GREMLIN Database
RIHA - Pyrimidine-specific ribonucleoside hydrolase RihA
UniProt: P41409 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12701
Length: 311 (304)
Sequences: 4007 (2918)
Seq/√Len: 167.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_C110_K3.8071.00
106_E136_S3.7301.00
255_T293_D3.3151.00
175_E179_Q3.2041.00
135_N176_I2.9711.00
4_P29_D2.8251.00
167_I274_T2.7851.00
32_A107_L2.5711.00
67_A132_L2.4311.00
113_R137_H2.4031.00
194_K293_D2.3991.00
175_E262_G2.3981.00
258_E289_T2.3311.00
35_S46_L2.3151.00
134_L141_H2.2771.00
250_K298_G2.2751.00
3_L146_R2.2311.00
22_A245_I2.1621.00
34_T104_A2.1341.00
113_R143_K2.1231.00
122_V245_I2.1171.00
11_P49_V2.1101.00
110_K114_E2.1051.00
7_L124_T2.0821.00
167_I174_A2.0521.00
4_P31_K2.0471.00
192_T240_H2.0441.00
19_I33_I2.0391.00
113_R139_E2.0271.00
256_S291_M1.9971.00
118_P145_A1.9701.00
123_S130_V1.9671.00
109_A137_H1.9071.00
50_L63_V1.9051.00
162_A273_M1.8961.00
295_D298_G1.8691.00
123_S149_I1.8641.00
64_A107_L1.8321.00
20_V56_L1.8241.00
146_R185_V1.7881.00
8_D129_N1.7771.00
6_L34_T1.7651.00
31_K119_V1.7421.00
133_L137_H1.7371.00
112_L119_V1.7341.00
239_L242_P1.7321.00
264_E270_T1.6631.00
47_R51_R1.6491.00
123_S127_Q1.6311.00
9_C124_T1.6251.00
214_T218_E1.6131.00
42_P65_G1.6121.00
23_L30_V1.6061.00
120_T148_V1.6021.00
64_A100_Q1.5871.00
3_L145_A1.5871.00
73_R271_Q1.5801.00
112_L143_K1.5721.00
127_Q177_V1.5481.00
247_W254_F1.5441.00
301_D305_D1.5321.00
109_A133_L1.5221.00
25_S306_R1.5181.00
107_L111_T1.5181.00
187_A291_M1.5041.00
153_A156_L1.5041.00
50_L98_A1.4991.00
253_L298_G1.4981.00
5_I122_V1.4671.00
133_L140_L1.4581.00
149_I186_M1.4581.00
149_I167_I1.4551.00
149_I178_F1.4531.00
43_E65_G1.4271.00
172_E271_Q1.4271.00
108_M133_L1.4261.00
297_Q301_D1.4241.00
111_T114_E1.4081.00
103_T136_S1.4061.00
54_T97_F1.4041.00
42_P46_L1.3971.00
112_L133_L1.3931.00
109_A140_L1.3761.00
137_H140_L1.3731.00
103_T106_E1.3661.00
185_V289_T1.3491.00
111_T119_V1.3471.00
206_R217_A1.3431.00
204_R301_D1.3091.00
130_V147_I1.2921.00
73_R172_E1.2841.00
3_L120_T1.2801.00
4_P115_S1.2761.00
246_A299_F1.2751.00
106_E110_K1.2701.00
9_C49_V1.2521.00
246_A302_L1.2491.00
21_L302_L1.2401.00
167_I178_F1.2391.00
122_V248_L1.2381.00
127_Q149_I1.2311.00
47_R94_E1.2221.00
116_A143_K1.2191.00
120_T146_R1.2191.00
178_F186_M1.2061.00
6_L32_A1.2021.00
112_L140_L1.2021.00
121_I144_I1.2011.00
46_L65_G1.1961.00
147_I182_I1.1901.00
175_E265_T1.1891.00
257_V292_V1.1891.00
115_S118_P1.1871.00
71_L131_A1.1841.00
243_C254_F1.1721.00
151_G167_I1.1711.00
83_G86_G1.1611.00
35_S49_V1.1591.00
270_T273_M1.1591.00
23_L61_I1.1501.00
146_R183_P1.1481.00
85_S91_A1.1461.00
148_V248_L1.1441.00
53_L61_I1.1421.00
256_S289_T1.1381.00
7_L30_V1.1311.00
185_V247_W1.1271.00
25_S249_L1.1271.00
264_E267_G1.1221.00
243_C294_V1.1211.00
54_T95_P1.1201.00
148_V247_W1.1201.00
69_K135_N1.1181.00
7_L22_A1.1161.00
27_E306_R1.1121.00
204_R304_A1.1111.00
40_Q44_K1.1111.00
259_R290_V1.1091.00
55_L215_I1.1071.00
201_D300_V1.0931.00
261_V288_A1.0831.00
196_Q236_G1.0791.00
105_V133_L1.0751.00
203_E207_A1.0681.00
112_L144_I1.0660.99
23_L58_R1.0660.99
144_I182_I1.0600.99
264_E268_K1.0570.99
53_L63_V1.0540.99
7_L19_I1.0540.99
108_M140_L1.0510.99
72_M172_E1.0470.99
41_T44_K1.0420.99
31_K111_T1.0410.99
17_I303_L1.0400.99
85_S88_D1.0340.99
259_R276_V1.0290.99
160_T163_A1.0280.99
185_V256_S1.0280.99
154_M188_G1.0260.99
108_M130_V1.0210.99
84_E89_G1.0170.99
262_G269_Y1.0160.99
112_L115_S1.0120.99
209_G214_T1.0070.99
267_G270_T1.0070.99
122_V244_T1.0060.99
264_E269_Y1.0020.99
33_I53_L1.0000.99
270_T275_V0.9980.99
108_M112_L0.9930.99
30_V124_T0.9850.99
126_P169_V0.9820.99
54_T96_T0.9800.99
139_E142_S0.9740.99
260_W284_N0.9730.99
105_V136_S0.9720.99
123_S147_I0.9660.99
244_T248_L0.9620.99
142_S145_A0.9590.99
132_L135_N0.9580.99
82_H86_G0.9530.99
13_H223_F0.9410.99
11_P45_T0.9410.99
201_D304_A0.9360.99
199_V203_E0.9340.99
198_H201_D0.9310.99
195_A294_V0.9300.99
97_F100_Q0.9280.99
4_P118_P0.9240.99
64_A102_C0.9230.99
150_M192_T0.9200.99
109_A113_R0.9190.98
250_K302_L0.9160.98
21_L306_R0.9150.98
6_L107_L0.9080.98
121_I130_V0.9050.98
16_A52_M0.9040.98
5_I28_L0.9040.98
179_Q262_G0.9020.98
149_I184_V0.9010.98
31_K115_S0.9000.98
40_Q45_T0.8960.98
32_A111_T0.8930.98
206_R221_D0.8880.98
247_W256_S0.8870.98
81_V226_Y0.8870.98
23_L53_L0.8860.98
171_P271_Q0.8840.98
246_A253_L0.8800.98
34_T129_N0.8780.98
46_L99_P0.8780.98
187_A247_W0.8760.98
37_A169_V0.8750.98
252_E298_G0.8720.98
43_E68_V0.8720.98
42_P45_T0.8670.98
186_M290_V0.8650.98
6_L108_M0.8630.98
120_T145_A0.8620.98
163_A168_Y0.8550.98
109_A136_S0.8550.98
147_I184_V0.8520.98
134_L180_S0.8520.98
116_A119_V0.8510.98
67_A128_T0.8470.97
20_V216_V0.8450.97
85_S89_G0.8450.97
65_G99_P0.8390.97
178_F184_V0.8380.97
183_P289_T0.8370.97
263_V274_T0.8350.97
164_E189_L0.8330.97
260_W287_N0.8310.97
34_T108_M0.8290.97
225_E229_D0.8260.97
148_V244_T0.8240.97
54_T59_T0.8130.97
23_L56_L0.8100.97
80_N159_W0.8100.97
78_A81_V0.8090.97
118_P143_K0.8070.97
71_L173_A0.8070.97
71_L132_L0.8060.97
6_L119_V0.8000.96
301_D304_A0.7980.96
254_F291_M0.7930.96
188_G191_V0.7920.96
189_L240_H0.7910.96
76_I168_Y0.7870.96
165_F169_V0.7860.96
35_S45_T0.7820.96
105_V132_L0.7810.96
154_M186_M0.7760.96
21_L246_A0.7730.96
33_I49_V0.7720.96
127_Q174_A0.7690.95
250_K253_L0.7610.95
195_A299_F0.7590.95
17_I216_V0.7590.95
22_A28_L0.7570.95
13_H88_D0.7520.95
39_N48_N0.7510.95
50_L97_F0.7490.95
298_G302_L0.7480.95
71_L135_N0.7480.95
258_E287_N0.7470.95
157_G163_A0.7470.95
56_L212_V0.7440.95
28_L249_L0.7440.95
260_W286_P0.7430.95
245_I248_L0.7420.95
8_D34_T0.7410.94
112_L141_H0.7400.94
72_M176_I0.7400.94
150_M241_D0.7390.94
47_R95_P0.7390.94
187_A244_T0.7370.94
160_T168_Y0.7370.94
46_L50_L0.7320.94
178_F274_T0.7310.94
244_T247_W0.7290.94
18_A245_I0.7270.94
58_R61_I0.7240.94
156_L193_H0.7230.94
44_K47_R0.7200.94
52_M215_I0.7200.94
67_A103_T0.7160.93
211_P214_T0.7140.93
19_I22_A0.7130.93
115_S119_V0.7130.93
134_L144_I0.7110.93
115_S143_K0.7110.93
172_E265_T0.7100.93
112_L137_H0.7080.93
6_L111_T0.7060.93
261_V274_T0.7060.93
35_S129_N0.7040.93
15_D241_D0.7020.93
186_M274_T0.7020.93
20_V52_M0.7000.93
5_I22_A0.6960.92
209_G213_S0.6960.92
22_A122_V0.6940.92
112_L116_A0.6940.92
215_I219_L0.6910.92
71_L176_I0.6880.92
121_I147_I0.6870.92
12_G16_A0.6840.92
53_L58_R0.6830.92
124_T244_T0.6820.92
154_M292_V0.6770.91
296_R300_V0.6760.91
127_Q167_I0.6740.91
117_E143_K0.6710.91
114_E117_E0.6710.91
117_E145_A0.6700.91
36_S125_G0.6680.91
14_D241_D0.6670.91
34_T107_L0.6640.91
253_L302_L0.6600.90
206_R214_T0.6580.90
120_T248_L0.6520.90
41_T77_I0.6510.90
247_W291_M0.6480.90
302_L306_R0.6460.89
243_C299_F0.6420.89
146_R251_P0.6410.89
105_V109_A0.6400.89
146_R289_T0.6370.89
32_A64_A0.6340.89
141_H181_G0.6330.88
69_K74_E0.6320.88
155_G190_D0.6290.88
210_N213_S0.6290.88
191_V294_V0.6260.88
158_N189_L0.6250.88
302_L305_D0.6250.88
153_A157_G0.6250.88
19_I23_L0.6230.88
134_L182_I0.6210.87
4_P117_E0.6200.87
140_L143_K0.6190.87
107_L110_K0.6160.87
196_Q238_P0.6150.87
153_A190_D0.6140.87
17_I220_L0.6130.87
37_A165_F0.6090.86
216_V219_L0.6090.86
255_T292_V0.6070.86
85_S90_P0.6070.86
148_V187_A0.6060.86
30_V33_I0.6050.86
146_R247_W0.6040.86
111_T115_S0.6040.86
36_S129_N0.6030.86
141_H144_I0.6020.86
141_H182_I0.5990.86
208_I213_S0.5990.86
176_I179_Q0.5950.85
201_D204_R0.5930.85
35_S65_G0.5920.85
50_L99_P0.5920.85
42_P68_V0.5900.85
227_H237_A0.5890.85
187_A256_S0.5890.85
137_H143_K0.5890.85
172_E266_Q0.5840.84
105_V112_L0.5830.84
127_Q130_V0.5830.84
133_L136_S0.5810.84
174_A177_V0.5810.84
257_V278_Y0.5790.84
49_V53_L0.5780.83
150_M240_H0.5750.83
204_R207_A0.5740.83
200_E203_E0.5700.83
128_T170_D0.5690.83
51_R55_L0.5680.82
38_G126_P0.5660.82
259_R292_V0.5660.82
98_A101_N0.5640.82
28_L248_L0.5640.82
159_W168_Y0.5610.82
71_L128_T0.5610.82
197_I237_A0.5600.82
53_L59_T0.5590.81
217_A221_D0.5590.81
56_L216_V0.5580.81
267_G271_Q0.5580.81
151_G174_A0.5570.81
104_A129_N0.5570.81
154_M276_V0.5560.81
202_T221_D0.5550.81
72_M175_E0.5540.81
256_S292_V0.5540.81
81_V89_G0.5530.81
106_E109_A0.5510.81
142_S146_R0.5510.81
186_M288_A0.5510.81
102_C106_E0.5490.80
75_L169_V0.5490.80
148_V185_V0.5490.80
228_K235_V0.5490.80
77_I80_N0.5480.80
124_T149_I0.5470.80
12_G240_H0.5460.80
24_A306_R0.5460.80
201_D205_F0.5440.80
224_L237_A0.5410.79
140_L144_I0.5400.79
269_Y275_V0.5400.79
206_R218_E0.5390.79
197_I220_L0.5370.79
201_D296_R0.5360.79
154_M190_D0.5350.79
205_F213_S0.5340.78
90_P218_E0.5340.78
134_L176_I0.5340.78
191_V194_K0.5330.78
51_R85_S0.5320.78
72_M135_N0.5290.78
132_L136_S0.5280.78
59_T97_F0.5280.78
70_P73_R0.5260.77
47_R50_L0.5250.77
28_L122_V0.5250.77
25_S302_L0.5230.77
158_N163_A0.5220.77
221_D225_E0.5210.77
21_L245_I0.5200.77
65_G68_V0.5180.76
86_G89_G0.5180.76
59_T62_P0.5160.76
153_A164_E0.5150.76
11_P48_N0.5150.76
102_C114_E0.5140.76
108_M121_I0.5140.76
134_L140_L0.5140.76
38_G48_N0.5140.76
260_W282_T0.5130.76
216_V307_L0.5130.76
51_R95_P0.5110.75
150_M158_N0.5100.75
80_N89_G0.5100.75
193_H276_V0.5080.75
104_A108_M0.5070.75
18_A124_T0.5050.75
261_V290_V0.5050.75
10_D14_D0.5050.75
154_M261_V0.5050.75
195_A243_C0.5030.74
265_T271_Q0.5010.74
173_A177_V0.5010.74
158_N164_E0.5000.74
109_A112_L0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wr2A 4 0.9678 100 0.044 Contact Map
2masA 3 0.9936 100 0.061 Contact Map
1q8fA 4 0.9904 100 0.062 Contact Map
4kpoA 2 0.9904 100 0.07 Contact Map
4kpnA 2 0.9904 100 0.071 Contact Map
3t8jA 3 0.9839 100 0.084 Contact Map
3t8iA 3 0.9775 100 0.098 Contact Map
3fz0A 3 0.9743 100 0.103 Contact Map
4i71A 2 0.955 100 0.135 Contact Map
3epwA 2 0.9711 100 0.14 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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