GREMLIN Database
AZOR - FMN-dependent NADH-azoreductase
UniProt: P41407 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12695
Length: 201 (183)
Sequences: 4948 (3531)
Seq/√Len: 261.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_K37_E3.9231.00
39_T86_A3.5511.00
39_T83_E2.9721.00
41_R83_E2.9551.00
24_Y192_K2.8861.00
50_V103_T2.8451.00
120_R127_E2.7311.00
3_K39_T2.6701.00
85_K117_V2.6461.00
23_D27_E2.3951.00
25_F138_I2.3641.00
82_A86_A2.3011.00
42_D45_A2.2431.00
50_V107_N2.2031.00
135_A161_L2.2031.00
3_K86_A2.0191.00
4_V36_D2.0161.00
181_P185_A2.0001.00
137_V171_F1.9861.00
6_V26_V1.9481.00
9_S104_Q1.8521.00
78_D82_A1.8421.00
81_I117_V1.8061.00
8_K22_S1.7841.00
113_A164_I1.7721.00
135_A166_I1.7581.00
89_V136_I1.7181.00
109_F160_F1.6991.00
18_S140_S1.6831.00
22_S93_A1.6161.00
101_I156_Y1.5981.00
24_Y28_Q1.5971.00
8_K40_V1.5421.00
189_S192_K1.5391.00
11_I97_Y1.5161.00
90_I135_A1.4921.00
76_L79_E1.4821.00
82_A85_K1.4731.00
24_Y27_E1.4521.00
185_A189_S1.4421.00
25_F29_W1.4411.00
109_F113_A1.4401.00
26_V30_R1.4361.00
8_K19_N1.4101.00
49_P52_D1.4041.00
84_L112_V1.3871.00
89_V134_K1.3401.00
82_A117_V1.3321.00
27_E30_R1.3091.00
27_E31_E1.3051.00
29_W36_D1.3011.00
134_K170_K1.2931.00
81_I118_T1.2921.00
44_A104_Q1.2921.00
113_A160_F1.2911.00
151_D155_P1.2901.00
61_P70_Q1.2751.00
28_Q31_E1.2671.00
4_V89_V1.2361.00
12_L15_Y1.2331.00
4_V29_W1.2201.00
90_I166_I1.2101.00
184_A188_Q1.2021.00
21_L195_I1.1991.00
130_V166_I1.1901.00
189_S193_A1.1891.00
6_V23_D1.1771.00
18_S93_A1.1761.00
99_F163_F1.1691.00
6_V22_S1.1411.00
21_L140_S1.1291.00
180_G183_M1.1211.00
17_Q177_I1.1191.00
9_S105_L1.1141.00
22_S40_V1.1091.00
46_N79_E1.1061.00
87_H90_I1.1041.00
46_N80_L1.0911.00
52_D55_L1.0801.00
36_D89_V1.0731.00
120_R129_L1.0701.00
84_L90_I1.0661.00
112_V164_I1.0661.00
56_V60_R1.0641.00
106_K110_D1.0521.00
75_A79_E1.0401.00
6_V40_V1.0361.00
190_D194_A1.0281.00
78_D117_V1.0271.00
152_L155_P1.0271.00
5_L83_E1.0251.00
17_Q184_A1.0221.00
50_V111_L1.0211.00
122_T125_G1.0161.00
85_K130_V1.0121.00
122_T127_E1.0101.00
11_I104_Q1.0101.00
29_W89_V1.0071.00
134_K168_D0.9991.00
154_T158_S0.9971.00
183_M186_K0.9871.00
144_I175_E0.9831.00
83_E108_Y0.9801.00
77_S114_R0.9781.00
107_N111_L0.9771.00
7_L92_I0.9581.00
25_F136_I0.9551.00
94_A105_L0.9461.00
4_V91_V0.9431.00
141_R173_F0.9391.00
28_Q192_K0.9331.00
20_Q192_K0.9321.00
103_T107_N0.9321.00
98_N110_D0.9271.00
41_R80_L0.9241.00
23_D40_V0.9121.00
48_I111_L0.9001.00
48_I107_N0.8991.00
80_L108_Y0.8991.00
94_A137_V0.8861.00
141_R175_E0.8841.00
144_I176_G0.8821.00
186_K190_D0.8821.00
81_I114_R0.8811.00
92_I105_L0.8751.00
41_R108_Y0.8731.00
78_D114_R0.8621.00
37_E86_A0.8601.00
20_Q184_A0.8521.00
182_E186_K0.8521.00
26_V40_V0.8490.99
101_I105_L0.8470.99
145_H150_T0.8460.99
139_T173_F0.8360.99
158_S162_G0.8350.99
17_Q188_Q0.8330.99
109_F156_Y0.8320.99
84_L108_Y0.8250.99
7_L41_R0.8180.99
127_E131_T0.8120.99
30_R37_E0.8110.99
145_H148_G0.8070.99
5_L87_H0.8060.99
121_Y126_P0.8020.99
13_A53_G0.8000.99
151_D154_T0.8000.99
7_L43_L0.7970.99
146_K150_T0.7960.99
13_A45_A0.7940.99
88_D133_K0.7940.99
138_I191_A0.7920.99
27_E192_K0.7900.99
17_Q174_A0.7860.99
21_L138_I0.7830.99
141_R153_V0.7800.99
92_I161_L0.7740.99
181_P184_A0.7690.99
39_T87_H0.7550.99
109_F157_L0.7500.99
77_S81_I0.7470.99
97_Y102_S0.7420.99
98_N119_F0.7410.99
120_R123_E0.7390.99
8_K23_D0.7350.99
50_V104_Q0.7250.98
84_L130_V0.7240.98
132_G168_D0.7240.98
77_S111_L0.7220.98
94_A153_V0.7200.98
152_L159_T0.7190.98
137_V161_L0.7180.98
58_A74_L0.7160.98
96_M141_R0.7140.98
76_L111_L0.7130.98
55_L74_L0.7090.98
25_F91_V0.7090.98
55_L111_L0.7050.98
136_I172_V0.7030.98
52_D56_V0.6980.98
46_N83_E0.6970.98
19_N22_S0.6950.98
76_L80_L0.6900.98
95_P102_S0.6840.98
55_L59_L0.6830.98
51_L55_L0.6820.98
144_I147_D0.6760.97
96_M153_V0.6720.97
21_L174_A0.6710.97
17_Q20_Q0.6680.97
97_Y104_Q0.6610.97
31_E34_S0.6580.97
187_A190_D0.6510.97
56_V59_L0.6490.97
12_L57_G0.6430.97
79_E82_A0.6380.96
182_E185_A0.6380.96
140_S177_I0.6290.96
103_T111_L0.6280.96
92_I157_L0.6280.96
79_E83_E0.6240.96
6_V93_A0.6190.96
9_S44_A0.6180.96
99_F159_T0.6160.96
170_K194_A0.6150.96
28_Q34_S0.6140.96
122_T126_P0.6110.95
46_N76_L0.6100.95
192_K195_I0.6100.95
161_L169_V0.6100.95
21_L191_A0.6090.95
132_G167_T0.6070.95
188_Q191_A0.6050.95
3_K87_H0.6040.95
43_L104_Q0.5990.95
139_T153_V0.5960.95
100_N106_K0.5950.95
186_K189_S0.5950.95
138_I172_V0.5940.95
141_R148_G0.5930.95
25_F89_V0.5920.95
58_A61_P0.5900.95
171_F174_A0.5860.94
20_Q188_Q0.5840.94
179_Y183_M0.5780.94
145_H175_E0.5780.94
100_N156_Y0.5740.94
3_K88_D0.5740.94
124_N127_E0.5720.94
134_K166_I0.5710.94
155_P159_T0.5700.93
80_L83_E0.5680.93
81_I85_K0.5680.93
8_K93_A0.5670.93
99_F143_G0.5660.93
162_G169_V0.5660.93
8_K42_D0.5580.93
96_M145_H0.5570.93
96_M139_T0.5560.93
190_D193_A0.5560.93
10_S18_S0.5540.92
30_R34_S0.5470.92
52_D73_A0.5460.92
84_L164_I0.5450.92
72_E75_A0.5400.92
71_Q75_A0.5360.91
83_E86_A0.5350.91
24_Y188_Q0.5350.91
49_P76_L0.5350.91
185_A188_Q0.5330.91
75_A78_D0.5290.91
73_A76_L0.5280.91
5_L41_R0.5270.91
152_L156_Y0.5270.91
41_R46_N0.5250.90
156_Y160_F0.5250.90
179_Y187_A0.5250.90
185_A192_K0.5240.90
22_S26_V0.5240.90
99_F113_A0.5220.90
55_L77_S0.5210.90
43_L80_L0.5200.90
93_A138_I0.5190.90
158_S171_F0.5170.90
20_Q24_Y0.5160.90
48_I76_L0.5160.90
154_T171_F0.5150.90
94_A102_S0.5120.89
160_F164_I0.5120.89
172_V175_E0.5110.89
77_S80_L0.5080.89
137_V169_V0.5060.89
154_T157_L0.5060.89
81_I112_V0.5010.88
179_Y184_A0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w77A 2 0.995 100 0.346 Contact Map
3w7aA 2 0.995 100 0.347 Contact Map
1d4aA 2 0.9851 100 0.349 Contact Map
2hpvA 2 0.9851 100 0.357 Contact Map
4n65A 2 0.9751 100 0.358 Contact Map
1t5bA 2 0.99 100 0.362 Contact Map
4c0xA 2 0.9851 100 0.362 Contact Map
4gi5A 2 0.9851 100 0.371 Contact Map
3u7iA 2 0.99 100 0.371 Contact Map
4fglA 2 0.9851 100 0.397 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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