.8241.00
449_F452_W0.8231.00
249_V253_V0.8201.00
70_A73_Y0.8151.00
435_I439_N0.8151.00
39_S248_S0.8141.00
12_F154_S0.8121.00
328_N331_G0.8121.00
449_F454_Y0.8111.00
189_A193_N0.8081.00
254_F273_M0.8071.00
42_M50_Y0.8051.00
188_D191_I0.8051.00
81_G454_Y0.8031.00
410_V414_I0.7991.00
29_I106_R0.7981.00
84_W379_F0.7981.00
334_A338_W0.7971.00
107_V297_F0.7971.00
182_A185_I0.7941.00
130_I133_V0.7941.00
24_S28_V0.7921.00
341_F345_I0.7901.00
441_G446_F0.7891.00
187_V191_I0.7881.00
320_F324_T0.7881.00
435_I440_V0.7871.00
108_I127_T0.7861.00
442_G449_F0.7851.00
151_P154_S0.7851.00
168_I172_G0.7841.00
416_I419_V0.7811.00
11_K232_V0.7801.00
173_T177_G0.7791.00
175_L178_G0.7791.00
368_M372_A0.7771.00
44_F47_T0.7751.00
76_V383_A0.7731.00
70_A74_A0.7681.00
107_V296_M0.7671.00
43_F47_T0.7651.00
26_N30_N0.7651.00
435_I446_F0.7641.00
5_K221_D0.7631.00
214_S306_T0.7621.00
179_V183_D0.7621.00
64_L397_D0.7591.00
384_Y407_I0.7591.00
135_F348_M0.7551.00
173_T176_V0.7551.00
398_F401_G0.7541.00
210_G377_P0.7541.00
128_T348_M0.7471.00
44_F245_S0.7411.00
190_M195_N0.7321.00
90_Y442_G0.7321.00
394_L397_D0.7281.00
409_V413_L0.7271.00
388_R392_D0.7271.00
437_F442_G0.7221.00
61_F384_Y0.7181.00
5_K309_K0.7171.00
230_V233_I0.7161.00
269_V274_A0.7151.00
182_A187_V0.7131.00
144_N148_M0.7121.00
434_T440_V0.7111.00
191_I194_F0.7111.00
23_Y28_V0.7101.00
432_I442_G0.7101.00
436_I439_N0.7091.00
437_F447_L0.7081.00
105_P365_I0.7051.00
432_I437_F0.7011.00
378_L414_I0.7011.00
132_M349_I0.7001.00
12_F151_P0.7001.00
61_F75_W0.7001.00
40_A252_N0.6991.00
440_V451_W0.6981.00
247_S270_F0.6971.00
443_I449_F0.6951.00
64_L67_N0.6941.00
138_S304_T0.6941.00
33_I36_G0.6931.00
439_N444_V0.6931.00
434_T442_G0.6921.00
268_Q271_H0.6891.00
99_F369_T0.6891.00
438_Y449_F0.6871.00
436_I442_G0.6861.00
175_L250_L0.6861.00
142_S305_A0.6841.00
8_T146_A0.6841.00
191_I198_F0.6831.00
79_S386_N0.6831.00
384_Y388_R0.6811.00
192_P195_N0.6801.00
23_Y160_M0.6791.00
180_Q186_T0.6781.00
436_I444_V0.6771.00
37_L40_A0.6771.00
412_M415_A0.6771.00
188_D192_P0.6741.00
385_L389_A0.6731.00
432_I449_F0.6721.00
168_I247_S0.6671.00
128_T131_S0.6671.00
140_W143_T0.6671.00
417_F420_G0.6671.00
172_G246_V0.6651.00
264_G269_V0.6651.00
185_I190_M0.6631.00
19_F157_S0.6631.00
188_D193_N0.6631.00
407_I421_F0.6611.00
381_M411_S0.6611.00
309_K312_F0.6581.00
436_I451_W0.6571.00
194_F197_A0.6571.00
73_Y77_K0.6571.00
304_T308_V0.6571.00
22_V236_A0.6561.00
438_Y443_I0.6541.00
329_E334_A0.6541.00
417_F421_F0.6521.00
44_F50_Y0.6511.00
342_L345_I0.6511.00
224_G230_V0.6501.00
184_A189_A0.6481.00
438_Y444_V0.6451.00
446_F449_F0.6431.00
390_K393_H0.6431.00
112_S127_T0.6421.00
80_L383_A0.6411.00
395_P399_R0.6391.00
92_Y96_N0.6391.00
15_L232_V0.6391.00
97_L340_Q0.6381.00
69_E312_F0.6381.00
387_L391_L0.6381.00
413_L417_F0.6361.00
99_F102_S0.6331.00
239_F243_L0.6331.00
446_F451_W0.6331.00
333_P336_A0.6331.00
21_A302_M0.6321.00
438_Y450_A0.6321.00
407_I414_I0.6311.00
435_I442_G0.6311.00
83_R87_I0.6291.00
143_T330_N0.6271.00
150_G154_S0.6251.00
235_L238_I0.6251.00
8_T12_F0.6241.00
142_S337_A0.6241.00
138_S297_F0.6241.00
84_W87_I0.6211.00
324_T336_A0.6201.00
79_S387_L0.6201.00
195_N198_F0.6201.00
308_V336_A0.6201.00
383_A387_L0.6191.00
402_S405_T0.6181.00
37_L252_N0.6181.00
442_G450_A0.6171.00
408_I411_S0.6171.00
407_I411_S0.6161.00
41_P45_L0.6151.00
134_L300_L0.6151.00
311_F339_I0.6151.00
37_L257_S0.6151.00
414_I418_A0.6151.00
216_A233_I0.6131.00
98_F368_M0.6131.00
91_T376_P0.6131.00
323_K339_I0.6121.00
190_M193_N0.6111.00
434_T445_I0.6101.00
15_L18_T0.6101.00
58_I380_I0.6061.00
193_N196_W0.6041.00
143_T337_A0.6041.00
114_A290_L0.6031.00
401_G405_T0.6021.00
179_V185_I0.6021.00
101_T347_L0.6011.00
246_V250_L0.5991.00
42_M47_T0.5981.00
54_F414_I0.5971.00
103_L106_R0.5971.00
418_A421_F0.5961.00
148_M151_P0.5941.00
20_A157_S0.5931.00
55_C212_A0.5921.00
73_Y85_A0.5901.00
18_T22_V0.5901.00
57_I410_V0.5881.00
108_I111_A0.5881.00
181_P187_V0.5881.00
450_A453_K0.5871.00
435_I443_I0.5871.00
42_M46_A0.5871.00
432_I445_I0.5851.00
184_A190_M0.5841.00
279_L284_M0.5831.00
390_K394_L0.5821.00
439_N442_G0.5811.00
433_L438_Y0.5811.00
111_A134_L0.5801.00
439_N446_F0.5801.00
30_N366_I0.5801.00
43_F51_F0.5801.00
440_V443_I0.5791.00
438_Y445_I0.5771.00
95_V373_S0.5771.00
73_Y89_A0.5771.00
97_L343_I0.5771.00
101_T365_I0.5761.00
170_L174_A0.5761.00
110_Y292_S0.5761.00
372_A376_P0.5761.00
21_A214_S0.5751.00
446_F454_Y0.5741.00
220_N312_F0.5741.00
221_D327_L0.5731.00
226_S397_D0.5721.00
413_L416_I0.5691.00
195_N199_L0.5691.00
60_E401_G0.5691.00
41_P198_F0.5681.00
410_V413_L0.5681.00
315_I324_T0.5671.00
250_L253_V0.5661.00
398_F402_S0.5641.00
135_F345_I0.5641.00
435_I448_G0.5641.00
210_G213_E0.5631.00
159_L291_V0.5621.00
391_L396_R0.5601.00
25_F28_V0.5591.00
217_V306_T0.5591.00
95_V98_F0.5591.00
72_V213_E0.5591.00
62_V216_A0.5581.00
96_N303_W0.5571.00
199_L416_I0.5561.00
197_A200_G0.5561.00
183_D190_M0.5561.00
280_P286_R0.5551.00
181_P190_M0.5551.00
61_F79_S0.5541.00
400_M406_G0.5531.00
52_I409_V0.5531.00
150_G301_L0.5521.00
433_L440_V0.5511.00
55_C59_A0.5511.00
247_S251_I0.5491.00
40_A50_Y0.5481.00
436_I441_G0.5481.00
431_N438_Y0.5481.00
21_A303_W0.5471.00
113_Y289_G0.5471.00
72_V217_V0.5461.00
251_I270_F0.5451.00
239_F242_V0.5441.00
192_P196_W0.5441.00
136_A139_T0.5441.00
45_L202_T0.5431.00
222_V229_F0.5411.00
146_A218_Y0.5411.00
400_M403_R0.5401.00
145_G148_M0.5401.00
339_I343_I0.5391.00
417_F422_V0.5381.00
104_L108_I0.5381.00
183_D187_V0.5381.00
175_L254_F0.5371.00
34_E200_G0.5361.00
154_S158_T0.5351.00
229_F233_I0.5341.00
112_S116_L0.5341.00
389_A393_H0.5331.00
59_A63_S0.5321.00
439_N450_A0.5321.00
183_D189_A0.5311.00
411_S421_F0.5301.00
434_T451_W0.5301.00
440_V447_L0.5291.00
28_V160_M0.5291.00
42_M45_L0.5281.00
287_F291_V0.5271.00
441_G452_W0.5261.00
159_L163_L0.5251.00
44_F51_F0.5251.00
139_T304_T0.5251.00
62_V229_F0.5251.00
43_F49_F0.5241.00
179_V184_A0.5221.00
24_S29_I0.5211.00
19_F22_V0.5201.00
185_I191_I0.5191.00
99_F103_L0.5171.00
103_L300_L0.5171.00
295_A298_G0.5171.00
170_L278_G0.5161.00
134_L297_F0.5161.00
221_D333_P0.5151.00
54_F213_E0.5151.00
437_F450_A0.5151.00
435_I449_F0.5141.00
23_Y243_L0.5131.00
25_F30_N0.5131.00
434_T443_I0.5111.00
443_I450_A0.5101.00
255_V272_G0.5101.00
445_I448_G0.5071.00
451_W454_Y0.5071.00
346_P349_I0.5061.00
12_F15_L0.5051.00
162_L165_L0.5041.00
47_T51_F0.5031.00
447_L454_Y0.5031.00
106_R110_Y0.5011.00
199_L420_G0.5001.00
182_A190_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8826 100 0.302 Contact Map
4djkA 2 0.9057 100 0.313 Contact Map
3giaA 1 0.8973 100 0.351 Contact Map
2jlnA 1 0.8784 98.9 0.859 Contact Map
3dh4A 3 0.9015 98.8 0.862 Contact Map
2xq2A 2 0.9036 98.8 0.865 Contact Map
2a65A 2 0.9078 98.1 0.89 Contact Map
4xp4A 1 0.9182 97.7 0.899 Contact Map
4wgvA 2 0.782 97.7 0.9 Contact Map
4us3A 1 0.8155 97.3 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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