GREMLIN Database
PAT - Putrescine aminotransferase
UniProt: P42588 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12718
Length: 459 (385)
Sequences: 20615 (12266)
Seq/√Len: 625.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_Q112_A4.2451.00
258_R262_D3.9911.00
411_Q447_K3.9001.00
75_T83_E3.5241.00
215_I256_A3.5221.00
365_M439_E3.3581.00
132_T348_N3.1581.00
70_A77_V3.0611.00
282_K288_H2.8501.00
354_N357_A2.8271.00
365_M435_I2.7631.00
102_V352_E2.7311.00
376_E446_R2.6511.00
105_S109_N2.6331.00
358_Q362_K2.5471.00
434_T437_Q2.5161.00
211_P217_A2.4401.00
87_C441_V2.3581.00
132_T351_L2.3251.00
369_G442_I2.3231.00
256_A259_K2.2791.00
345_A348_N2.2781.00
102_V345_A2.2521.00
259_K263_E2.1931.00
361_Q435_I2.1881.00
102_V349_V2.1871.00
100_N349_V2.1781.00
75_T437_Q2.1611.00
219_R263_E2.1551.00
69_Q79_T2.1491.00
411_Q451_A2.1241.00
407_E410_R2.1181.00
407_E451_A2.0301.00
77_V83_E1.9991.00
377_Y446_R1.9841.00
413_V444_A1.9481.00
369_G439_E1.9341.00
172_T231_D1.9081.00
129_L343_A1.8981.00
132_T344_L1.8971.00
236_I269_I1.8891.00
367_L371_R1.7991.00
104_V108_Q1.7991.00
364_D368_D1.7921.00
143_Y316_E1.7861.00
147_C310_G1.7841.00
124_P128_M1.7731.00
407_E411_Q1.7691.00
218_M257_V1.7681.00
349_V353_Q1.7621.00
440_L444_A1.7541.00
316_E320_S1.7501.00
78_D82_Q1.7461.00
235_V261_C1.7421.00
107_V342_A1.7321.00
82_Q412_R1.7311.00
382_Q396_V1.7301.00
131_K135_A1.7291.00
172_T208_R1.7261.00
177_S211_P1.7051.00
69_Q113_K1.7041.00
237_L257_V1.6901.00
219_R223_N1.6821.00
107_V111_L1.6631.00
213_G250_P1.6611.00
142_K316_E1.6611.00
75_T440_L1.6131.00
72_S101_P1.6121.00
367_L386_G1.5871.00
377_Y450_A1.5861.00
369_G372_Q1.5841.00
222_L266_A1.5691.00
154_V297_C1.5681.00
176_T253_Y1.5511.00
298_L311_A1.5451.00
83_E440_L1.5361.00
282_K360_E1.5321.00
130_A146_F1.5261.00
307_M339_A1.5061.00
369_G443_K1.5061.00
303_G309_I1.4981.00
210_V221_A1.4951.00
362_K365_M1.4791.00
164_Y318_V1.4781.00
74_N437_Q1.4681.00
362_K438_C1.4541.00
216_E220_T1.4411.00
137_T313_I1.4351.00
109_N113_K1.4341.00
74_N432_T1.4251.00
219_R256_A1.4241.00
252_G255_T1.4161.00
367_L391_M1.4101.00
132_T135_A1.4051.00
78_D84_F1.3811.00
270_L286_C1.3811.00
298_L313_I1.3741.00
345_A349_V1.3731.00
128_M344_L1.3721.00
174_I232_V1.3691.00
258_R268_M1.3581.00
173_F234_A1.3571.00
407_E448_A1.3471.00
358_Q361_Q1.3461.00
144_S313_I1.3441.00
408_M415_V1.3441.00
258_R261_C1.3401.00
309_I340_C1.3381.00
161_A269_I1.3361.00
411_Q448_A1.3341.00
101_P105_S1.3301.00
371_R374_A1.3301.00
156_A312_T1.3281.00
344_L348_N1.3241.00
158_L173_F1.3241.00
68_W76_L1.3241.00
175_A209_H1.3161.00
215_I260_L1.3111.00
282_K287_E1.3101.00
365_M369_G1.3091.00
128_M348_N1.3061.00
369_G446_R1.3011.00
157_A297_C1.2981.00
190_A207_F1.2961.00
136_L351_L1.2921.00
302_L309_I1.2871.00
446_R450_A1.2781.00
216_E219_R1.2751.00
100_N353_Q1.2741.00
373_L442_I1.2731.00
237_L254_L1.2561.00
252_G289_E1.2561.00
433_L438_C1.2551.00
357_A361_Q1.2541.00
223_N264_F1.2531.00
270_L291_V1.2521.00
164_Y321_V1.2501.00
283_M287_E1.2451.00
135_A351_L1.2421.00
362_K435_I1.2401.00
134_A144_S1.2361.00
235_V257_V1.2351.00
154_V236_I1.2321.00
302_L311_A1.2301.00
70_A113_K1.2231.00
309_I343_A1.2231.00
286_C296_L1.2211.00
107_V338_L1.2211.00
72_S99_R1.2191.00
289_E387_K1.2101.00
373_L446_R1.2071.00
143_Y320_S1.1901.00
105_S108_Q1.1881.00
106_A345_A1.1871.00
295_I314_A1.1831.00
96_V349_V1.1751.00
348_N352_E1.1591.00
292_Q315_T1.1571.00
255_T259_K1.1451.00
219_R260_L1.1451.00
147_C312_T1.1431.00
104_V111_L1.1431.00
408_M444_A1.1411.00
288_H387_K1.1391.00
437_Q440_L1.1381.00
170_K265_G1.1371.00
104_V112_A1.1301.00
267_L318_V1.1271.00
108_Q111_L1.1251.00
99_R104_V1.1231.00
165_Q233_A1.1191.00
75_T85_I1.1141.00
190_A236_I1.0941.00
72_S83_E1.0891.00
443_K447_K1.0851.00
295_I312_T1.0831.00
413_V441_V1.0821.00
146_F340_C1.0701.00
278_G356_P1.0701.00
356_P359_A1.0701.00
408_M413_V1.0661.00
368_D372_Q1.0651.00
408_M448_A1.0651.00
284_F298_L1.0571.00
219_R264_F1.0511.00
129_L344_L1.0511.00
435_I439_E1.0501.00
151_T187_A1.0471.00
255_T290_N1.0381.00
211_P214_N1.0381.00
360_E364_D1.0351.00
140_K292_Q1.0331.00
212_F249_P1.0241.00
349_V352_E1.0191.00
74_N85_I1.0181.00
261_C266_A1.0171.00
219_R259_K1.0151.00
411_Q444_A1.0141.00
440_L443_K1.0101.00
69_Q124_P1.0081.00
160_L312_T0.9951.00
158_L190_A0.9921.00
304_G346_T0.9901.00
103_V342_A0.9831.00
175_A236_I0.9791.00
69_Q81_G0.9781.00
377_Y380_L0.9721.00
281_G287_E0.9711.00
257_V268_M0.9691.00
208_R221_A0.9681.00
350_L355_L0.9671.00
439_E443_K0.9621.00
96_V346_T0.9531.00
189_S204_L0.9361.00
403_N407_E0.9331.00
136_L283_M0.9331.00
153_S297_C0.9321.00
95_N301_A0.9321.00
240_I387_K0.9311.00
72_S77_V0.9301.00
374_A381_V0.9291.00
176_T212_F0.9261.00
350_L356_P0.9251.00
436_E439_E0.9231.00
358_Q435_I0.9201.00
67_E79_T0.9201.00
239_P270_L0.9191.00
404_F452_M0.9161.00
172_T223_N0.9151.00
217_A220_T0.9141.00
176_T249_P0.9111.00
260_L264_F0.9091.00
222_L232_V0.9081.00
382_Q394_E0.9071.00
341_A345_A0.9071.00
392_A424_T0.9061.00
259_K262_D0.9021.00
355_L359_A0.9011.00
151_T184_S0.8951.00
94_F304_G0.8941.00
277_M350_L0.8911.00
85_I437_Q0.8901.00
210_V218_M0.8891.00
254_L289_E0.8871.00
132_T136_L0.8861.00
406_S410_R0.8841.00
251_P255_T0.8811.00
141_L313_I0.8801.00
69_Q77_V0.8801.00
357_A360_E0.8781.00
87_C433_L0.8751.00
394_E423_K0.8741.00
74_N434_T0.8721.00
105_S112_A0.8711.00
67_E127_A0.8671.00
248_L387_K0.8611.00
288_H360_E0.8611.00
234_A269_I0.8601.00
109_N112_A0.8581.00
172_T232_V0.8551.00
85_I440_L0.8541.00
148_N152_E0.8531.00
171_F206_G0.8511.00
171_F231_D0.8511.00
383_E394_E0.8491.00
102_V105_S0.8451.00
210_V217_A0.8431.00
102_V348_N0.8381.00
369_G438_C0.8381.00
161_A234_A0.8311.00
229_G264_F0.8311.00
96_V103_V0.8281.00
252_G256_A0.8251.00
87_C413_V0.8241.00
160_L314_A0.8231.00
157_A269_I0.8211.00
307_M338_L0.8201.00
371_R375_R0.8161.00
136_L347_I0.8121.00
164_Y267_L0.8101.00
138_P286_C0.8071.00
363_G367_L0.8041.00
433_L441_V0.8031.00
74_N430_P0.8031.00
109_N341_A0.8021.00
249_P252_G0.8021.00
373_L377_Y0.7991.00
389_M433_L0.7981.00
161_A267_L0.7981.00
258_R291_V0.7971.00
79_T124_P0.7961.00
277_M347_I0.7951.00
265_G317_E0.7951.00
165_Q265_G0.7941.00
390_L428_E0.7911.00
92_G428_E0.7891.00
147_C153_S0.7891.00
356_P360_E0.7841.00
102_V106_A0.7831.00
275_T390_L0.7821.00
368_D371_R0.7811.00
372_Q376_E0.7791.00
163_A328_L0.7771.00
376_E450_A0.7731.00
218_M235_V0.7731.00
134_A141_L0.7721.00
129_L340_C0.7711.00
262_D292_Q0.7701.00
133_L313_I0.7691.00
283_M356_P0.7681.00
427_I445_A0.7671.00
73_L432_T0.7661.00
277_M302_L0.7641.00
68_W71_G0.7631.00
128_M132_T0.7611.00
402_Y406_S0.7611.00
235_V266_A0.7581.00
262_D268_M0.7571.00
242_G274_Q0.7511.00
361_Q365_M0.7501.00
261_C268_M0.7481.00
158_L236_I0.7471.00
395_F404_F0.7461.00
286_C291_V0.7451.00
331_T334_G0.7431.00
85_I441_V0.7431.00
385_R394_E0.7411.00
125_L341_A0.7381.00
144_S311_A0.7371.00
404_F445_A0.7361.00
448_A452_M0.7351.00
139_G296_L0.7351.00
372_Q375_R0.7351.00
447_K451_A0.7351.00
284_F296_L0.7341.00
248_L386_G0.7301.00
138_P287_E0.7281.00
365_M368_D0.7281.00
149_S152_E0.7261.00
165_Q169_G0.7241.00
240_I280_T0.7241.00
239_P254_L0.7241.00
88_L416_A0.7221.00
161_A295_I0.7211.00
106_A342_A0.7201.00
132_T347_I0.7191.00
256_A260_L0.7181.00
298_L302_L0.7171.00
407_E452_M0.7151.00
103_V304_G0.7131.00
277_M298_L0.7131.00
174_I218_M0.7131.00
232_V266_A0.7131.00
359_A363_G0.7111.00
110_Q113_K0.7111.00
159_K329_H0.7091.00
384_A391_M0.7071.00
283_M351_L0.7071.00
396_V399_E0.7061.00
126_R130_A0.7061.00
111_L338_L0.7051.00
177_S209_H0.7051.00
217_A221_A0.7051.00
372_Q446_R0.7041.00
220_T227_K0.7021.00
154_V187_A0.7021.00
404_F448_A0.7011.00
228_T231_D0.7001.00
280_T288_H0.6961.00
176_T210_V0.6961.00
222_L260_L0.6961.00
197_R201_M0.6951.00
386_G391_M0.6941.00
141_L296_L0.6931.00
125_L129_L0.6911.00
405_A417_G0.6891.00
89_G428_E0.6891.00
160_L322_L0.6891.00
441_V444_A0.6881.00
127_A131_K0.6881.00
164_Y317_E0.6871.00
71_G114_Q0.6851.00
268_M291_V0.6841.00
242_G390_L0.6831.00
125_L344_L0.6811.00
99_R111_L0.6791.00
277_M283_M0.6791.00
125_L340_C0.6781.00
384_A393_I0.6761.00
394_E424_T0.6741.00
325_N328_L0.6741.00
363_G386_G0.6741.00
317_E320_S0.6721.00
123_D126_R0.6721.00
82_Q410_R0.6721.00
113_K124_P0.6711.00
362_K389_M0.6701.00
147_C152_E0.6691.00
194_S198_K0.6691.00
162_K202_P0.6681.00
237_L268_M0.6681.00
76_L414_L0.6661.00
122_L127_A0.6651.00
129_L309_I0.6641.00
255_T289_E0.6611.00
361_Q364_D0.6611.00
377_Y449_L0.6601.00
186_G204_L0.6601.00
214_N217_A0.6581.00
436_E440_L0.6571.00
156_A329_H0.6571.00
136_L284_F0.6561.00
318_V321_V0.6561.00
180_F183_K0.6541.00
408_M445_A0.6541.00
365_M438_C0.6541.00
107_V115_P0.6531.00
404_F408_M0.6501.00
85_I413_V0.6491.00
269_I295_I0.6481.00
366_L442_I0.6451.00
96_V355_L0.6421.00
425_I445_A0.6361.00
254_L270_L0.6341.00
241_Q244_G0.6341.00
395_F449_L0.6331.00
222_L264_F0.6321.00
362_K433_L0.6321.00
374_A383_E0.6311.00
393_I445_A0.6301.00
278_G350_L0.6301.00
273_V297_C0.6301.00
315_T318_V0.6301.00
137_T296_L0.6291.00
374_A384_A0.6291.00
442_I446_R0.6271.00
403_N406_S0.6241.00
170_K266_A0.6231.00
172_T206_G0.6221.00
358_Q438_C0.6211.00
215_I219_R0.6201.00
71_G76_L0.6181.00
314_A319_F0.6151.00
277_M284_F0.6121.00
358_Q434_T0.6091.00
157_A295_I0.6091.00
427_I441_V0.6081.00
448_A451_A0.6081.00
413_V440_L0.6051.00
111_L342_A0.6051.00
241_Q247_I0.6041.00
165_Q170_K0.6041.00
194_S197_R0.6031.00
138_P141_L0.6031.00
362_K434_T0.6021.00
342_A345_A0.6001.00
137_T298_L0.6001.00
359_A431_L0.6001.00
137_T284_F0.6001.00
110_Q125_L0.5981.00
299_A333_F0.5961.00
103_V345_A0.5961.00
160_L295_I0.5961.00
140_K315_T0.5951.00
176_T257_V0.5941.00
366_L391_M0.5921.00
251_P289_E0.5921.00
67_E122_L0.5921.00
299_A310_G0.5901.00
251_P387_K0.5891.00
134_A142_K0.5891.00
95_N431_L0.5881.00
125_L128_M0.5881.00
89_G430_P0.5871.00
218_M256_A0.5871.00
103_V346_T0.5861.00
74_N433_L0.5841.00
262_D317_E0.5811.00
381_V393_I0.5801.00
445_A449_L0.5801.00
106_A109_N0.5781.00
174_I221_A0.5771.00
364_D367_L0.5771.00
190_A193_K0.5751.00
175_A207_F0.5741.00
83_E444_A0.5741.00
380_L396_V0.5731.00
150_G273_V0.5721.00
88_L414_L0.5711.00
240_I390_L0.5701.00
136_L282_K0.5691.00
366_L438_C0.5691.00
202_P206_G0.5681.00
70_A83_E0.5651.00
239_P286_C0.5631.00
162_K185_L0.5621.00
172_T227_K0.5621.00
235_V262_D0.5601.00
444_A448_A0.5601.00
286_C293_P0.5601.00
218_M260_L0.5571.00
69_Q72_S0.5571.00
110_Q114_Q0.5561.00
134_A313_I0.5551.00
283_M347_I0.5551.00
129_L146_F0.5551.00
170_K231_D0.5541.00
260_L263_E0.5541.00
406_S409_F0.5541.00
366_L369_G0.5541.00
95_N350_L0.5521.00
393_I427_I0.5511.00
444_A447_K0.5511.00
239_P275_T0.5501.00
381_V449_L0.5481.00
274_Q426_R0.5481.00
359_A389_M0.5471.00
106_A348_N0.5461.00
216_E256_A0.5461.00
295_I318_V0.5461.00
365_M442_I0.5461.00
223_N263_E0.5440.99
71_G94_F0.5440.99
283_M350_L0.5430.99
218_M253_Y0.5430.99
243_E426_R0.5420.99
369_G373_L0.5410.99
85_I433_L0.5400.99
66_V69_Q0.5400.99
432_T437_Q0.5390.99
176_T237_L0.5390.99
257_V266_A0.5390.99
248_L289_E0.5380.99
385_R392_A0.5380.99
345_A352_E0.5370.99
215_I257_V0.5360.99
96_V100_N0.5360.99
433_L437_Q0.5350.99
274_Q390_L0.5330.99
344_L351_L0.5330.99
409_F414_L0.5300.99
134_A137_T0.5290.99
72_S75_T0.5280.99
192_A209_H0.5280.99
183_K327_F0.5270.99
104_V304_G0.5270.99
374_A449_L0.5250.99
121_L414_L0.5240.99
210_V253_Y0.5230.99
441_V445_A0.5230.99
438_C441_V0.5220.99
220_T223_N0.5200.99
336_N339_A0.5190.99
115_P307_M0.5190.99
395_F400_I0.5190.99
68_W121_L0.5180.99
212_F241_Q0.5170.99
113_K125_L0.5170.99
208_R232_V0.5170.99
430_P433_L0.5160.99
404_F449_L0.5140.99
68_W114_Q0.5140.99
158_L186_G0.5130.99
412_R444_A0.5120.99
158_L207_F0.5110.99
364_D371_R0.5110.99
103_V349_V0.5100.99
439_E442_I0.5090.99
272_E285_A0.5090.99
138_P142_K0.5090.99
103_V107_V0.5080.99
385_R424_T0.5080.99
183_K330_T0.5050.99
413_V448_A0.5040.99
267_L295_I0.5040.99
400_I403_N0.5040.99
301_A304_G0.5010.99
440_L447_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uoxA 3 0.9782 100 0.372 Contact Map
4atqA 7 0.9172 100 0.405 Contact Map
4a0gA 2 0.9673 100 0.405 Contact Map
2ykyA 4 0.9041 100 0.407 Contact Map
2epjA 2 0.8715 100 0.412 Contact Map
4e3qA 3 0.8998 100 0.413 Contact Map
1z7dA 2 0.8148 100 0.414 Contact Map
3oksA 2 0.9107 100 0.415 Contact Map
3hmuA 2 0.9129 100 0.418 Contact Map
4ffcA 4 0.9216 100 0.42 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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