GREMLIN Database
NLPE - Lipoprotein NlpE
UniProt: P40710 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12137
Length: 236 (223)
Sequences: 128 (84)
Seq/√Len: 5.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_C54_C4.5240.96
158_D180_E3.8370.91
61_L71_M3.5000.86
73_E108_S3.3220.83
155_Y158_D3.2150.80
108_S227_P2.9070.73
57_I76_L2.8400.71
155_Y180_E2.7430.68
207_N210_T2.6200.64
165_C231_C2.5080.61
129_S132_N2.2850.53
151_G165_C2.1230.48
42_P137_A2.0910.47
98_L143_P2.0260.44
155_Y159_A1.9850.43
52_A127_I1.9680.42
45_W82_P1.9510.42
75_Y89_G1.9210.41
6_I16_F1.8990.40
26_E69_W1.8210.38
163_T170_R1.8130.37
111_R118_E1.8000.37
191_E209_D1.7860.36
201_H220_D1.7590.36
159_A172_M1.7480.35
53_D75_Y1.7470.35
55_E77_G1.7240.35
208_P219_P1.6950.34
49_L131_F1.6900.33
206_G226_Y1.6500.32
45_W72_N1.6440.32
119_M164_D1.6290.32
43_Q137_A1.5940.31
187_R197_S1.5880.30
142_L201_H1.5550.29
11_A35_A1.5500.29
59_T73_E1.5470.29
49_L189_H1.5220.29
9_A13_I1.5090.28
52_A180_E1.5010.28
79_R161_T1.4930.28
93_R99_V1.4770.27
157_A180_E1.4730.27
80_E230_D1.4570.27
158_D184_L1.4550.27
6_I115_D1.4550.27
104_K224_K1.4500.27
16_F125_N1.4440.26
222_A228_N1.4390.26
77_G125_N1.4360.26
42_P202_F1.4330.26
180_E209_D1.4100.26
187_R190_S1.4070.25
194_V225_F1.4030.25
15_L27_V1.3900.25
150_R200_G1.3850.25
10_M15_L1.3800.25
164_D167_T1.3720.25
148_T213_P1.3680.24
44_S61_L1.3390.24
152_M227_P1.3380.24
100_L124_G1.3350.24
55_E112_A1.3290.23
6_I9_A1.3240.23
58_E76_L1.3220.23
209_D212_A1.2730.22
151_G231_C1.2650.22
153_Y175_N1.2610.22
156_M159_A1.2590.22
71_M149_L1.2400.21
49_L184_L1.2360.21
20_G110_Y1.2350.21
131_F167_T1.2310.21
7_V11_A1.2120.21
18_L49_L1.2100.21
151_G168_G1.2010.20
61_L75_Y1.1990.20
165_C168_G1.1870.20
78_A204_L1.1860.20
94_T137_A1.1760.20
7_V108_S1.1710.20
20_G43_Q1.1700.20
12_V17_T1.1680.20
142_L179_L1.1680.20
153_Y177_A1.1670.20
84_S110_Y1.1650.20
203_T227_P1.1640.20
95_A98_L1.1620.20
212_A223_G1.1600.20
90_T128_E1.1520.19
53_D56_G1.1460.19
214_T218_A1.1370.19
217_L228_N1.1230.19
177_A221_T1.1230.19
20_G67_G1.1230.19
139_Q198_V1.1080.18
134_T140_S1.1070.18
174_A221_T1.1030.18
142_L153_Y1.0980.18
20_G121_D1.0960.18
10_M178_E1.0930.18
49_L69_W1.0870.18
102_D192_K1.0830.18
111_R147_M1.0820.18
63_L117_L1.0750.18
53_D120_L1.0720.18
45_W112_A1.0620.18
50_P89_G1.0570.17
206_G227_P1.0560.17
50_P135_L1.0460.17
159_A193_P1.0430.17
145_T153_Y1.0340.17
41_M62_F1.0320.17
112_A117_L1.0280.17
45_W178_E1.0260.17
205_E213_P1.0240.17
104_K232_S1.0240.17
156_M180_E1.0230.17
85_F211_G1.0200.17
51_C56_G1.0160.17
85_F167_T1.0120.17
83_S207_N1.0100.17
207_N212_A1.0100.17
93_R111_R0.9950.16
186_A216_V0.9740.16
68_T99_V0.9660.16
57_I162_F0.9650.16
176_N182_S0.9640.16
16_F134_T0.9630.16
73_E119_M0.9630.16
114_G186_A0.9560.16
169_K194_V0.9550.16
103_S156_M0.9540.15
67_G211_G0.9470.15
67_G202_F0.9470.15
47_G51_C0.9470.15
70_V140_S0.9450.15
89_G135_L0.9450.15
155_Y209_D0.9410.15
45_W171_F0.9340.15
90_T161_T0.9330.15
55_E82_P0.9320.15
90_T104_K0.9310.15
56_G162_F0.9300.15
4_K61_L0.9290.15
78_A115_D0.9270.15
44_S186_A0.9160.15
48_V56_G0.9100.15
198_V217_L0.9090.15
50_P183_Y0.9040.15
120_L162_F0.8970.14
149_L189_H0.8910.14
21_C54_C0.8900.14
68_T109_Y0.8890.14
153_Y179_L0.8850.14
100_L117_L0.8830.14
121_D164_D0.8710.14
19_M199_E0.8680.14
49_L110_Y0.8670.14
13_I191_E0.8580.14
104_K150_R0.8560.14
85_F157_A0.8500.14
15_L152_M0.8480.14
91_W163_T0.8470.14
68_T92_A0.8430.14
205_E214_T0.8420.14
151_G200_G0.8410.14
179_L182_S0.8250.13
194_V220_D0.8210.13
133_Y225_F0.8160.13
153_Y219_P0.8090.13
37_E190_S0.8070.13
208_P227_P0.8060.13
7_V82_P0.8040.13
53_D57_I0.8030.13
119_M147_M0.8020.13
10_M221_T0.7990.13
12_V16_F0.7900.13
21_C51_C0.7890.13
64_E142_L0.7880.13
100_L129_S0.7870.13
151_G160_A0.7850.13
160_A225_F0.7820.13
162_F179_L0.7760.13
88_Y164_D0.7740.13
68_T73_E0.7710.12
97_K105_G0.7680.12
74_R115_D0.7670.12
110_Y117_L0.7620.12
206_G210_T0.7620.12
214_T230_D0.7600.12
16_F26_E0.7580.12
66_D183_Y0.7560.12
184_L216_V0.7550.12
62_F93_R0.7550.12
149_L197_S0.7530.12
21_C124_G0.7520.12
60_S224_K0.7500.12
51_C133_Y0.7500.12
68_T175_N0.7500.12
220_D227_P0.7480.12
52_A158_D0.7450.12
12_V182_S0.7430.12
59_T117_L0.7420.12
47_G54_C0.7420.12
188_G216_V0.7400.12
86_A146_P0.7370.12
152_M213_P0.7350.12
159_A217_L0.7340.12
180_E184_L0.7280.12
63_L99_V0.7220.12
85_F179_L0.7200.12
7_V57_I0.7170.12
72_N137_A0.7100.12
38_L93_R0.7090.12
73_E141_S0.7080.12
162_F194_V0.7070.12
222_A226_Y0.7060.12
98_L110_Y0.7040.12
48_V138_A0.7040.12
184_L209_D0.7010.11
212_A230_D0.7000.11
188_G195_L0.6990.11
198_V224_K0.6970.11
45_W141_S0.6970.11
19_M46_R0.6930.11
27_V46_R0.6890.11
74_R149_L0.6870.11
53_D165_C0.6870.11
24_R40_P0.6840.11
25_A174_A0.6840.11
41_M137_A0.6810.11
187_R202_F0.6770.11
88_Y202_F0.6740.11
197_S226_Y0.6710.11
51_C75_Y0.6670.11
145_T205_E0.6630.11
129_S151_G0.6610.11
226_Y232_S0.6600.11
45_W170_R0.6580.11
123_E148_T0.6580.11
90_T172_M0.6550.11
206_G209_D0.6550.11
50_P133_Y0.6530.11
83_S210_T0.6530.11
152_M167_T0.6520.11
95_A111_R0.6460.11
149_L161_T0.6450.11
44_S88_Y0.6430.11
90_T169_K0.6390.11
36_A40_P0.6380.11
145_T196_L0.6350.11
66_D151_G0.6320.11
146_P179_L0.6300.11
35_A69_W0.6290.10
69_W72_N0.6280.10
127_I143_P0.6260.10
67_G101_T0.6260.10
2_V21_C0.6250.10
71_M74_R0.6250.10
64_E76_L0.6220.10
141_S187_R0.6220.10
13_I123_E0.6210.10
3_K18_L0.6170.10
52_A129_S0.6150.10
18_L40_P0.6150.10
192_K230_D0.6140.10
56_G75_Y0.6130.10
171_F205_E0.6130.10
16_F133_Y0.6100.10
102_D118_E0.6100.10
109_Y211_G0.6100.10
158_D176_N0.6030.10
157_A179_L0.6020.10
147_M225_F0.5990.10
167_T181_R0.5980.10
73_E126_P0.5970.10
9_A36_A0.5970.10
157_A165_C0.5960.10
43_Q62_F0.5950.10
52_A131_F0.5940.10
6_I125_N0.5930.10
56_G217_L0.5920.10
56_G116_A0.5890.10
27_V191_E0.5890.10
27_V80_E0.5870.10
8_T23_N0.5860.10
177_A214_T0.5830.10
18_L62_F0.5770.10
48_V168_G0.5760.10
16_F198_V0.5750.10
191_E200_G0.5750.10
159_A173_V0.5730.10
101_T105_G0.5700.10
110_Y121_D0.5640.10
122_R170_R0.5630.10
160_A194_V0.5630.10
9_A12_V0.5620.10
53_D117_L0.5620.10
3_K8_T0.5600.10
178_E207_N0.5590.10
74_R126_P0.5590.10
15_L224_K0.5540.10
197_S206_G0.5490.10
147_M164_D0.5480.09
129_S165_C0.5470.09
169_K176_N0.5430.09
145_T220_D0.5430.09
6_I11_A0.5390.09
144_M222_A0.5370.09
11_A15_L0.5370.09
53_D231_C0.5370.09
43_Q94_T0.5340.09
62_F215_K0.5330.09
22_N94_T0.5330.09
214_T223_G0.5330.09
51_C63_L0.5280.09
7_V227_P0.5280.09
16_F27_V0.5280.09
49_L113_K0.5230.09
82_P159_A0.5230.09
62_F94_T0.5210.09
88_Y147_M0.5210.09
23_N114_G0.5190.09
55_E64_E0.5180.09
46_R82_P0.5170.09
7_V112_A0.5140.09
9_A19_M0.5130.09
50_P54_C0.5130.09
12_V133_Y0.5130.09
42_P55_E0.5090.09
149_L200_G0.5080.09
173_V216_V0.5040.09
54_C63_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z4iA 1 0.8263 100 0.238 Contact Map
4u3qA 1 0.3686 100 0.648 Contact Map
3lhnA 4 0.4449 100 0.662 Contact Map
4peuA 1 0.7415 76.2 0.95 Contact Map
4lmhA 3 0.6568 53.6 0.956 Contact Map
3zbiC 1 0.1144 42.7 0.959 Contact Map
4orrA 2 0.5297 35.9 0.961 Contact Map
4pj0V 1 0.4237 30.9 0.962 Contact Map
4lm8A 1 0.5466 23.3 0.964 Contact Map
4jg9A 2 0.5042 22 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.