GREMLIN Database
SPRT - Protein SprT
UniProt: P39902 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12122
Length: 165 (135)
Sequences: 1828 (1696)
Seq/√Len: 146.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_K157_H4.4591.00
103_M106_V4.3241.00
103_M119_L3.4881.00
130_R154_R3.2331.00
155_C158_C3.1611.00
120_Q144_N2.9051.00
106_V119_L2.7621.00
105_N132_K2.6531.00
136_H139_T2.4571.00
106_V123_R2.1451.00
154_R161_Q2.1351.00
103_M107_L2.0151.00
30_G33_Y1.9951.00
133_C147_V1.9121.00
132_K144_N1.8571.00
113_R137_Q1.8471.00
137_Q141_R1.7301.00
106_V110_P1.7011.00
91_R95_H1.6941.00
145_R148_R1.6801.00
105_N157_H1.6331.00
130_R134_Q1.6331.00
91_R94_P1.6171.00
113_R117_F1.5821.00
129_Y153_Y1.5591.00
104_E120_Q1.5131.00
118_E142_R1.5061.00
29_L33_Y1.5051.00
117_F120_Q1.4811.00
124_R128_P1.3501.00
103_M123_R1.3051.00
142_R145_R1.2911.00
33_Y36_P1.2781.00
108_G135_E1.2701.00
116_Q119_L1.2631.00
115_H118_E1.2331.00
119_L123_R1.2201.00
127_F151_A1.2191.00
103_M108_G1.2191.00
103_M110_P1.2131.00
85_V88_H1.1911.00
131_C147_V1.1911.00
39_S47_A1.1871.00
156_V161_Q1.1731.00
132_K138_L1.1701.00
145_R153_Y1.1641.00
112_R115_H1.1561.00
131_C143_H1.1501.00
121_S126_T1.1350.99
109_V161_Q1.1170.99
115_H136_H1.1140.99
77_P83_L1.1020.99
31_R34_P1.0730.99
34_P38_L1.0690.99
136_H142_R1.0540.99
40_Y46_S1.0500.99
149_G152_V1.0380.99
107_L134_Q1.0370.99
133_C143_H1.0360.99
31_R35_E1.0270.99
148_R152_V1.0200.99
127_F149_G1.0090.99
49_T53_E1.0060.99
109_V142_R1.0040.99
114_T138_L1.0000.99
121_S145_R0.9940.99
154_R157_H0.9840.98
40_Y43_R0.9790.98
71_F76_V0.9690.98
93_A96_G0.9620.98
122_V125_N0.9620.98
43_R47_A0.9580.98
36_P39_S0.9570.98
131_C158_C0.9560.98
111_A115_H0.9510.98
112_R118_E0.9490.98
63_L78_H0.9490.98
45_T49_T0.9440.98
117_F141_R0.9330.98
43_R49_T0.9310.98
67_N76_V0.9260.98
77_P80_L0.9120.97
121_S128_P0.9080.97
110_P123_R0.9030.97
135_E160_E0.8920.97
65_L69_E0.8870.97
120_Q141_R0.8820.97
117_F138_L0.8770.97
38_L41_T0.8690.97
111_A118_E0.8680.97
30_G37_K0.8620.96
114_T157_H0.8620.96
32_N35_E0.8610.96
104_E156_V0.8550.96
117_F144_N0.8540.96
95_H98_E0.8380.96
141_R163_V0.8290.96
58_R66_E0.8230.95
127_F145_R0.8230.95
65_L75_V0.8210.95
47_A52_L0.8100.95
43_R46_S0.8070.95
136_H141_R0.8040.95
92_V96_G0.7980.95
102_M109_V0.7950.94
143_H147_V0.7930.94
97_K142_R0.7890.94
84_L90_G0.7880.94
92_V95_H0.7830.94
151_A155_C0.7810.94
58_R64_L0.7810.94
142_R146_V0.7610.93
93_A97_K0.7570.93
114_T162_L0.7510.93
91_R98_E0.7480.93
85_V89_F0.7480.93
138_L141_R0.7470.92
92_V97_K0.7420.92
137_Q140_V0.7420.92
65_L71_F0.7350.92
105_N120_Q0.7280.91
117_F142_R0.7250.91
158_C162_L0.7240.91
80_L84_L0.7230.91
150_E160_E0.7100.90
37_K41_T0.7090.90
56_E63_L0.7080.90
37_K43_R0.7080.90
84_L89_F0.7070.90
77_P81_A0.6990.90
79_E85_V0.6980.90
94_P98_E0.6970.90
67_N71_F0.6960.90
30_G35_E0.6940.89
38_L44_G0.6910.89
75_V78_H0.6880.89
56_E60_N0.6830.89
139_T142_R0.6700.88
146_V163_V0.6690.88
125_N128_P0.6610.87
103_M116_Q0.6530.86
130_R139_T0.6420.85
150_E153_Y0.6410.85
145_R149_G0.6380.85
33_Y41_T0.6350.85
135_E139_T0.6340.85
80_L83_L0.6330.85
115_H156_V0.6330.85
102_M149_G0.6310.84
143_H155_C0.6240.84
146_V159_G0.6140.83
137_Q142_R0.6120.83
32_N36_P0.6110.83
101_W127_F0.6100.82
29_L35_E0.6070.82
136_H163_V0.6050.82
35_E39_S0.6020.82
69_E78_H0.6020.82
29_L34_P0.5980.81
79_E83_L0.5940.81
46_S49_T0.5930.81
96_G102_M0.5890.80
64_L81_A0.5890.80
46_S52_L0.5860.80
77_P84_L0.5850.80
48_G53_E0.5840.80
92_V104_E0.5820.79
60_N73_E0.5780.79
112_R141_R0.5780.79
72_I83_L0.5750.79
117_F132_K0.5750.79
59_L79_E0.5730.78
48_G54_S0.5670.78
52_L56_E0.5660.78
118_E136_H0.5660.78
54_S63_L0.5630.77
100_K109_V0.5600.77
34_P37_K0.5590.77
29_L32_N0.5580.77
46_S50_A0.5570.76
35_E44_G0.5560.76
36_P53_E0.5530.76
83_L86_W0.5410.74
57_I67_N0.5400.74
45_T48_G0.5390.74
117_F161_Q0.5370.74
57_I64_L0.5370.74
73_E82_H0.5350.74
94_P97_K0.5340.73
99_W127_F0.5340.73
107_L122_V0.5340.73
108_G124_R0.5230.72
58_R61_P0.5230.72
32_N39_S0.5220.72
154_R159_G0.5220.72
99_W102_M0.5170.71
36_P41_T0.5150.71
52_L60_N0.5120.70
151_A163_V0.5100.70
145_R151_A0.5080.70
145_R150_E0.5070.70
128_P131_C0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ee8A 1 0.497 99.5 0.551 Contact Map
2ghfA 1 0.503 99.5 0.554 Contact Map
2dmdA 1 0.4424 99.4 0.561 Contact Map
2jp9A 1 0.4303 99.4 0.564 Contact Map
2wbsA 1 0.4121 99.4 0.566 Contact Map
2yt9A 1 0.4364 99.4 0.566 Contact Map
2i13A 1 0.5636 99.4 0.567 Contact Map
2ebtA 1 0.4848 99.4 0.568 Contact Map
4x9jA 1 0.4121 99.4 0.569 Contact Map
2kmkA 1 0.4 99.4 0.569 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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