GREMLIN Database
GSPG - Putative type II secretion system protein G
UniProt: P41442 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12886
Length: 145 (131)
Sequences: 1142 (753)
Seq/√Len: 65.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_A102_P4.4781.00
135_I138_W3.9161.00
100_A106_D3.8111.00
125_P135_I3.5231.00
74_E78_E2.6231.00
57_D96_K2.5941.00
59_Y71_Q2.3851.00
108_V121_L2.3491.00
125_P131_T2.3271.00
112_P119_D2.2581.00
36_N39_K2.0471.00
123_A131_T1.9691.00
134_D138_W1.9651.00
105_N127_G1.9561.00
102_P107_Y1.9511.00
59_Y65_H1.9301.00
68_T71_Q1.9221.00
37_K41_D1.9201.00
108_V123_A1.8981.00
134_D137_N1.8411.00
38_E134_D1.8181.00
82_L86_A1.8101.00
56_L120_L1.7521.00
65_H71_Q1.6210.99
113_G119_D1.6060.99
57_D66_Y1.5500.99
50_V53_E1.5460.99
48_D107_Y1.5330.99
52_L120_L1.5320.99
115_H119_D1.4810.98
63_N86_A1.4690.98
56_L66_Y1.4630.98
44_K48_D1.4350.98
110_V114_E1.4060.98
89_Y93_G1.3980.98
71_Q86_A1.3810.98
113_G116_G1.3680.97
69_T111_N1.3400.97
20_V23_G1.3160.97
111_N118_Y1.3160.97
53_E120_L1.3100.97
79_A86_A1.3060.97
126_D137_N1.2990.97
53_E118_Y1.2860.96
89_Y92_E1.2310.95
56_L59_Y1.2010.95
19_I25_L1.1900.94
16_M20_V1.1770.94
80_P89_Y1.1610.94
62_D94_Y1.1370.93
49_I53_E1.1310.93
11_T22_I1.1230.92
59_Y75_S1.1180.92
52_L95_I1.1080.92
123_A129_M1.1020.92
15_I25_L1.1010.92
75_S80_P1.0990.91
19_I27_S1.0970.91
34_M37_K1.0720.90
72_G75_S1.0650.90
15_I22_I1.0550.90
45_A107_Y1.0300.89
74_E77_V1.0230.88
11_T17_V1.0220.88
34_M60_K1.0180.88
21_I40_A1.0170.88
87_A105_N1.0100.88
42_K46_V0.9940.87
125_P133_D0.9830.86
24_V37_K0.9760.86
45_A49_I0.9430.84
68_T72_G0.9160.82
21_I31_P0.8870.80
52_L98_L0.8830.80
27_S31_P0.8790.79
53_E95_I0.8630.78
123_A133_D0.8510.77
57_D95_I0.8450.77
109_L118_Y0.8440.76
26_A31_P0.8410.76
92_E95_I0.8190.74
19_I42_K0.8110.74
50_V54_N0.8070.73
32_N117_A0.8050.73
65_H125_P0.8030.73
41_D47_S0.7990.72
31_P62_D0.7990.72
60_K66_Y0.7990.72
59_Y86_A0.7960.72
126_D130_G0.7950.72
131_T137_N0.7920.72
108_V127_G0.7850.71
10_F31_P0.7710.70
17_V31_P0.7660.69
91_K94_Y0.7660.69
22_I25_L0.7650.69
89_Y94_Y0.7620.69
17_V33_L0.7610.69
42_K122_S0.7450.67
30_V34_M0.7450.67
41_D54_N0.7440.67
40_A43_Q0.7400.67
53_E56_L0.7400.67
62_D90_N0.7380.66
112_P117_A0.7370.66
10_F25_L0.7290.65
56_L73_L0.7200.64
38_E42_K0.7160.64
5_D8_R0.7140.64
126_D131_T0.7120.64
45_A122_S0.7090.63
24_V48_D0.7080.63
91_K95_I0.7060.63
24_V44_K0.7040.63
71_Q75_S0.7040.63
48_D51_A0.7020.62
46_V50_V0.6970.62
81_T106_D0.6970.62
36_N90_N0.6900.61
24_V43_Q0.6900.61
11_T16_M0.6830.60
10_F23_G0.6670.59
126_D134_D0.6630.58
74_E132_E0.6620.58
59_Y63_N0.6580.57
26_A30_V0.6570.57
69_T75_S0.6570.57
40_A54_N0.6560.57
110_V129_M0.6530.57
11_T14_E0.6520.57
95_I98_L0.6520.57
10_F15_I0.6490.56
9_G12_L0.6470.56
19_I117_A0.6460.56
109_L131_T0.6420.56
48_D102_P0.6380.55
49_I120_L0.6340.55
39_K43_Q0.6280.54
43_Q47_S0.6280.54
28_L35_G0.6230.53
19_I43_Q0.6220.53
55_A62_D0.6190.53
63_N88_N0.6140.52
130_G137_N0.6110.52
82_L87_A0.6110.52
74_E114_E0.6110.52
31_P36_N0.6090.52
81_T86_A0.6070.52
43_Q46_V0.6060.51
79_A82_L0.6050.51
5_D74_E0.6030.51
32_N47_S0.6010.51
28_L51_A0.6010.51
65_H82_L0.6010.51
37_K44_K0.5990.51
38_E41_D0.5960.50
47_S51_A0.5920.50
125_P138_W0.5840.49
28_L31_P0.5750.48
16_M37_K0.5670.47
17_V54_N0.5670.47
22_I118_Y0.5600.46
34_M116_G0.5570.46
42_K134_D0.5540.45
13_L36_N0.5530.45
44_K53_E0.5520.45
41_D64_H0.5480.45
15_I19_I0.5470.45
60_K99_P0.5460.44
13_L33_L0.5430.44
33_L36_N0.5430.44
13_L41_D0.5420.44
91_K133_D0.5380.43
94_Y99_P0.5350.43
7_Q79_A0.5340.43
30_V44_K0.5330.43
112_P115_H0.5270.42
52_L107_Y0.5270.42
13_L28_L0.5260.42
49_I58_M0.5260.42
56_L79_A0.5230.42
39_K90_N0.5200.41
89_Y95_I0.5130.41
48_D52_L0.5130.41
78_E128_E0.5120.40
109_L123_A0.5080.40
28_L32_N0.5080.40
13_L43_Q0.5070.40
32_N35_G0.5050.40
30_V99_P0.5040.40
28_L44_K0.5040.40
73_L76_L0.5030.39
74_E82_L0.5020.39
29_V99_P0.5010.39
77_V97_R0.5010.39
14_E18_V0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gn9A 1 0.7448 100 0.419 Contact Map
2kepA 1 0.731 100 0.422 Contact Map
3g20A 1 0.8138 100 0.424 Contact Map
1t92A 2 0.7379 100 0.424 Contact Map
2hi2A 1 0.8759 99.8 0.619 Contact Map
3sokA 1 0.869 99.8 0.63 Contact Map
2m7gA 1 0.4207 99.5 0.716 Contact Map
1oqwA 1 0.8069 99.2 0.757 Contact Map
4noaA 1 0.6483 56.8 0.93 Contact Map
2m3kA 1 0.5862 53.1 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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