GREMLIN Database
YBEM - Putative hydrolase YbeM
UniProt: P39874 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13162
Length: 262 (243)
Sequences: 14791 (10204)
Seq/√Len: 654.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_E141_K3.1001.00
2_L235_E3.0191.00
13_V16_K2.6571.00
190_R193_D2.4281.00
214_I234_A2.4261.00
85_V109_A2.4071.00
216_D220_V2.3991.00
20_I229_P2.3661.00
83_I97_V2.3341.00
21_C42_L2.3251.00
95_M109_A2.2681.00
226_S230_A2.2531.00
4_A233_M2.2061.00
184_S224_A2.1831.00
145_M156_A2.1401.00
4_A33_A2.1331.00
143_G159_Q2.1031.00
5_A199_V2.0371.00
22_A71_E1.9951.00
22_A67_R1.9921.00
26_A74_R1.9851.00
78_T100_Q1.9731.00
225_A230_A1.9661.00
37_A168_V1.9451.00
5_A201_A1.9211.00
26_A75_N1.9191.00
72_S79_T1.9131.00
137_V140_M1.8601.00
36_F77_M1.8531.00
93_W109_A1.8511.00
31_N233_M1.8131.00
20_I23_S1.7861.00
165_E242_R1.7801.00
22_A26_A1.7791.00
225_A232_I1.7711.00
3_V199_V1.7511.00
185_T188_A1.7471.00
69_R99_L1.7461.00
34_S138_E1.7311.00
197_Y217_P1.7161.00
91_R126_D1.7151.00
27_Q31_N1.6611.00
78_T98_A1.6371.00
95_M107_R1.6251.00
100_Q138_E1.6171.00
167_L196_C1.6131.00
96_L144_L1.5831.00
141_K165_E1.5811.00
142_V166_I1.5791.00
33_A233_M1.5541.00
23_S27_Q1.5511.00
98_A144_L1.5441.00
6_G36_F1.5291.00
68_L81_L1.5251.00
26_A71_E1.5221.00
70_R74_R1.5081.00
215_I221_T1.4841.00
35_L168_V1.4681.00
25_M36_F1.4641.00
223_A232_I1.4481.00
78_T105_V1.4411.00
37_A201_A1.4401.00
96_L170_P1.4401.00
80_I98_A1.4361.00
184_S188_A1.4311.00
80_I96_L1.4211.00
240_R243_Q1.4081.00
18_A67_R1.3991.00
187_L200_A1.3951.00
80_I168_V1.3941.00
21_C38_L1.3871.00
19_E23_S1.3831.00
11_T16_K1.3781.00
156_A167_L1.3751.00
145_M169_L1.3701.00
199_V214_I1.3651.00
78_T137_V1.3591.00
115_D122_S1.3451.00
65_L97_V1.3431.00
24_L27_Q1.3351.00
99_L104_I1.3141.00
25_M79_T1.3001.00
197_Y222_I1.2961.00
120_Q123_R1.2831.00
15_E19_E1.2771.00
85_V95_M1.2691.00
145_M155_L1.2621.00
16_K19_E1.2431.00
25_M71_E1.2431.00
6_G38_L1.2381.00
80_I144_L1.2321.00
185_T192_L1.2241.00
6_G231_L1.2191.00
83_I107_R1.2101.00
71_E75_N1.2101.00
216_D222_I1.2021.00
191_A198_M1.1921.00
28_A231_L1.1891.00
142_V168_V1.1831.00
19_E67_R1.1831.00
61_E65_L1.1721.00
34_S100_Q1.1711.00
148_Y152_F1.1661.00
203_E207_K1.1491.00
156_A169_L1.1481.00
66_G69_R1.1481.00
243_Q247_Q1.1481.00
154_E157_L1.1461.00
16_K20_I1.1271.00
43_L64_F1.1241.00
66_G70_R1.1211.00
216_D240_R1.1151.00
166_I199_V1.1141.00
211_Q224_A1.1131.00
65_L99_L1.1061.00
158_A162_Q1.0971.00
93_W126_D1.0881.00
187_L198_M1.0791.00
57_A60_L1.0681.00
164_A167_L1.0611.00
33_A36_F1.0591.00
97_V107_R1.0571.00
18_A22_A1.0471.00
20_I24_L1.0451.00
160_A196_C1.0411.00
22_A74_R1.0401.00
52_L55_K1.0401.00
8_F24_L1.0391.00
25_M77_M1.0391.00
58_Q62_G1.0301.00
70_R73_K1.0151.00
143_G164_A1.0071.00
24_L231_L1.0031.00
184_S213_R0.9911.00
8_F21_C0.9731.00
242_R246_A0.9711.00
61_E66_G0.9671.00
134_L141_K0.9661.00
67_R70_R0.9621.00
78_T138_E0.9611.00
157_L194_T0.9601.00
67_R71_E0.9581.00
6_G24_L0.9581.00
98_A135_L0.9541.00
191_A215_I0.9501.00
134_L164_A0.9491.00
68_L79_T0.9441.00
81_L99_L0.9411.00
26_A30_E0.9381.00
187_L215_I0.9361.00
22_A70_R0.9311.00
108_Y132_A0.9301.00
5_A214_I0.9301.00
58_Q64_F0.9281.00
137_V142_V0.9261.00
106_A135_L0.9251.00
140_M166_I0.9171.00
76_M100_Q0.9151.00
187_L213_R0.9151.00
27_Q30_E0.9151.00
29_A77_M0.9131.00
140_M165_E0.9101.00
185_T189_A0.9081.00
183_W200_A0.9041.00
41_A125_V0.9041.00
110_K147_C0.9041.00
18_A68_L0.8991.00
21_C68_L0.8911.00
5_A232_I0.8881.00
71_E74_R0.8771.00
237_T240_R0.8771.00
222_I234_A0.8711.00
65_L104_I0.8671.00
15_E63_E0.8531.00
223_A234_A0.8521.00
59_L86_P0.8491.00
112_H149_D0.8391.00
204_C228_M0.8371.00
44_A61_E0.8311.00
239_E242_R0.8311.00
221_T224_A0.8271.00
28_A33_A0.8251.00
2_L233_M0.8201.00
136_E139_G0.8171.00
62_G66_G0.8151.00
69_R103_N0.8141.00
5_A212_S0.8131.00
25_M75_N0.8081.00
52_L57_A0.8061.00
108_Y149_D0.8051.00
85_V107_R0.8041.00
197_Y236_V0.8031.00
197_Y241_V0.8001.00
38_L42_L0.8001.00
239_E243_Q0.7941.00
41_A46_D0.7941.00
106_A132_A0.7911.00
23_S26_A0.7901.00
135_L142_V0.7891.00
29_A75_N0.7881.00
62_G65_L0.7881.00
169_L198_M0.7851.00
4_A231_L0.7851.00
111_L131_I0.7821.00
157_L161_L0.7781.00
15_E67_R0.7781.00
111_L155_L0.7731.00
94_N110_K0.7721.00
14_W18_A0.7711.00
7_Q212_S0.7711.00
172_A203_E0.7701.00
165_E238_P0.7691.00
25_M38_L0.7681.00
145_M159_Q0.7611.00
9_A204_C0.7531.00
4_A36_F0.7461.00
35_L139_G0.7451.00
3_V236_V0.7441.00
241_V245_R0.7441.00
88_T91_R0.7431.00
4_A28_A0.7421.00
197_Y240_R0.7381.00
10_V203_E0.7361.00
150_L169_L0.7351.00
7_Q210_G0.7291.00
13_V17_N0.7271.00
115_D120_Q0.7231.00
8_F42_L0.7231.00
19_E22_A0.7221.00
37_A80_I0.7191.00
150_L187_L0.7161.00
2_L31_N0.7141.00
21_C25_M0.7131.00
35_L80_I0.7081.00
14_W64_F0.7071.00
218_F244_V0.7031.00
159_Q164_A0.7031.00
69_R104_I0.6991.00
140_M238_P0.6981.00
174_V179_K0.6971.00
240_R244_V0.6961.00
97_V104_I0.6931.00
31_N231_L0.6841.00
21_C81_L0.6811.00
57_A62_G0.6791.00
94_N147_C0.6781.00
35_L78_T0.6781.00
9_A229_P0.6711.00
65_L69_R0.6681.00
30_E75_N0.6681.00
213_R221_T0.6631.00
72_S75_N0.6581.00
41_A84_H0.6531.00
61_E83_I0.6501.00
42_L81_L0.6481.00
69_R72_S0.6471.00
53_S56_S0.6451.00
160_A251_L0.6451.00
65_L81_L0.6431.00
173_W179_K0.6431.00
56_S59_L0.6401.00
51_D55_K0.6401.00
18_A71_E0.6381.00
104_I107_R0.6371.00
167_L198_M0.6331.00
37_A199_V0.6311.00
114_Y148_Y0.6301.00
98_A142_V0.6271.00
238_P242_R0.6261.00
204_C229_P0.6261.00
84_H125_V0.6251.00
180_E211_Q0.6231.00
33_A77_M0.6221.00
121_E124_R0.6191.00
202_G212_S0.6181.00
175_R180_E0.6171.00
160_A194_T0.6141.00
181_H184_S0.6121.00
220_V240_R0.6121.00
78_T139_G0.6111.00
14_W58_Q0.6091.00
112_H152_F0.6031.00
151_R173_W0.6031.00
18_A64_F0.5991.00
58_Q61_E0.5991.00
213_R224_A0.5971.00
88_T109_A0.5971.00
8_F20_I0.5961.00
85_V93_W0.5961.00
155_L159_Q0.5951.00
151_R186_L0.5941.00
94_N146_T0.5921.00
111_L158_A0.5901.00
64_F67_R0.5851.00
181_H188_A0.5841.00
51_D54_V0.5841.00
63_E66_G0.5821.00
82_T94_N0.5771.00
22_A75_N0.5741.00
28_A32_D0.5741.00
48_H52_L0.5731.00
27_Q231_L0.5701.00
136_E140_M0.5691.00
57_A61_E0.5681.00
158_A161_L0.5661.00
114_Y151_R0.5651.00
190_R194_T0.5641.00
40_E147_C0.5631.00
85_V97_V0.5631.00
28_A77_M0.5601.00
173_W183_W0.5601.00
60_L65_L0.5601.00
148_Y151_R0.5591.00
9_A203_E0.5581.00
96_L146_T0.5581.00
78_T142_V0.5581.00
46_D147_C0.5571.00
26_A29_A0.5571.00
28_A36_F0.5551.00
11_T20_I0.5541.00
34_S139_G0.5531.00
114_Y174_V0.5531.00
184_S211_Q0.5511.00
86_P92_A0.5511.00
186_L189_A0.5491.00
52_L56_S0.5471.00
184_S221_T0.5431.00
175_R209_I0.5421.00
156_A190_R0.5371.00
173_W200_A0.5361.00
189_A192_L0.5351.00
46_D125_V0.5351.00
131_I155_L0.5341.00
114_Y147_C0.5341.00
188_A221_T0.5300.99
72_S99_L0.5300.99
134_L162_Q0.5270.99
108_Y128_G0.5260.99
241_V244_V0.5260.99
141_K162_Q0.5250.99
114_Y173_W0.5240.99
15_E18_A0.5220.99
14_W17_N0.5220.99
21_C24_L0.5190.99
29_A76_M0.5180.99
76_M101_A0.5170.99
195_T244_V0.5150.99
34_S76_M0.5150.99
157_L251_L0.5140.99
165_E241_V0.5140.99
24_L229_P0.5140.99
29_A32_D0.5130.99
121_E125_V0.5120.99
119_I123_R0.5090.99
144_L170_P0.5070.99
191_A219_G0.5060.99
159_Q167_L0.5060.99
101_A105_V0.5050.99
60_L97_V0.5040.99
238_P241_V0.5030.99
171_A183_W0.5020.99
151_R183_W0.5010.99
143_G167_L0.5000.99
131_I159_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vhhA 5 0.9962 100 0.142 Contact Map
4izuA 2 0.9389 100 0.151 Contact Map
2w1vA 2 0.9809 100 0.161 Contact Map
3p8kA 2 0.9695 100 0.164 Contact Map
1emsA 3 0.9885 100 0.171 Contact Map
3ivzA 2 0.9542 100 0.171 Contact Map
1uf5A 4 0.9962 100 0.18 Contact Map
3wuyA 2 0.9313 100 0.18 Contact Map
1f89A 2 0.9427 100 0.185 Contact Map
2dyuA 5 0.9733 100 0.187 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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