GREMLIN Database
MTOX - N-methyl-L-tryptophan oxidase
UniProt: P40874 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12669
Length: 372 (337)
Sequences: 30540 (22661)
Seq/√Len: 1234.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_A164_C5.6591.00
33_A171_P3.8511.00
4_D194_K3.3561.00
4_D27_N3.3451.00
171_P187_A3.2191.00
29_L167_L3.1681.00
174_A185_E3.1511.00
6_I193_A3.1111.00
6_I184_I3.0281.00
176_R185_E2.6411.00
27_N165_A2.5571.00
6_I31_T2.5361.00
72_D86_R2.5191.00
31_T191_Y2.5051.00
22_T162_A2.4351.00
5_L21_A2.4201.00
118_D121_G2.4021.00
66_R348_E2.3411.00
5_L26_L2.2281.00
22_T164_C2.2111.00
122_I137_G2.1841.00
26_L355_Q2.1721.00
23_R77_H2.1641.00
17_A197_I2.1221.00
178_D183_T2.0491.00
24_A355_Q1.9861.00
20_Y348_E1.9781.00
115_E121_G1.9631.00
6_I191_Y1.9591.00
156_I160_K1.9321.00
173_T187_A1.9311.00
195_K330_L1.9291.00
73_E77_H1.8571.00
173_T185_E1.8481.00
15_A156_I1.8321.00
22_T159_A1.8221.00
20_Y347_G1.8211.00
286_S290_P1.8111.00
19_Y158_L1.8081.00
332_I346_L1.7581.00
121_G124_A1.7481.00
352_D357_K1.7431.00
23_R162_A1.7271.00
176_R183_T1.7111.00
15_A152_I1.6941.00
158_L161_E1.6911.00
335_L346_L1.6731.00
186_T191_Y1.6691.00
157_Q160_K1.6561.00
183_T192_Q1.6331.00
167_L170_C1.6281.00
156_I166_Q1.6261.00
330_L354_A1.6191.00
158_L162_A1.6181.00
195_K354_A1.5971.00
197_I354_A1.5951.00
4_D29_L1.5801.00
330_L350_A1.5781.00
24_A357_K1.5741.00
170_C186_T1.5731.00
119_A123_M1.5721.00
70_L73_E1.5701.00
223_Y226_D1.5671.00
20_Y24_A1.5641.00
204_V333_T1.5481.00
198_V204_V1.5451.00
19_Y23_R1.5411.00
5_L195_K1.5401.00
105_H109_Q1.5311.00
98_T101_A1.5281.00
175_I182_V1.5241.00
101_A105_H1.5221.00
172_V184_I1.5091.00
31_T167_L1.5001.00
83_I150_L1.5001.00
177_H182_V1.4981.00
70_L348_E1.4861.00
101_A116_K1.4751.00
332_I350_A1.4691.00
36_P168_F1.4641.00
282_A286_S1.4531.00
347_G351_A1.4471.00
157_Q161_E1.4361.00
6_I29_L1.4141.00
31_T193_A1.4081.00
293_R300_G1.4031.00
115_E141_T1.3991.00
105_H108_E1.3931.00
4_D26_L1.3891.00
218_K310_Y1.3891.00
29_L191_Y1.3831.00
24_A352_D1.3801.00
10_S30_M1.3771.00
104_A108_E1.3681.00
193_A196_A1.3611.00
16_A20_Y1.3581.00
29_L165_A1.3571.00
13_V332_I1.3511.00
20_Y23_R1.3421.00
178_D192_Q1.3411.00
66_R69_T1.3321.00
41_G44_H1.3291.00
113_N142_D1.3271.00
36_P156_I1.3211.00
19_Y162_A1.3091.00
198_V329_T1.3081.00
17_A332_I1.3041.00
150_L153_K1.2881.00
147_R150_L1.2871.00
10_S36_P1.2871.00
12_S343_A1.2871.00
285_G305_G1.2811.00
35_M168_F1.2751.00
71_W151_A1.2681.00
236_P239_T1.2581.00
102_N105_H1.2561.00
115_E139_F1.2541.00
7_I18_G1.2511.00
185_E190_E1.2511.00
21_A351_A1.2431.00
177_H326_H1.2341.00
224_Q303_L1.2331.00
34_H38_H1.2291.00
30_M166_Q1.2281.00
13_V335_L1.2221.00
73_E76_R1.2201.00
236_P240_G1.2171.00
69_T73_E1.2151.00
175_I196_A1.2091.00
18_G30_M1.2021.00
8_I200_A1.2021.00
24_A351_A1.1941.00
159_A166_Q1.1931.00
178_D181_G1.1751.00
348_E352_D1.1741.00
15_A159_A1.1721.00
84_F144_G1.1681.00
349_I352_D1.1641.00
198_V331_L1.1601.00
8_I196_A1.1511.00
120_Q124_A1.1471.00
330_L353_F1.1351.00
31_T172_V1.1271.00
18_G164_C1.1241.00
88_G139_F1.1241.00
15_A30_M1.1241.00
98_T102_N1.1231.00
58_E62_P1.1221.00
289_F293_R1.1151.00
121_G125_R1.1131.00
167_L191_Y1.1021.00
117_L121_G1.1011.00
182_V328_N1.0981.00
182_V196_A1.0941.00
235_F239_T1.0941.00
149_E153_K1.0931.00
67_A71_W1.0921.00
186_T189_G1.0911.00
235_F238_F1.0901.00
297_P300_G1.0831.00
72_D76_R1.0801.00
195_K198_V1.0771.00
323_L331_L1.0721.00
17_A347_G1.0681.00
18_G28_V1.0621.00
35_M169_N1.0581.00
7_I17_A1.0451.00
37_P152_I1.0431.00
37_P168_F1.0261.00
96_D135_Y1.0241.00
117_L125_R1.0181.00
170_C191_Y1.0171.00
186_T190_E1.0121.00
332_I335_L1.0071.00
34_H39_Q1.0021.00
200_A204_V0.9941.00
99_F102_N0.9871.00
322_T327_D0.9791.00
170_C188_D0.9791.00
17_A199_C0.9701.00
318_F321_D0.9691.00
183_T190_E0.9671.00
65_L69_T0.9671.00
8_I198_V0.9661.00
15_A166_Q0.9641.00
175_I184_I0.9601.00
316_E321_D0.9601.00
291_F294_N0.9601.00
125_R139_F0.9591.00
199_C332_I0.9571.00
104_A116_K0.9541.00
290_P294_N0.9541.00
293_R298_G0.9541.00
21_A26_L0.9531.00
290_P293_R0.9471.00
115_E125_R0.9461.00
196_A328_N0.9451.00
146_L151_A0.9381.00
10_S32_D0.9361.00
260_I292_L0.9351.00
326_H329_T0.9321.00
103_V106_S0.9281.00
195_K322_T0.9251.00
13_V199_C0.9201.00
18_G159_A0.9181.00
16_A155_W0.9161.00
28_V164_C0.9141.00
75_S82_P0.9061.00
154_T158_L0.9051.00
16_A347_G0.9041.00
351_A354_A0.9001.00
317_D320_I0.8991.00
68_Q72_D0.8951.00
156_I168_F0.8931.00
234_K238_F0.8921.00
177_H328_N0.8881.00
233_N236_P0.8831.00
66_R70_L0.8801.00
160_K165_A0.8791.00
200_A207_L0.8781.00
49_L52_H0.8711.00
146_L340_F0.8701.00
78_N158_L0.8561.00
177_H181_G0.8541.00
26_L195_K0.8531.00
285_G289_F0.8521.00
181_G192_Q0.8501.00
8_I172_V0.8501.00
206_D209_P0.8491.00
309_T312_N0.8421.00
48_R51_R0.8411.00
235_F240_G0.8401.00
195_K328_N0.8391.00
24_A348_E0.8301.00
281_V284_D0.8291.00
49_L53_A0.8231.00
20_Y70_L0.8221.00
4_D192_Q0.8201.00
318_F322_T0.8191.00
19_Y159_A0.8161.00
48_R52_H0.8151.00
176_R192_Q0.8121.00
151_A340_F0.8081.00
237_A240_G0.8081.00
104_A138_L0.8071.00
101_A104_A0.8041.00
236_P241_E0.8021.00
22_T27_N0.8021.00
320_I323_L0.8011.00
287_E290_P0.8011.00
71_W343_A0.8001.00
198_V208_L0.7991.00
22_T28_V0.7991.00
234_K239_T0.7981.00
320_I346_L0.7981.00
19_Y155_W0.7941.00
16_A344_S0.7941.00
67_A70_L0.7911.00
90_I122_I0.7911.00
173_T186_T0.7901.00
316_E320_I0.7891.00
182_V329_T0.7881.00
154_T157_Q0.7871.00
32_D168_F0.7871.00
108_E113_N0.7861.00
21_A354_A0.7811.00
44_H47_T0.7801.00
194_K328_N0.7771.00
151_A344_S0.7751.00
222_W225_A0.7711.00
171_P206_D0.7681.00
119_A122_I0.7661.00
120_Q123_M0.7661.00
344_S347_G0.7651.00
270_H279_A0.7641.00
102_N106_S0.7631.00
60_Y64_V0.7611.00
320_I324_P0.7591.00
27_N194_K0.7541.00
177_H327_D0.7531.00
88_G141_T0.7521.00
257_A303_L0.7511.00
58_E61_V0.7501.00
32_D35_M0.7491.00
108_E114_V0.7471.00
217_R265_G0.7471.00
31_T186_T0.7461.00
17_A354_A0.7431.00
233_N239_T0.7381.00
107_A112_L0.7381.00
222_W259_K0.7351.00
5_L197_I0.7341.00
224_Q227_G0.7341.00
338_H341_K0.7331.00
68_Q71_W0.7321.00
343_A347_G0.7301.00
287_E291_F0.7291.00
107_A111_Q0.7251.00
90_I137_G0.7211.00
45_G48_R0.7201.00
61_V65_L0.7191.00
181_G194_K0.7191.00
16_A343_A0.7171.00
308_C311_D0.7171.00
23_R158_L0.7161.00
219_V265_G0.7161.00
185_E188_D0.7141.00
12_S340_F0.7131.00
48_R53_A0.7121.00
43_H306_A0.7121.00
93_G100_L0.7111.00
289_F305_G0.7101.00
181_G327_D0.7061.00
293_R299_I0.7041.00
172_V175_I0.7031.00
100_L104_A0.7031.00
159_A163_G0.7011.00
335_L340_F0.7011.00
66_R345_V0.6991.00
10_S168_F0.6981.00
214_Q266_G0.6981.00
62_P65_L0.6971.00
4_D191_Y0.6971.00
67_A345_V0.6971.00
74_L78_N0.6961.00
26_L29_L0.6961.00
36_P166_Q0.6941.00
30_M159_A0.6931.00
238_F241_E0.6911.00
197_I350_A0.6901.00
151_A155_W0.6901.00
223_Y260_I0.6871.00
86_R142_D0.6841.00
59_K64_V0.6831.00
317_D321_D0.6791.00
177_H180_D0.6791.00
59_K62_P0.6751.00
167_L190_E0.6751.00
117_L122_I0.6751.00
116_K136_I0.6721.00
81_D150_L0.6721.00
64_V68_Q0.6711.00
351_A355_Q0.6701.00
122_I125_R0.6701.00
4_D193_A0.6691.00
208_L331_L0.6681.00
313_S319_I0.6661.00
83_I147_R0.6651.00
216_V312_N0.6651.00
291_F295_V0.6621.00
90_I139_F0.6611.00
249_Y261_G0.6601.00
170_C187_A0.6601.00
221_A302_C0.6591.00
261_G266_G0.6561.00
152_I156_I0.6521.00
306_A309_T0.6511.00
283_S286_S0.6511.00
233_N238_F0.6501.00
320_I350_A0.6471.00
330_L357_K0.6471.00
6_I196_A0.6471.00
17_A350_A0.6461.00
62_P66_R0.6451.00
293_R301_C0.6441.00
107_A110_W0.6441.00
10_S156_I0.6431.00
103_V107_A0.6421.00
223_Y302_C0.6401.00
31_T170_C0.6401.00
282_A285_G0.6391.00
322_T330_L0.6381.00
170_C189_G0.6381.00
335_L338_H0.6371.00
106_S109_Q0.6351.00
173_T188_D0.6351.00
85_V145_F0.6341.00
322_T353_F0.6331.00
246_D251_F0.6321.00
5_L28_V0.6321.00
308_C312_N0.6311.00
259_K263_H0.6291.00
12_S152_I0.6281.00
332_I347_G0.6241.00
71_W75_S0.6221.00
65_L68_Q0.6201.00
69_T72_D0.6171.00
10_S37_P0.6141.00
213_V311_D0.6131.00
237_A241_E0.6121.00
172_V186_T0.6101.00
345_V348_E0.6091.00
40_H44_H0.6081.00
316_E319_I0.6071.00
251_F254_E0.6071.00
153_K157_Q0.6071.00
71_W74_L0.6061.00
180_D327_D0.6051.00
150_L154_T0.6041.00
222_W304_Y0.6031.00
235_F241_E0.6031.00
16_A151_A0.6021.00
182_V326_H0.6021.00
113_N141_T0.6011.00
116_K138_L0.6011.00
13_V346_L0.6011.00
104_A114_V0.6001.00
29_L193_A0.5991.00
173_T176_R0.5981.00
35_M38_H0.5971.00
292_L299_I0.5971.00
122_I134_N0.5951.00
123_M127_P0.5951.00
108_E111_Q0.5931.00
20_Y351_A0.5921.00
47_T50_I0.5921.00
265_G284_D0.5891.00
224_Q257_A0.5891.00
30_M164_C0.5881.00
37_P156_I0.5881.00
352_D356_D0.5861.00
70_L74_L0.5861.00
123_M130_R0.5841.00
233_N237_A0.5821.00
43_H47_T0.5821.00
64_V67_A0.5811.00
71_W344_S0.5811.00
220_F306_A0.5801.00
337_G341_K0.5791.00
286_S289_F0.5781.00
175_I329_T0.5771.00
290_P300_G0.5771.00
130_R133_D0.5761.00
265_G268_V0.5761.00
322_T328_N0.5741.00
345_V349_I0.5711.00
187_A190_E0.5701.00
321_D324_P0.5701.00
248_Y251_F0.5701.00
216_V220_F0.5681.00
95_A135_Y0.5661.00
117_L139_F0.5661.00
234_K237_A0.5641.00
24_A356_D0.5631.00
47_T53_A0.5611.00
221_A288_A0.5601.00
41_G152_I0.5581.00
89_V143_S0.5561.00
246_D249_Y0.5561.00
264_N337_G0.5561.00
184_I196_A0.5541.00
284_D288_A0.5541.00
108_E112_L0.5541.00
258_L261_G0.5521.00
107_A114_V0.5521.00
25_G28_V0.5521.00
5_L354_A0.5491.00
6_I194_K0.5481.00
313_S334_G0.5471.00
118_D122_I0.5461.00
26_L194_K0.5461.00
41_G47_T0.5441.00
19_Y22_T0.5431.00
40_H43_H0.5411.00
45_G50_I0.5411.00
318_F324_P0.5401.00
47_T51_R0.5391.00
263_H284_D0.5351.00
72_D84_F0.5341.00
260_I263_H0.5311.00
7_I28_V0.5291.00
160_K166_Q0.5291.00
106_S110_W0.5281.00
335_L343_A0.5281.00
267_Q270_H0.5251.00
177_H183_T0.5231.00
217_R307_A0.5221.00
181_G328_N0.5211.00
337_G340_F0.5191.00
61_V64_V0.5171.00
10_S166_Q0.5161.00
296_L299_I0.5151.00
29_L194_K0.5151.00
67_A72_D0.5141.00
318_F323_L0.5141.00
78_N82_P0.5131.00
83_I86_R0.5121.00
126_W129_I0.5121.00
233_N241_E0.5111.00
70_L77_H0.5111.00
30_M156_I0.5111.00
256_D261_G0.5101.00
44_H48_R0.5101.00
5_L194_K0.5091.00
118_D124_A0.5091.00
7_I14_G0.5071.00
49_L54_Y0.5071.00
254_E257_A0.5071.00
316_E324_P0.5051.00
74_L77_H0.5051.00
40_H46_D0.5041.00
99_F103_V0.5031.00
316_E322_T0.5031.00
313_S318_F0.5031.00
315_D318_F0.5021.00
45_G49_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uzzA 1 1 100 0.226 Contact Map
2gf3A 1 0.9946 100 0.239 Contact Map
4h1bA 1 0.9597 100 0.239 Contact Map
1y56B 1 0.957 100 0.277 Contact Map
3axbA 2 0.9677 100 0.282 Contact Map
1ryiA 4 0.9435 100 0.283 Contact Map
4x9mA 1 0.9677 100 0.285 Contact Map
4rslA 1 0.9812 100 0.293 Contact Map
3pvcA 1 0.9382 100 0.294 Contact Map
2gagB 1 0.9543 100 0.296 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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