GREMLIN Database
GNTT - High-affinity gluconate transporter
UniProt: P39835 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12380
Length: 438 (415)
Sequences: 5763 (3884)
Seq/√Len: 190.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
262_P266_T3.9071.00
332_T335_S3.7611.00
294_S297_K3.7051.00
284_S287_Q3.4651.00
87_T91_K3.1541.00
9_G312_F3.1101.00
12_L34_A3.0961.00
314_Q318_D2.9341.00
323_K327_S2.9071.00
190_G193_Y2.9031.00
262_P265_A2.8721.00
9_G35_V2.8551.00
231_V272_I2.8331.00
77_D291_T2.8251.00
408_T411_E2.8151.00
11_I15_L2.7511.00
222_F226_V2.7511.00
338_L428_L2.6301.00
221_S224_V2.5941.00
42_P45_K2.5261.00
87_T222_F2.5101.00
49_S318_D2.4921.00
421_T425_V2.4901.00
87_T90_A2.4491.00
425_V429_V2.4081.00
341_W424_S2.4061.00
15_L19_R2.4061.00
180_I184_P2.3701.00
429_V433_L2.3281.00
327_S330_H2.2921.00
77_D287_Q2.2681.00
223_G227_W2.2641.00
196_V199_G2.1881.00
82_Q86_T2.1721.00
193_Y196_V2.1271.00
344_A361_A2.1121.00
193_Y197_L2.0841.00
52_A56_G2.0671.00
232_P236_M1.9911.00
48_G52_A1.9811.00
45_K48_G1.9591.00
194_A197_L1.9451.00
110_F113_F1.8541.00
414_K418_M1.8151.00
237_A240_A1.7901.00
228_T232_P1.7891.00
222_F225_S1.7861.00
167_F383_V1.7841.00
192_V196_V1.7461.00
140_G405_F1.7421.00
340_A383_V1.7231.00
324_Y328_M1.7021.00
190_G194_A1.7011.00
369_I379_M1.6971.00
12_L31_V1.6911.00
101_V104_T1.6711.00
345_A389_I1.6531.00
225_S228_T1.6511.00
42_P46_V1.6471.00
239_R243_E1.6441.00
73_K77_D1.6241.00
271_L275_F1.6201.00
349_I390_F1.6171.00
418_M422_I1.6011.00
189_A193_Y1.5951.00
163_I358_A1.5891.00
373_G376_P1.5881.00
200_I204_I1.5841.00
113_F116_V1.5781.00
262_P267_L1.5701.00
12_L16_L1.5701.00
114_Y117_G1.5621.00
266_T270_V1.5611.00
200_I203_P1.5501.00
34_A38_M1.5351.00
266_T269_A1.5341.00
130_A136_L1.5261.00
287_Q290_D1.5231.00
188_L192_V1.5071.00
54_V62_A1.5051.00
174_T377_E1.5031.00
5_I38_M1.5031.00
240_A243_E1.4981.00
190_G197_L1.4951.00
229_S236_M1.4941.00
94_K131_S1.4891.00
188_L426_C1.4821.00
83_R87_T1.4801.00
105_G108_V1.4761.00
265_A270_V1.4751.00
176_L180_I1.4741.00
99_W191_P1.4721.00
223_G226_V1.4531.00
104_T108_V1.4511.00
432_L435_N1.4511.00
263_V267_L1.4411.00
13_L31_V1.4401.00
206_E210_S1.4321.00
396_P400_L1.4181.00
290_D294_S1.4141.00
409_I413_I1.3971.00
396_P401_F1.3961.00
69_A292_L1.3901.00
174_T380_V1.3811.00
313_K317_V1.3761.00
101_V108_V1.3761.00
39_Q42_P1.3751.00
227_W231_V1.3701.00
31_V34_A1.3671.00
199_G203_P1.3631.00
269_A273_A1.3471.00
192_V195_R1.3441.00
224_V227_W1.3431.00
152_G388_V1.3421.00
286_D290_D1.3371.00
272_I276_T1.3351.00
238_M242_A1.3221.00
201_D205_P1.3221.00
73_K291_T1.3141.00
57_T310_G1.3131.00
385_S431_C1.3091.00
220_P224_V1.2971.00
22_M27_A1.2971.00
235_L268_I1.2871.00
77_D294_S1.2851.00
101_V105_G1.2761.00
49_S314_Q1.2761.00
265_A273_A1.2741.00
236_M240_A1.2701.00
389_I424_S1.2591.00
410_G414_K1.2571.00
101_V107_T1.2491.00
228_T236_M1.2491.00
104_T107_T1.2421.00
370_A376_P1.2401.00
382_A386_G1.2371.00
198_K202_K1.2291.00
261_D266_T1.2261.00
78_C277_F1.2241.00
338_L432_L1.2151.00
236_M239_R1.2151.00
102_V105_G1.2141.00
81_A85_A1.2131.00
191_P195_R1.2111.00
110_F114_Y1.2061.00
353_S356_V1.2031.00
176_L179_T1.2001.00
419_L423_I1.1921.00
264_M268_I1.1901.00
195_R198_K1.1851.00
306_I396_P1.1841.00
372_T376_P1.1831.00
111_A115_E1.1701.00
242_A246_L1.1631.00
171_M175_L1.1571.00
115_E396_P1.1561.00
109_G117_G1.1451.00
270_V274_M1.1401.00
199_G202_K1.1381.00
274_M278_G1.1371.00
86_T131_S1.1361.00
231_V235_L1.1271.00
273_A277_F1.1261.00
221_S225_S1.1241.00
225_S232_P1.1211.00
219_M223_G1.1181.00
266_T274_M1.1121.00
263_V266_T1.1121.00
179_T183_I1.1111.00
181_L434_L1.1021.00
427_G431_C1.1021.00
430_G434_L1.1011.00
235_L239_R1.0981.00
86_T90_A1.0961.00
53_G314_Q1.0901.00
232_P235_L1.0871.00
192_V197_L1.0861.00
260_G273_A1.0851.00
378_L434_L1.0851.00
320_G323_K1.0851.00
397_G401_F1.0841.00
41_M49_S1.0831.00
171_M176_L1.0811.00
270_V276_T1.0801.00
71_L269_A1.0771.00
389_I421_T1.0771.00
175_L178_G1.0751.00
115_E306_I1.0751.00
274_M277_F1.0711.00
109_G115_E1.0651.00
261_D264_M1.0631.00
234_V238_M1.0631.00
385_S427_G1.0621.00
74_M273_A1.0611.00
402_K409_I1.0591.00
265_A276_T1.0551.00
222_F227_W1.0511.00
113_F117_G1.0511.00
118_F404_Y1.0481.00
241_I245_I1.0451.00
265_A269_A1.0421.00
80_G225_S1.0411.00
381_I431_C1.0401.00
191_P196_V1.0391.00
191_P194_A1.0351.00
35_V38_M1.0351.00
64_I306_I1.0341.00
177_Y381_I1.0311.00
201_D204_I1.0301.00
391_S395_D1.0281.00
261_D265_A1.0251.00
82_Q217_E1.0221.00
239_R244_M1.0211.00
182_A186_V1.0201.00
233_V237_A1.0201.00
141_V145_A1.0191.00
45_K49_S1.0141.00
341_W428_L1.0131.00
402_K412_T1.0121.00
103_L107_T1.0101.00
411_E414_K1.0081.00
6_V10_V1.0061.00
52_A55_G1.0011.00
166_I362_G0.9991.00
206_E209_Y0.9991.00
164_A167_F0.9991.00
181_L430_G0.9970.99
239_R242_A0.9970.99
50_I311_A0.9860.99
219_M222_F0.9850.99
243_E246_L0.9850.99
222_F236_M0.9830.99
220_P225_S0.9810.99
27_A31_V0.9800.99
183_I187_I0.9760.99
162_A359_I0.9720.99
220_P234_V0.9640.99
111_A116_V0.9610.99
197_L200_I0.9570.99
226_V230_L0.9540.99
116_V119_V0.9480.99
225_S236_M0.9450.99
9_G34_A0.9450.99
44_D48_G0.9430.99
332_T337_L0.9330.99
16_L27_A0.9320.99
199_G204_I0.9320.99
420_E423_I0.9310.99
189_A423_I0.9270.99
178_G181_L0.9270.99
224_V228_T0.9250.99
264_M267_L0.9250.99
227_W234_V0.9250.99
40_G43_L0.9190.99
40_G45_K0.9170.99
170_D173_K0.9150.99
260_G265_A0.9100.99
283_R287_Q0.9080.99
314_Q317_V0.9040.99
349_I389_I0.9040.99
222_F228_T0.9020.99
220_P232_P0.9010.99
150_T157_H0.8950.99
175_L180_I0.8950.99
267_L271_L0.8890.99
271_L277_F0.8880.99
187_I192_V0.8870.99
150_T154_L0.8870.99
354_A391_S0.8870.99
228_T276_T0.8850.99
83_R225_S0.8810.99
224_V232_P0.8800.99
232_P239_R0.8790.99
262_P269_A0.8790.99
358_A387_S0.8780.99
417_S421_T0.8730.99
110_F115_E0.8720.99
390_F417_S0.8720.99
240_A245_I0.8700.99
222_F230_L0.8650.99
101_V106_F0.8630.99
71_L270_V0.8630.99
68_G295_S0.8610.99
351_L360_T0.8600.98
96_H100_A0.8580.98
241_I244_M0.8570.98
174_T178_G0.8540.98
205_P209_Y0.8540.98
109_G113_F0.8520.98
391_S416_W0.8510.98
283_R288_I0.8490.98
216_E219_M0.8480.98
416_W420_E0.8470.98
214_F217_E0.8410.98
407_L411_E0.8390.98
202_K205_P0.8390.98
83_R222_F0.8390.98
171_M180_I0.8360.98
348_R395_D0.8290.98
96_H106_F0.8290.98
412_T416_W0.8270.98
428_L432_L0.8250.98
111_A114_Y0.8230.98
174_T177_Y0.8200.98
102_V106_F0.8200.98
287_Q291_T0.8180.98
221_S226_V0.8140.98
133_N199_G0.8140.98
237_A241_I0.8120.98
96_H108_V0.8100.98
266_T273_A0.8090.98
73_K294_S0.8080.98
221_S228_T0.8080.98
148_S420_E0.8060.98
16_L22_M0.8050.98
240_A244_M0.8040.98
93_G100_A0.8040.98
266_T277_F0.8030.98
5_I9_G0.8020.98
25_F304_L0.8010.98
171_M178_G0.8000.98
7_A11_I0.8000.98
35_V312_F0.7990.98
230_L237_A0.7990.98
264_M269_A0.7990.98
261_D270_V0.7980.98
114_Y397_G0.7970.98
164_A170_D0.7970.98
53_G56_G0.7960.98
215_S219_M0.7960.98
366_A370_A0.7960.98
344_A357_A0.7950.97
274_M292_L0.7910.97
332_T336_P0.7910.97
153_F427_G0.7880.97
348_R354_A0.7880.97
377_E381_I0.7870.97
263_V273_A0.7870.97
52_A318_D0.7870.97
378_L431_C0.7860.97
232_P237_A0.7850.97
220_P223_G0.7840.97
220_P228_T0.7830.97
226_V232_P0.7760.97
231_V234_V0.7760.97
182_A185_T0.7740.97
222_F229_S0.7730.97
423_I427_G0.7710.97
340_A365_A0.7680.97
221_S227_W0.7680.97
375_S378_L0.7670.97
214_F218_E0.7660.97
345_A424_S0.7640.97
35_V315_V0.7610.97
129_A139_V0.7590.97
141_V415_S0.7580.97
177_Y180_I0.7570.97
103_L106_F0.7560.97
264_M270_V0.7560.97
391_S397_G0.7550.97
115_E119_V0.7540.97
273_A276_T0.7540.97
12_L19_R0.7530.97
357_A395_D0.7490.96
237_A244_M0.7460.96
351_L356_V0.7460.96
417_S424_S0.7420.96
264_M277_F0.7410.96
262_P273_A0.7390.96
102_V186_V0.7370.96
173_K176_L0.7370.96
223_G228_T0.7370.96
48_G51_K0.7350.96
188_L191_P0.7350.96
357_A361_A0.7350.96
233_V236_M0.7340.96
102_V108_V0.7340.96
299_I303_L0.7310.96
193_Y422_I0.7270.96
160_P164_A0.7270.96
12_L15_L0.7270.96
221_S232_P0.7250.96
63_L67_F0.7240.96
117_G147_L0.7240.96
258_F261_D0.7230.96
211_A215_S0.7150.95
109_G112_L0.7150.95
232_P240_A0.7140.95
354_A387_S0.7140.95
111_A117_G0.7120.95
91_K94_K0.7120.95
262_P270_V0.7110.95
112_L115_E0.7110.95
40_G44_D0.7100.95
381_I385_S0.7090.95
348_R357_A0.7060.95
100_A107_T0.7040.95
26_I270_V0.7040.95
308_G312_F0.7030.95
415_S418_M0.7030.95
223_G237_A0.7010.95
8_I12_L0.7000.95
200_I205_P0.6980.95
284_S288_I0.6970.95
47_I51_K0.6950.95
137_L203_P0.6950.95
73_K76_A0.6920.94
185_T430_G0.6920.94
43_L46_V0.6910.94
185_T189_A0.6910.94
88_L92_F0.6910.94
410_G413_I0.6900.94
348_R391_S0.6870.94
189_A196_V0.6870.94
15_L18_I0.6840.94
80_G83_R0.6830.94
275_F278_G0.6820.94
329_M343_I0.6820.94
177_Y377_E0.6800.94
109_G150_T0.6800.94
16_L30_L0.6790.94
315_V318_D0.6780.94
37_L43_L0.6780.94
369_I372_T0.6770.94
173_K377_E0.6770.94
166_I363_G0.6760.94
109_G116_V0.6750.94
134_I138_Y0.6740.94
345_A390_F0.6710.94
126_F136_L0.6700.93
184_P430_G0.6690.93
39_Q43_L0.6690.93
94_K132_A0.6690.93
32_A36_G0.6690.93
216_E234_V0.6680.93
238_M243_E0.6680.93
148_S388_V0.6660.93
223_G234_V0.6660.93
213_T216_E0.6650.93
340_A379_M0.6640.93
10_V13_L0.6630.93
293_V297_K0.6610.93
138_Y142_P0.6600.93
278_G288_I0.6590.93
227_W230_L0.6570.93
263_V271_L0.6550.93
277_F288_I0.6550.93
91_K95_K0.6540.93
86_T219_M0.6520.93
84_I225_S0.6510.92
216_E221_S0.6460.92
63_L66_G0.6460.92
172_G176_L0.6460.92
263_V270_V0.6450.92
426_C430_G0.6450.92
33_L264_M0.6450.92
229_S232_P0.6420.92
348_R387_S0.6420.92
367_P372_T0.6410.92
96_H107_T0.6400.92
184_P188_L0.6390.92
239_R245_I0.6340.91
116_V159_G0.6330.91
262_P275_F0.6310.91
99_W103_L0.6310.91
96_H101_V0.6300.91
144_A397_G0.6300.91
108_V182_A0.6290.91
5_I34_A0.6270.91
267_L277_F0.6260.91
50_I53_G0.6260.91
135_P200_I0.6250.91
333_N339_M0.6250.91
238_M244_M0.6230.91
198_K201_D0.6210.91
114_Y118_F0.6210.91
396_P399_W0.6210.91
23_N26_I0.6200.91
333_N337_L0.6200.91
52_A314_Q0.6190.90
205_P208_L0.6190.90
231_V269_A0.6190.90
33_L211_A0.6190.90
336_P379_M0.6180.90
216_E220_P0.6170.90
129_A134_I0.6130.90
100_A106_F0.6130.90
106_F110_F0.6130.90
96_H99_W0.6120.90
229_S233_V0.6100.90
154_L157_H0.6090.90
228_T235_L0.6090.90
345_A349_I0.6070.90
222_F232_P0.6060.90
96_H102_V0.6060.90
259_L263_V0.6050.89
273_A278_G0.6030.89
431_C435_N0.6030.89
218_E221_S0.6010.89
125_V129_A0.6000.89
261_D269_A0.5990.89
263_V277_F0.5970.89
218_E223_G0.5970.89
234_V239_R0.5960.89
49_S53_G0.5950.89
228_T231_V0.5950.89
426_C429_V0.5940.89
221_S236_M0.5940.89
223_G245_I0.5930.89
265_A277_F0.5900.88
25_F29_V0.5890.88
367_P371_T0.5880.88
174_T180_I0.5880.88
223_G232_P0.5880.88
227_W276_T0.5850.88
6_V9_G0.5840.88
266_T278_G0.5840.88
344_A387_S0.5830.88
327_S331_E0.5830.88
164_A174_T0.5820.88
305_I359_I0.5810.88
265_A268_I0.5800.87
34_A37_L0.5790.87
324_Y327_S0.5760.87
151_H155_P0.5740.87
390_F413_I0.5740.87
340_A344_A0.5710.87
181_L185_T0.5710.87
392_H420_E0.5710.87
187_I191_P0.5690.86
102_V107_T0.5680.86
356_V360_T0.5680.86
349_I417_S0.5680.86
430_G433_L0.5660.86
227_W233_V0.5660.86
193_Y418_M0.5660.86
31_V35_V0.5650.86
225_S229_S0.5650.86
372_T375_S0.5640.86
354_A396_P0.5630.86
274_M288_I0.5610.86
110_F150_T0.5610.86
145_A416_W0.5600.86
220_P227_W0.5580.85
171_M182_A0.5580.85
221_S238_M0.5580.85
109_G114_Y0.5570.85
227_W235_L0.5570.85
151_H156_P0.5560.85
292_L295_S0.5560.85
102_V142_P0.5560.85
270_V277_F0.5550.85
265_A271_L0.5520.85
112_L117_G0.5510.85
230_L234_V0.5510.85
145_A419_L0.5500.85
262_P268_I0.5480.84
215_S331_E0.5480.84
259_L264_M0.5480.84
9_G39_Q0.5480.84
122_L405_F0.5450.84
140_G407_L0.5430.84
29_V67_F0.5430.84
133_N201_D0.5430.84
153_F385_S0.5420.84
112_L266_T0.5420.84
160_P354_A0.5400.83
190_G196_V0.5390.83
178_G184_P0.5360.83
32_A315_V0.5360.83
113_F159_G0.5330.83
8_I34_A0.5300.82
180_I189_A0.5300.82
141_V419_L0.5290.82
190_G195_R0.5280.82
230_L236_M0.5270.82
379_M411_E0.5250.82
146_A150_T0.5240.82
188_L194_A0.5240.82
272_I275_F0.5220.81
165_T170_D0.5200.81
90_A198_K0.5200.81
196_V202_K0.5190.81
278_G281_R0.5190.81
185_T426_C0.5180.81
65_M68_G0.5160.81
229_S235_L0.5140.80
118_F122_L0.5140.80
9_G13_L0.5130.80
225_S239_R0.5130.80
37_L41_M0.5120.80
296_I300_A0.5120.80
157_H358_A0.5120.80
41_M45_K0.5100.80
5_I321_V0.5100.80
27_A30_L0.5100.80
36_G46_V0.5100.80
117_G157_H0.5100.80
212_K215_S0.5090.80
203_P206_E0.5080.80
223_G230_L0.5080.80
391_S420_E0.5080.80
262_P277_F0.5080.80
221_S229_S0.5070.79
242_A245_I0.5060.79
13_L17_M0.5060.79
100_A108_V0.5060.79
90_A93_G0.5050.79
218_E222_F0.5050.79
5_I31_V0.5040.79
258_F262_P0.5040.79
148_S397_G0.5040.79
290_D293_V0.5040.79
144_A392_H0.5030.79
390_F421_T0.5030.79
226_V236_M0.5020.79
361_A383_V0.5020.79
224_V272_I0.5020.79
169_A174_T0.5020.79
21_K27_A0.5010.79
334_I338_L0.5000.79
30_L34_A0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.9795 100 0.556 Contact Map
4r0cA 3 0.9726 100 0.569 Contact Map
4f35D 2 0.9018 100 0.609 Contact Map
4pd6A 3 0.7671 81.4 0.94 Contact Map
3qe7A 2 0.4475 58.3 0.949 Contact Map
2cfqA 1 0.8265 54.2 0.951 Contact Map
4dx5A 3 0.3584 49.5 0.952 Contact Map
3aqpA 1 0.3311 44.2 0.954 Contact Map
3qnqA 2 0.4658 31.1 0.957 Contact Map
2nwlA 3 0.742 23.2 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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