GREMLIN Database
TORS - Sensor protein TorS
UniProt: P39453 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12617
Length: 914 (786)
Sequences: 721 (650)
Seq/√Len: 23.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
732_V744_L6.9851.00
709_V727_F6.3331.00
416_V420_T5.3321.00
688_E694_Q4.6601.00
732_V745_A4.4331.00
416_V419_R4.3761.00
412_L416_V4.3181.00
466_A485_I4.3131.00
609_L646_A4.2991.00
433_A437_A3.9051.00
519_F557_G3.7641.00
461_G488_S3.7591.00
412_L419_R3.5921.00
386_R389_D3.5851.00
434_R437_A3.5211.00
384_G389_D3.5141.00
718_L744_L3.5001.00
395_M398_F3.4751.00
561_R636_L3.4171.00
687_I717_A3.3651.00
604_I608_K3.3501.00
694_Q710_A3.3411.00
427_V430_H3.2091.00
649_T652_V3.1861.00
474_A478_Q3.1711.00
745_A777_F3.1181.00
465_T696_I3.0911.00
461_G696_I3.0881.00
412_L420_T3.0511.00
637_A658_L3.0251.00
686_L697_T2.8790.99
565_V636_L2.8020.99
455_I459_L2.8020.99
413_A419_R2.7920.99
434_R438_E2.7500.99
413_A416_V2.7480.99
463_L489_G2.7220.99
645_S657_C2.7010.99
732_V748_L2.6930.99
712_G716_Q2.6610.99
576_F618_Q2.6590.99
713_N738_D2.6000.99
745_A757_L2.5520.99
472_N478_Q2.5490.99
749_A778_R2.5270.98
413_A420_T2.5200.98
451_M499_I2.4750.98
732_V759_G2.4190.98
461_G693_T2.3940.98
445_S506_E2.3740.98
683_R707_Q2.3510.98
595_V658_L2.3190.97
620_S623_R2.3120.97
461_G465_T2.3070.97
732_V777_F2.2700.97
772_R777_F2.2700.97
711_V720_T2.2460.97
682_L798_L2.2300.97
688_E710_A2.1950.96
391_I398_F2.1710.96
419_R423_L2.1510.96
466_A489_G2.1440.96
730_A744_L2.1420.96
367_L398_F2.1290.96
638_Q643_E2.0760.95
734_F777_F2.0740.95
577_T600_S2.0680.95
585_R596_E2.0500.94
444_K492_L2.0290.94
463_L467_Q1.9960.94
512_V561_R1.9930.94
462_I482_L1.9840.93
605_D608_K1.9810.93
560_R604_I1.9750.93
420_T423_L1.9490.93
444_K447_F1.9380.93
570_L584_L1.9290.92
450_A735_D1.9260.92
694_Q712_G1.9220.92
744_L748_L1.9160.92
714_A737_P1.9120.92
689_D741_G1.9100.92
459_L465_T1.8760.91
434_R615_P1.8740.91
759_G777_F1.8730.91
634_S638_Q1.8720.91
618_Q624_G1.8660.91
735_D763_H1.8490.91
423_L427_V1.8400.91
740_D743_T1.8360.90
734_F772_R1.8260.90
504_A626_T1.8060.90
620_S624_G1.8040.90
495_I557_G1.7780.89
460_Y488_S1.7770.89
693_T759_G1.7690.89
405_L409_R1.7420.88
456_R575_R1.7410.88
447_F492_L1.7320.88
359_P398_F1.7240.87
515_S557_G1.7120.87
440_A640_M1.7090.87
416_V423_L1.7080.87
455_I499_I1.6990.87
447_F456_R1.6980.87
561_R731_L1.6920.86
150_E153_R1.6880.86
536_V582_I1.6810.86
477_A654_S1.6790.86
475_L478_Q1.6700.86
759_G772_R1.6690.86
715_A738_D1.6670.85
447_F454_E1.6650.85
692_L696_I1.6470.85
412_L423_L1.6430.85
536_V574_L1.6290.84
455_I495_I1.6280.84
452_S456_R1.6200.84
458_P575_R1.6160.84
565_V637_A1.6160.84
445_S505_I1.6160.84
711_V714_A1.6110.83
498_D561_R1.6100.83
602_C623_R1.6070.83
520_E553_C1.6050.83
532_M574_L1.6040.83
498_D564_Q1.6020.83
694_Q727_F1.5960.83
504_A618_Q1.5870.82
369_R374_D1.5810.82
415_Q419_R1.5790.82
461_G692_L1.5730.82
454_E762_A1.5710.82
448_L451_M1.5700.82
433_A438_E1.5690.82
452_S458_P1.5520.81
557_G640_M1.5450.81
748_L777_F1.5450.81
689_D733_D1.5440.81
485_I489_G1.5400.80
363_Q395_M1.5290.80
359_P387_E1.5280.80
454_E457_T1.5280.80
684_L729_A1.5250.80
445_S451_M1.5150.79
686_L708_I1.5140.79
619_V623_R1.5040.79
449_A620_S1.4970.79
498_D636_L1.4930.78
619_V624_G1.4880.78
443_A640_M1.4860.78
604_I611_E1.4780.78
204_N207_R1.4760.78
409_R412_L1.4730.77
373_G398_F1.4700.77
637_A654_S1.4700.77
735_D761_S1.4680.77
444_K458_P1.4670.77
458_P492_L1.4540.76
490_E644_L1.4500.76
730_A755_L1.4470.76
441_S445_S1.4420.76
582_I713_N1.4420.76
444_K452_S1.4390.76
10_W17_A1.4310.75
779_G797_Y1.4300.75
633_S644_L1.4230.75
437_A493_L1.4170.75
444_K456_R1.4140.74
779_G793_L1.4130.74
456_R576_F1.4130.74
437_A732_V1.4120.74
736_L739_I1.4120.74
489_G504_A1.4100.74
389_D392_G1.4080.74
465_T561_R1.4050.74
399_R402_V1.4030.74
514_V640_M1.4000.74
759_G764_V1.3920.73
465_T777_F1.3900.73
714_A762_A1.3870.73
714_A739_I1.3830.73
387_E391_I1.3820.73
647_T655_C1.3790.72
449_A504_A1.3770.72
492_L575_R1.3750.72
458_P576_F1.3740.72
745_A759_G1.3720.72
731_L790_L1.3700.72
422_E430_H1.3690.72
576_F624_G1.3650.72
441_S449_A1.3650.72
694_Q732_V1.3590.71
721_L748_L1.3580.71
387_E398_F1.3490.71
575_R618_Q1.3470.71
480_D695_R1.3440.70
744_L777_F1.3430.70
468_L481_D1.3410.70
448_L457_T1.3410.70
565_V633_S1.3360.70
395_M399_R1.3330.70
185_A189_L1.3330.70
398_F402_V1.3290.70
735_D768_T1.3290.70
488_S690_N1.3270.69
516_D557_G1.3240.69
498_D508_G1.3180.69
577_T618_Q1.3160.69
456_R492_L1.3130.69
735_D759_G1.3110.69
387_E396_D1.3100.68
452_S492_L1.3070.68
576_F623_R1.3060.68
419_R422_E1.3030.68
748_L761_S1.3020.68
454_E618_Q1.3000.68
696_I749_A1.2990.68
539_R577_T1.2920.67
458_P577_T1.2870.67
444_K575_R1.2850.67
689_D714_A1.2820.67
561_R564_Q1.2810.67
415_Q420_T1.2750.66
499_I604_I1.2700.66
457_T618_Q1.2700.66
636_L731_L1.2670.66
501_D504_A1.2650.66
370_L398_F1.2640.66
456_R577_T1.2630.66
515_S559_P1.2570.65
505_I639_A1.2570.65
759_G776_L1.2520.65
770_R774_S1.2510.65
127_V131_L1.2480.65
713_N716_Q1.2410.64
449_A457_T1.2310.64
604_I607_A1.2290.63
412_L415_Q1.2280.63
452_S575_R1.2260.63
454_E492_L1.2240.63
391_I394_L1.2230.63
744_L759_G1.2230.63
451_M631_T1.2210.63
210_A214_Q1.2180.63
214_Q219_N1.2180.63
721_L730_A1.2170.63
363_Q398_F1.2140.62
451_M455_I1.2110.62
212_R215_Q1.2110.62
457_T492_L1.2090.62
461_G780_I1.2090.62
77_M81_Q1.2080.62
492_L501_D1.2030.62
564_Q575_R1.2030.62
449_A618_Q1.1990.61
456_R618_Q1.1980.61
757_L777_F1.1960.61
555_L662_L1.1960.61
502_Y758_I1.1930.61
757_L778_R1.1920.61
688_E744_L1.1920.61
387_E395_M1.1900.61
441_S444_K1.1850.61
498_D512_V1.1840.60
416_V421_A1.1810.60
449_A501_D1.1790.60
764_V777_F1.1750.60
444_K576_F1.1750.60
512_V635_R1.1740.60
693_T762_A1.1730.60
441_S465_T1.1720.60
359_P395_M1.1710.60
498_D582_I1.1680.59
731_L744_L1.1680.59
447_F576_F1.1640.59
360_L387_E1.1640.59
449_A452_S1.1630.59
356_V387_E1.1610.59
577_T632_I1.1600.59
595_V633_S1.1580.59
464_G564_Q1.1560.59
491_S495_I1.1520.58
585_R598_E1.1490.58
444_K577_T1.1480.58
455_I491_S1.1460.58
461_G574_L1.1430.58
694_Q777_F1.1430.58
454_E575_R1.1420.58
496_L507_A1.1410.58
761_S785_V1.1390.57
152_A155_A1.1370.57
448_L492_L1.1370.57
495_I639_A1.1370.57
492_L576_F1.1340.57
779_G796_H1.1330.57
759_G762_A1.1290.57
461_G466_A1.1280.57
448_L455_I1.1270.57
794_L797_Y1.1260.57
492_L618_Q1.1240.56
433_A445_S1.1210.56
732_V757_L1.1200.56
493_L740_D1.1180.56
561_R749_A1.1180.56
714_A741_G1.1110.55
688_E759_G1.1110.55
449_A492_L1.1090.55
444_K448_L1.1070.55
736_L740_D1.1060.55
201_N204_N1.1060.55
612_I644_L1.0960.54
451_M493_L1.0950.54
713_N736_L1.0940.54
737_P762_A1.0930.54
686_L706_A1.0920.54
749_A755_L1.0920.54
444_K449_A1.0890.54
444_K618_Q1.0850.54
731_L759_G1.0850.54
492_L762_A1.0840.54
518_P556_M1.0810.53
700_M744_L1.0800.53
447_F618_Q1.0770.53
507_A616_F1.0760.53
359_P389_D1.0740.53
713_N719_E1.0740.53
433_A443_A1.0730.53
395_M402_V1.0710.53
499_I504_A1.0710.53
91_K95_L1.0710.53
504_A620_S1.0690.53
714_A736_L1.0670.52
688_E736_L1.0670.52
460_Y693_T1.0640.52
214_Q217_V1.0630.52
608_K611_E1.0630.52
23_S38_E1.0610.52
444_K454_E1.0600.52
437_A443_A1.0520.51
373_G387_E1.0500.51
520_E523_P1.0500.51
717_A727_F1.0500.51
693_T778_R1.0440.51
689_D783_K1.0440.51
458_P632_I1.0430.51
416_V582_I1.0430.51
83_R92_I1.0410.51
455_I727_F1.0400.51
474_A631_T1.0400.51
446_A688_E1.0390.50
387_E394_L1.0380.50
745_A748_L1.0370.50
458_P618_Q1.0340.50
366_A373_G1.0320.50
144_I154_L1.0300.50
459_L551_M1.0260.50
735_D760_F1.0250.49
469_L482_L1.0240.49
452_S576_F1.0220.49
565_V658_L1.0210.49
367_L391_I1.0190.49
447_F577_T1.0170.49
646_A656_F1.0170.49
359_P373_G1.0170.49
767_E780_I1.0160.49
735_D777_F1.0150.49
637_A692_L1.0150.49
202_Q205_E1.0150.49
693_T732_V1.0090.48
501_D618_Q1.0090.48
608_K612_I1.0080.48
749_A757_L1.0070.48
449_A740_D1.0070.48
444_K457_T1.0050.48
200_V204_N1.0040.48
447_F458_P1.0040.48
415_Q423_L1.0030.48
41_N46_I1.0020.48
92_I96_L0.9990.48
448_L456_R0.9980.48
764_V782_P0.9970.48
95_L99_L0.9940.47
715_A719_E0.9940.47
562_I595_V0.9900.47
441_S503_S0.9880.47
478_Q658_L0.9850.47
737_P740_D0.9800.46
528_T532_M0.9790.46
642_G661_P0.9770.46
457_T575_R0.9730.46
501_D561_R0.9700.46
541_I651_E0.9590.45
200_V203_M0.9590.45
445_S503_S0.9580.45
718_L739_I0.9580.45
688_E713_N0.9580.45
497_N576_F0.9570.45
55_L240_V0.9540.45
497_N656_F0.9540.45
693_T776_L0.9520.44
690_N693_T0.9510.44
562_I637_A0.9510.44
449_A460_Y0.9500.44
492_L577_T0.9490.44
575_R632_I0.9490.44
564_Q632_I0.9480.44
517_E559_P0.9480.44
465_T488_S0.9480.44
363_Q380_P0.9450.44
730_A757_L0.9440.44
449_A577_T0.9430.44
276_Y280_S0.9430.44
460_Y505_I0.9390.44
462_I557_G0.9380.43
576_F616_F0.9370.43
445_S640_M0.9370.43
576_F626_T0.9340.43
456_R506_E0.9340.43
462_I505_I0.9330.43
452_S457_T0.9330.43
452_S501_D0.9330.43
769_L780_I0.9320.43
501_D505_I0.9320.43
460_Y632_I0.9310.43
592_Q661_P0.9300.43
457_T576_F0.9290.43
489_G494_T0.9280.43
528_T571_S0.9280.43
426_L430_H0.9270.43
460_Y468_L0.9260.43
501_D506_E0.9250.43
566_I595_V0.9240.43
454_E620_S0.9230.42
394_L398_F0.9230.42
515_S624_G0.9210.42
618_Q623_R0.9190.42
448_L499_I0.9190.42
156_Q160_N0.9190.42
660_L756_V0.9170.42
135_Q138_Q0.9160.42
528_T566_I0.9160.42
460_Y474_A0.9150.42
92_I95_L0.9150.42
213_V216_M0.9150.42
693_T749_A0.9130.42
488_S748_L0.9120.42
715_A739_I0.9120.42
491_S502_Y0.9120.42
759_G765_I0.9110.42
474_A531_L0.9100.42
447_F452_S0.9100.42
463_L780_I0.9090.41
146_A149_D0.9090.41
568_N616_F0.9090.41
648_S651_E0.9080.41
437_A690_N0.9070.41
455_I498_D0.9070.41
697_T759_G0.9050.41
206_L214_Q0.9040.41
131_L138_Q0.9040.41
449_A454_E0.9040.41
447_F504_A0.9030.41
741_G783_K0.9030.41
735_D780_I0.9030.41
311_I398_F0.9030.41
612_I656_F0.9020.41
466_A481_D0.9010.41
690_N760_F0.9010.41
437_A496_L0.9000.41
449_A455_I0.8990.41
693_T736_L0.8990.41
365_Q565_V0.8980.41
711_V716_Q0.8980.41
393_R582_I0.8960.41
83_R95_L0.8960.41
238_N247_Q0.8960.41
573_A790_L0.8960.41
449_A458_P0.8950.41
499_I506_E0.8940.40
455_I604_I0.8940.40
92_I99_L0.8930.40
169_T172_G0.8920.40
499_I624_G0.8910.40
449_A456_R0.8910.40
391_I395_M0.8880.40
759_G763_H0.8870.40
555_L686_L0.8850.40
447_F575_R0.8850.40
452_S564_Q0.8850.40
718_L748_L0.8840.40
504_A577_T0.8840.40
742_I772_R0.8840.40
443_A705_G0.8840.40
26_V479_R0.8840.40
456_R632_I0.8820.40
454_E499_I0.8820.40
114_Q118_R0.8810.40
457_T498_D0.8790.39
455_I690_N0.8780.39
742_I785_V0.8770.39
455_I489_G0.8750.39
450_A575_R0.8740.39
505_I640_M0.8740.39
721_L755_L0.8710.39
452_S618_Q0.8700.39
689_D737_P0.8690.39
732_V736_L0.8660.39
528_T780_I0.8650.39
23_S345_I0.8650.39
506_E640_M0.8630.38
749_A777_F0.8620.38
481_D760_F0.8610.38
732_V775_S0.8590.38
24_T28_W0.8580.38
437_A640_M0.8570.38
465_T761_S0.8540.38
461_G484_A0.8530.38
683_R709_V0.8490.37
235_Q238_N0.8480.37
491_S692_L0.8480.37
448_L452_S0.8470.37
450_A577_T0.8470.37
679_L706_A0.8450.37
541_I577_T0.8430.37
209_S214_Q0.8430.37
515_S519_F0.8420.37
496_L505_I0.8420.37
465_T694_Q0.8420.37
456_R497_N0.8420.37
434_R443_A0.8390.37
461_G491_S0.8390.37
682_L728_A0.8380.37
736_L741_G0.8380.37
733_D783_K0.8360.37
564_Q636_L0.8360.37
532_M760_F0.8360.37
26_V31_L0.8340.37
706_A735_D0.8330.36
331_Y335_L0.8330.36
445_S449_A0.8310.36
547_I551_M0.8310.36
206_L209_S0.8290.36
440_A505_I0.8280.36
154_L158_Q0.8270.36
499_I661_P0.8270.36
420_T441_S0.8260.36
504_A624_G0.8250.36
620_S735_D0.8250.36
454_E564_Q0.8250.36
200_V205_E0.8240.36
451_M506_E0.8220.36
535_R793_L0.8210.36
603_G627_G0.8210.36
688_E764_V0.8200.36
465_T491_S0.8190.36
769_L779_G0.8180.35
215_Q219_N0.8180.35
452_S577_T0.8170.35
214_Q220_L0.8140.35
727_F772_R0.8140.35
388_L419_R0.8130.35
579_E654_S0.8110.35
437_A445_S0.8100.35
454_E576_F0.8090.35
615_P732_V0.8080.35
8_R459_L0.8080.35
733_D741_G0.8070.35
449_A571_S0.8070.35
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474_A597_V0.5090.19
708_I785_V0.5090.19
781_I785_V0.5090.19
455_I561_R0.5080.19
50_N70_T0.5080.19
450_A502_Y0.5080.19
577_T744_L0.5080.19
562_I718_L0.5070.19
441_S617_V0.5070.19
583_I624_G0.5070.19
570_L574_L0.5070.19
555_L593_W0.5060.19
305_S308_V0.5060.19
448_L463_L0.5060.19
461_G560_R0.5060.19
561_R640_M0.5050.19
374_D379_F0.5040.19
457_T505_I0.5040.19
437_A505_I0.5040.19
579_E647_T0.5040.19
781_I790_L0.5040.19
760_F777_F0.5030.19
604_I609_L0.5020.19
460_Y575_R0.5020.19
81_Q89_S0.5010.18
450_A462_I0.5010.18
452_S561_R0.5010.18
499_I602_C0.5000.18
207_R217_V0.5000.18
434_R640_M0.5000.18
121_R147_A0.5000.18
457_T624_G0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.3337 100 0.718 Contact Map
4bixA 2 0.2505 100 0.75 Contact Map
4mpcA 2 0.3403 100 0.758 Contact Map
4e01A 3 0.3009 100 0.759 Contact Map
4ctiA 2 0.2505 100 0.759 Contact Map
2q8gA 2 0.337 100 0.767 Contact Map
4q20A 2 0.2516 100 0.769 Contact Map
4gczA 2 0.3982 100 0.769 Contact Map
3jz3A 2 0.1751 100 0.773 Contact Map
2c2aA 2 0.2549 100 0.774 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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