GREMLIN Database
MLTB - Membrane-bound lytic murein transglycosylase B
UniProt: P41052 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12699
Length: 361 (300)
Sequences: 2062 (1350)
Seq/√Len: 77.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_V269_D3.6881.00
145_W152_P3.6421.00
195_E229_S3.5631.00
89_D93_R3.3691.00
143_R147_V3.1251.00
245_N248_D3.0811.00
88_L176_D2.7621.00
144_A254_G2.6851.00
258_N261_K2.6711.00
124_P128_Q2.5341.00
273_V329_L2.5131.00
221_M247_W2.5071.00
144_A253_I2.4541.00
134_W156_V2.4191.00
238_F254_G2.3441.00
65_D75_R2.3361.00
138_E142_N2.3331.00
69_N75_R2.2561.00
172_T177_A2.2551.00
198_T229_S2.1971.00
87_R92_L2.1961.00
148_Y236_V2.1941.00
67_M193_S2.1401.00
69_N78_L2.1171.00
141_L156_V2.0731.00
239_S249_P2.0441.00
198_T232_K2.0171.00
174_I221_M2.0001.00
269_D329_L1.9931.00
137_Y250_V1.9771.00
174_I215_G1.9711.00
153_E356_A1.9641.00
75_R79_Q1.9641.00
95_M187_R1.9631.00
209_D212_N1.9481.00
65_D79_Q1.9191.00
73_F204_R1.9111.00
235_A244_I1.9001.00
137_Y140_A1.8961.00
315_L327_Y1.8621.00
157_G352_G1.8411.00
90_S93_R1.8191.00
237_D241_D1.8051.00
82_L196_L1.7391.00
191_Y227_M1.7371.00
82_L85_A1.7321.00
78_L82_L1.6971.00
74_D204_R1.6961.00
133_F136_Q1.6641.00
280_P283_P1.6611.00
155_I253_I1.6311.00
142_N145_W1.6301.00
77_Q204_R1.6211.00
224_G256_V1.6101.00
79_Q83_S1.6061.00
71_H201_L1.5991.00
205_D232_K1.5971.00
173_R176_D1.5961.00
148_Y238_F1.5831.00
203_A210_P1.5610.99
290_Y294_Q1.5440.99
290_Y298_A1.5330.99
294_Q298_A1.5290.99
291_S294_Q1.5240.99
130_G165_W1.5230.99
261_K267_K1.5130.99
154_I352_G1.5080.99
67_M71_H1.5020.99
173_R210_P1.4920.99
161_V347_A1.4900.99
73_F197_E1.4790.99
195_E198_T1.4770.99
158_I338_Y1.4730.99
271_V349_W1.4490.99
289_K333_Y1.4450.99
134_W355_V1.4380.99
234_Y262_A1.4180.99
231_Y244_I1.4100.99
56_N183_F1.4100.99
133_F137_Y1.3990.99
274_M326_W1.3990.99
54_F184_N1.3970.99
158_I344_Y1.3940.99
112_G121_F1.3880.99
226_F255_S1.3820.99
85_A176_D1.3780.99
175_L196_L1.3720.99
60_A183_F1.3650.99
87_R184_N1.3640.99
207_Q244_I1.3620.99
169_M223_Y1.3620.99
112_G120_K1.3410.98
60_A64_I1.3400.98
61_Q82_L1.3390.98
73_F78_L1.3320.98
90_S94_L1.3250.98
199_F213_L1.3220.98
266_V330_P1.3200.98
139_D142_N1.3200.98
88_L91_V1.3100.98
90_S172_T1.3090.98
258_N262_A1.3050.98
92_L96_D1.2910.98
147_V238_F1.2880.98
82_L175_L1.2820.98
94_L172_T1.2770.98
350_Q354_A1.2650.98
349_W353_Q1.2650.98
294_Q297_A1.2540.97
223_Y252_A1.2470.97
140_A144_A1.2460.97
250_V253_I1.2360.97
336_T345_A1.2020.97
206_E244_I1.1990.97
303_Q306_L1.1990.97
71_H197_E1.1960.97
112_G116_R1.1950.97
277_G315_L1.1950.97
156_V355_V1.1910.97
65_D69_N1.1900.96
129_N132_V1.1890.96
157_G355_V1.1860.96
338_Y344_Y1.1800.96
237_D242_G1.1660.96
336_T342_T1.1610.96
230_S259_Y1.1590.96
114_W341_S1.1580.96
57_N60_A1.1550.96
134_W138_E1.1490.96
127_V354_A1.1460.96
129_N167_R1.1180.95
143_R238_F1.1170.95
132_V136_Q1.1070.95
142_N146_Q1.1060.95
333_Y336_T1.1010.95
271_V353_Q1.0950.94
64_I196_L1.0890.94
276_N301_T1.0860.94
270_Q273_V1.0760.94
86_K176_D1.0740.94
121_F161_V1.0610.93
231_Y235_A1.0550.93
241_D249_P1.0550.93
192_F227_M1.0540.93
221_M231_Y1.0460.93
336_T340_H1.0350.93
155_I256_V1.0280.92
230_S234_Y1.0280.92
95_M184_N1.0270.92
73_F77_Q1.0200.92
129_N133_F1.0100.92
151_P154_I1.0100.92
174_I199_F1.0070.92
73_F201_L1.0050.91
296_A308_N1.0040.91
134_W141_L0.9970.91
263_H334_T0.9880.91
275_A315_L0.9780.90
127_V355_V0.9750.90
351_L355_V0.9710.90
195_E227_M0.9670.90
164_R168_V0.9650.90
85_A179_A0.9570.89
140_A143_R0.9520.89
234_Y258_N0.9470.89
277_G325_Y0.9470.89
292_I296_A0.9430.89
272_A349_W0.9420.89
234_Y263_H0.9410.88
144_A257_A0.9410.88
142_N152_P0.9360.88
224_G252_A0.9330.88
201_L232_K0.9320.88
122_I347_A0.9310.88
230_S263_H0.9300.88
91_V177_A0.9280.88
151_P356_A0.9240.88
254_G257_A0.9230.88
350_Q353_Q0.9210.87
164_R167_R0.9190.87
88_L172_T0.9190.87
252_A256_V0.9150.87
273_V302_P0.9120.87
274_M324_Q0.9100.87
78_L204_R0.9090.87
293_S308_N0.9060.87
114_W118_R0.9060.87
131_V355_V0.9010.86
149_G267_K0.8960.86
139_D143_R0.8900.86
168_V171_K0.8890.85
286_F314_L0.8790.85
73_F82_L0.8780.85
296_A309_H0.8770.85
195_E233_Q0.8770.85
134_W152_P0.8700.84
236_V254_G0.8660.84
216_S220_A0.8640.84
272_A326_W0.8620.84
82_L200_L0.8540.83
175_L203_A0.8530.83
54_F58_P0.8530.83
124_P354_A0.8500.83
91_V181_L0.8450.82
58_P61_Q0.8440.82
95_M186_P0.8420.82
302_P306_L0.8400.82
69_N79_Q0.8390.82
163_T256_V0.8370.82
94_L97_N0.8360.82
159_I256_V0.8340.82
346_M350_Q0.8330.82
74_D77_Q0.8320.81
64_I68_V0.8290.81
201_L204_R0.8280.81
125_D164_R0.8260.81
154_I335_I0.8250.81
96_D187_R0.8250.81
272_A328_G0.8230.81
131_V134_W0.8180.80
127_V351_L0.8160.80
115_L319_V0.8160.80
179_A196_L0.8150.80
259_Y335_I0.8130.80
61_Q65_D0.8040.79
282_L285_G0.8030.79
170_G215_G0.8000.79
277_G300_L0.8000.79
159_I223_Y0.7940.78
97_N111_N0.7910.78
314_L333_Y0.7900.78
53_D56_N0.7810.77
154_I348_V0.7800.77
114_W343_H0.7780.77
135_N139_D0.7770.77
57_N179_A0.7760.77
78_L200_L0.7720.76
283_P290_Y0.7710.76
144_A155_I0.7700.76
319_V324_Q0.7690.76
328_G345_A0.7620.75
154_I349_W0.7600.75
212_N248_D0.7600.75
326_W350_Q0.7600.75
190_E194_G0.7590.75
191_Y230_S0.7570.75
221_M246_L0.7540.75
330_P334_T0.7510.74
330_P333_Y0.7480.74
275_A300_L0.7470.74
320_G323_Y0.7450.74
92_L95_M0.7440.74
188_R218_A0.7440.74
270_Q329_L0.7410.73
301_T305_P0.7380.73
243_H279_A0.7380.73
70_K197_E0.7360.73
147_V279_A0.7340.73
67_M197_E0.7280.72
114_W338_Y0.7260.72
335_I345_A0.7210.71
152_P155_I0.7200.71
141_L145_W0.7170.71
141_L152_P0.7160.71
231_Y247_W0.7150.71
181_L215_G0.7150.71
263_H337_R0.7140.71
316_R323_Y0.7130.71
138_E152_P0.7130.71
125_D129_N0.7120.70
64_I193_S0.7110.70
84_Q176_D0.7100.70
292_I329_L0.7090.70
277_G317_L0.7090.70
313_S327_Y0.7090.70
208_D213_L0.7090.70
283_P298_A0.7060.70
202_M231_Y0.7020.69
77_Q81_I0.7020.69
82_L179_A0.7020.69
189_A193_S0.6930.68
208_D247_W0.6930.68
146_Q297_A0.6920.68
197_E201_L0.6920.68
65_D68_V0.6920.68
213_L221_M0.6900.68
226_F230_S0.6820.67
85_A196_L0.6810.67
296_A301_T0.6810.67
66_K193_S0.6800.67
272_A353_Q0.6770.67
85_A175_L0.6760.66
48_M51_G0.6750.66
170_G255_S0.6750.66
64_I78_L0.6740.66
114_W319_V0.6700.66
115_L119_K0.6690.66
181_L218_A0.6680.66
202_M213_L0.6680.66
191_Y259_Y0.6680.66
134_W144_A0.6660.65
65_D78_L0.6660.65
87_R176_D0.6660.65
68_V75_R0.6640.65
64_I82_L0.6610.65
288_T314_L0.6590.64
100_P117_Y0.6570.64
123_T126_N0.6570.64
314_L327_Y0.6530.64
195_E256_V0.6520.64
208_D244_I0.6490.63
135_N138_E0.6460.63
156_V160_G0.6450.63
169_M224_G0.6430.63
318_D323_Y0.6410.62
274_M323_Y0.6410.62
302_P327_Y0.6400.62
303_Q307_G0.6350.62
273_V292_I0.6330.61
227_M340_H0.6330.61
136_Q250_V0.6320.61
126_N164_R0.6310.61
236_V258_N0.6310.61
59_N62_Q0.6290.61
226_F258_N0.6290.61
218_A227_M0.6290.61
68_V72_G0.6240.60
199_F202_M0.6220.60
144_A252_A0.6220.60
202_M208_D0.6210.60
71_H204_R0.6200.60
91_V172_T0.6200.60
121_F347_A0.6190.60
349_W352_G0.6160.59
126_N160_G0.6120.59
234_Y337_R0.6100.59
126_N170_G0.6100.59
269_D311_Q0.6080.58
175_L179_A0.6080.58
207_Q243_H0.6060.58
229_S233_Q0.6060.58
256_V259_Y0.6050.58
201_L205_D0.6020.58
147_V261_K0.5990.57
189_A227_M0.5940.57
114_W176_D0.5930.56
113_A319_V0.5920.56
143_R146_Q0.5920.56
234_Y336_T0.5920.56
326_W346_M0.5890.56
151_P267_K0.5860.56
124_P131_V0.5860.56
95_M181_L0.5850.55
80_E132_V0.5850.55
81_I203_A0.5850.55
255_S259_Y0.5840.55
348_V351_L0.5830.55
276_N303_Q0.5830.55
227_M230_S0.5820.55
63_F71_H0.5790.55
203_A213_L0.5770.54
163_T246_L0.5750.54
290_Y295_L0.5750.54
121_F348_V0.5740.54
217_F324_Q0.5730.54
238_F332_F0.5730.54
198_T227_M0.5720.54
286_F333_Y0.5720.54
88_L177_A0.5700.53
113_A116_R0.5690.53
117_Y220_A0.5680.53
199_F203_A0.5660.53
75_R78_L0.5660.53
63_F67_M0.5650.53
153_E156_V0.5620.52
52_G277_G0.5620.52
263_H338_Y0.5620.52
295_L327_Y0.5620.52
246_L249_P0.5610.52
174_I227_M0.5610.52
148_Y257_A0.5610.52
181_L184_N0.5600.52
203_A208_D0.5580.52
292_I306_L0.5580.52
55_A69_N0.5570.52
56_N59_N0.5560.52
94_L163_T0.5540.51
67_M70_K0.5520.51
302_P305_P0.5500.51
292_I305_P0.5460.50
296_A305_P0.5460.50
264_G334_T0.5450.50
64_I192_F0.5440.50
238_F253_I0.5420.50
194_G234_Y0.5390.50
158_I263_H0.5390.50
163_T263_H0.5390.50
152_P156_V0.5390.50
308_N311_Q0.5380.49
340_H343_H0.5370.49
142_N268_G0.5360.49
73_F200_L0.5350.49
94_L100_P0.5340.49
160_G355_V0.5340.49
169_M214_K0.5330.49
173_R354_A0.5330.49
186_P263_H0.5320.49
76_Q128_Q0.5300.48
78_L81_I0.5300.48
202_M244_I0.5300.48
317_L325_Y0.5300.48
270_Q302_P0.5290.48
155_I259_Y0.5280.48
144_A238_F0.5270.48
50_M53_D0.5270.48
292_I315_L0.5270.48
191_Y194_G0.5260.48
63_F193_S0.5260.48
260_F264_G0.5230.47
97_N184_N0.5220.47
148_Y151_P0.5200.47
252_A260_F0.5200.47
84_Q211_L0.5200.47
275_A302_P0.5200.47
336_T341_S0.5190.47
323_Y354_A0.5190.47
149_G186_P0.5190.47
169_M250_V0.5170.47
100_P112_G0.5150.46
132_V167_R0.5150.46
280_P284_N0.5140.46
121_F336_T0.5140.46
117_Y226_F0.5140.46
131_V135_N0.5120.46
158_I224_G0.5120.46
179_A247_W0.5120.46
99_A217_F0.5120.46
118_R350_Q0.5120.46
227_M231_Y0.5090.46
101_T191_Y0.5090.46
191_Y202_M0.5090.46
68_V271_V0.5090.46
140_A238_F0.5080.46
313_S328_G0.5070.45
60_A224_G0.5050.45
176_D344_Y0.5050.45
132_V137_Y0.5040.45
205_D231_Y0.5030.45
224_G338_Y0.5010.45
140_A253_I0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4anrA 1 0.8061 100 0.282 Contact Map
1qusA 1 0.8643 100 0.292 Contact Map
3gxrA 1 0.5097 99.6 0.872 Contact Map
4p0gA 1 0.7452 99.4 0.886 Contact Map
4g9sA 1 0.4986 99.3 0.887 Contact Map
3w6bA 1 0.4266 99.3 0.889 Contact Map
1gbsA 1 0.4875 99.2 0.893 Contact Map
1qsaA 1 0.7119 99.2 0.894 Contact Map
4hjzA 1 0.4598 99.2 0.896 Contact Map
4cfpA 1 0.7424 98.6 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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