ZNUB - ECOLI - GREMLIN Contacts

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ZNUB - High-affinity zinc uptake system membrane protein ZnuB

UniProt:	P39832	Sequences: MIELLFPGWLAGIMLACAAGPLGSFVVWRRMSYFGDTLAHASLLGVAFGLLLDVNPFYAVIAVTLLLAGGLVWLEKRPQLAIDTLLGIMAHSALSLGLVVVSLMSNIRVDLMAYLFGDLLAVTPEDLISIAIGVVIVVAILFWQWRNLLSMTISPDLAFVDGVKLQRVKLLLMLVTALTIGVAMKFVGALIITSLLIIPAATARRFARTPEQMAGVAVLVGMVAVTGGLTFSAVYDTPAGPSVVLCAALLFILSMMKKQAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12368
Length:	261 (254)
Sequences:	5073 (3226)
Seq/√Len:	202.4

ECOLI - ZNUB
BACSU - ZNUB MNTD MNTC
HALSA - Q9HHR8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
206_F	254_S	4.147	1.00
12_G	225_V	3.913	1.00
128_I	132_I	3.685	1.00
224_A	250_L	3.305	1.00
227_G	246_C	3.029	1.00
92_S	248_A	2.996	1.00
224_A	247_A	2.810	1.00
209_T	212_Q	2.801	1.00
237_T	242_S	2.681	1.00
216_V	220_V	2.664	1.00
207_A	213_M	2.645	1.00
11_A	122_V	2.609	1.00
215_G	219_L	2.476	1.00
207_A	212_Q	2.476	1.00
14_M	134_V	2.359	1.00
202_T	220_V	2.356	1.00
13_I	222_M	2.315	1.00
140_I	171_L	2.247	1.00
207_A	216_V	2.239	1.00
164_K	167_R	2.236	1.00
202_T	254_S	2.183	1.00
208_R	212_Q	2.162	1.00
84_T	201_A	2.125	1.00
14_M	131_A	2.116	1.00
204_R	213_M	1.963	1.00
23_G	200_A	1.929	1.00
99_V	245_L	1.899	1.00
49_G	59_A	1.862	1.00
11_A	130_I	1.824	1.00
202_T	250_L	1.822	1.00
224_A	246_C	1.820	1.00
18_A	134_V	1.796	1.00
203_A	216_V	1.775	1.00
167_R	171_L	1.762	1.00
11_A	127_L	1.756	1.00
194_S	244_V	1.728	1.00
150_S	157_L	1.701	1.00
21_P	141_L	1.700	1.00
159_F	166_Q	1.699	1.00
231_F	246_C	1.685	1.00
157_L	161_D	1.678	1.00
12_G	119_L	1.677	1.00
220_V	224_A	1.677	1.00
232_S	239_A	1.663	1.00
21_P	138_V	1.652	1.00
144_Q	147_N	1.651	1.00
220_V	250_L	1.643	1.00
16_A	225_V	1.630	1.00
231_F	235_Y	1.627	1.00
17_C	218_V	1.622	1.00
253_L	257_K	1.610	1.00
135_V	139_A	1.592	1.00
140_I	175_V	1.587	1.00
65_L	174_L	1.576	1.00
124_P	128_I	1.565	1.00
230_T	234_V	1.533	1.00
223_V	227_G	1.522	1.00
155_P	169_K	1.489	1.00
223_V	250_L	1.468	1.00
129_S	132_I	1.462	1.00
24_S	213_M	1.421	1.00
245_L	249_L	1.420	1.00
140_I	144_Q	1.411	1.00
238_P	241_P	1.411	1.00
133_G	182_V	1.399	1.00
202_T	247_A	1.393	1.00
148_L	172_L	1.383	1.00
151_M	165_L	1.382	1.00
212_Q	215_G	1.368	1.00
69_G	174_L	1.363	1.00
5_L	233_A	1.361	1.00
35_G	196_L	1.353	1.00
76_K	166_Q	1.338	1.00
94_L	190_L	1.337	1.00
158_A	165_L	1.333	1.00
41_A	67_L	1.331	1.00
145_W	214_A	1.328	1.00
144_Q	171_L	1.306	1.00
126_D	185_K	1.303	1.00
144_Q	168_V	1.302	1.00
13_I	226_T	1.286	1.00
61_I	178_L	1.275	1.00
44_L	97_G	1.271	1.00
205_R	254_S	1.256	1.00
24_S	214_A	1.247	1.00
7_P	124_P	1.242	1.00
229_L	239_A	1.213	1.00
212_Q	216_V	1.203	1.00
149_L	210_P	1.203	1.00
249_L	253_L	1.189	1.00
218_V	222_M	1.182	1.00
158_A	163_V	1.175	1.00
51_L	100_V	1.175	1.00
215_G	218_V	1.174	1.00
36_D	40_H	1.172	1.00
69_G	73_W	1.166	1.00
29_R	155_P	1.166	1.00
132_I	136_I	1.163	1.00
47_A	100_V	1.161	1.00
250_L	254_S	1.160	1.00
163_V	168_V	1.158	1.00
29_R	152_T	1.153	1.00
211_E	215_G	1.152	1.00
9_W	226_T	1.142	1.00
80_L	251_F	1.142	1.00
138_V	142_F	1.130	1.00
140_I	148_L	1.121	1.00
36_D	90_A	1.115	1.00
195_L	247_A	1.106	1.00
24_S	217_A	1.102	1.00
145_W	211_E	1.097	1.00
25_F	141_L	1.095	1.00
8_G	229_L	1.087	1.00
228_G	243_V	1.085	1.00
203_A	220_V	1.085	1.00
15_L	19_A	1.081	1.00
198_I	247_A	1.061	1.00
206_F	216_V	1.059	1.00
88_I	201_A	1.058	1.00
202_T	224_A	1.053	1.00
231_F	242_S	1.046	1.00
219_L	223_V	1.045	1.00
26_V	176_T	1.041	1.00
252_I	256_M	1.034	1.00
55_N	58_Y	1.032	1.00
20_G	217_A	1.031	1.00
43_L	97_G	1.026	1.00
148_L	168_V	1.005	1.00
203_A	207_A	1.002	1.00
10_L	127_L	0.991	1.00
167_R	170_L	0.989	1.00
164_K	168_V	0.987	1.00
12_G	243_V	0.981	1.00
73_W	77_R	0.980	1.00
125_E	128_I	0.975	1.00
181_G	190_L	0.971	1.00
147_N	168_V	0.962	0.99
6_F	10_L	0.958	0.99
128_I	131_A	0.955	0.99
139_A	143_W	0.947	0.99
133_G	137_V	0.947	0.99
99_V	237_T	0.945	0.99
124_P	127_L	0.943	0.99
25_F	214_A	0.937	0.99
202_T	205_R	0.936	0.99
47_A	101_V	0.924	0.99
58_Y	62_A	0.917	0.99
205_R	255_M	0.916	0.99
205_R	258_K	0.915	0.99
41_A	44_L	0.904	0.99
60_V	64_T	0.904	0.99
150_S	158_A	0.902	0.99
26_V	33_Y	0.898	0.99
18_A	179_T	0.897	0.99
134_V	138_V	0.897	0.99
221_G	225_V	0.895	0.99
72_V	173_M	0.893	0.99
37_T	86_L	0.884	0.99
48_F	100_V	0.882	0.99
10_L	14_M	0.876	0.99
66_L	70_G	0.875	0.99
107_I	110_D	0.868	0.99
131_A	135_V	0.865	0.99
136_I	139_A	0.863	0.99
151_M	168_V	0.862	0.99
20_G	218_V	0.860	0.99
157_L	160_V	0.860	0.99
148_L	151_M	0.859	0.99
118_D	189_A	0.854	0.99
118_D	241_P	0.854	0.99
4_L	8_G	0.852	0.99
43_L	101_V	0.849	0.99
48_F	63_V	0.847	0.99
144_Q	172_L	0.843	0.99
102_S	238_P	0.830	0.98
49_G	53_D	0.829	0.98
155_P	159_F	0.824	0.98
54_V	59_A	0.817	0.98
214_A	218_V	0.816	0.98
87_G	197_I	0.809	0.98
62_A	66_L	0.809	0.98
137_V	179_T	0.808	0.98
35_G	116_F	0.800	0.98
51_L	104_M	0.796	0.98
202_T	251_F	0.794	0.98
11_A	186_F	0.791	0.98
42_S	64_T	0.789	0.98
36_D	197_I	0.788	0.98
25_F	145_W	0.787	0.98
145_W	149_L	0.787	0.98
254_S	258_K	0.787	0.98
198_I	248_A	0.780	0.98
59_A	63_V	0.779	0.98
28_W	152_T	0.775	0.98
214_A	217_A	0.773	0.98
39_A	153_I	0.772	0.98
32_S	197_I	0.771	0.97
80_L	85_L	0.771	0.97
92_S	96_L	0.767	0.97
166_Q	169_K	0.766	0.97
126_D	129_S	0.765	0.97
69_G	170_L	0.764	0.97
4_L	7_P	0.764	0.97
65_L	69_G	0.753	0.97
12_G	229_L	0.750	0.97
20_G	200_A	0.749	0.97
80_L	84_T	0.749	0.97
202_T	206_F	0.748	0.97
29_R	169_K	0.747	0.97
54_V	58_Y	0.745	0.97
25_F	29_R	0.741	0.97
18_A	137_V	0.740	0.97
226_T	230_T	0.734	0.97
74_L	89_M	0.733	0.97
142_F	215_G	0.733	0.97
9_W	229_L	0.733	0.97
183_A	192_I	0.731	0.97
21_P	214_A	0.731	0.97
12_G	16_A	0.729	0.96
150_S	161_D	0.728	0.96
58_Y	61_I	0.725	0.96
137_V	175_V	0.723	0.96
172_L	176_T	0.723	0.96
254_S	257_K	0.722	0.96
8_G	120_L	0.721	0.96
47_A	93_A	0.719	0.96
13_I	16_A	0.718	0.96
127_L	131_A	0.717	0.96
18_A	182_V	0.717	0.96
6_F	9_W	0.715	0.96
220_V	254_S	0.714	0.96
16_A	222_M	0.713	0.96
249_L	256_M	0.713	0.96
73_W	170_L	0.711	0.96
49_G	54_V	0.709	0.96
22_L	175_V	0.707	0.96
99_V	241_P	0.706	0.96
119_L	239_A	0.705	0.96
130_I	182_V	0.697	0.95
242_S	246_C	0.694	0.95
17_C	222_M	0.689	0.95
141_L	214_A	0.689	0.95
25_F	148_L	0.689	0.95
142_F	146_R	0.688	0.95
128_I	231_F	0.686	0.95
143_W	147_N	0.686	0.95
176_T	196_L	0.684	0.95
96_L	99_V	0.682	0.95
35_G	197_I	0.680	0.95
110_D	113_A	0.679	0.95
23_G	247_A	0.676	0.95
119_L	243_V	0.675	0.95
11_A	119_L	0.672	0.95
14_M	127_L	0.671	0.94
5_L	229_L	0.670	0.94
246_C	250_L	0.670	0.94
20_G	24_S	0.666	0.94
120_L	221_G	0.666	0.94
38_L	64_T	0.666	0.94
173_M	184_M	0.666	0.94
16_A	20_G	0.665	0.94
48_F	62_A	0.664	0.94
27_V	32_S	0.663	0.94
174_L	178_L	0.659	0.94
39_A	81_A	0.656	0.94
21_P	218_V	0.653	0.94
47_A	94_L	0.650	0.93
17_C	138_V	0.643	0.93
231_F	234_V	0.642	0.93
15_L	183_A	0.637	0.93
36_D	193_T	0.635	0.93
37_T	43_L	0.634	0.93
37_T	44_L	0.634	0.93
5_L	230_T	0.632	0.93
5_L	8_G	0.631	0.92
9_W	230_T	0.630	0.92
39_A	42_S	0.629	0.92
132_I	135_V	0.626	0.92
248_A	252_I	0.626	0.92
15_L	186_F	0.626	0.92
45_G	59_A	0.623	0.92
216_V	219_L	0.623	0.92
16_A	240_G	0.622	0.92
72_V	169_K	0.621	0.92
39_A	43_L	0.621	0.92
154_S	157_L	0.621	0.92
209_T	213_M	0.618	0.92
25_F	172_L	0.613	0.91
8_G	119_L	0.612	0.91
169_K	173_M	0.612	0.91
15_L	190_L	0.611	0.91
148_L	156_D	0.609	0.91
123_T	126_D	0.603	0.91
65_L	178_L	0.602	0.91
145_W	210_P	0.602	0.91
17_C	221_G	0.599	0.90
40_H	43_L	0.597	0.90
122_V	186_F	0.596	0.90
28_W	35_G	0.591	0.90
68_A	177_A	0.590	0.90
216_V	254_S	0.590	0.90
82_I	173_M	0.586	0.89
67_L	93_A	0.584	0.89
4_L	116_F	0.584	0.89
76_K	169_K	0.582	0.89
113_A	118_D	0.582	0.89
7_P	27_V	0.582	0.89
24_S	27_V	0.578	0.89
63_V	66_L	0.576	0.89
131_A	134_V	0.575	0.89
142_F	249_L	0.572	0.88
80_L	83_D	0.571	0.88
111_L	244_V	0.571	0.88
125_E	135_V	0.570	0.88
87_G	201_A	0.566	0.88
227_G	231_F	0.566	0.88
20_G	196_L	0.566	0.88
60_V	172_L	0.565	0.88
139_A	142_F	0.565	0.88
72_V	200_A	0.564	0.88
19_A	191_I	0.563	0.87
42_S	114_Y	0.561	0.87
70_G	89_M	0.561	0.87
70_G	73_W	0.557	0.87
147_N	164_K	0.557	0.87
23_G	29_R	0.555	0.87
91_H	95_S	0.554	0.87
144_Q	148_L	0.553	0.87
125_E	129_S	0.553	0.87
75_E	82_I	0.553	0.87
130_I	186_F	0.553	0.87
101_V	109_V	0.552	0.86
179_T	192_I	0.552	0.86
77_R	159_F	0.551	0.86
102_S	118_D	0.550	0.86
227_G	250_L	0.550	0.86
208_R	258_K	0.545	0.86
239_A	242_S	0.544	0.86
60_V	90_A	0.542	0.85
49_G	55_N	0.542	0.85
35_G	39_A	0.541	0.85
33_Y	78_P	0.539	0.85
89_M	93_A	0.539	0.85
97_G	239_A	0.539	0.85
133_G	178_L	0.536	0.85
101_V	112_M	0.533	0.85
34_F	153_I	0.533	0.85
126_D	238_P	0.532	0.84
25_F	152_T	0.531	0.84
168_V	171_L	0.530	0.84
43_L	107_I	0.530	0.84
86_L	192_I	0.529	0.84
75_E	169_K	0.529	0.84
10_L	131_A	0.527	0.84
107_I	112_M	0.525	0.84
219_L	222_M	0.525	0.84
44_L	90_A	0.524	0.84
92_S	95_S	0.524	0.84
108_R	186_F	0.522	0.83
67_L	71_L	0.520	0.83
114_Y	185_K	0.520	0.83
42_S	184_M	0.520	0.83
246_C	249_L	0.518	0.83
90_A	95_S	0.517	0.83
24_S	46_V	0.516	0.83
151_M	169_K	0.516	0.83
166_Q	170_L	0.515	0.82
60_V	179_T	0.514	0.82
35_G	193_T	0.514	0.82
50_L	109_V	0.514	0.82
109_V	112_M	0.513	0.82
41_A	93_A	0.512	0.82
73_W	76_K	0.510	0.82
23_G	31_M	0.508	0.82
44_L	94_L	0.507	0.82
177_A	183_A	0.507	0.82
126_D	184_M	0.503	0.81
100_V	103_L	0.503	0.81
90_A	93_A	0.500	0.81
62_A	65_L	0.500	0.81
26_V	184_M	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nq2A	2	0.9655	100	0.517	Contact Map
2qi9A	2	0.9693	100	0.518	Contact Map
4g1uA	2	0.9579	100	0.538	Contact Map
2zy9A	2	0.3755	43.6	0.943	Contact Map
2xq2A	2	0.6475	5.6	0.963	Contact Map
4u9nA	2	0.3678	3.8	0.966	Contact Map
4b19A	1	0.1149	3.2	0.967	Contact Map
2l2tA	2	0.1686	3.2	0.967	Contact Map
2kv5A	1	0.1264	2.7	0.968	Contact Map
3iqcA	2	0.1303	2.4	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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