GREMLIN Database
PDXK - Pyridoxine kinase
UniProt: P40191 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12642
Length: 283 (247)
Sequences: 6225 (4363)
Seq/√Len: 277.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_T152_L3.2851.00
104_K148_Y2.9341.00
36_V46_V2.9031.00
173_D176_S2.7721.00
169_K183_S2.7541.00
66_G69_P2.6311.00
63_F79_A2.6021.00
242_G247_K2.5881.00
42_N242_G2.5741.00
193_V235_F2.5311.00
248_A251_D2.5041.00
78_R109_W2.3961.00
97_M106_L2.2141.00
163_L194_V2.2051.00
74_S108_E2.1321.00
94_T124_V2.1301.00
53_L72_W2.0831.00
44_L241_S2.0821.00
135_I139_P2.0721.00
217_N250_T2.0611.00
178_I216_V2.0311.00
39_I241_S1.9691.00
18_I44_L1.9531.00
53_L68_I1.9471.00
143_E147_Q1.9381.00
64_Y75_G1.9381.00
242_G245_K1.9341.00
111_T148_Y1.9041.00
39_I46_V1.8961.00
171_C180_A1.8871.00
73_F102_Q1.8821.00
24_Q33_S1.8451.00
20_A48_A1.8291.00
130_D134_G1.8151.00
39_I44_L1.8071.00
67_A98_G1.7451.00
205_E220_S1.7281.00
191_W249_L1.7211.00
247_K255_R1.7121.00
174_L218_V1.6671.00
74_S105_I1.6601.00
164_E170_N1.6541.00
77_L109_W1.6411.00
239_L253_V1.6351.00
257_G261_L1.6311.00
185_L211_V1.6291.00
109_W112_A1.6211.00
242_G255_R1.5611.00
74_S109_W1.5481.00
172_R176_S1.5331.00
110_L122_I1.5121.00
33_S48_A1.5001.00
18_I39_I1.4971.00
20_A39_I1.4791.00
261_L265_R1.4781.00
181_A194_V1.4661.00
124_V153_A1.4661.00
49_V77_L1.4621.00
103_I145_Y1.4611.00
70_D105_I1.4591.00
262_E265_R1.4531.00
17_D90_R1.4501.00
94_T122_I1.4461.00
78_R82_E1.4351.00
207_Q218_V1.4311.00
100_A140_D1.4281.00
156_I184_L1.4001.00
67_A99_T1.3991.00
222_S265_R1.3991.00
178_I218_V1.3911.00
206_M257_G1.3831.00
137_V141_L1.3671.00
66_G72_W1.3571.00
68_I72_W1.3531.00
219_I254_H1.3331.00
17_D47_F1.3311.00
32_N50_P1.3161.00
167_T184_L1.3011.00
211_V216_V1.2911.00
70_D101_S1.2671.00
191_W212_T1.2641.00
24_Q54_L1.2631.00
121_L154_Q1.2551.00
221_H257_G1.2501.00
181_A211_V1.2441.00
154_Q190_K1.2331.00
217_N254_H1.2051.00
164_E171_C1.2001.00
63_F82_E1.1941.00
108_E148_Y1.1761.00
221_H261_L1.1721.00
58_P83_R1.1721.00
135_I142_P1.1711.00
169_K179_A1.1671.00
81_Q89_L1.1641.00
81_Q112_A1.1621.00
78_R112_A1.1601.00
247_K251_D1.1591.00
123_M240_I1.1531.00
17_D84_D1.1491.00
99_T102_Q1.1471.00
38_A234_L1.1461.00
250_T254_H1.1361.00
49_V73_F1.1341.00
209_V218_V1.1291.00
103_I144_A1.1161.00
243_L249_L1.1141.00
164_E180_A1.1121.00
146_R187_D1.1041.00
177_A209_V1.1031.00
18_I244_L1.1001.00
146_R166_L1.0981.00
71_E75_G1.0981.00
183_S186_S1.0971.00
17_D88_Q1.0921.00
42_N238_Q1.0801.00
97_M103_I1.0791.00
155_G249_L1.0761.00
150_L156_I1.0611.00
55_S75_G1.0561.00
64_Y72_W1.0551.00
42_N241_S1.0551.00
251_D254_H1.0501.00
182_K186_S1.0491.00
183_S187_D1.0471.00
44_L245_K1.0341.00
144_A148_Y1.0331.00
185_L213_A1.0281.00
55_S72_W1.0231.00
179_A183_S1.0201.00
24_Q50_P1.0181.00
174_L178_I1.0121.00
38_A42_N1.0091.00
254_H258_L1.0081.00
105_I108_E1.0041.00
167_T183_S1.0001.00
38_A238_Q0.9981.00
146_R168_G0.9921.00
155_G239_L0.9911.00
178_I182_K0.9851.00
100_A104_K0.9841.00
16_A90_R0.9831.00
185_L192_V0.9801.00
104_K144_A0.9781.00
123_M243_L0.9691.00
207_Q220_S0.9681.00
107_A152_L0.9641.00
72_W75_G0.9601.00
191_W210_V0.9561.00
21_V106_L0.9561.00
135_I165_I0.9531.00
215_S250_T0.9501.00
228_L264_M0.9471.00
47_F89_L0.9441.00
100_A144_A0.9391.00
185_L189_L0.9391.00
155_G193_V0.9361.00
52_V96_Y0.9301.00
179_A182_K0.9181.00
129_G165_I0.9181.00
91_A240_I0.9111.00
154_Q249_L0.9081.00
239_L256_A0.9081.00
101_S104_K0.9081.00
234_L259_R0.9041.00
219_I253_V0.9011.00
262_E266_Y0.8991.00
84_D88_Q0.8961.00
81_Q109_W0.8941.00
176_S179_A0.8921.00
98_G102_Q0.8921.00
142_P146_R0.8911.00
142_P165_I0.8911.00
47_F84_D0.8861.00
17_D89_L0.8841.00
174_L209_V0.8821.00
219_I257_G0.8741.00
224_V261_L0.8701.00
182_K216_V0.8691.00
108_E112_A0.8691.00
224_V264_M0.8691.00
154_Q191_W0.8661.00
24_Q48_A0.8651.00
156_I192_V0.8631.00
103_I137_V0.8611.00
27_Y54_L0.8431.00
113_L120_L0.8301.00
42_N245_K0.8220.99
238_Q259_R0.8210.99
205_E222_S0.8160.99
169_K176_S0.8150.99
94_T97_M0.8110.99
26_V48_A0.8050.99
210_V219_I0.8030.99
143_E146_R0.8020.99
174_L207_Q0.7970.99
155_G191_W0.7940.99
70_D74_S0.7930.99
74_S78_R0.7910.99
44_L244_L0.7810.99
75_G79_A0.7780.99
177_A199_G0.7760.99
75_G78_R0.7730.99
258_L262_E0.7720.99
26_V54_L0.7710.99
63_F75_G0.7710.99
29_S229_K0.7660.99
26_V55_S0.7600.99
247_K252_A0.7580.99
243_L246_G0.7510.99
210_V253_V0.7500.99
144_A147_Q0.7470.99
23_S51_T0.7450.99
39_I240_I0.7450.99
47_F80_L0.7390.99
92_V120_L0.7350.99
155_G253_V0.7350.99
18_I241_S0.7330.99
175_D178_I0.7300.99
208_V257_G0.7270.99
193_V210_V0.7220.99
93_T237_A0.7200.99
171_C176_S0.7200.99
185_L191_W0.7170.99
243_L252_A0.7150.99
39_I237_A0.7150.99
211_V214_D0.7150.99
92_V122_I0.7090.98
107_A149_L0.7070.98
19_V47_F0.7050.98
92_V110_L0.7040.98
161_F198_S0.7030.98
159_N162_E0.7030.98
104_K147_Q0.7020.98
209_V216_V0.6990.98
52_V67_A0.6980.98
251_D255_R0.6980.98
212_T215_S0.6940.98
160_I164_E0.6940.98
208_V211_V0.6920.98
33_S36_V0.6920.98
27_Y84_D0.6890.98
34_I234_L0.6850.98
160_I199_G0.6840.98
260_V264_M0.6810.98
93_T236_C0.6760.98
210_V249_L0.6760.98
94_T110_L0.6730.98
81_Q113_L0.6730.98
150_L189_L0.6720.98
99_T138_K0.6720.98
20_A236_C0.6660.98
105_I109_W0.6610.98
51_T102_Q0.6600.98
22_Q35_A0.6600.98
185_L190_K0.6550.97
268_Q271_E0.6530.97
24_Q32_N0.6520.97
107_A111_T0.6500.97
153_A156_I0.6460.97
82_E113_L0.6450.97
245_K255_R0.6420.97
24_Q53_L0.6410.97
145_Y150_L0.6400.97
212_T217_N0.6390.97
107_A148_Y0.6370.97
38_A259_R0.6350.97
70_D73_F0.6350.97
41_Q259_R0.6320.97
207_Q211_V0.6310.97
84_D90_R0.6300.97
94_T236_C0.6280.97
73_F105_I0.6270.97
25_V31_G0.6260.97
103_I141_L0.6240.97
169_K180_A0.6220.97
18_I240_I0.6210.97
96_Y136_Y0.6190.96
185_L188_T0.6150.96
178_I211_V0.6140.96
98_G138_K0.6130.96
246_G252_A0.6130.96
257_G260_V0.6120.96
124_V149_L0.6120.96
37_P45_N0.6110.96
268_Q272_S0.6100.96
133_S136_Y0.6100.96
109_W113_L0.6060.96
255_R258_L0.6060.96
171_C177_A0.6050.96
206_M223_R0.6040.96
163_L180_A0.6020.96
107_A124_V0.6010.96
128_I137_V0.6000.96
108_E111_T0.5980.96
130_D136_Y0.5960.96
35_A93_T0.5960.96
172_R200_N0.5930.96
166_L184_L0.5920.95
42_N255_R0.5910.95
193_V253_V0.5870.95
81_Q92_V0.5870.95
125_D158_P0.5860.95
84_D89_L0.5810.95
163_L184_L0.5800.95
58_P273_D0.5780.95
161_F164_E0.5780.95
56_N229_K0.5760.95
185_L212_T0.5740.95
234_L263_V0.5730.95
21_V77_L0.5710.94
190_K213_A0.5710.94
32_N48_A0.5700.94
27_Y45_N0.5700.94
64_Y71_E0.5690.94
122_I152_L0.5690.94
123_M155_G0.5600.94
194_V209_V0.5590.94
155_G256_A0.5570.94
160_I171_C0.5560.94
198_S223_R0.5540.94
78_R113_L0.5540.94
259_R263_V0.5540.94
248_A252_A0.5540.94
56_N79_A0.5540.94
91_A236_C0.5530.94
30_V229_K0.5520.93
20_A46_V0.5510.93
174_L220_S0.5510.93
129_G134_G0.5500.93
104_K108_E0.5500.93
222_S261_L0.5500.93
114_R154_Q0.5500.93
62_T82_E0.5490.93
79_A82_E0.5450.93
37_P40_K0.5380.93
52_V98_G0.5380.93
181_A192_V0.5370.93
212_T216_V0.5370.93
231_T260_V0.5370.93
182_K185_L0.5350.92
69_P72_W0.5350.92
129_G135_I0.5350.92
59_H63_F0.5310.92
253_V256_A0.5310.92
57_T79_A0.5290.92
103_I149_L0.5280.92
49_V80_L0.5280.92
219_I250_T0.5270.92
210_V250_T0.5270.92
57_T63_F0.5260.92
256_A260_V0.5250.92
19_V49_V0.5250.92
182_K211_V0.5190.91
62_T83_R0.5180.91
125_D159_N0.5170.91
266_Y269_Q0.5160.91
193_V239_L0.5160.91
91_A244_L0.5150.91
80_L89_L0.5140.91
25_V35_A0.5130.91
23_S30_V0.5130.91
50_P53_L0.5120.91
160_I177_A0.5100.90
175_D179_A0.5090.90
167_T192_V0.5080.90
131_I231_T0.5040.90
59_H272_S0.5010.90
124_V145_Y0.5010.90
157_T239_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ddmA 2 0.9788 100 0.362 Contact Map
3pzsA 2 0.9505 100 0.381 Contact Map
3rm5A 2 0.9329 100 0.392 Contact Map
2yxtA 3 0.9435 100 0.398 Contact Map
2i5bA 2 0.9223 100 0.403 Contact Map
3mbhA 5 0.9435 100 0.41 Contact Map
3h74A 2 0.9117 100 0.42 Contact Map
4yl5A 2 0.7986 100 0.43 Contact Map
3zs7A 2 0.8905 100 0.434 Contact Map
1ub0A 2 0.8657 100 0.447 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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