GREMLIN Database
QSEC - Sensor protein QseC
UniProt: P40719 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13027
Length: 449 (422)
Sequences: 46648 (39809)
Seq/√Len: 1937.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
386_R444_E3.9641.00
387_D391_G3.9141.00
423_Q427_K3.7391.00
311_I348_G3.7091.00
434_E446_K3.3021.00
259_T279_L3.2211.00
384_I444_E2.9941.00
377_T384_I2.9401.00
397_L437_N2.9311.00
336_R375_D2.8821.00
368_S388_N2.8131.00
348_G429_H2.7711.00
263_Q280_H2.7271.00
310_E347_T2.7181.00
336_R373_V2.7061.00
338_T377_T2.6331.00
256_K284_D2.6071.00
375_D386_R2.5791.00
373_V388_N2.5761.00
426_A431_M2.5731.00
422_V433_V2.5701.00
438_A441_G2.5631.00
263_Q277_L2.5611.00
393_T396_A2.5351.00
384_I446_K2.5171.00
310_E345_K2.5101.00
356_L426_A2.4871.00
392_V400_I2.4201.00
435_F445_A2.4051.00
377_T386_R2.3601.00
401_G433_V2.3451.00
436_G444_E2.3441.00
379_N384_I2.3381.00
312_P315_D2.3311.00
436_G446_K2.2801.00
397_L435_F2.2451.00
396_A399_R2.2281.00
319_S354_S2.2101.00
338_T375_D2.1601.00
309_A350_P2.1551.00
334_D373_V2.1231.00
214_S217_R2.1081.00
256_K283_I2.1001.00
324_I358_R2.1001.00
234_M237_E2.0681.00
256_K287_T2.0401.00
399_R402_E2.0321.00
437_N443_F2.0211.00
239_R243_D2.0091.00
426_A447_V2.0071.00
308_V347_T1.9831.00
356_L425_I1.9801.00
348_G353_L1.9671.00
394_P397_L1.9221.00
287_T291_D1.9141.00
212_V217_R1.9081.00
368_S372_S1.9041.00
328_A365_V1.8821.00
425_I429_H1.8531.00
30_F34_K1.8451.00
356_L422_V1.8431.00
399_R405_Y1.8331.00
396_A405_Y1.8241.00
362_D366_R1.8051.00
372_S388_N1.7991.00
235_V239_R1.7881.00
392_V396_A1.7651.00
260_E280_H1.7631.00
349_Q352_L1.7491.00
198_M202_D1.7361.00
357_V383_F1.7201.00
226_L230_T1.7011.00
427_K432_N1.6951.00
263_Q273_K1.6731.00
314_E318_Q1.6621.00
259_T280_H1.6551.00
383_F447_V1.6441.00
396_A407_P1.6411.00
220_V224_N1.6091.00
401_G435_F1.5991.00
359_N422_V1.5851.00
213_P217_R1.5741.00
280_H284_D1.5621.00
92_T96_R1.5371.00
193_A218_P1.5321.00
375_D388_N1.5211.00
258_Q275_A1.5201.00
262_A276_L1.4951.00
227_F230_T1.4941.00
323_D354_S1.4861.00
255_L283_I1.4711.00
352_L355_L1.4671.00
232_A236_R1.4581.00
319_S350_P1.4571.00
437_N441_G1.4561.00
392_V443_F1.4511.00
193_A197_R1.4501.00
402_E405_Y1.4441.00
312_P343_S1.4411.00
368_S374_V1.4381.00
237_E241_T1.4371.00
233_M237_E1.4331.00
393_T439_E1.4271.00
426_A433_V1.4221.00
397_L401_G1.4191.00
352_L428_L1.4131.00
224_N227_F1.4101.00
216_V220_V1.4061.00
350_P354_S1.4041.00
255_L279_L1.3941.00
424_R427_K1.3881.00
325_Y329_Q1.3831.00
231_H235_V1.3811.00
312_P345_K1.3761.00
256_K280_H1.3701.00
247_E355_L1.3581.00
254_A258_Q1.3541.00
321_V337_L1.3461.00
318_Q337_L1.3441.00
254_A282_G1.3341.00
178_M182_L1.3261.00
437_N440_Q1.3201.00
314_E378_L1.3101.00
265_S272_R1.2981.00
262_A272_R1.2771.00
243_D403_R1.2741.00
268_D272_R1.2681.00
314_E339_L1.2631.00
356_L447_V1.2591.00
352_L425_I1.2591.00
367_Y406_R1.2571.00
316_L320_S1.2511.00
259_T283_I1.2451.00
190_N193_A1.2371.00
223_L226_L1.2361.00
327_T330_Q1.2331.00
258_Q278_Q1.2281.00
288_R351_L1.2241.00
400_I435_F1.2031.00
320_S358_R1.2011.00
240_F244_A1.1971.00
277_L281_S1.1961.00
387_D442_G1.1931.00
401_G423_Q1.1861.00
386_R438_A1.1841.00
320_S324_I1.1831.00
198_M205_K1.1831.00
406_R412_A1.1811.00
31_V35_Q1.1751.00
339_L378_L1.1741.00
314_E343_S1.1721.00
182_L186_L1.1621.00
157_L161_A1.1571.00
161_A165_I1.1471.00
259_T263_Q1.1361.00
185_E188_P1.1361.00
257_V261_V1.1321.00
359_N362_D1.1291.00
62_E66_A1.1211.00
268_D271_A1.1191.00
291_D295_T1.1151.00
410_Q413_T1.1121.00
254_A257_V1.1111.00
394_P437_N1.1101.00
317_L378_L1.1081.00
306_Q349_Q1.1041.00
202_D205_K1.1001.00
37_T41_D1.0981.00
231_H234_M1.0961.00
259_T276_L1.0951.00
308_V429_H1.0931.00
249_R291_D1.0901.00
267_D272_R1.0861.00
320_S354_S1.0831.00
401_G445_A1.0741.00
233_M236_R1.0721.00
435_F443_F1.0701.00
392_V397_L1.0691.00
274_K278_Q1.0501.00
29_S33_W1.0471.00
353_L429_H1.0471.00
273_K277_L1.0431.00
195_A207_L1.0401.00
364_A374_V1.0391.00
217_R220_V1.0391.00
206_P228_A1.0301.00
196_L223_L1.0291.00
315_D319_S1.0281.00
216_V219_L1.0271.00
197_R218_P1.0241.00
222_S225_Q1.0221.00
311_I316_L1.0211.00
354_S358_R1.0201.00
340_N379_N1.0151.00
10_R183_G1.0131.00
256_K260_E1.0131.00
33_W160_V1.0101.00
91_F97_M1.0081.00
344_I380_A1.0061.00
333_I368_S1.0041.00
357_V385_V1.0001.00
49_M53_K0.9951.00
360_L422_V0.9891.00
392_V435_F0.9891.00
323_D358_R0.9841.00
292_Q352_L0.9801.00
403_R424_R0.9761.00
360_L433_V0.9741.00
294_L297_S0.9721.00
183_G187_A0.9701.00
208_N224_N0.9671.00
313_L383_F0.9651.00
209_A212_V0.9641.00
357_V361_L0.9601.00
239_R403_R0.9581.00
234_M238_R0.9401.00
196_L222_S0.9391.00
130_R135_T0.9361.00
45_D49_M0.9361.00
175_L179_M0.9361.00
176_I180_V0.9341.00
324_I361_L0.9341.00
282_G285_R0.9321.00
316_L348_G0.9291.00
321_V325_Y0.9281.00
358_R362_D0.9281.00
288_R292_Q0.9261.00
417_L421_I0.9231.00
188_P192_L0.9221.00
281_S319_S0.9191.00
193_A222_S0.9161.00
266_D272_R0.9131.00
247_E359_N0.9111.00
278_Q282_G0.9091.00
320_S323_D0.9081.00
392_V398_A0.9051.00
232_A235_V0.9041.00
12_R214_S0.9021.00
400_I445_A0.8931.00
48_L52_A0.8931.00
189_L193_A0.8921.00
87_T100_N0.8911.00
367_Y390_P0.8911.00
270_Q273_K0.8901.00
206_P224_N0.8861.00
250_S254_A0.8841.00
220_V223_L0.8821.00
41_D45_D0.8811.00
332_K371_G0.8811.00
422_V426_A0.8811.00
279_L283_I0.8801.00
225_Q229_R0.8801.00
34_K37_T0.8791.00
227_F231_H0.8771.00
312_P344_I0.8771.00
324_I362_D0.8761.00
246_H250_S0.8741.00
51_F54_R0.8741.00
217_R221_E0.8741.00
351_L354_S0.8731.00
197_R222_S0.8731.00
307_D349_Q0.8721.00
241_T244_A0.8721.00
308_V430_G0.8711.00
89_A144_V0.8691.00
117_F122_L0.8691.00
361_L376_V0.8661.00
356_L429_H0.8641.00
43_L47_Q0.8641.00
52_A56_S0.8631.00
431_M447_V0.8621.00
334_D337_L0.8611.00
44_F47_Q0.8611.00
318_Q322_M0.8601.00
209_A221_E0.8551.00
327_T362_D0.8541.00
34_K38_D0.8521.00
179_M183_G0.8511.00
247_E251_P0.8501.00
180_V184_R0.8481.00
142_R146_G0.8481.00
317_L357_V0.8451.00
62_E65_A0.8451.00
63_I67_D0.8431.00
283_I287_T0.8431.00
47_Q50_L0.8431.00
223_L227_F0.8401.00
387_D443_F0.8361.00
360_L445_A0.8311.00
277_L280_H0.8291.00
423_Q432_N0.8291.00
424_R428_L0.8281.00
274_K277_L0.8281.00
160_V164_L0.8271.00
308_V348_G0.8231.00
161_A164_L0.8211.00
190_N194_L0.8211.00
182_L185_E0.8171.00
360_L426_A0.8161.00
392_V437_N0.8131.00
86_L89_A0.8121.00
64_N67_D0.8091.00
292_Q355_L0.8051.00
199_R203_S0.8051.00
206_P227_F0.8021.00
261_V265_S0.8011.00
408_P411_T0.7981.00
46_T49_M0.7951.00
43_L46_T0.7951.00
138_D141_Y0.7931.00
295_T355_L0.7921.00
393_T407_P0.7901.00
355_L425_I0.7891.00
406_R414_G0.7891.00
360_L447_V0.7881.00
320_S361_L0.7881.00
89_A97_M0.7881.00
200_D204_E0.7871.00
39_N43_L0.7861.00
195_A205_K0.7841.00
149_W153_E0.7841.00
207_L224_N0.7831.00
321_V335_V0.7811.00
333_I337_L0.7801.00
248_L286_A0.7771.00
56_S60_L0.7761.00
332_K370_Q0.7731.00
394_P398_A0.7701.00
212_V220_V0.7691.00
258_Q282_G0.7691.00
249_R287_T0.7681.00
253_T257_V0.7681.00
52_A55_L0.7681.00
42_E45_D0.7661.00
284_D287_T0.7651.00
296_L420_S0.7641.00
285_R354_S0.7631.00
47_Q51_F0.7631.00
278_Q281_S0.7611.00
199_R202_D0.7601.00
184_R187_A0.7601.00
194_L198_M0.7601.00
67_D71_Q0.7591.00
229_R232_A0.7581.00
191_K195_A0.7571.00
311_I350_P0.7571.00
135_T142_R0.7561.00
322_M325_Y0.7541.00
252_L290_V0.7541.00
197_R200_D0.7531.00
26_L30_F0.7531.00
295_T352_L0.7521.00
207_L220_V0.7511.00
45_D48_L0.7511.00
157_L160_V0.7501.00
60_L64_N0.7501.00
87_T146_G0.7501.00
97_M100_N0.7491.00
241_T245_A0.7471.00
306_Q428_L0.7471.00
20_L24_T0.7461.00
318_Q321_V0.7451.00
387_D390_P0.7441.00
92_T98_V0.7441.00
328_A374_V0.7431.00
326_H330_Q0.7431.00
384_I436_G0.7431.00
158_A162_G0.7401.00
326_H329_Q0.7401.00
369_P372_S0.7391.00
242_S245_A0.7361.00
397_L436_G0.7361.00
33_W37_T0.7341.00
162_G165_I0.7341.00
434_E447_V0.7321.00
294_L298_R0.7281.00
317_L376_V0.7271.00
156_A160_V0.7271.00
164_L168_L0.7261.00
272_R275_A0.7261.00
342_H380_A0.7251.00
258_Q279_L0.7251.00
200_D203_S0.7241.00
133_W142_R0.7221.00
391_G443_F0.7211.00
214_S218_P0.7211.00
45_D130_R0.7171.00
244_A293_L0.7161.00
352_L429_H0.7161.00
390_P412_A0.7151.00
394_P438_A0.7151.00
376_V385_V0.7141.00
366_R412_A0.7121.00
313_L346_R0.7111.00
306_Q352_L0.7111.00
205_K209_A0.7091.00
213_P216_V0.7091.00
421_I425_I0.7091.00
246_H359_N0.7091.00
130_R133_W0.7071.00
319_S323_D0.7071.00
333_I365_V0.7051.00
187_A191_K0.7031.00
328_A335_V0.7021.00
218_P222_S0.7021.00
219_L223_L0.7021.00
364_A385_V0.7001.00
328_A331_A0.6961.00
236_R239_R0.6961.00
263_Q276_L0.6921.00
318_Q339_L0.6901.00
400_I420_S0.6891.00
196_L219_L0.6891.00
59_D63_I0.6891.00
218_P221_E0.6871.00
221_E225_Q0.6871.00
11_V15_L0.6861.00
40_V43_L0.6851.00
253_T256_K0.6851.00
338_T379_N0.6851.00
196_L226_L0.6851.00
52_A145_V0.6831.00
91_F144_V0.6821.00
199_R225_Q0.6781.00
265_S268_D0.6781.00
220_V227_F0.6751.00
168_L172_P0.6751.00
328_A333_I0.6741.00
141_Y145_V0.6731.00
280_H283_I0.6721.00
315_D350_P0.6721.00
258_Q262_A0.6721.00
324_I365_V0.6711.00
199_R204_E0.6711.00
366_R414_G0.6681.00
38_D41_D0.6641.00
41_D44_F0.6641.00
235_V238_R0.6641.00
63_I66_A0.6601.00
369_P388_N0.6591.00
187_A190_N0.6591.00
322_M326_H0.6581.00
193_A196_L0.6581.00
254_A278_Q0.6571.00
355_L358_R0.6561.00
124_G127_D0.6561.00
209_A220_V0.6561.00
222_S226_L0.6541.00
55_L58_L0.6511.00
275_A279_L0.6501.00
323_D327_T0.6481.00
196_L199_R0.6471.00
50_L53_K0.6471.00
189_L192_L0.6471.00
238_R300_D0.6461.00
311_I347_T0.6461.00
66_A69_M0.6451.00
314_E344_I0.6441.00
329_Q332_K0.6431.00
247_E289_L0.6421.00
46_T50_L0.6421.00
282_G323_D0.6411.00
191_K194_L0.6401.00
42_E46_T0.6391.00
340_N344_I0.6381.00
368_S371_G0.6371.00
352_L356_L0.6361.00
422_V425_I0.6351.00
327_T331_A0.6351.00
284_D288_R0.6341.00
402_E423_Q0.6341.00
10_R190_N0.6341.00
442_G445_A0.6311.00
219_L222_S0.6291.00
378_L383_F0.6271.00
186_L190_N0.6271.00
361_L374_V0.6271.00
92_T95_G0.6251.00
189_L219_L0.6231.00
240_F247_E0.6221.00
30_F33_W0.6211.00
374_V385_V0.6201.00
133_W144_V0.6191.00
420_S424_R0.6191.00
248_L251_P0.6181.00
243_D247_E0.6181.00
35_Q38_D0.6181.00
27_L31_V0.6171.00
321_V376_V0.6161.00
400_I405_Y0.6131.00
390_P443_F0.6111.00
340_N378_L0.6101.00
53_K56_S0.6091.00
247_E421_I0.6071.00
19_I22_S0.6031.00
261_V275_A0.6031.00
321_V324_I0.6021.00
100_N103_D0.6011.00
66_A70_A0.6011.00
275_A278_Q0.6011.00
35_Q39_N0.5971.00
328_A332_K0.5961.00
228_A232_A0.5951.00
246_H251_P0.5941.00
271_A275_A0.5941.00
374_V378_L0.5931.00
50_L54_R0.5931.00
258_Q283_I0.5931.00
240_F243_D0.5921.00
17_F178_M0.5901.00
406_R413_T0.5901.00
316_L353_L0.5891.00
53_K57_T0.5891.00
224_N228_A0.5881.00
201_P205_K0.5871.00
160_V163_Q0.5851.00
331_A368_S0.5851.00
68_R71_Q0.5851.00
238_R243_D0.5841.00
31_V34_K0.5831.00
44_F48_L0.5831.00
393_T397_L0.5821.00
116_G119_D0.5821.00
58_L62_E0.5801.00
195_A198_M0.5801.00
188_P212_V0.5791.00
192_L196_L0.5791.00
306_Q429_H0.5771.00
247_E250_S0.5761.00
226_L229_R0.5761.00
386_R440_Q0.5761.00
272_R276_L0.5751.00
361_L365_V0.5741.00
317_L320_S0.5731.00
16_I20_L0.5731.00
266_D273_K0.5731.00
239_R424_R0.5731.00
316_L354_S0.5711.00
397_L445_A0.5711.00
154_D158_A0.5681.00
122_L125_E0.5661.00
286_A290_V0.5651.00
153_E157_L0.5651.00
398_A402_E0.5641.00
245_A251_P0.5621.00
295_T298_R0.5611.00
276_L280_H0.5601.00
61_N65_A0.5601.00
174_M178_M0.5591.00
129_W133_W0.5591.00
250_S257_V0.5591.00
192_L220_V0.5591.00
287_T290_V0.5581.00
426_A432_N0.5571.00
36_T39_N0.5561.00
324_I327_T0.5561.00
293_L404_F0.5551.00
40_V44_F0.5531.00
314_E337_L0.5521.00
300_D403_R0.5521.00
221_E224_N0.5521.00
158_A161_A0.5511.00
19_I26_L0.5501.00
83_D86_L0.5501.00
38_D42_E0.5491.00
165_I169_V0.5481.00
117_F120_G0.5471.00
209_A217_R0.5431.00
61_N64_N0.5421.00
262_A275_A0.5421.00
48_L51_F0.5421.00
22_S26_L0.5411.00
334_D371_G0.5401.00
39_N42_E0.5391.00
37_T40_V0.5391.00
267_D271_A0.5371.00
238_R242_S0.5371.00
212_V216_V0.5361.00
251_P286_A0.5361.00
18_L21_A0.5361.00
340_N343_S0.5351.00
148_E151_Y0.5331.00
265_S275_A0.5321.00
57_T61_N0.5321.00
392_V445_A0.5321.00
189_L216_V0.5311.00
141_Y147_Q0.5311.00
219_L224_N0.5311.00
10_R14_T0.5301.00
281_S284_D0.5291.00
344_I347_T0.5281.00
331_A370_Q0.5281.00
255_L259_T0.5281.00
65_A68_R0.5271.00
225_Q228_A0.5261.00
230_T233_M0.5261.00
296_L424_R0.5251.00
84_D87_T0.5241.00
249_R286_A0.5241.00
240_F245_A0.5241.00
134_M137_P0.5231.00
253_T258_Q0.5211.00
97_M101_D0.5211.00
74_N78_H0.5201.00
353_L357_V0.5191.00
121_Q125_E0.5181.00
375_D378_L0.5161.00
32_A36_T0.5151.00
12_R184_R0.5141.00
296_L403_R0.5141.00
89_A100_N0.5131.00
369_P390_P0.5121.00
260_E264_L0.5111.00
21_A174_M0.5111.00
238_R241_T0.5101.00
79_G83_D0.5091.00
85_A88_F0.5091.00
292_Q351_L0.5091.00
316_L319_S0.5081.00
315_D318_Q0.5081.00
129_W146_G0.5071.00
255_L282_G0.5071.00
36_T159_I0.5061.00
344_I378_L0.5061.00
57_T60_L0.5061.00
184_R188_P0.5061.00
242_S403_R0.5051.00
312_P316_L0.5041.00
162_G166_P0.5031.00
78_H82_D0.5031.00
248_L290_V0.5021.00
331_A365_V0.5021.00
391_G400_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.5902 100 0.362 Contact Map
4bixA 2 0.49 100 0.414 Contact Map
4ctiA 2 0.4922 100 0.44 Contact Map
3jz3A 2 0.3541 100 0.454 Contact Map
4q20A 2 0.4967 100 0.467 Contact Map
4mpcA 2 0.6437 100 0.481 Contact Map
4gczA 2 0.7817 100 0.484 Contact Map
3a0rA 2 0.7127 100 0.49 Contact Map
2q8gA 2 0.6459 100 0.498 Contact Map
3d36A 2 0.4744 100 0.5 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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