YFEH - ECOLI - GREMLIN Contacts

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YFEH - Uncharacterized protein YfeH

UniProt:	P39836	Sequences: MKLFRILDPFTLTLITVVLLASFFPARGDFVPFFENLTTAAIALLFFMHGAKLSREAIIAGGGHWRLHLWVMCSTFVLFPILGVLFAWWKPVNVDPMLYSGFLYLCILPATVQSAIAFTSMAGGNVAAAVCSASASSLLGIFLSPLLVGLVMNVHGAGGSLEQVGKIMLQLLLPFVLGHLSRPWIGDWVSRNKKWIAKTDQTSILLVVYTAFSEAVVNGIWHKVGWGSLLFIVVVSCVLLAIVIVVNVFMARRLSFNKADEITIVFCGSKKSLANGIPMANILFPTSVIGMMVLPLMIFHQIQLMVCAVLARRYKRQTEQLQAQQESSADKA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12376
Length:	332 (297)
Sequences:	5892 (3346)
Seq/√Len:	194.2

ECOLI - YFEH
BACSU - YOCS ARSB YBAS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
125_N	260_D	7.327	1.00
47_F	181_S	6.852	1.00
249_F	253_R	3.487	1.00
258_K	262_I	3.275	1.00
159_G	162_E	3.185	1.00
59_I	63_G	3.135	1.00
119_T	124_G	3.009	1.00
47_F	177_L	2.989	1.00
257_N	260_D	2.873	1.00
102_F	235_V	2.806	1.00
252_R	261_E	2.704	1.00
75_T	110_A	2.653	1.00
276_G	296_L	2.577	1.00
251_A	261_E	2.475	1.00
240_L	306_V	2.448	1.00
82_L	242_I	2.362	1.00
251_A	264_I	2.330	1.00
57_A	60_A	2.236	1.00
104_Y	280_A	2.219	1.00
56_E	59_I	2.167	1.00
79_F	243_V	2.154	1.00
73_C	77_V	2.146	1.00
245_V	249_F	2.123	1.00
107_I	147_L	2.120	1.00
76_F	143_L	2.079	1.00
17_V	205_L	2.048	1.00
176_V	180_L	2.009	1.00
129_A	263_T	1.997	1.00
248_V	261_E	1.997	1.00
256_F	264_I	1.997	1.00
83_G	106_C	1.971	1.00
72_M	139_L	1.968	1.00
313_R	317_Q	1.955	1.00
90_K	235_V	1.949	1.00
69_L	73_C	1.926	1.00
139_L	143_L	1.923	1.00
12_L	16_T	1.921	1.00
84_V	88_W	1.804	1.00
86_F	235_V	1.795	1.00
81_I	85_L	1.794	1.00
15_I	19_L	1.783	1.00
82_L	243_V	1.775	1.00
85_L	89_W	1.767	1.00
74_S	247_N	1.766	1.00
237_C	302_I	1.762	1.00
87_A	99_Y	1.757	1.00
119_T	263_T	1.748	1.00
302_I	306_V	1.730	1.00
13_T	17_V	1.719	1.00
230_L	234_V	1.708	1.00
182_R	190_S	1.702	1.00
60_A	63_G	1.693	1.00
310_L	314_Y	1.685	1.00
54_S	182_R	1.673	1.00
180_L	184_W	1.670	1.00
286_T	290_G	1.668	1.00
312_R	316_R	1.584	1.00
91_P	95_D	1.575	1.00
161_L	165_G	1.567	1.00
185_I	188_W	1.534	1.00
119_T	129_A	1.526	1.00
262_I	314_Y	1.512	1.00
19_L	22_S	1.507	1.00
70_W	254_L	1.504	1.00
70_W	264_I	1.486	1.00
105_L	299_F	1.480	1.00
242_I	246_V	1.475	1.00
16_T	20_L	1.449	1.00
108_L	276_G	1.439	1.00
256_F	260_D	1.437	1.00
261_E	265_V	1.429	1.00
125_N	259_A	1.424	1.00
312_R	315_K	1.422	1.00
110_A	133_A	1.420	1.00
36_N	40_A	1.419	1.00
65_W	69_L	1.405	1.00
29_D	32_P	1.398	1.00
10_F	14_L	1.369	1.00
190_S	193_K	1.365	1.00
169_L	173_L	1.336	1.00
25_P	28_G	1.333	1.00
122_A	311_A	1.330	1.00
168_M	173_L	1.327	1.00
21_A	28_G	1.316	1.00
181_S	185_I	1.313	1.00
91_P	94_V	1.298	1.00
97_M	291_M	1.297	1.00
265_V	314_Y	1.297	1.00
251_A	256_F	1.290	1.00
258_K	317_Q	1.287	1.00
187_D	191_R	1.286	1.00
40_A	43_A	1.281	1.00
237_C	306_V	1.275	1.00
24_F	27_R	1.249	1.00
309_V	313_R	1.247	1.00
100_S	152_M	1.240	1.00
74_S	78_L	1.237	1.00
13_T	205_L	1.233	1.00
273_L	300_H	1.232	1.00
54_S	57_A	1.228	1.00
67_L	256_F	1.227	1.00
74_S	268_G	1.227	1.00
188_W	192_N	1.220	1.00
75_T	271_K	1.219	1.00
76_F	136_S	1.209	1.00
147_L	151_V	1.207	1.00
114_S	271_K	1.207	1.00
257_N	261_E	1.202	1.00
143_L	146_L	1.196	1.00
85_L	88_W	1.189	1.00
113_Q	244_I	1.187	1.00
179_H	183_P	1.174	1.00
107_I	148_V	1.164	1.00
30_F	34_F	1.156	1.00
248_V	258_K	1.148	1.00
71_V	132_S	1.141	1.00
72_M	135_A	1.138	1.00
46_F	50_G	1.135	1.00
115_A	267_C	1.132	1.00
95_D	99_Y	1.130	1.00
19_L	23_F	1.130	1.00
110_A	115_A	1.115	1.00
75_T	133_A	1.108	1.00
22_S	220_I	1.097	1.00
30_F	33_F	1.097	1.00
27_R	30_F	1.097	1.00
26_A	30_F	1.097	1.00
187_D	190_S	1.092	1.00
50_G	178_G	1.092	1.00
204_I	208_V	1.086	1.00
131_C	134_S	1.079	1.00
143_L	147_L	1.079	1.00
74_S	250_M	1.079	1.00
68_H	135_A	1.067	1.00
250_M	254_L	1.060	1.00
261_E	314_Y	1.056	1.00
64_H	125_N	1.051	1.00
29_D	33_F	1.049	1.00
18_V	21_A	1.044	1.00
10_F	17_V	1.038	1.00
98_L	232_I	1.032	1.00
60_A	131_C	1.031	1.00
111_T	114_S	1.030	1.00
188_W	191_R	1.027	1.00
140_G	144_S	1.025	1.00
56_E	60_A	1.009	1.00
276_G	295_P	1.002	1.00
26_A	29_D	1.002	1.00
165_G	169_L	0.997	1.00
64_H	260_D	0.996	1.00
67_L	128_A	0.982	0.99
82_L	85_L	0.971	0.99
241_A	245_V	0.970	0.99
248_V	265_V	0.969	0.99
70_W	256_F	0.967	0.99
103_L	107_I	0.966	0.99
66_R	256_F	0.965	0.99
75_T	129_A	0.961	0.99
199_T	203_S	0.945	0.99
307_C	311_A	0.945	0.99
123_G	318_T	0.940	0.99
299_F	303_Q	0.931	0.99
300_H	304_L	0.929	0.99
285_P	290_G	0.925	0.99
110_A	132_S	0.914	0.99
216_V	220_I	0.913	0.99
158_G	162_E	0.911	0.99
158_G	163_Q	0.908	0.99
17_V	21_A	0.907	0.99
81_I	151_V	0.905	0.99
34_F	210_T	0.898	0.99
227_G	231_F	0.895	0.99
266_F	270_K	0.894	0.99
299_F	304_L	0.891	0.99
103_L	151_V	0.889	0.99
136_S	271_K	0.886	0.99
43_A	177_L	0.883	0.99
232_I	236_S	0.882	0.99
37_L	40_A	0.876	0.99
71_V	264_I	0.875	0.99
41_A	203_S	0.875	0.99
16_T	19_L	0.875	0.99
94_V	231_F	0.873	0.99
31_V	34_F	0.873	0.99
95_D	231_F	0.865	0.99
241_A	309_V	0.860	0.99
87_A	103_L	0.855	0.99
13_T	16_T	0.850	0.98
123_G	315_K	0.845	0.98
184_W	187_D	0.843	0.98
182_R	186_G	0.840	0.98
167_I	172_L	0.838	0.98
162_E	165_G	0.836	0.98
118_F	270_K	0.835	0.98
41_A	207_V	0.832	0.98
315_K	318_T	0.832	0.98
67_L	260_D	0.823	0.98
127_A	130_V	0.823	0.98
11_T	14_L	0.821	0.98
20_L	23_F	0.815	0.98
51_A	171_L	0.813	0.98
73_C	250_M	0.809	0.98
132_S	264_I	0.806	0.98
91_P	96_P	0.804	0.98
252_R	255_S	0.803	0.98
110_A	129_A	0.801	0.98
17_V	20_L	0.798	0.98
75_T	267_C	0.798	0.98
258_K	261_E	0.797	0.98
238_V	242_I	0.797	0.98
86_F	242_I	0.794	0.98
20_L	24_F	0.792	0.98
278_P	282_I	0.791	0.98
42_I	46_F	0.789	0.98
115_A	133_A	0.787	0.97
186_G	190_S	0.783	0.97
55_R	183_P	0.782	0.97
137_S	275_N	0.782	0.97
58_I	61_G	0.780	0.97
95_D	98_L	0.779	0.97
71_V	267_C	0.776	0.97
12_L	15_I	0.776	0.97
79_F	106_C	0.772	0.97
98_L	228_S	0.772	0.97
251_A	255_S	0.772	0.97
137_S	272_S	0.771	0.97
34_F	40_A	0.770	0.97
244_I	310_L	0.769	0.97
102_F	236_S	0.767	0.97
248_V	252_R	0.767	0.97
111_T	267_C	0.766	0.97
180_L	183_P	0.764	0.97
165_G	168_M	0.764	0.97
131_C	135_A	0.764	0.97
164_V	168_M	0.761	0.97
14_L	208_V	0.761	0.97
160_S	163_Q	0.757	0.97
259_A	263_T	0.755	0.97
104_Y	144_S	0.747	0.97
10_F	25_P	0.746	0.97
297_M	301_Q	0.745	0.97
195_W	198_K	0.742	0.96
114_S	129_A	0.742	0.96
111_T	115_A	0.741	0.96
63_G	69_L	0.740	0.96
48_M	200_D	0.735	0.96
200_D	207_V	0.734	0.96
75_T	136_S	0.730	0.96
70_W	251_A	0.730	0.96
39_T	43_A	0.730	0.96
146_L	150_L	0.727	0.96
133_A	267_C	0.725	0.96
75_T	132_S	0.725	0.96
303_Q	307_C	0.724	0.96
273_L	303_Q	0.724	0.96
44_L	199_T	0.721	0.96
110_A	266_F	0.715	0.96
27_R	34_F	0.713	0.96
142_F	146_L	0.711	0.95
160_S	164_V	0.709	0.95
110_A	137_S	0.708	0.95
108_L	144_S	0.697	0.95
15_I	18_V	0.696	0.95
10_F	13_T	0.695	0.95
252_R	258_K	0.693	0.95
267_C	271_K	0.693	0.95
100_S	148_V	0.691	0.95
228_S	232_I	0.691	0.95
129_A	267_C	0.690	0.95
87_A	90_K	0.689	0.95
209_Y	213_S	0.689	0.95
187_D	316_R	0.688	0.95
86_F	238_V	0.688	0.95
177_L	181_S	0.688	0.95
94_V	98_L	0.688	0.95
120_S	123_G	0.685	0.94
210_T	214_E	0.683	0.94
192_N	195_W	0.681	0.94
249_F	252_R	0.678	0.94
125_N	257_N	0.678	0.94
72_M	131_C	0.677	0.94
294_L	297_M	0.675	0.94
90_K	238_V	0.674	0.94
45_L	113_Q	0.673	0.94
57_A	127_A	0.673	0.94
118_F	121_M	0.670	0.94
300_H	303_Q	0.667	0.94
97_M	292_M	0.666	0.94
302_I	305_M	0.663	0.93
22_S	218_N	0.660	0.93
111_T	272_S	0.658	0.93
161_L	164_V	0.652	0.93
45_L	50_G	0.650	0.93
124_G	262_I	0.649	0.93
18_V	212_F	0.649	0.93
128_A	260_D	0.649	0.93
60_A	64_H	0.648	0.93
67_L	264_I	0.647	0.93
265_V	269_S	0.647	0.93
244_I	265_V	0.644	0.92
119_T	277_I	0.640	0.92
23_F	27_R	0.638	0.92
111_T	270_K	0.637	0.92
308_A	312_R	0.637	0.92
99_Y	102_F	0.635	0.92
49_H	117_A	0.631	0.92
194_K	198_K	0.631	0.92
204_I	215_A	0.630	0.92
62_G	131_C	0.630	0.92
42_I	128_A	0.630	0.92
262_I	318_T	0.629	0.92
83_G	102_F	0.627	0.91
70_W	250_M	0.626	0.91
181_S	189_V	0.625	0.91
299_F	305_M	0.622	0.91
204_I	274_A	0.621	0.91
10_F	22_S	0.613	0.90
19_L	33_F	0.613	0.90
29_D	254_L	0.613	0.90
77_V	81_I	0.612	0.90
67_L	132_S	0.611	0.90
20_L	28_G	0.611	0.90
182_R	193_K	0.610	0.90
305_M	309_V	0.609	0.90
14_L	18_V	0.608	0.90
188_W	194_K	0.607	0.90
268_G	271_K	0.606	0.90
239_L	303_Q	0.604	0.90
116_I	136_S	0.603	0.90
117_A	266_F	0.603	0.90
21_A	216_V	0.601	0.90
248_V	317_Q	0.601	0.90
108_L	140_G	0.600	0.90
130_V	175_F	0.599	0.89
72_M	132_S	0.599	0.89
290_G	303_Q	0.599	0.89
12_L	19_L	0.598	0.89
87_A	102_F	0.598	0.89
130_V	133_A	0.596	0.89
204_I	207_V	0.596	0.89
99_Y	103_L	0.596	0.89
40_A	44_L	0.595	0.89
19_L	31_V	0.594	0.89
146_L	149_G	0.593	0.89
114_S	267_C	0.593	0.89
122_A	266_F	0.592	0.89
46_F	49_H	0.588	0.89
14_L	17_V	0.586	0.88
136_S	143_L	0.585	0.88
277_I	281_N	0.585	0.88
88_W	99_Y	0.582	0.88
193_K	197_A	0.579	0.88
252_R	257_N	0.579	0.88
197_A	200_D	0.579	0.88
113_Q	304_L	0.579	0.88
75_T	114_S	0.577	0.88
21_A	25_P	0.575	0.87
44_L	48_M	0.573	0.87
75_T	115_A	0.571	0.87
243_V	269_S	0.571	0.87
38_T	269_S	0.570	0.87
244_I	247_N	0.569	0.87
215_A	218_N	0.569	0.87
19_L	30_F	0.569	0.87
14_L	25_P	0.567	0.87
28_G	32_P	0.566	0.87
86_F	239_L	0.566	0.87
308_A	311_A	0.565	0.87
27_R	31_V	0.564	0.86
248_V	262_I	0.564	0.86
105_L	273_L	0.564	0.86
56_E	234_V	0.563	0.86
62_G	65_W	0.563	0.86
129_A	266_F	0.563	0.86
280_A	292_M	0.562	0.86
219_G	228_S	0.561	0.86
32_P	214_E	0.561	0.86
138_L	242_I	0.560	0.86
110_A	267_C	0.560	0.86
180_L	233_V	0.560	0.86
87_A	154_V	0.558	0.86
105_L	303_Q	0.557	0.86
290_G	294_L	0.557	0.86
228_S	231_F	0.555	0.86
164_V	167_I	0.553	0.85
78_L	246_V	0.551	0.85
241_A	306_V	0.551	0.85
240_L	243_V	0.550	0.85
129_A	133_A	0.548	0.85
120_S	126_V	0.545	0.85
24_F	28_G	0.545	0.85
251_A	265_V	0.544	0.84
196_I	199_T	0.543	0.84
86_F	90_K	0.541	0.84
74_S	77_V	0.540	0.84
118_F	266_F	0.537	0.84
197_A	279_M	0.537	0.84
204_I	211_A	0.537	0.84
132_S	136_S	0.537	0.84
180_L	191_R	0.536	0.84
274_A	278_P	0.536	0.84
64_H	67_L	0.534	0.83
173_L	318_T	0.534	0.83
115_A	271_K	0.531	0.83
38_T	274_A	0.530	0.83
281_N	293_V	0.530	0.83
197_A	201_Q	0.529	0.83
104_Y	148_V	0.529	0.83
17_V	25_P	0.528	0.83
51_A	196_I	0.528	0.83
234_V	237_C	0.526	0.82
190_S	253_R	0.526	0.82
310_L	313_R	0.526	0.82
148_V	152_M	0.526	0.82
52_K	120_S	0.523	0.82
36_N	39_T	0.523	0.82
19_L	316_R	0.523	0.82
169_L	180_L	0.521	0.82
111_T	300_H	0.521	0.82
157_A	161_L	0.519	0.82
115_A	130_V	0.519	0.82
137_S	279_M	0.517	0.81
163_Q	167_I	0.516	0.81
71_V	263_T	0.516	0.81
239_L	299_F	0.516	0.81
11_T	17_V	0.515	0.81
240_L	307_C	0.514	0.81
277_I	293_V	0.514	0.81
24_F	29_D	0.511	0.81
104_Y	279_M	0.510	0.81
16_T	217_V	0.510	0.81
138_L	142_F	0.509	0.80
41_A	206_L	0.509	0.80
295_P	306_V	0.509	0.80
128_A	263_T	0.508	0.80
23_F	34_F	0.508	0.80
239_L	274_A	0.507	0.80
244_I	277_I	0.507	0.80
118_F	207_V	0.504	0.80
113_Q	303_Q	0.504	0.80
247_N	253_R	0.501	0.79
168_M	172_L	0.501	0.79
28_G	31_V	0.501	0.79
167_I	207_V	0.501	0.79
86_F	102_F	0.500	0.79
270_K	307_C	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zuxA	1	0.9127	100	0.276	Contact Map
4n7wA	2	0.9247	100	0.282	Contact Map
4bwzA	2	0.9367	98.5	0.846	Contact Map
4czbA	2	0.9187	97.8	0.869	Contact Map
4cz8A	2	0.9036	96.8	0.891	Contact Map
1zcdA	1	0.9036	88.8	0.922	Contact Map
2cfqA	1	0.6054	45.9	0.945	Contact Map
3w4tA	1	0.9307	34.6	0.949	Contact Map
4m64A	1	0.6235	30.7	0.95	Contact Map
4pypA	1	0.8916	30.1	0.95	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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