GREMLIN Database
YFEH - Uncharacterized protein YfeH
UniProt: P39836 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12376
Length: 332 (297)
Sequences: 5892 (3346)
Seq/√Len: 194.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_N260_D7.3271.00
47_F181_S6.8521.00
249_F253_R3.4871.00
258_K262_I3.2751.00
159_G162_E3.1851.00
59_I63_G3.1351.00
119_T124_G3.0091.00
47_F177_L2.9891.00
257_N260_D2.8731.00
102_F235_V2.8061.00
252_R261_E2.7041.00
75_T110_A2.6531.00
276_G296_L2.5771.00
251_A261_E2.4751.00
240_L306_V2.4481.00
82_L242_I2.3621.00
251_A264_I2.3301.00
57_A60_A2.2361.00
104_Y280_A2.2191.00
56_E59_I2.1671.00
79_F243_V2.1541.00
73_C77_V2.1461.00
245_V249_F2.1231.00
107_I147_L2.1201.00
76_F143_L2.0791.00
17_V205_L2.0481.00
176_V180_L2.0091.00
129_A263_T1.9971.00
248_V261_E1.9971.00
256_F264_I1.9971.00
83_G106_C1.9711.00
72_M139_L1.9681.00
313_R317_Q1.9551.00
90_K235_V1.9491.00
69_L73_C1.9261.00
139_L143_L1.9231.00
12_L16_T1.9211.00
84_V88_W1.8041.00
86_F235_V1.7951.00
81_I85_L1.7941.00
15_I19_L1.7831.00
82_L243_V1.7751.00
85_L89_W1.7671.00
74_S247_N1.7661.00
237_C302_I1.7621.00
87_A99_Y1.7571.00
119_T263_T1.7481.00
302_I306_V1.7301.00
13_T17_V1.7191.00
230_L234_V1.7081.00
182_R190_S1.7021.00
60_A63_G1.6931.00
310_L314_Y1.6851.00
54_S182_R1.6731.00
180_L184_W1.6701.00
286_T290_G1.6681.00
312_R316_R1.5841.00
91_P95_D1.5751.00
161_L165_G1.5671.00
185_I188_W1.5341.00
119_T129_A1.5261.00
262_I314_Y1.5121.00
19_L22_S1.5071.00
70_W254_L1.5041.00
70_W264_I1.4861.00
105_L299_F1.4801.00
242_I246_V1.4751.00
16_T20_L1.4491.00
108_L276_G1.4391.00
256_F260_D1.4371.00
261_E265_V1.4291.00
125_N259_A1.4241.00
312_R315_K1.4221.00
110_A133_A1.4201.00
36_N40_A1.4191.00
65_W69_L1.4051.00
29_D32_P1.3981.00
10_F14_L1.3691.00
190_S193_K1.3651.00
169_L173_L1.3361.00
25_P28_G1.3331.00
122_A311_A1.3301.00
168_M173_L1.3271.00
21_A28_G1.3161.00
181_S185_I1.3131.00
91_P94_V1.2981.00
97_M291_M1.2971.00
265_V314_Y1.2971.00
251_A256_F1.2901.00
258_K317_Q1.2871.00
187_D191_R1.2861.00
40_A43_A1.2811.00
237_C306_V1.2751.00
24_F27_R1.2491.00
309_V313_R1.2471.00
100_S152_M1.2401.00
74_S78_L1.2371.00
13_T205_L1.2331.00
273_L300_H1.2321.00
54_S57_A1.2281.00
67_L256_F1.2271.00
74_S268_G1.2271.00
188_W192_N1.2201.00
75_T271_K1.2191.00
76_F136_S1.2091.00
147_L151_V1.2071.00
114_S271_K1.2071.00
257_N261_E1.2021.00
143_L146_L1.1961.00
85_L88_W1.1891.00
113_Q244_I1.1871.00
179_H183_P1.1741.00
107_I148_V1.1641.00
30_F34_F1.1561.00
248_V258_K1.1481.00
71_V132_S1.1411.00
72_M135_A1.1381.00
46_F50_G1.1351.00
115_A267_C1.1321.00
95_D99_Y1.1301.00
19_L23_F1.1301.00
110_A115_A1.1151.00
75_T133_A1.1081.00
22_S220_I1.0971.00
30_F33_F1.0971.00
27_R30_F1.0971.00
26_A30_F1.0971.00
187_D190_S1.0921.00
50_G178_G1.0921.00
204_I208_V1.0861.00
131_C134_S1.0791.00
143_L147_L1.0791.00
74_S250_M1.0791.00
68_H135_A1.0671.00
250_M254_L1.0601.00
261_E314_Y1.0561.00
64_H125_N1.0511.00
29_D33_F1.0491.00
18_V21_A1.0441.00
10_F17_V1.0381.00
98_L232_I1.0321.00
60_A131_C1.0311.00
111_T114_S1.0301.00
188_W191_R1.0271.00
140_G144_S1.0251.00
56_E60_A1.0091.00
276_G295_P1.0021.00
26_A29_D1.0021.00
165_G169_L0.9971.00
64_H260_D0.9961.00
67_L128_A0.9820.99
82_L85_L0.9710.99
241_A245_V0.9700.99
248_V265_V0.9690.99
70_W256_F0.9670.99
103_L107_I0.9660.99
66_R256_F0.9650.99
75_T129_A0.9610.99
199_T203_S0.9450.99
307_C311_A0.9450.99
123_G318_T0.9400.99
299_F303_Q0.9310.99
300_H304_L0.9290.99
285_P290_G0.9250.99
110_A132_S0.9140.99
216_V220_I0.9130.99
158_G162_E0.9110.99
158_G163_Q0.9080.99
17_V21_A0.9070.99
81_I151_V0.9050.99
34_F210_T0.8980.99
227_G231_F0.8950.99
266_F270_K0.8940.99
299_F304_L0.8910.99
103_L151_V0.8890.99
136_S271_K0.8860.99
43_A177_L0.8830.99
232_I236_S0.8820.99
37_L40_A0.8760.99
71_V264_I0.8750.99
41_A203_S0.8750.99
16_T19_L0.8750.99
94_V231_F0.8730.99
31_V34_F0.8730.99
95_D231_F0.8650.99
241_A309_V0.8600.99
87_A103_L0.8550.99
13_T16_T0.8500.98
123_G315_K0.8450.98
184_W187_D0.8430.98
182_R186_G0.8400.98
167_I172_L0.8380.98
162_E165_G0.8360.98
118_F270_K0.8350.98
41_A207_V0.8320.98
315_K318_T0.8320.98
67_L260_D0.8230.98
127_A130_V0.8230.98
11_T14_L0.8210.98
20_L23_F0.8150.98
51_A171_L0.8130.98
73_C250_M0.8090.98
132_S264_I0.8060.98
91_P96_P0.8040.98
252_R255_S0.8030.98
110_A129_A0.8010.98
17_V20_L0.7980.98
75_T267_C0.7980.98
258_K261_E0.7970.98
238_V242_I0.7970.98
86_F242_I0.7940.98
20_L24_F0.7920.98
278_P282_I0.7910.98
42_I46_F0.7890.98
115_A133_A0.7870.97
186_G190_S0.7830.97
55_R183_P0.7820.97
137_S275_N0.7820.97
58_I61_G0.7800.97
95_D98_L0.7790.97
71_V267_C0.7760.97
12_L15_I0.7760.97
79_F106_C0.7720.97
98_L228_S0.7720.97
251_A255_S0.7720.97
137_S272_S0.7710.97
34_F40_A0.7700.97
244_I310_L0.7690.97
102_F236_S0.7670.97
248_V252_R0.7670.97
111_T267_C0.7660.97
180_L183_P0.7640.97
165_G168_M0.7640.97
131_C135_A0.7640.97
164_V168_M0.7610.97
14_L208_V0.7610.97
160_S163_Q0.7570.97
259_A263_T0.7550.97
104_Y144_S0.7470.97
10_F25_P0.7460.97
297_M301_Q0.7450.97
195_W198_K0.7420.96
114_S129_A0.7420.96
111_T115_A0.7410.96
63_G69_L0.7400.96
48_M200_D0.7350.96
200_D207_V0.7340.96
75_T136_S0.7300.96
70_W251_A0.7300.96
39_T43_A0.7300.96
146_L150_L0.7270.96
133_A267_C0.7250.96
75_T132_S0.7250.96
303_Q307_C0.7240.96
273_L303_Q0.7240.96
44_L199_T0.7210.96
110_A266_F0.7150.96
27_R34_F0.7130.96
142_F146_L0.7110.95
160_S164_V0.7090.95
110_A137_S0.7080.95
108_L144_S0.6970.95
15_I18_V0.6960.95
10_F13_T0.6950.95
252_R258_K0.6930.95
267_C271_K0.6930.95
100_S148_V0.6910.95
228_S232_I0.6910.95
129_A267_C0.6900.95
87_A90_K0.6890.95
209_Y213_S0.6890.95
187_D316_R0.6880.95
86_F238_V0.6880.95
177_L181_S0.6880.95
94_V98_L0.6880.95
120_S123_G0.6850.94
210_T214_E0.6830.94
192_N195_W0.6810.94
249_F252_R0.6780.94
125_N257_N0.6780.94
72_M131_C0.6770.94
294_L297_M0.6750.94
90_K238_V0.6740.94
45_L113_Q0.6730.94
57_A127_A0.6730.94
118_F121_M0.6700.94
300_H303_Q0.6670.94
97_M292_M0.6660.94
302_I305_M0.6630.93
22_S218_N0.6600.93
111_T272_S0.6580.93
161_L164_V0.6520.93
45_L50_G0.6500.93
124_G262_I0.6490.93
18_V212_F0.6490.93
128_A260_D0.6490.93
60_A64_H0.6480.93
67_L264_I0.6470.93
265_V269_S0.6470.93
244_I265_V0.6440.92
119_T277_I0.6400.92
23_F27_R0.6380.92
111_T270_K0.6370.92
308_A312_R0.6370.92
99_Y102_F0.6350.92
49_H117_A0.6310.92
194_K198_K0.6310.92
204_I215_A0.6300.92
62_G131_C0.6300.92
42_I128_A0.6300.92
262_I318_T0.6290.92
83_G102_F0.6270.91
70_W250_M0.6260.91
181_S189_V0.6250.91
299_F305_M0.6220.91
204_I274_A0.6210.91
10_F22_S0.6130.90
19_L33_F0.6130.90
29_D254_L0.6130.90
77_V81_I0.6120.90
67_L132_S0.6110.90
20_L28_G0.6110.90
182_R193_K0.6100.90
305_M309_V0.6090.90
14_L18_V0.6080.90
188_W194_K0.6070.90
268_G271_K0.6060.90
239_L303_Q0.6040.90
116_I136_S0.6030.90
117_A266_F0.6030.90
21_A216_V0.6010.90
248_V317_Q0.6010.90
108_L140_G0.6000.90
130_V175_F0.5990.89
72_M132_S0.5990.89
290_G303_Q0.5990.89
12_L19_L0.5980.89
87_A102_F0.5980.89
130_V133_A0.5960.89
204_I207_V0.5960.89
99_Y103_L0.5960.89
40_A44_L0.5950.89
19_L31_V0.5940.89
146_L149_G0.5930.89
114_S267_C0.5930.89
122_A266_F0.5920.89
46_F49_H0.5880.89
14_L17_V0.5860.88
136_S143_L0.5850.88
277_I281_N0.5850.88
88_W99_Y0.5820.88
193_K197_A0.5790.88
252_R257_N0.5790.88
197_A200_D0.5790.88
113_Q304_L0.5790.88
75_T114_S0.5770.88
21_A25_P0.5750.87
44_L48_M0.5730.87
75_T115_A0.5710.87
243_V269_S0.5710.87
38_T269_S0.5700.87
244_I247_N0.5690.87
215_A218_N0.5690.87
19_L30_F0.5690.87
14_L25_P0.5670.87
28_G32_P0.5660.87
86_F239_L0.5660.87
308_A311_A0.5650.87
27_R31_V0.5640.86
248_V262_I0.5640.86
105_L273_L0.5640.86
56_E234_V0.5630.86
62_G65_W0.5630.86
129_A266_F0.5630.86
280_A292_M0.5620.86
219_G228_S0.5610.86
32_P214_E0.5610.86
138_L242_I0.5600.86
110_A267_C0.5600.86
180_L233_V0.5600.86
87_A154_V0.5580.86
105_L303_Q0.5570.86
290_G294_L0.5570.86
228_S231_F0.5550.86
164_V167_I0.5530.85
78_L246_V0.5510.85
241_A306_V0.5510.85
240_L243_V0.5500.85
129_A133_A0.5480.85
120_S126_V0.5450.85
24_F28_G0.5450.85
251_A265_V0.5440.84
196_I199_T0.5430.84
86_F90_K0.5410.84
74_S77_V0.5400.84
118_F266_F0.5370.84
197_A279_M0.5370.84
204_I211_A0.5370.84
132_S136_S0.5370.84
180_L191_R0.5360.84
274_A278_P0.5360.84
64_H67_L0.5340.83
173_L318_T0.5340.83
115_A271_K0.5310.83
38_T274_A0.5300.83
281_N293_V0.5300.83
197_A201_Q0.5290.83
104_Y148_V0.5290.83
17_V25_P0.5280.83
51_A196_I0.5280.83
234_V237_C0.5260.82
190_S253_R0.5260.82
310_L313_R0.5260.82
148_V152_M0.5260.82
52_K120_S0.5230.82
36_N39_T0.5230.82
19_L316_R0.5230.82
169_L180_L0.5210.82
111_T300_H0.5210.82
157_A161_L0.5190.82
115_A130_V0.5190.82
137_S279_M0.5170.81
163_Q167_I0.5160.81
71_V263_T0.5160.81
239_L299_F0.5160.81
11_T17_V0.5150.81
240_L307_C0.5140.81
277_I293_V0.5140.81
24_F29_D0.5110.81
104_Y279_M0.5100.81
16_T217_V0.5100.81
138_L142_F0.5090.80
41_A206_L0.5090.80
295_P306_V0.5090.80
128_A263_T0.5080.80
23_F34_F0.5080.80
239_L274_A0.5070.80
244_I277_I0.5070.80
118_F207_V0.5040.80
113_Q303_Q0.5040.80
247_N253_R0.5010.79
168_M172_L0.5010.79
28_G31_V0.5010.79
167_I207_V0.5010.79
86_F102_F0.5000.79
270_K307_C0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.9127 100 0.276 Contact Map
4n7wA 2 0.9247 100 0.282 Contact Map
4bwzA 2 0.9367 98.5 0.846 Contact Map
4czbA 2 0.9187 97.8 0.869 Contact Map
4cz8A 2 0.9036 96.8 0.891 Contact Map
1zcdA 1 0.9036 88.8 0.922 Contact Map
2cfqA 1 0.6054 45.9 0.945 Contact Map
3w4tA 1 0.9307 34.6 0.949 Contact Map
4m64A 1 0.6235 30.7 0.95 Contact Map
4pypA 1 0.8916 30.1 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0107 seconds.