GREMLIN Database
RCSD - Phosphotransferase RcsD
UniProt: P39838 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12385
Length: 890 (765)
Sequences: 1023 (903)
Seq/√Len: 32.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
748_L754_E6.3351.00
749_L754_E6.2711.00
721_I732_Y6.2071.00
751_S754_E6.0301.00
700_V706_R5.0991.00
620_M660_I4.8971.00
527_F565_G4.6641.00
725_E743_L4.5801.00
441_E445_N4.3601.00
751_S755_S4.2481.00
748_L751_S4.1041.00
451_A455_Y3.9291.00
441_E444_V3.8761.00
737_T749_L3.7971.00
484_A495_L3.6971.00
615_V619_E3.6461.00
750_L754_E3.6051.00
663_R666_L3.6011.00
748_L755_S3.5061.00
343_S347_N3.4121.00
737_T764_Q3.1581.00
705_I764_Q3.1481.00
584_S629_N3.0961.00
749_L755_S3.0301.00
737_T750_L2.9301.00
748_L753_D2.9261.00
706_R722_T2.8921.00
698_V709_V2.8921.00
565_G654_L2.8791.00
483_S708_I2.8641.00
749_L753_D2.8161.00
659_N671_S2.7991.00
629_N637_G2.7431.00
727_L743_L2.7061.00
700_V741_S2.7061.00
481_A499_A2.6791.00
452_Q455_Y2.6731.00
648_D652_R2.6211.00
340_N343_S2.6171.00
616_S619_E2.4861.00
569_A650_L2.4731.00
466_M469_I2.4681.00
227_T233_L2.4480.99
479_S483_S2.4000.99
514_M629_N2.3990.99
442_V445_N2.3410.99
606_F672_V2.2870.99
635_R638_K2.2870.99
385_A388_L2.2370.99
381_S385_A2.2340.99
770_N775_M2.2210.99
343_S346_V2.2130.99
747_G754_E2.1970.99
764_Q775_M2.1740.99
376_N382_N2.1520.99
470_G474_K2.1360.99
340_N346_V2.1250.99
739_N764_Q2.1240.99
700_V764_Q2.1220.98
473_L477_A2.1200.98
700_V722_T2.1150.98
695_C719_T2.0970.98
750_L762_P2.0910.98
544_I590_I2.0680.98
613_E637_G2.0610.98
736_L764_Q2.0580.98
366_L436_R2.0230.98
739_N775_M1.9790.98
469_I509_I1.9780.98
737_T751_S1.9750.98
593_E607_R1.9550.97
481_A485_A1.9550.97
479_S498_Q1.9430.97
391_H412_I1.9420.97
777_E795_S1.9280.97
438_Q442_V1.9180.97
585_T611_T1.9130.97
767_V770_N1.9020.97
609_L669_R1.9000.97
629_N638_K1.8920.97
741_S744_T1.8850.97
632_Q635_R1.8830.97
474_K583_T1.8770.97
469_I473_L1.8760.97
475_E502_L1.8660.97
369_L433_F1.8610.96
423_R426_V1.8570.96
574_L606_F1.8510.96
470_G475_E1.8470.96
472_A629_N1.8410.96
461_G654_L1.8350.96
768_N772_S1.8300.96
565_G676_M1.8270.96
584_S638_K1.8270.96
382_N385_A1.8040.96
467_K629_N1.7940.96
466_M473_L1.7840.96
633_N638_K1.7710.95
484_A499_A1.7700.95
522_S654_L1.7680.95
573_I672_V1.7630.95
412_I415_E1.7570.95
467_K635_R1.7560.95
701_T746_S1.7530.95
573_I651_A1.7440.95
470_G502_L1.7430.95
766_C770_N1.7410.95
569_A572_R1.7340.95
633_N637_G1.7260.95
508_E572_R1.7210.95
632_Q638_K1.7180.94
475_E583_T1.6990.94
651_A672_V1.6990.94
617_I663_R1.6930.94
584_S637_G1.6900.94
737_T775_M1.6860.94
739_N770_N1.6820.94
605_T671_S1.6800.94
737_T762_P1.6800.94
745_A748_L1.6710.94
594_V606_F1.6670.94
476_P502_L1.6660.94
470_G583_T1.6600.93
709_V765_L1.6570.93
547_K585_T1.6550.93
540_V575_L1.6440.93
357_N360_I1.6420.93
367_G435_I1.6400.93
508_E569_A1.6380.93
340_N347_N1.6370.93
474_K502_L1.6220.93
467_K506_V1.6200.93
622_N628_I1.6100.92
737_T773_N1.6080.92
520_W569_A1.5900.92
479_S708_I1.5860.92
459_Q463_M1.5460.91
502_L583_T1.5390.90
438_Q441_E1.5370.90
619_E622_N1.5370.90
750_L755_S1.5310.90
476_P583_T1.5290.90
700_V739_N1.5220.90
565_G570_L1.5200.90
470_G511_L1.5080.90
438_Q445_N1.5030.89
526_L564_R1.5020.89
630_Q633_N1.4920.89
706_R741_S1.4910.89
712_Q737_T1.4900.89
452_Q456_E1.4890.89
470_G476_P1.4870.89
462_R470_G1.4710.88
764_Q770_N1.4670.88
634_D637_G1.4660.88
695_C721_I1.4600.88
703_A706_R1.4580.88
459_Q462_R1.4550.88
629_N635_R1.4550.88
382_N398_T1.4540.88
705_I737_T1.4540.88
593_E609_L1.4500.88
481_A645_W1.4500.88
472_A644_F1.4490.88
747_G751_S1.4490.88
613_E633_N1.4420.87
578_M592_L1.4290.87
465_F502_L1.4290.87
735_F760_I1.4160.86
461_G482_E1.4060.86
726_R742_N1.4050.86
34_M39_Q1.4030.86
549_L590_I1.3960.86
479_S704_E1.3880.85
462_R502_L1.3870.85
691_L718_A1.3840.85
743_L749_L1.3800.85
523_E565_G1.3800.85
740_P764_Q1.3790.85
616_S664_D1.3770.85
507_D511_L1.3740.85
440_R443_L1.3730.85
479_S484_A1.3700.84
462_R475_E1.3640.84
742_N746_S1.3620.84
762_P775_M1.3550.84
474_K584_S1.3540.84
498_Q766_C1.3380.83
470_G584_S1.3370.83
766_C778_A1.3370.83
741_S766_C1.3360.83
694_V796_P1.3340.83
739_N778_A1.3320.83
585_T588_G1.3300.83
709_V764_Q1.3280.82
465_F474_K1.3240.82
461_G498_Q1.3240.82
475_E511_L1.3160.82
726_R744_T1.3110.82
445_N448_L1.3070.81
634_D638_K1.3060.81
468_N480_L1.3010.81
501_V505_L1.2960.81
463_M640_D1.2960.81
479_S705_I1.2960.81
495_L499_A1.2930.81
630_Q638_K1.2910.81
661_K669_R1.2900.81
455_Y482_E1.2890.81
473_L501_V1.2840.80
465_F583_T1.2840.80
514_M640_D1.2820.80
467_K585_T1.2740.80
455_Y461_G1.2710.80
699_D741_S1.2670.79
750_L766_C1.2660.79
139_E142_P1.2640.79
474_K511_L1.2560.79
705_I775_M1.2550.79
440_R444_V1.2500.78
615_V644_F1.2440.78
455_Y654_L1.2410.78
754_E762_P1.2410.78
739_N766_C1.2400.78
615_V660_I1.2400.78
495_L670_Y1.2330.77
423_R433_F1.2280.77
702_S705_I1.2280.77
468_N740_P1.2260.77
390_P414_N1.2260.77
166_L169_G1.2240.77
737_T741_S1.2210.77
706_R724_D1.2200.77
750_L775_M1.2130.76
701_T781_Q1.2120.76
603_R675_K1.2110.76
737_T743_L1.2070.76
770_N778_A1.2040.76
771_M775_M1.2000.75
539_S551_L1.1990.75
528_S531_D1.1990.75
444_V447_K1.1980.75
458_N461_G1.1970.75
475_E584_S1.1960.75
381_S384_I1.1910.75
726_R741_S1.1910.75
466_M474_K1.1870.75
469_I515_L1.1810.74
699_D749_L1.1800.74
705_I776_Q1.1760.74
774_A778_A1.1730.74
477_A483_S1.1720.74
466_M511_L1.1670.73
572_R646_L1.1660.73
465_F470_G1.1640.73
737_T740_P1.1630.73
480_L503_V1.1620.73
477_A732_Y1.1610.73
573_I650_L1.1600.73
462_R583_T1.1600.73
512_A702_S1.1600.73
698_V720_C1.1590.73
227_T290_M1.1580.73
563_R676_M1.1530.72
370_V430_T1.1440.72
696_V718_A1.1430.72
458_N466_M1.1410.72
506_V515_L1.1380.71
696_V734_I1.1380.71
741_S745_A1.1360.71
474_K629_N1.1330.71
75_Y80_A1.1310.71
382_N388_L1.1300.71
629_N644_F1.1300.71
71_T75_Y1.1280.71
467_K584_S1.1220.70
451_A461_G1.1190.70
462_R476_P1.1180.70
632_Q637_G1.1180.70
476_P585_T1.1140.70
382_N430_T1.1120.70
430_T433_F1.1120.70
451_A456_E1.1120.70
481_A503_V1.1090.69
764_Q774_A1.1070.69
511_L584_S1.1060.69
463_M516_A1.1030.69
467_K470_G1.1010.69
525_V567_R1.1010.69
524_T565_G1.0990.69
478_Q498_Q1.0990.69
754_E760_I1.0960.69
448_L451_A1.0960.69
217_T227_T1.0950.69
767_V777_E1.0950.69
502_L584_S1.0940.68
701_T742_N1.0910.68
695_C732_Y1.0890.68
354_R357_N1.0870.68
468_N712_Q1.0860.68
462_R474_K1.0860.68
466_M475_E1.0860.68
472_A475_E1.0850.68
357_N381_S1.0820.68
573_I654_L1.0820.68
746_S781_Q1.0820.68
699_D706_R1.0800.67
754_E775_M1.0800.67
490_P698_V1.0770.67
650_L654_L1.0760.67
468_N478_Q1.0750.67
477_A675_K1.0750.67
647_S672_V1.0720.67
725_E737_T1.0710.67
414_N418_E1.0710.67
483_S732_Y1.0680.67
420_R423_R1.0670.66
652_R657_H1.0670.66
705_I739_N1.0660.66
513_N517_D1.0560.66
472_A635_R1.0540.65
699_D737_T1.0530.65
473_L483_S1.0530.65
465_F475_E1.0520.65
466_M470_G1.0500.65
705_I774_A1.0470.65
737_T766_C1.0470.65
696_V713_L1.0470.65
735_F762_P1.0470.65
467_K474_K1.0460.65
749_L775_M1.0440.65
465_F469_I1.0440.65
470_G646_L1.0420.65
470_G629_N1.0420.65
473_L702_S1.0410.65
577_L672_V1.0400.64
465_F629_N1.0400.64
472_A584_S1.0380.64
517_D629_N1.0340.64
506_V516_A1.0320.64
585_T642_L1.0310.64
476_P584_S1.0300.64
506_V512_A1.0300.64
705_I741_S1.0260.63
569_A783_I1.0240.63
466_M477_A1.0210.63
531_D796_P1.0210.63
700_V725_E1.0190.63
61_Q64_V1.0170.63
502_L511_L1.0170.63
469_I477_A1.0150.63
737_T754_E1.0140.62
440_R445_N1.0130.62
754_E776_Q1.0110.62
520_W604_L1.0110.62
660_I670_Y1.0100.62
623_L657_H1.0080.62
462_R466_M1.0060.62
584_S633_N1.0040.62
644_F668_T1.0040.62
763_G767_V1.0000.61
411_T419_I0.9990.61
468_N585_T0.9960.61
473_L505_L0.9950.61
583_T629_N0.9940.61
777_E791_E0.9920.61
475_E629_N0.9920.61
605_T673_H0.9910.61
473_L732_Y0.9900.61
475_E569_A0.9890.60
577_L608_I0.9890.60
371_H385_A0.9870.60
752_D755_S0.9870.60
466_M476_P0.9870.60
749_L764_Q0.9840.60
416_L419_I0.9840.60
432_I435_I0.9780.60
583_T646_L0.9760.59
463_M502_L0.9760.59
751_S775_M0.9750.59
777_E794_E0.9750.59
462_R465_F0.9750.59
278_K295_Q0.9740.59
764_Q773_N0.9640.58
709_V712_Q0.9640.58
474_K646_L0.9630.58
64_V71_T0.9620.58
708_I775_M0.9600.58
511_L520_W0.9600.58
437_D445_N0.9580.58
507_D516_A0.9570.58
467_K583_T0.9560.58
540_V582_V0.9560.58
486_K623_L0.9530.58
412_I419_I0.9530.58
472_A583_T0.9520.58
470_G572_R0.9490.57
606_F647_S0.9480.57
584_S642_L0.9470.57
74_I78_I0.9460.57
419_I423_R0.9440.57
471_D576_L0.9440.57
238_L241_P0.9440.57
472_A615_V0.9430.57
642_L646_L0.9430.57
511_L583_T0.9410.57
475_E508_E0.9410.57
510_Q624_H0.9390.56
467_K475_E0.9360.56
501_V539_S0.9350.56
227_T230_A0.9330.56
370_V385_A0.9330.56
472_A476_P0.9300.56
483_S637_G0.9300.56
238_L242_G0.9290.56
584_S646_L0.9280.56
483_S775_M0.9280.56
349_E353_L0.9240.55
644_F670_Y0.9210.55
480_L704_E0.9180.55
747_G755_S0.9170.55
766_C775_M0.9160.55
523_E635_R0.9150.54
474_K585_T0.9140.54
475_E572_R0.9120.54
506_V741_S0.9120.54
607_R671_S0.9110.54
595_D605_T0.9060.54
35_G39_Q0.9030.54
505_L557_L0.9020.53
568_D615_V0.9010.53
354_R358_E0.9000.53
164_K169_G0.8980.53
466_M547_K0.8970.53
471_D580_Y0.8970.53
478_Q705_I0.8950.53
487_L653_K0.8940.53
597_D605_T0.8910.53
472_A572_R0.8910.53
531_D625_F0.8910.53
467_K472_A0.8900.52
713_L763_G0.8900.52
702_S709_V0.8900.52
700_V765_L0.8860.52
465_F476_P0.8860.52
469_I516_A0.8860.52
736_L788_A0.8850.52
448_L623_L0.8840.52
721_I730_Q0.8810.52
473_L508_E0.8810.52
22_F29_V0.8800.52
293_V297_P0.8790.52
757_V760_I0.8770.51
584_S644_F0.8760.51
624_H639_A0.8750.51
706_R775_M0.8750.51
483_S635_R0.8740.51
420_R426_V0.8720.51
467_K642_L0.8720.51
756_G762_P0.8720.51
423_R427_A0.8710.51
414_N420_R0.8700.51
29_V38_V0.8690.51
390_P412_I0.8690.51
473_L499_A0.8660.50
705_I747_G0.8650.50
364_L368_L0.8650.50
716_W737_T0.8630.50
431_Q434_I0.8630.50
726_R737_T0.8630.50
465_F585_T0.8630.50
747_G750_L0.8620.50
469_I503_V0.8610.50
371_H433_F0.8610.50
372_D439_D0.8610.50
502_L629_N0.8590.50
726_R746_S0.8590.50
418_E433_F0.8570.50
616_S623_L0.8570.50
768_N778_A0.8560.50
350_L579_Q0.8560.50
615_V620_M0.8540.49
509_I516_A0.8540.49
31_L34_M0.8530.49
501_V654_L0.8530.49
541_L545_K0.8520.49
479_S487_L0.8510.49
483_S565_G0.8510.49
480_L487_L0.8510.49
520_W584_S0.8510.49
471_D643_A0.8500.49
736_L765_L0.8500.49
584_S635_R0.8480.49
589_K700_V0.8480.49
461_G469_I0.8480.49
740_P765_L0.8470.49
502_L507_D0.8450.49
478_Q486_K0.8420.48
770_N780_L0.8420.48
370_V433_F0.8410.48
745_A779_V0.8400.48
479_S482_E0.8380.48
702_S740_P0.8370.48
466_M502_L0.8370.48
725_E750_L0.8360.48
395_Q412_I0.8350.48
465_F584_S0.8330.48
476_P511_L0.8330.48
479_S505_L0.8300.47
218_T227_T0.8280.47
576_L580_Y0.8280.47
495_L503_V0.8250.47
734_I796_P0.8250.47
741_S763_G0.8220.47
473_L775_M0.8190.47
236_N240_P0.8190.47
572_R642_L0.8170.46
476_P646_L0.8160.46
425_Q439_D0.8160.46
484_A503_V0.8160.46
21_R24_L0.8160.46
576_L643_A0.8150.46
381_S388_L0.8140.46
478_Q513_N0.8140.46
463_M512_A0.8130.46
473_L718_A0.8120.46
475_E585_T0.8120.46
705_I723_P0.8120.46
477_A505_L0.8110.46
646_L654_L0.8110.46
128_M136_W0.8110.46
509_I578_M0.8100.46
742_N745_A0.8100.46
767_V773_N0.8100.46
458_N462_R0.8080.46
447_K452_Q0.8080.46
482_E575_L0.8040.45
88_E91_Q0.8020.45
474_K572_R0.8010.45
415_E418_E0.8010.45
411_T418_E0.8000.45
477_A506_V0.7990.45
475_E507_D0.7980.45
479_S676_M0.7970.45
585_T646_L0.7970.45
508_E646_L0.7970.45
372_D377_R0.7970.45
418_E423_R0.7960.45
201_N211_H0.7960.45
474_K507_D0.7960.45
398_T413_N0.7950.45
372_D425_Q0.7950.45
747_G753_D0.7940.45
466_M572_R0.7930.44
723_P726_R0.7930.44
483_S739_N0.7930.44
70_V74_I0.7920.44
495_L766_C0.7890.44
503_V506_V0.7890.44
712_Q785_V0.7870.44
454_L457_K0.7850.44
364_L367_G0.7850.44
699_D709_V0.7850.44
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510_Q643_A0.5050.24
489_A636_Y0.5040.23
706_R721_I0.5040.23
131_Y146_Y0.5030.23
132_L142_P0.5020.23
479_S770_N0.5020.23
151_Q166_L0.5020.23
115_G131_Y0.5020.23
149_N169_G0.5010.23
764_Q777_E0.5010.23
705_I713_L0.5000.23
478_Q646_L0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.364 100 0.701 Contact Map
4gczA 2 0.373 100 0.704 Contact Map
3a0rA 2 0.3371 100 0.721 Contact Map
4r3aA 1 0.3135 100 0.764 Contact Map
4q20A 2 0.2506 100 0.768 Contact Map
4mpcA 2 0.3584 100 0.768 Contact Map
2c2aA 2 0.2528 100 0.769 Contact Map
4e01A 3 0.3169 100 0.77 Contact Map
2q8gA 2 0.3584 100 0.774 Contact Map
3jz3A 2 0.1753 100 0.776 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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