GREMLIN Database
ZNUB - High-affinity zinc uptake system membrane protein ZnuB
UniProt: P39832 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12368
Length: 261 (254)
Sequences: 5073 (3226)
Seq/√Len: 202.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
206_F254_S4.1471.00
12_G225_V3.9131.00
128_I132_I3.6851.00
224_A250_L3.3051.00
227_G246_C3.0291.00
92_S248_A2.9961.00
224_A247_A2.8101.00
209_T212_Q2.8011.00
237_T242_S2.6811.00
216_V220_V2.6641.00
207_A213_M2.6451.00
11_A122_V2.6091.00
215_G219_L2.4761.00
207_A212_Q2.4761.00
14_M134_V2.3591.00
202_T220_V2.3561.00
13_I222_M2.3151.00
140_I171_L2.2471.00
207_A216_V2.2391.00
164_K167_R2.2361.00
202_T254_S2.1831.00
208_R212_Q2.1621.00
84_T201_A2.1251.00
14_M131_A2.1161.00
204_R213_M1.9631.00
23_G200_A1.9291.00
99_V245_L1.8991.00
49_G59_A1.8621.00
11_A130_I1.8241.00
202_T250_L1.8221.00
224_A246_C1.8201.00
18_A134_V1.7961.00
203_A216_V1.7751.00
167_R171_L1.7621.00
11_A127_L1.7561.00
194_S244_V1.7281.00
150_S157_L1.7011.00
21_P141_L1.7001.00
159_F166_Q1.6991.00
231_F246_C1.6851.00
157_L161_D1.6781.00
12_G119_L1.6771.00
220_V224_A1.6771.00
232_S239_A1.6631.00
21_P138_V1.6521.00
144_Q147_N1.6511.00
220_V250_L1.6431.00
16_A225_V1.6301.00
231_F235_Y1.6271.00
17_C218_V1.6221.00
253_L257_K1.6101.00
135_V139_A1.5921.00
140_I175_V1.5871.00
65_L174_L1.5761.00
124_P128_I1.5651.00
230_T234_V1.5331.00
223_V227_G1.5221.00
155_P169_K1.4891.00
223_V250_L1.4681.00
129_S132_I1.4621.00
24_S213_M1.4211.00
245_L249_L1.4201.00
140_I144_Q1.4111.00
238_P241_P1.4111.00
133_G182_V1.3991.00
202_T247_A1.3931.00
148_L172_L1.3831.00
151_M165_L1.3821.00
212_Q215_G1.3681.00
69_G174_L1.3631.00
5_L233_A1.3611.00
35_G196_L1.3531.00
76_K166_Q1.3381.00
94_L190_L1.3371.00
158_A165_L1.3331.00
41_A67_L1.3311.00
145_W214_A1.3281.00
144_Q171_L1.3061.00
126_D185_K1.3031.00
144_Q168_V1.3021.00
13_I226_T1.2861.00
61_I178_L1.2751.00
44_L97_G1.2711.00
205_R254_S1.2561.00
24_S214_A1.2471.00
7_P124_P1.2421.00
229_L239_A1.2131.00
212_Q216_V1.2031.00
149_L210_P1.2031.00
249_L253_L1.1891.00
218_V222_M1.1821.00
158_A163_V1.1751.00
51_L100_V1.1751.00
215_G218_V1.1741.00
36_D40_H1.1721.00
69_G73_W1.1661.00
29_R155_P1.1661.00
132_I136_I1.1631.00
47_A100_V1.1611.00
250_L254_S1.1601.00
163_V168_V1.1581.00
29_R152_T1.1531.00
211_E215_G1.1521.00
9_W226_T1.1421.00
80_L251_F1.1421.00
138_V142_F1.1301.00
140_I148_L1.1211.00
36_D90_A1.1151.00
195_L247_A1.1061.00
24_S217_A1.1021.00
145_W211_E1.0971.00
25_F141_L1.0951.00
8_G229_L1.0871.00
228_G243_V1.0851.00
203_A220_V1.0851.00
15_L19_A1.0811.00
198_I247_A1.0611.00
206_F216_V1.0591.00
88_I201_A1.0581.00
202_T224_A1.0531.00
231_F242_S1.0461.00
219_L223_V1.0451.00
26_V176_T1.0411.00
252_I256_M1.0341.00
55_N58_Y1.0321.00
20_G217_A1.0311.00
43_L97_G1.0261.00
148_L168_V1.0051.00
203_A207_A1.0021.00
10_L127_L0.9911.00
167_R170_L0.9891.00
164_K168_V0.9871.00
12_G243_V0.9811.00
73_W77_R0.9801.00
125_E128_I0.9751.00
181_G190_L0.9711.00
147_N168_V0.9620.99
6_F10_L0.9580.99
128_I131_A0.9550.99
139_A143_W0.9470.99
133_G137_V0.9470.99
99_V237_T0.9450.99
124_P127_L0.9430.99
25_F214_A0.9370.99
202_T205_R0.9360.99
47_A101_V0.9240.99
58_Y62_A0.9170.99
205_R255_M0.9160.99
205_R258_K0.9150.99
41_A44_L0.9040.99
60_V64_T0.9040.99
150_S158_A0.9020.99
26_V33_Y0.8980.99
18_A179_T0.8970.99
134_V138_V0.8970.99
221_G225_V0.8950.99
72_V173_M0.8930.99
37_T86_L0.8840.99
48_F100_V0.8820.99
10_L14_M0.8760.99
66_L70_G0.8750.99
107_I110_D0.8680.99
131_A135_V0.8650.99
136_I139_A0.8630.99
151_M168_V0.8620.99
20_G218_V0.8600.99
157_L160_V0.8600.99
148_L151_M0.8590.99
118_D189_A0.8540.99
118_D241_P0.8540.99
4_L8_G0.8520.99
43_L101_V0.8490.99
48_F63_V0.8470.99
144_Q172_L0.8430.99
102_S238_P0.8300.98
49_G53_D0.8290.98
155_P159_F0.8240.98
54_V59_A0.8170.98
214_A218_V0.8160.98
87_G197_I0.8090.98
62_A66_L0.8090.98
137_V179_T0.8080.98
35_G116_F0.8000.98
51_L104_M0.7960.98
202_T251_F0.7940.98
11_A186_F0.7910.98
42_S64_T0.7890.98
36_D197_I0.7880.98
25_F145_W0.7870.98
145_W149_L0.7870.98
254_S258_K0.7870.98
198_I248_A0.7800.98
59_A63_V0.7790.98
28_W152_T0.7750.98
214_A217_A0.7730.98
39_A153_I0.7720.98
32_S197_I0.7710.97
80_L85_L0.7710.97
92_S96_L0.7670.97
166_Q169_K0.7660.97
126_D129_S0.7650.97
69_G170_L0.7640.97
4_L7_P0.7640.97
65_L69_G0.7530.97
12_G229_L0.7500.97
20_G200_A0.7490.97
80_L84_T0.7490.97
202_T206_F0.7480.97
29_R169_K0.7470.97
54_V58_Y0.7450.97
25_F29_R0.7410.97
18_A137_V0.7400.97
226_T230_T0.7340.97
74_L89_M0.7330.97
142_F215_G0.7330.97
9_W229_L0.7330.97
183_A192_I0.7310.97
21_P214_A0.7310.97
12_G16_A0.7290.96
150_S161_D0.7280.96
58_Y61_I0.7250.96
137_V175_V0.7230.96
172_L176_T0.7230.96
254_S257_K0.7220.96
8_G120_L0.7210.96
47_A93_A0.7190.96
13_I16_A0.7180.96
127_L131_A0.7170.96
18_A182_V0.7170.96
6_F9_W0.7150.96
220_V254_S0.7140.96
16_A222_M0.7130.96
249_L256_M0.7130.96
73_W170_L0.7110.96
49_G54_V0.7090.96
22_L175_V0.7070.96
99_V241_P0.7060.96
119_L239_A0.7050.96
130_I182_V0.6970.95
242_S246_C0.6940.95
17_C222_M0.6890.95
141_L214_A0.6890.95
25_F148_L0.6890.95
142_F146_R0.6880.95
128_I231_F0.6860.95
143_W147_N0.6860.95
176_T196_L0.6840.95
96_L99_V0.6820.95
35_G197_I0.6800.95
110_D113_A0.6790.95
23_G247_A0.6760.95
119_L243_V0.6750.95
11_A119_L0.6720.95
14_M127_L0.6710.94
5_L229_L0.6700.94
246_C250_L0.6700.94
20_G24_S0.6660.94
120_L221_G0.6660.94
38_L64_T0.6660.94
173_M184_M0.6660.94
16_A20_G0.6650.94
48_F62_A0.6640.94
27_V32_S0.6630.94
174_L178_L0.6590.94
39_A81_A0.6560.94
21_P218_V0.6530.94
47_A94_L0.6500.93
17_C138_V0.6430.93
231_F234_V0.6420.93
15_L183_A0.6370.93
36_D193_T0.6350.93
37_T43_L0.6340.93
37_T44_L0.6340.93
5_L230_T0.6320.93
5_L8_G0.6310.92
9_W230_T0.6300.92
39_A42_S0.6290.92
132_I135_V0.6260.92
248_A252_I0.6260.92
15_L186_F0.6260.92
45_G59_A0.6230.92
216_V219_L0.6230.92
16_A240_G0.6220.92
72_V169_K0.6210.92
39_A43_L0.6210.92
154_S157_L0.6210.92
209_T213_M0.6180.92
25_F172_L0.6130.91
8_G119_L0.6120.91
169_K173_M0.6120.91
15_L190_L0.6110.91
148_L156_D0.6090.91
123_T126_D0.6030.91
65_L178_L0.6020.91
145_W210_P0.6020.91
17_C221_G0.5990.90
40_H43_L0.5970.90
122_V186_F0.5960.90
28_W35_G0.5910.90
68_A177_A0.5900.90
216_V254_S0.5900.90
82_I173_M0.5860.89
67_L93_A0.5840.89
4_L116_F0.5840.89
76_K169_K0.5820.89
113_A118_D0.5820.89
7_P27_V0.5820.89
24_S27_V0.5780.89
63_V66_L0.5760.89
131_A134_V0.5750.89
142_F249_L0.5720.88
80_L83_D0.5710.88
111_L244_V0.5710.88
125_E135_V0.5700.88
87_G201_A0.5660.88
227_G231_F0.5660.88
20_G196_L0.5660.88
60_V172_L0.5650.88
139_A142_F0.5650.88
72_V200_A0.5640.88
19_A191_I0.5630.87
42_S114_Y0.5610.87
70_G89_M0.5610.87
70_G73_W0.5570.87
147_N164_K0.5570.87
23_G29_R0.5550.87
91_H95_S0.5540.87
144_Q148_L0.5530.87
125_E129_S0.5530.87
75_E82_I0.5530.87
130_I186_F0.5530.87
101_V109_V0.5520.86
179_T192_I0.5520.86
77_R159_F0.5510.86
102_S118_D0.5500.86
227_G250_L0.5500.86
208_R258_K0.5450.86
239_A242_S0.5440.86
60_V90_A0.5420.85
49_G55_N0.5420.85
35_G39_A0.5410.85
33_Y78_P0.5390.85
89_M93_A0.5390.85
97_G239_A0.5390.85
133_G178_L0.5360.85
101_V112_M0.5330.85
34_F153_I0.5330.85
126_D238_P0.5320.84
25_F152_T0.5310.84
168_V171_L0.5300.84
43_L107_I0.5300.84
86_L192_I0.5290.84
75_E169_K0.5290.84
10_L131_A0.5270.84
107_I112_M0.5250.84
219_L222_M0.5250.84
44_L90_A0.5240.84
92_S95_S0.5240.84
108_R186_F0.5220.83
67_L71_L0.5200.83
114_Y185_K0.5200.83
42_S184_M0.5200.83
246_C249_L0.5180.83
90_A95_S0.5170.83
24_S46_V0.5160.83
151_M169_K0.5160.83
166_Q170_L0.5150.82
60_V179_T0.5140.82
35_G193_T0.5140.82
50_L109_V0.5140.82
109_V112_M0.5130.82
41_A93_A0.5120.82
73_W76_K0.5100.82
23_G31_M0.5080.82
44_L94_L0.5070.82
177_A183_A0.5070.82
126_D184_M0.5030.81
100_V103_L0.5030.81
90_A93_A0.5000.81
62_A65_L0.5000.81
26_V184_M0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9655 100 0.517 Contact Map
2qi9A 2 0.9693 100 0.518 Contact Map
4g1uA 2 0.9579 100 0.538 Contact Map
2zy9A 2 0.3755 43.6 0.943 Contact Map
2xq2A 2 0.6475 5.6 0.963 Contact Map
4u9nA 2 0.3678 3.8 0.966 Contact Map
4b19A 1 0.1149 3.2 0.967 Contact Map
2l2tA 2 0.1686 3.2 0.967 Contact Map
2kv5A 1 0.1264 2.7 0.968 Contact Map
3iqcA 2 0.1303 2.4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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