GREMLIN Database
YCBF - Uncharacterized fimbrial chaperone YcbF
UniProt: P40876 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12397
Length: 236 (213)
Sequences: 2881 (2181)
Seq/√Len: 149.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
180_N196_V3.2431.00
62_I142_L3.2261.00
178_Y198_P3.0151.00
165_N170_Q3.0151.00
114_L196_V2.9211.00
38_P41_R2.9151.00
172_T202_Q2.9011.00
198_P201_S2.8491.00
111_R200_K2.8331.00
30_V140_F2.8071.00
162_W171_L2.7281.00
161_R172_T2.6611.00
107_L115_F2.6221.00
170_Q204_Q2.5301.00
35_F117_L2.5211.00
35_F44_I2.4741.00
170_Q202_Q2.4531.00
56_W121_S2.4401.00
143_F196_V2.4201.00
40_D147_E2.4041.00
155_E158_Q2.3851.00
35_F99_L2.3521.00
171_L205_T2.2291.00
222_N228_S2.2181.00
53_Q92_G2.2141.00
143_F178_Y2.1301.00
163_T170_Q2.1121.00
55_S90_K2.0741.00
63_N139_V2.0671.00
61_K118_S1.9961.00
120_A137_R1.9261.00
160_L171_L1.8841.00
38_P44_I1.8081.00
108_P113_T1.7871.00
60_S97_L1.7841.00
160_L179_I1.7831.00
149_L177_Y1.7691.00
55_S88_L1.7421.00
80_L99_L1.6921.00
30_V119_I1.6891.00
82_A97_L1.6531.00
156_A179_I1.6361.00
159_Q175_T1.6191.00
90_K93_T1.6191.00
152_D155_E1.6131.00
63_N118_S1.5951.00
62_I78_A1.5771.00
156_A220_A1.5681.00
118_S139_V1.5571.00
46_I117_L1.5471.00
114_L143_F1.5201.00
101_R105_D1.5091.00
163_T172_T1.5071.00
183_Q219_R1.4851.00
179_I220_A1.4851.00
222_N226_G1.4341.00
160_L181_L1.4081.00
58_I87_I1.3911.00
168_G204_Q1.3871.00
37_F44_I1.3541.00
153_P156_A1.3171.00
197_V203_R1.3131.00
80_L142_L1.3101.00
39_A109_V1.2691.00
162_W218_W1.2591.00
47_L94_T1.2551.00
30_V46_I1.2501.00
43_S98_R1.2491.00
82_A99_L1.2471.00
114_L180_N1.2311.00
52_S121_S1.2271.00
35_F140_F1.2251.00
176_P200_K1.1971.00
108_P111_R1.1951.00
61_K139_V1.1861.00
180_N220_A1.1841.00
185_S217_A1.1711.00
101_R144_W1.1671.00
39_A147_E1.1541.00
28_V89_L1.1421.00
99_L142_L1.1401.00
48_L89_L1.1381.00
220_A228_S1.1270.99
101_R106_I1.1190.99
185_S190_A1.1180.99
182_I227_L1.1160.99
169_V207_W1.1080.99
157_Y179_I1.1070.99
64_R76_V1.1060.99
126_K133_K1.0840.99
32_G46_I1.0710.99
157_Y218_W1.0640.99
66_T73_A1.0580.99
181_L197_V1.0510.99
126_K131_S1.0440.99
29_V32_G1.0440.99
61_K120_A1.0360.99
10_L18_L1.0260.99
117_L142_L1.0230.99
97_L117_L1.0210.99
87_I95_G1.0170.99
27_G121_S1.0160.99
116_E139_V1.0100.99
165_N204_Q1.0050.99
165_N168_G1.0000.99
39_A144_W0.9940.99
121_S136_M0.9800.99
28_V58_I0.9730.98
95_G120_A0.9720.98
37_F100_L0.9620.98
31_G47_L0.9450.98
97_L119_I0.9390.98
181_L220_A0.9370.98
49_T94_T0.9320.98
63_N116_E0.9260.98
37_F80_L0.9220.98
82_A117_L0.9160.98
151_G177_Y0.9100.98
31_G94_T0.9050.98
159_Q174_P0.9030.98
10_L13_F0.8950.97
219_R227_L0.8910.97
135_A162_W0.8910.97
89_L94_T0.8890.97
48_L58_I0.8880.97
162_W184_V0.8850.97
107_L111_R0.8790.97
52_S56_W0.8780.97
12_I15_V0.8780.97
185_S188_G0.8760.97
141_K221_I0.8720.97
148_G151_G0.8680.97
30_V48_L0.8660.97
34_R145_R0.8640.97
178_Y199_P0.8560.97
130_Q133_K0.8550.97
27_G51_T0.8540.97
62_I82_A0.8500.96
172_T200_K0.8490.96
21_A25_Q0.8430.96
116_E120_A0.8420.96
60_S82_A0.8390.96
110_D200_K0.8380.96
186_V216_V0.8370.96
35_F46_I0.8170.96
182_I221_I0.8160.96
95_G121_S0.8140.95
187_N211_I0.8130.95
64_R74_S0.8120.95
114_L178_Y0.7930.95
161_R174_P0.7900.95
115_F144_W0.7840.94
62_I122_V0.7800.94
14_A17_S0.7740.94
36_I145_R0.7590.93
118_S137_R0.7580.93
153_P157_Y0.7570.93
32_G35_F0.7570.93
56_W60_S0.7520.93
87_I97_L0.7490.93
60_S119_I0.7460.93
187_N214_C0.7450.93
153_P179_I0.7450.93
119_I140_F0.7430.93
157_Y220_A0.7420.93
162_W169_V0.7410.93
167_Q204_Q0.7400.93
180_N194_V0.7360.92
29_V51_T0.7330.92
112_E145_R0.7310.92
27_G56_W0.7280.92
181_L226_G0.7260.92
151_G155_E0.7240.92
118_S141_K0.7230.92
169_V184_V0.7230.92
89_L95_G0.7220.92
10_L15_V0.7180.91
89_L93_T0.7180.91
37_F101_R0.7140.91
109_V148_G0.7110.91
56_W120_A0.7080.91
47_L86_L0.7060.91
110_D145_R0.6990.90
157_Y160_L0.6990.90
66_T75_T0.6960.90
65_P116_E0.6940.90
58_I89_L0.6890.90
64_R77_P0.6890.90
59_N120_A0.6880.90
11_L14_A0.6870.90
34_R146_P0.6870.90
29_V138_S0.6850.89
113_T144_W0.6850.89
34_R141_K0.6840.89
194_V205_T0.6790.89
141_K180_N0.6790.89
184_V205_T0.6780.89
208_C211_I0.6730.89
107_L113_T0.6710.88
121_S135_A0.6700.88
111_R146_P0.6690.88
99_L117_L0.6690.88
13_F16_L0.6660.88
20_V24_L0.6650.88
169_V216_V0.6650.88
15_V18_L0.6640.88
55_S124_S0.6560.87
64_R78_A0.6560.87
98_R123_P0.6490.87
86_L94_T0.6470.87
116_E141_K0.6450.86
157_Y175_T0.6410.86
189_K210_A0.6360.86
141_K145_R0.6350.86
85_P122_V0.6330.85
147_E150_P0.6320.85
136_M194_V0.6300.85
30_V51_T0.6290.85
20_V25_Q0.6240.85
151_G156_A0.6230.84
38_P143_F0.6210.84
110_D113_T0.6200.84
34_R223_D0.6190.84
28_V56_W0.6180.84
16_L21_A0.6170.84
128_E227_L0.6150.84
168_G206_S0.6110.83
107_L110_D0.6090.83
155_E159_Q0.6010.82
116_E180_N0.5980.82
65_P114_L0.5980.82
103_E106_I0.5960.82
51_T124_S0.5950.82
60_S95_G0.5940.82
63_N73_A0.5930.81
37_F42_E0.5880.81
22_G25_Q0.5830.80
197_V201_S0.5810.80
61_K138_S0.5810.80
30_V57_L0.5800.80
60_S87_I0.5790.80
123_P135_A0.5770.80
30_V138_S0.5770.80
48_L124_S0.5770.80
191_L210_A0.5760.80
157_Y174_P0.5760.80
33_T145_R0.5760.80
181_L218_W0.5750.79
23_E211_I0.5730.79
80_L144_W0.5730.79
164_R209_Q0.5710.79
57_L120_A0.5710.79
21_A24_L0.5700.79
185_S219_R0.5700.79
45_S55_S0.5690.79
19_L190_A0.5690.79
116_E119_I0.5670.79
186_V215_H0.5650.78
127_V161_R0.5590.78
100_L199_P0.5580.77
56_W89_L0.5570.77
65_P139_V0.5540.77
46_I99_L0.5510.77
57_L177_Y0.5490.76
152_D177_Y0.5480.76
121_S137_R0.5480.76
11_L19_L0.5480.76
189_K211_I0.5450.76
81_L100_L0.5450.76
219_R229_A0.5440.76
145_R199_P0.5430.75
122_V136_M0.5420.75
59_N98_R0.5420.75
25_Q169_V0.5410.75
43_S61_K0.5400.75
184_V207_W0.5400.75
132_V139_V0.5390.75
183_Q190_A0.5380.75
22_G206_S0.5370.75
76_V79_P0.5370.75
203_R206_S0.5360.75
12_I53_Q0.5340.74
37_F41_R0.5320.74
52_S120_A0.5320.74
169_V204_Q0.5320.74
16_L19_L0.5310.74
146_P199_P0.5300.74
63_N134_V0.5300.74
116_E137_R0.5290.74
57_L85_P0.5250.73
48_L119_I0.5250.73
164_R212_A0.5250.73
106_I109_V0.5240.73
79_P113_T0.5240.73
121_S218_W0.5240.73
164_R167_Q0.5230.73
62_I115_F0.5200.72
131_S135_A0.5180.72
65_P73_A0.5160.72
15_V22_G0.5150.72
178_Y201_S0.5150.72
160_L220_A0.5150.72
45_S134_V0.5140.71
193_N227_L0.5140.71
221_I228_S0.5130.71
125_G133_K0.5130.71
57_L88_L0.5110.71
61_K116_E0.5100.71
187_N192_S0.5090.71
60_S99_L0.5070.70
145_R177_Y0.5070.70
23_E26_A0.5060.70
162_W196_V0.5030.70
47_L134_V0.5030.70
63_N120_A0.5030.70
109_V147_E0.5020.70
11_L192_S0.5020.70
133_K136_M0.5020.70
186_V207_W0.5010.70
17_S21_A0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co7B 1 0.8305 100 0.168 Contact Map
1klfA 1 0.8517 100 0.178 Contact Map
1l4iA 2 0.8136 100 0.181 Contact Map
3q48A 1 0.8051 100 0.186 Contact Map
2xg5A 1 0.8517 100 0.209 Contact Map
4djmA 1 0.8517 100 0.212 Contact Map
3gfuC 1 0.8263 100 0.212 Contact Map
4ay0A 2 0.8051 100 0.216 Contact Map
4ncdA 2 0.8178 100 0.276 Contact Map
1mspA 3 0.4788 93.1 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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