SPRT - ECOLI - GREMLIN Contacts

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SPRT - Protein SprT

UniProt:	P39902	Sequences: MKTSRLPIAIQQAVMRRLREKLAQANLKLGRNYPEPKLSYTQRGTSAGTAWLESYEIRLNPVLLLENSEAFIEEVVPHELAHLLVWKHFGRVAPHGKEWKWMMENVLGVPARRTHQFELQSVRRNTFPYRCKCQEHQLTVRRHNRVVRGEAVYRCVHCGEQLVAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12122
Length:	165 (135)
Sequences:	1828 (1696)
Seq/√Len:	146.0

ECOLI - SPRT
HALSA - F2Z681 O51967
SULSO - Q97ZR7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
132_K	157_H	4.459	1.00
103_M	106_V	4.324	1.00
103_M	119_L	3.488	1.00
130_R	154_R	3.233	1.00
155_C	158_C	3.161	1.00
120_Q	144_N	2.905	1.00
106_V	119_L	2.762	1.00
105_N	132_K	2.653	1.00
136_H	139_T	2.457	1.00
106_V	123_R	2.145	1.00
154_R	161_Q	2.135	1.00
103_M	107_L	2.015	1.00
30_G	33_Y	1.995	1.00
133_C	147_V	1.912	1.00
132_K	144_N	1.857	1.00
113_R	137_Q	1.847	1.00
137_Q	141_R	1.730	1.00
106_V	110_P	1.701	1.00
91_R	95_H	1.694	1.00
145_R	148_R	1.680	1.00
105_N	157_H	1.633	1.00
130_R	134_Q	1.633	1.00
91_R	94_P	1.617	1.00
113_R	117_F	1.582	1.00
129_Y	153_Y	1.559	1.00
104_E	120_Q	1.513	1.00
118_E	142_R	1.506	1.00
29_L	33_Y	1.505	1.00
117_F	120_Q	1.481	1.00
124_R	128_P	1.350	1.00
103_M	123_R	1.305	1.00
142_R	145_R	1.291	1.00
33_Y	36_P	1.278	1.00
108_G	135_E	1.270	1.00
116_Q	119_L	1.263	1.00
115_H	118_E	1.233	1.00
119_L	123_R	1.220	1.00
127_F	151_A	1.219	1.00
103_M	108_G	1.219	1.00
103_M	110_P	1.213	1.00
85_V	88_H	1.191	1.00
131_C	147_V	1.191	1.00
39_S	47_A	1.187	1.00
156_V	161_Q	1.173	1.00
132_K	138_L	1.170	1.00
145_R	153_Y	1.164	1.00
112_R	115_H	1.156	1.00
131_C	143_H	1.150	1.00
121_S	126_T	1.135	0.99
109_V	161_Q	1.117	0.99
115_H	136_H	1.114	0.99
77_P	83_L	1.102	0.99
31_R	34_P	1.073	0.99
34_P	38_L	1.069	0.99
136_H	142_R	1.054	0.99
40_Y	46_S	1.050	0.99
149_G	152_V	1.038	0.99
107_L	134_Q	1.037	0.99
133_C	143_H	1.036	0.99
31_R	35_E	1.027	0.99
148_R	152_V	1.020	0.99
127_F	149_G	1.009	0.99
49_T	53_E	1.006	0.99
109_V	142_R	1.004	0.99
114_T	138_L	1.000	0.99
121_S	145_R	0.994	0.99
154_R	157_H	0.984	0.98
40_Y	43_R	0.979	0.98
71_F	76_V	0.969	0.98
93_A	96_G	0.962	0.98
122_V	125_N	0.962	0.98
43_R	47_A	0.958	0.98
36_P	39_S	0.957	0.98
131_C	158_C	0.956	0.98
111_A	115_H	0.951	0.98
112_R	118_E	0.949	0.98
63_L	78_H	0.949	0.98
45_T	49_T	0.944	0.98
117_F	141_R	0.933	0.98
43_R	49_T	0.931	0.98
67_N	76_V	0.926	0.98
77_P	80_L	0.912	0.97
121_S	128_P	0.908	0.97
110_P	123_R	0.903	0.97
135_E	160_E	0.892	0.97
65_L	69_E	0.887	0.97
120_Q	141_R	0.882	0.97
117_F	138_L	0.877	0.97
38_L	41_T	0.869	0.97
111_A	118_E	0.868	0.97
30_G	37_K	0.862	0.96
114_T	157_H	0.862	0.96
32_N	35_E	0.861	0.96
104_E	156_V	0.855	0.96
117_F	144_N	0.854	0.96
95_H	98_E	0.838	0.96
141_R	163_V	0.829	0.96
58_R	66_E	0.823	0.95
127_F	145_R	0.823	0.95
65_L	75_V	0.821	0.95
47_A	52_L	0.810	0.95
43_R	46_S	0.807	0.95
136_H	141_R	0.804	0.95
92_V	96_G	0.798	0.95
102_M	109_V	0.795	0.94
143_H	147_V	0.793	0.94
97_K	142_R	0.789	0.94
84_L	90_G	0.788	0.94
92_V	95_H	0.783	0.94
151_A	155_C	0.781	0.94
58_R	64_L	0.781	0.94
142_R	146_V	0.761	0.93
93_A	97_K	0.757	0.93
114_T	162_L	0.751	0.93
91_R	98_E	0.748	0.93
85_V	89_F	0.748	0.93
138_L	141_R	0.747	0.92
92_V	97_K	0.742	0.92
137_Q	140_V	0.742	0.92
65_L	71_F	0.735	0.92
105_N	120_Q	0.728	0.91
117_F	142_R	0.725	0.91
158_C	162_L	0.724	0.91
80_L	84_L	0.723	0.91
150_E	160_E	0.710	0.90
37_K	41_T	0.709	0.90
56_E	63_L	0.708	0.90
37_K	43_R	0.708	0.90
84_L	89_F	0.707	0.90
77_P	81_A	0.699	0.90
79_E	85_V	0.698	0.90
94_P	98_E	0.697	0.90
67_N	71_F	0.696	0.90
30_G	35_E	0.694	0.89
38_L	44_G	0.691	0.89
75_V	78_H	0.688	0.89
56_E	60_N	0.683	0.89
139_T	142_R	0.670	0.88
146_V	163_V	0.669	0.88
125_N	128_P	0.661	0.87
103_M	116_Q	0.653	0.86
130_R	139_T	0.642	0.85
150_E	153_Y	0.641	0.85
145_R	149_G	0.638	0.85
33_Y	41_T	0.635	0.85
135_E	139_T	0.634	0.85
80_L	83_L	0.633	0.85
115_H	156_V	0.633	0.85
102_M	149_G	0.631	0.84
143_H	155_C	0.624	0.84
146_V	159_G	0.614	0.83
137_Q	142_R	0.612	0.83
32_N	36_P	0.611	0.83
101_W	127_F	0.610	0.82
29_L	35_E	0.607	0.82
136_H	163_V	0.605	0.82
35_E	39_S	0.602	0.82
69_E	78_H	0.602	0.82
29_L	34_P	0.598	0.81
79_E	83_L	0.594	0.81
46_S	49_T	0.593	0.81
96_G	102_M	0.589	0.80
64_L	81_A	0.589	0.80
46_S	52_L	0.586	0.80
77_P	84_L	0.585	0.80
48_G	53_E	0.584	0.80
92_V	104_E	0.582	0.79
60_N	73_E	0.578	0.79
112_R	141_R	0.578	0.79
72_I	83_L	0.575	0.79
117_F	132_K	0.575	0.79
59_L	79_E	0.573	0.78
48_G	54_S	0.567	0.78
52_L	56_E	0.566	0.78
118_E	136_H	0.566	0.78
54_S	63_L	0.563	0.77
100_K	109_V	0.560	0.77
34_P	37_K	0.559	0.77
29_L	32_N	0.558	0.77
46_S	50_A	0.557	0.76
35_E	44_G	0.556	0.76
36_P	53_E	0.553	0.76
83_L	86_W	0.541	0.74
57_I	67_N	0.540	0.74
45_T	48_G	0.539	0.74
117_F	161_Q	0.537	0.74
57_I	64_L	0.537	0.74
73_E	82_H	0.535	0.74
94_P	97_K	0.534	0.73
99_W	127_F	0.534	0.73
107_L	122_V	0.534	0.73
108_G	124_R	0.523	0.72
58_R	61_P	0.523	0.72
32_N	39_S	0.522	0.72
154_R	159_G	0.522	0.72
99_W	102_M	0.517	0.71
36_P	41_T	0.515	0.71
52_L	60_N	0.512	0.70
151_A	163_V	0.510	0.70
145_R	151_A	0.508	0.70
145_R	150_E	0.507	0.70
128_P	131_C	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ee8A	1	0.497	99.5	0.551	Contact Map
2ghfA	1	0.503	99.5	0.554	Contact Map
2dmdA	1	0.4424	99.4	0.561	Contact Map
2jp9A	1	0.4303	99.4	0.564	Contact Map
2wbsA	1	0.4121	99.4	0.566	Contact Map
2yt9A	1	0.4364	99.4	0.566	Contact Map
2i13A	1	0.5636	99.4	0.567	Contact Map
2ebtA	1	0.4848	99.4	0.568	Contact Map
4x9jA	1	0.4121	99.4	0.569	Contact Map
2kmkA	1	0.4	99.4	0.569	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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