RIR3 - ECOLI - GREMLIN Contacts

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RIR3 - Ribonucleoside-diphosphate reductase 2 subunit alpha

UniProt:	P39452	Sequences: MATTTAECLTQETMDYHALNAMLNLYDSAGRIQFDKDRQAVDAFIATHVRPNSVTFSSQQQRLNWLVNEGYYDESVLNRYSRDFVITLFTHAHTSGFRFQTFLGAWKFYTSYTLKTFDGKRYLEDFADRVTMVALTLAQGDETLALQLTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDVERVYGKPFADVAISQHYDELVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIAGRINMSNLCSEILQVNSASEYDENLDYTRTGHDISCNLGSLNIAHTMDSPDFARTVETAVRGLTAVSDMSHIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGETFAGFKQSRYASGEYFSQYLQGNWQPKTAKVGELFTRSGITLPTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRKEGKTGRVYYPAPFMTNENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKTLYYIRLRQMALEGTEIEGCVSCAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG20257
Length:	714 (633)
Sequences:	2952 (1062)
Seq/√Len:	42.2

ECOLI - RIR3 RIR1
BACSU - RIR1 NRDEB
HALSA - Q9HMU3 Q9HPG8
SULSO - Q97ZH9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
301_K	685_R	8.129	1.00
298_H	328_S	6.304	1.00
514_R	572_D	4.798	1.00
458_E	462_A	4.728	1.00
303_N	346_N	4.217	1.00
436_E	511_L	4.173	1.00
432_A	507_R	4.167	1.00
305_Q	344_Y	4.047	1.00
507_R	572_D	3.991	1.00
506_L	573_V	3.946	1.00
439_V	467_I	3.893	1.00
74_E	78_N	3.867	1.00
305_Q	346_N	3.864	1.00
147_Q	433_R	3.796	1.00
266_I	290_V	3.700	1.00
298_H	302_E	3.681	1.00
471_Q	498_F	3.552	1.00
510_M	572_D	3.460	1.00
491_L	652_E	3.371	1.00
486_G	636_Q	3.232	1.00
294_D	374_R	3.088	1.00
648_D	686_K	2.999	1.00
307_A	340_I	2.996	1.00
431_F	501_I	2.987	1.00
528_Y	578_I	2.951	1.00
572_D	576_Y	2.938	1.00
514_R	576_Y	2.932	1.00
432_A	504_H	2.924	1.00
216_E	264_P	2.904	1.00
192_R	195_N	2.895	1.00
196_S	456_S	2.882	1.00
648_D	682_Y	2.873	1.00
436_E	507_R	2.809	1.00
439_V	583_L	2.791	1.00
307_A	344_Y	2.787	1.00
267_L	343_K	2.777	1.00
88_L	135_L	2.712	1.00
392_L	660_G	2.671	1.00
571_D	575_R	2.657	1.00
492_D	496_L	2.649	1.00
330_H	333_E	2.630	1.00
644_E	682_Y	2.627	1.00
440_R	515_E	2.617	1.00
271_D	353_R	2.604	1.00
303_N	348_R	2.593	1.00
455_P	458_E	2.556	1.00
307_A	335_V	2.533	1.00
459_A	463_A	2.469	1.00
333_E	337_D	2.435	1.00
217_A	268_R	2.430	1.00
87_T	146_L	2.427	1.00
267_L	350_F	2.414	1.00
346_N	349_D	2.389	1.00
91_H	146_L	2.376	1.00
567_A	570_R	2.360	1.00
372_V	392_L	2.337	1.00
510_M	576_Y	2.291	1.00
309_F	314_V	2.214	1.00
510_M	514_R	2.169	1.00
308_L	345_L	2.169	1.00
211_L	231_V	2.124	0.99
535_S	570_R	2.112	0.99
565_M	568_Q	2.109	0.99
495_N	655_R	2.092	0.99
440_R	508_T	2.091	0.99
629_N	633_A	2.079	0.99
486_G	490_A	2.072	0.99
188_E	195_N	2.061	0.99
340_I	344_Y	2.041	0.99
482_G	634_L	2.040	0.99
326_A	329_Q	2.006	0.99
682_Y	686_K	2.004	0.99
418_G	438_A	2.002	0.99
157_F	418_G	1.991	0.99
316_R	319_G	1.989	0.99
432_A	503_W	1.965	0.99
506_L	578_I	1.950	0.99
267_L	353_R	1.937	0.99
567_A	571_D	1.896	0.99
235_M	283_I	1.883	0.99
325_V	329_Q	1.872	0.99
345_L	350_F	1.867	0.99
297_F	368_Y	1.863	0.99
294_D	684_W	1.863	0.99
156_R	430_D	1.843	0.98
184_E	189_S	1.835	0.98
491_L	649_T	1.807	0.98
412_D	454_V	1.785	0.98
267_L	345_L	1.781	0.98
392_L	690_T	1.770	0.98
146_L	150_D	1.766	0.98
425_T	434_T	1.740	0.98
43_A	47_T	1.736	0.98
295_I	298_H	1.733	0.98
292_I	366_I	1.727	0.98
332_D	336_A	1.715	0.97
378_I	520_F	1.705	0.97
191_G	198_L	1.704	0.97
436_E	508_T	1.701	0.97
571_D	574_M	1.696	0.97
239_E	285_T	1.687	0.97
490_A	649_T	1.686	0.97
510_M	569_L	1.666	0.97
523_F	574_M	1.659	0.97
191_G	237_M	1.652	0.97
67_V	77_L	1.646	0.97
299_L	304_A	1.643	0.97
96_G	153_L	1.640	0.97
372_V	690_T	1.635	0.97
232_I	272_T	1.633	0.97
137_L	441_G	1.629	0.96
568_Q	572_D	1.613	0.96
100_Q	130_V	1.612	0.96
138_A	148_L	1.609	0.96
91_H	131_T	1.602	0.96
355_A	676_I	1.602	0.96
477_Y	497_Y	1.587	0.96
88_L	131_T	1.584	0.96
480_R	626_F	1.584	0.96
505_A	583_L	1.583	0.96
533_Y	573_V	1.575	0.96
317_V	339_R	1.572	0.96
183_I	193_A	1.559	0.95
371_T	374_R	1.549	0.95
91_H	150_D	1.546	0.95
196_S	412_D	1.535	0.95
391_I	585_A	1.533	0.95
60_Q	82_R	1.530	0.95
41_V	45_I	1.530	0.95
144_L	147_Q	1.517	0.95
463_A	521_A	1.512	0.95
502_T	506_L	1.510	0.95
57_S	61_Q	1.509	0.95
313_D	341_R	1.507	0.95
299_L	307_A	1.504	0.94
496_L	563_R	1.499	0.94
191_G	241_A	1.498	0.94
556_S	560_L	1.466	0.94
59_Q	63_L	1.446	0.93
482_G	630_E	1.429	0.93
534_F	570_R	1.420	0.93
141_D	444_A	1.417	0.92
148_L	441_G	1.404	0.92
508_T	511_L	1.401	0.92
161_T	254_A	1.401	0.92
235_M	286_L	1.394	0.92
647_I	686_K	1.392	0.92
438_A	469_L	1.387	0.92
131_T	135_L	1.384	0.92
64_N	68_N	1.382	0.91
369_E	381_R	1.381	0.91
503_W	569_L	1.381	0.91
651_A	686_K	1.381	0.91
131_T	149_T	1.373	0.91
272_T	283_I	1.368	0.91
495_N	652_E	1.361	0.91
511_L	572_D	1.358	0.91
428_S	500_A	1.357	0.91
299_L	335_V	1.354	0.91
194_V	237_M	1.353	0.91
518_E	523_F	1.345	0.90
455_P	459_A	1.338	0.90
507_R	569_L	1.337	0.90
412_D	456_S	1.335	0.90
528_Y	533_Y	1.328	0.90
479_A	605_I	1.326	0.90
309_F	340_I	1.326	0.90
443_T	516_R	1.316	0.89
63_L	67_V	1.313	0.89
185_D	215_R	1.309	0.89
182_R	210_L	1.307	0.89
372_V	660_G	1.299	0.89
701_L	704_T	1.295	0.89
646_I	663_L	1.292	0.88
665_L	683_A	1.285	0.88
380_G	394_V	1.278	0.88
569_L	572_D	1.273	0.88
175_L	448_M	1.271	0.88
266_I	350_F	1.271	0.88
432_A	436_E	1.268	0.88
130_V	152_M	1.263	0.87
58_S	61_Q	1.262	0.87
56_F	80_Y	1.260	0.87
92_A	149_T	1.257	0.87
125_D	128_D	1.253	0.87
135_L	145_A	1.251	0.87
216_E	219_A	1.250	0.87
216_E	310_S	1.250	0.87
109_Y	113_T	1.240	0.86
108_F	113_T	1.239	0.86
486_G	645_K	1.237	0.86
49_V	58_S	1.236	0.86
197_A	209_F	1.233	0.86
503_W	565_M	1.233	0.86
644_E	648_D	1.224	0.86
629_N	632_L	1.224	0.86
524_K	529_A	1.223	0.86
420_L	435_V	1.219	0.85
195_N	199_Q	1.218	0.85
328_S	332_D	1.215	0.85
316_R	334_L	1.214	0.85
87_T	143_T	1.213	0.85
325_V	328_S	1.212	0.85
474_L	494_T	1.212	0.85
202_K	245_A	1.207	0.85
242_F	255_G	1.198	0.84
259_L	263_H	1.197	0.84
60_Q	64_N	1.196	0.84
379_A	522_G	1.189	0.84
502_T	584_Q	1.182	0.84
428_S	493_F	1.180	0.83
436_E	504_H	1.179	0.83
510_M	523_F	1.168	0.83
485_Y	601_S	1.168	0.83
185_D	190_I	1.167	0.83
426_M	477_Y	1.155	0.82
194_V	241_A	1.153	0.82
570_R	574_M	1.153	0.82
206_G	390_E	1.147	0.82
500_A	504_H	1.145	0.82
444_A	516_R	1.144	0.81
320_K	330_H	1.141	0.81
511_L	514_R	1.126	0.80
206_G	386_N	1.124	0.80
131_T	146_L	1.124	0.80
495_N	656_H	1.121	0.80
64_N	82_R	1.121	0.80
367_M	372_V	1.121	0.80
42_D	46_A	1.109	0.79
151_E	434_T	1.108	0.79
88_L	146_L	1.108	0.79
471_Q	501_I	1.106	0.79
443_T	579_Y	1.105	0.79
510_M	573_V	1.102	0.79
290_V	354_L	1.102	0.79
63_L	77_L	1.097	0.79
161_T	177_S	1.095	0.78
491_L	645_K	1.095	0.78
488_P	492_D	1.094	0.78
211_L	238_L	1.092	0.78
48_H	125_D	1.091	0.78
295_I	328_S	1.088	0.78
419_S	592_I	1.087	0.78
45_I	48_H	1.087	0.78
507_R	568_Q	1.087	0.78
358_Q	680_Q	1.085	0.78
88_L	91_H	1.084	0.78
427_D	430_D	1.084	0.78
131_T	145_A	1.083	0.78
116_T	120_K	1.074	0.77
422_I	471_Q	1.073	0.77
435_V	504_H	1.071	0.77
298_H	301_K	1.071	0.77
665_L	679_A	1.070	0.77
523_F	528_Y	1.069	0.77
463_A	522_G	1.069	0.77
473_N	476_G	1.069	0.77
178_C	388_C	1.065	0.77
219_A	312_Y	1.059	0.76
237_M	240_D	1.055	0.76
483_I	493_F	1.052	0.76
178_C	206_G	1.046	0.75
73_D	76_V	1.045	0.75
63_L	85_V	1.045	0.75
310_S	313_D	1.043	0.75
42_D	45_I	1.041	0.75
647_I	651_A	1.040	0.75
190_I	215_R	1.037	0.75
430_D	433_R	1.035	0.74
422_I	501_I	1.032	0.74
44_F	113_T	1.030	0.74
65_W	69_E	1.029	0.74
500_A	565_M	1.025	0.74
332_D	335_V	1.021	0.73
155_G	596_N	1.021	0.73
644_E	678_K	1.018	0.73
261_A	293_P	1.016	0.73
573_V	578_I	1.013	0.73
144_L	148_L	1.012	0.73
60_Q	85_V	1.010	0.73
150_D	154_S	1.009	0.73
497_Y	501_I	1.002	0.72
84_F	142_E	0.998	0.72
258_Y	289_G	0.997	0.72
510_M	578_I	0.985	0.71
236_K	282_R	0.983	0.71
330_H	334_L	0.983	0.71
162_P	177_S	0.979	0.70
206_G	388_C	0.979	0.70
59_Q	64_N	0.977	0.70
178_C	417_L	0.977	0.70
188_E	199_Q	0.977	0.70
297_F	300_A	0.975	0.70
431_F	497_Y	0.975	0.70
141_D	440_R	0.974	0.70
261_A	300_A	0.973	0.70
647_I	665_L	0.973	0.70
668_P	698_Q	0.970	0.70
295_I	332_D	0.970	0.70
564_E	568_Q	0.969	0.69
368_Y	683_A	0.968	0.69
186_N	189_S	0.968	0.69
178_C	390_E	0.967	0.69
86_I	90_T	0.966	0.69
504_H	507_R	0.960	0.69
445_V	467_I	0.960	0.69
494_T	653_A	0.960	0.69
231_V	259_L	0.959	0.69
301_K	681_I	0.958	0.69
678_K	681_I	0.957	0.68
317_V	337_D	0.956	0.68
45_I	55_T	0.955	0.68
63_L	66_L	0.952	0.68
528_Y	570_R	0.952	0.68
90_T	93_H	0.944	0.67
79_R	139_Q	0.944	0.67
97_F	127_A	0.944	0.67
654_T	661_L	0.939	0.67
304_A	346_N	0.938	0.67
133_V	164_F	0.935	0.67
525_Q	529_A	0.933	0.66
391_I	659_Q	0.929	0.66
506_L	533_Y	0.926	0.66
93_H	96_G	0.925	0.66
53_S	64_N	0.922	0.66
590_G	664_T	0.919	0.65
45_I	125_D	0.919	0.65
205_G	253_G	0.917	0.65
54_V	59_Q	0.917	0.65
463_A	525_Q	0.917	0.65
683_A	691_L	0.916	0.65
129_R	133_V	0.916	0.65
141_D	144_L	0.915	0.65
86_I	93_H	0.913	0.65
99_F	155_G	0.912	0.65
445_V	469_L	0.910	0.65
214_L	234_V	0.910	0.65
77_L	82_R	0.909	0.64
388_C	417_L	0.908	0.64
500_A	564_E	0.907	0.64
527_R	532_E	0.905	0.64
157_F	438_A	0.905	0.64
132_M	168_G	0.903	0.64
44_F	48_H	0.903	0.64
506_L	528_Y	0.898	0.63
436_E	572_D	0.895	0.63
511_L	576_Y	0.892	0.63
477_Y	493_F	0.890	0.63
429_P	432_A	0.890	0.63
344_Y	575_R	0.888	0.63
478_L	483_I	0.887	0.63
331_Y	335_V	0.887	0.63
96_G	150_D	0.886	0.62
518_E	524_K	0.885	0.62
149_T	153_L	0.883	0.62
236_K	240_D	0.882	0.62
325_V	374_R	0.880	0.62
303_N	575_R	0.880	0.62
297_F	681_I	0.878	0.62
178_C	386_N	0.877	0.62
206_G	251_R	0.875	0.61
371_T	375_A	0.875	0.61
82_R	86_I	0.874	0.61
601_S	666_F	0.872	0.61
682_Y	685_R	0.871	0.61
62_R	65_W	0.869	0.61
77_L	439_V	0.868	0.61
266_I	308_L	0.868	0.61
136_T	173_G	0.868	0.61
218_G	222_K	0.868	0.61
235_M	272_T	0.868	0.61
272_T	288_L	0.866	0.61
667_F	675_D	0.864	0.60
134_A	167_C	0.862	0.60
64_N	86_I	0.858	0.60
476_G	598_A	0.858	0.60
212_S	318_Y	0.857	0.60
54_V	57_S	0.857	0.60
93_H	127_A	0.856	0.60
299_L	347_A	0.850	0.59
274_R	282_R	0.850	0.59
178_C	251_R	0.849	0.59
432_A	511_L	0.849	0.59
94_T	128_D	0.846	0.59
262_H	327_I	0.845	0.59
501_I	584_Q	0.845	0.59
138_A	145_A	0.844	0.59
646_I	666_F	0.843	0.59
469_L	592_I	0.843	0.59
188_E	192_R	0.841	0.58
162_P	251_R	0.838	0.58
599_T	605_I	0.838	0.58
476_G	599_T	0.837	0.58
557_G	561_P	0.836	0.58
477_Y	481_E	0.836	0.58
489_E	492_D	0.834	0.58
351_F	681_I	0.832	0.58
426_M	481_E	0.832	0.58
297_F	684_W	0.829	0.57
317_V	334_L	0.827	0.57
533_Y	536_Q	0.825	0.57
37_D	41_V	0.825	0.57
557_G	560_L	0.825	0.57
413_I	466_A	0.821	0.57
60_Q	86_I	0.820	0.56
420_L	501_I	0.820	0.56
47_T	76_V	0.819	0.56
106_W	110_T	0.816	0.56
578_I	583_L	0.814	0.56
386_N	662_S	0.813	0.56
329_Q	333_E	0.813	0.56
294_D	371_T	0.808	0.55
229_S	246_N	0.807	0.55
199_Q	202_K	0.807	0.55
33_Q	101_T	0.807	0.55
500_A	560_L	0.804	0.55
608_K	637_D	0.803	0.55
447_D	579_Y	0.801	0.55
187_M	198_L	0.798	0.54
261_A	290_V	0.797	0.54
506_L	510_M	0.796	0.54
130_V	158_Q	0.796	0.54
302_E	685_R	0.796	0.54
53_S	89_F	0.795	0.54
273_K	363_Y	0.792	0.54
314_V	319_G	0.792	0.54
390_E	417_L	0.791	0.54
210_L	260_H	0.791	0.54
42_D	48_H	0.788	0.53
283_I	286_L	0.786	0.53
300_A	347_A	0.785	0.53
650_Y	663_L	0.784	0.53
638_A	666_F	0.783	0.53
194_V	238_L	0.783	0.53
377_P	394_V	0.783	0.53
483_I	648_D	0.781	0.53
667_F	679_A	0.780	0.53
650_Y	661_L	0.780	0.53
386_N	390_E	0.779	0.53
201_S	246_N	0.777	0.52
211_L	257_V	0.774	0.52
40_A	105_A	0.774	0.52
187_M	245_A	0.773	0.52
55_T	58_S	0.773	0.52
43_A	64_N	0.772	0.52
87_T	91_H	0.770	0.52
653_A	661_L	0.770	0.52
556_S	559_T	0.769	0.52
83_D	86_I	0.767	0.51
67_V	74_E	0.766	0.51
493_F	497_Y	0.765	0.51
348_R	352_Q	0.765	0.51
260_H	369_E	0.764	0.51
151_E	156_R	0.764	0.51
220_P	312_Y	0.761	0.51
568_Q	575_R	0.756	0.50
503_W	566_W	0.756	0.50
90_T	95_S	0.755	0.50
156_R	434_T	0.755	0.50
206_G	417_L	0.755	0.50
302_E	336_A	0.754	0.50
75_S	139_Q	0.753	0.50
159_P	441_G	0.753	0.50
37_D	455_P	0.753	0.50
416_N	446_S	0.751	0.50
58_S	62_R	0.751	0.50
524_K	575_R	0.750	0.50
85_V	89_F	0.749	0.50
160_A	177_S	0.748	0.50
523_F	569_L	0.747	0.50
472_M	589_T	0.746	0.50
527_R	536_Q	0.744	0.49
394_V	581_Q	0.744	0.49
605_I	641_I	0.740	0.49
251_R	388_C	0.740	0.49
678_K	682_Y	0.740	0.49
68_N	86_I	0.739	0.49
660_G	690_T	0.738	0.49
97_F	149_T	0.737	0.49
642_G	679_A	0.737	0.49
61_Q	65_W	0.736	0.49
141_D	516_R	0.736	0.49
273_K	288_L	0.735	0.48
67_V	76_V	0.733	0.48
64_N	70_G	0.731	0.48
66_L	72_Y	0.731	0.48
643_A	646_I	0.730	0.48
524_K	574_M	0.728	0.48
59_Q	67_V	0.728	0.48
377_P	582_N	0.727	0.48
440_R	516_R	0.726	0.48
257_V	286_L	0.726	0.48
485_Y	646_I	0.723	0.47
53_S	85_V	0.723	0.47
458_E	570_R	0.723	0.47
206_G	662_S	0.722	0.47
486_G	649_T	0.722	0.47
611_I	619_R	0.721	0.47
491_L	648_D	0.721	0.47
78_N	82_R	0.720	0.47
503_W	568_Q	0.719	0.47
423_A	480_R	0.718	0.47
536_Q	655_R	0.717	0.47
209_F	255_G	0.717	0.47
78_N	83_D	0.717	0.47
86_I	89_F	0.717	0.47
349_D	352_Q	0.716	0.47
300_A	348_R	0.716	0.47
320_K	326_A	0.715	0.47
223_R	242_F	0.714	0.46
270_L	365_Y	0.711	0.46
214_L	229_S	0.711	0.46
308_L	350_F	0.709	0.46
589_T	593_S	0.708	0.46
498_F	657_V	0.707	0.46
140_G	145_A	0.707	0.46
259_L	269_F	0.706	0.46
478_L	490_A	0.706	0.46
466_A	581_Q	0.705	0.46
60_Q	77_L	0.704	0.46
273_K	391_I	0.704	0.46
57_S	62_R	0.704	0.46
289_G	365_Y	0.704	0.46
647_I	688_I	0.704	0.46
291_V	369_E	0.702	0.45
179_F	205_G	0.702	0.45
82_R	488_P	0.701	0.45
386_N	588_P	0.701	0.45
46_A	57_S	0.700	0.45
440_R	444_A	0.699	0.45
48_H	123_L	0.698	0.45
67_V	75_S	0.698	0.45
426_M	480_R	0.698	0.45
208_A	350_F	0.698	0.45
484_A	634_L	0.697	0.45
55_T	59_Q	0.697	0.45
417_L	468_G	0.696	0.45
99_F	154_S	0.694	0.45
143_T	489_E	0.694	0.45
221_I	225_E	0.694	0.45
533_Y	578_I	0.693	0.45
395_N	413_I	0.691	0.44
48_H	57_S	0.690	0.44
47_T	58_S	0.689	0.44
41_V	125_D	0.689	0.44
464_S	581_Q	0.688	0.44
219_A	310_S	0.688	0.44
68_N	82_R	0.687	0.44
47_T	61_Q	0.687	0.44
163_T	445_V	0.687	0.44
350_F	354_L	0.687	0.44
162_P	388_C	0.686	0.44
139_Q	448_M	0.686	0.44
251_R	386_N	0.686	0.44
34_F	37_D	0.685	0.44
507_R	510_M	0.682	0.44
421_N	596_N	0.681	0.43
518_E	572_D	0.680	0.43
55_T	64_N	0.680	0.43
62_R	66_L	0.680	0.43
54_V	65_W	0.678	0.43
513_A	577_G	0.676	0.43
147_Q	437_T	0.676	0.43
289_G	363_Y	0.674	0.43
532_E	536_Q	0.674	0.43
445_V	449_S	0.673	0.43
150_D	430_D	0.673	0.43
69_E	89_F	0.673	0.43
532_E	574_M	0.672	0.43
49_V	55_T	0.672	0.43
184_E	214_L	0.672	0.43
523_F	578_I	0.671	0.42
300_A	681_I	0.671	0.42
368_Y	680_Q	0.671	0.42
79_R	90_T	0.671	0.42
507_R	511_L	0.670	0.42
473_N	599_T	0.670	0.42
261_A	350_F	0.670	0.42
299_L	332_D	0.669	0.42
432_A	500_A	0.668	0.42
38_R	41_V	0.667	0.42
570_R	578_I	0.667	0.42
588_P	662_S	0.666	0.42
315_E	319_G	0.666	0.42
231_V	235_M	0.666	0.42
652_E	655_R	0.666	0.42
213_N	383_N	0.664	0.42
327_I	331_Y	0.663	0.42
603_H	664_T	0.662	0.42
501_I	657_V	0.662	0.42
57_S	78_N	0.662	0.42
57_S	86_I	0.660	0.41
124_E	566_W	0.660	0.41
439_V	501_I	0.660	0.41
137_L	448_M	0.660	0.41
593_S	601_S	0.660	0.41
558_I	561_P	0.659	0.41
175_L	440_R	0.659	0.41
137_L	163_T	0.659	0.41
676_I	693_Y	0.658	0.41
336_A	429_P	0.657	0.41
152_M	438_A	0.657	0.41
58_S	64_N	0.657	0.41
93_H	98_R	0.656	0.41
155_G	424_H	0.656	0.41
134_A	223_R	0.656	0.41
586_V	657_V	0.655	0.41
258_Y	385_S	0.655	0.41
514_R	523_F	0.653	0.41
329_Q	332_D	0.653	0.41
392_L	688_I	0.652	0.41
58_S	86_I	0.652	0.41
389_S	692_Y	0.652	0.41
293_P	300_A	0.652	0.41
130_V	153_L	0.649	0.40
185_D	249_G	0.649	0.40
127_A	153_L	0.648	0.40
82_R	85_V	0.646	0.40
292_I	512_L	0.645	0.40
68_N	571_D	0.645	0.40
393_Q	658_D	0.645	0.40
229_S	248_L	0.645	0.40
53_S	60_Q	0.645	0.40
315_E	334_L	0.644	0.40
192_R	456_S	0.644	0.40
424_H	480_R	0.644	0.40
178_C	662_S	0.643	0.40
352_Q	677_N	0.643	0.40
234_V	244_Y	0.643	0.40
206_G	588_P	0.643	0.40
444_A	515_E	0.642	0.40
469_L	505_A	0.640	0.40
491_L	495_N	0.640	0.40
386_N	417_L	0.639	0.40
435_V	505_A	0.639	0.40
628_T	631_N	0.638	0.39
62_R	71_Y	0.638	0.39
506_L	658_D	0.638	0.39
580_N	583_L	0.637	0.39
572_D	575_R	0.635	0.39
390_E	415_C	0.634	0.39
502_T	600_S	0.633	0.39
197_A	418_G	0.632	0.39
700_A	703_G	0.631	0.39
120_K	492_D	0.631	0.39
258_Y	291_V	0.630	0.39
57_S	64_N	0.630	0.39
58_S	89_F	0.629	0.39
58_S	69_E	0.629	0.39
387_L	692_Y	0.627	0.39
330_H	337_D	0.626	0.38
229_S	273_K	0.626	0.38
46_A	55_T	0.625	0.38
162_P	362_G	0.624	0.38
387_L	693_Y	0.624	0.38
53_S	56_F	0.624	0.38
43_A	65_W	0.623	0.38
414_S	461_N	0.622	0.38
62_R	128_D	0.622	0.38
208_A	473_N	0.622	0.38
67_V	329_Q	0.621	0.38
428_S	497_Y	0.621	0.38
488_P	514_R	0.621	0.38
231_V	263_H	0.621	0.38
305_Q	336_A	0.621	0.38
166_N	202_K	0.620	0.38
247_Q	253_G	0.620	0.38
502_T	534_F	0.620	0.38
283_I	288_L	0.620	0.38
119_G	169_K	0.620	0.38
189_S	193_A	0.619	0.38
703_G	706_I	0.619	0.38
42_D	47_T	0.617	0.38
302_E	374_R	0.617	0.38
641_I	645_K	0.617	0.38
422_I	477_Y	0.615	0.37
567_A	574_M	0.614	0.37
152_M	245_A	0.614	0.37
527_R	530_S	0.613	0.37
702_E	707_E	0.612	0.37
514_R	575_R	0.611	0.37
429_P	524_K	0.611	0.37
314_V	318_Y	0.610	0.37
158_Q	596_N	0.610	0.37
56_F	77_L	0.610	0.37
378_I	581_Q	0.609	0.37
459_A	571_D	0.609	0.37
496_L	560_L	0.609	0.37
147_Q	436_E	0.608	0.37
426_M	430_D	0.608	0.37
316_R	330_H	0.607	0.37
162_P	178_C	0.607	0.37
593_S	600_S	0.607	0.37
90_T	304_A	0.606	0.37
178_C	588_P	0.606	0.37
155_G	421_N	0.605	0.37
135_L	146_L	0.605	0.37
420_L	434_T	0.605	0.37
75_S	79_R	0.605	0.37
136_T	167_C	0.605	0.37
45_I	57_S	0.604	0.36
296_T	306_M	0.604	0.36
77_L	80_Y	0.603	0.36
704_T	707_E	0.603	0.36
179_F	382_I	0.602	0.36
40_A	44_F	0.599	0.36
54_V	58_S	0.599	0.36
46_A	125_D	0.599	0.36
533_Y	570_R	0.598	0.36
274_R	353_R	0.597	0.36
483_I	489_E	0.596	0.36
435_V	497_Y	0.596	0.36
323_A	329_Q	0.596	0.36
431_F	435_V	0.596	0.36
59_Q	62_R	0.596	0.36
498_F	591_S	0.596	0.36
388_C	415_C	0.595	0.36
478_L	649_T	0.595	0.36
255_G	599_T	0.594	0.36
466_A	582_N	0.594	0.36
87_T	90_T	0.594	0.36
202_K	446_S	0.593	0.36
72_Y	76_V	0.592	0.35
48_H	70_G	0.591	0.35
563_R	567_A	0.591	0.35
681_I	685_R	0.590	0.35
464_S	522_G	0.590	0.35
106_W	109_Y	0.590	0.35
97_F	153_L	0.590	0.35
41_V	48_H	0.588	0.35
193_A	669_D	0.588	0.35
287_S	363_Y	0.588	0.35
337_D	349_D	0.588	0.35
677_N	681_I	0.587	0.35
463_A	489_E	0.587	0.35
414_S	449_S	0.587	0.35
59_Q	90_T	0.586	0.35
162_P	566_W	0.585	0.35
39_Q	42_D	0.585	0.35
376_N	382_I	0.584	0.35
530_S	578_I	0.584	0.35
59_Q	132_M	0.584	0.35
647_I	679_A	0.583	0.35
585_A	692_Y	0.582	0.35
34_F	43_A	0.581	0.34
137_L	445_V	0.580	0.34
366_I	680_Q	0.580	0.34
520_F	525_Q	0.580	0.34
196_S	454_V	0.579	0.34
45_I	94_T	0.579	0.34
211_L	235_M	0.577	0.34
150_D	433_R	0.576	0.34
496_L	499_Y	0.575	0.34
429_P	564_E	0.575	0.34
221_I	253_G	0.574	0.34
327_I	334_L	0.573	0.34
302_E	568_Q	0.573	0.34
643_A	679_A	0.573	0.34
58_S	65_W	0.573	0.34
43_A	46_A	0.573	0.34
350_F	576_Y	0.573	0.34
486_G	633_A	0.572	0.34
331_Y	334_L	0.572	0.34
314_V	317_V	0.572	0.34
697_R	700_A	0.571	0.34
174_E	449_S	0.570	0.34
44_F	151_E	0.570	0.34
73_D	78_N	0.569	0.33
503_W	507_R	0.568	0.33
326_A	330_H	0.568	0.33
179_F	416_N	0.566	0.33
354_L	366_I	0.566	0.33
298_H	685_R	0.566	0.33
55_T	61_Q	0.565	0.33
127_A	149_T	0.564	0.33
77_L	85_V	0.564	0.33
178_C	415_C	0.564	0.33
595_I	602_I	0.563	0.33
261_A	270_L	0.563	0.33
46_A	101_T	0.562	0.33
419_S	587_P	0.562	0.33
323_A	374_R	0.562	0.33
234_V	592_I	0.561	0.33
488_P	707_E	0.561	0.33
483_I	647_I	0.561	0.33
166_N	242_F	0.559	0.33
592_I	680_Q	0.559	0.33
432_A	564_E	0.559	0.33
84_F	87_T	0.559	0.33
388_C	468_G	0.559	0.33
240_D	243_S	0.558	0.33
59_Q	72_Y	0.558	0.33
428_S	496_L	0.558	0.33
173_G	450_H	0.558	0.33
45_I	62_R	0.558	0.33
124_E	362_G	0.557	0.32
46_A	54_V	0.557	0.32
62_R	123_L	0.556	0.32
203_R	505_A	0.556	0.32
325_V	429_P	0.555	0.32
199_Q	203_R	0.554	0.32
181_L	457_I	0.553	0.32
226_N	248_L	0.553	0.32
327_I	330_H	0.552	0.32
459_A	521_A	0.552	0.32
240_D	280_K	0.552	0.32
174_E	277_A	0.552	0.32
204_G	249_G	0.551	0.32
65_W	68_N	0.551	0.32
256_A	365_Y	0.550	0.32
373_N	382_I	0.549	0.32
163_T	413_I	0.549	0.32
238_L	257_V	0.549	0.32
103_L	200_L	0.548	0.32
285_T	591_S	0.548	0.32
209_F	257_V	0.548	0.32
251_R	390_E	0.547	0.32
292_I	295_I	0.547	0.32
429_P	433_R	0.546	0.32
465_H	580_N	0.545	0.31
79_R	140_G	0.545	0.31
512_L	580_N	0.545	0.31
415_C	468_G	0.544	0.31
526_S	531_G	0.544	0.31
191_G	194_V	0.544	0.31
428_S	431_F	0.544	0.31
108_F	595_I	0.543	0.31
193_A	238_L	0.543	0.31
295_I	299_L	0.543	0.31
46_A	96_G	0.541	0.31
209_F	418_G	0.541	0.31
124_E	526_S	0.541	0.31
323_A	326_A	0.541	0.31
58_S	576_Y	0.540	0.31
313_D	340_I	0.538	0.31
532_E	535_S	0.538	0.31
113_T	129_R	0.538	0.31
185_D	230_G	0.538	0.31
346_N	576_Y	0.538	0.31
176_V	416_N	0.537	0.31
182_R	396_S	0.537	0.31
58_S	344_Y	0.537	0.31
69_E	118_D	0.536	0.31
63_L	79_R	0.536	0.31
275_E	664_T	0.536	0.31
294_D	298_H	0.535	0.31
61_Q	68_N	0.535	0.31
659_Q	692_Y	0.535	0.31
355_A	673_T	0.535	0.31
42_D	73_D	0.534	0.31
258_Y	389_S	0.534	0.31
196_S	455_P	0.534	0.31
256_A	273_K	0.533	0.31
86_I	458_E	0.532	0.30
328_S	489_E	0.532	0.30
484_A	636_Q	0.531	0.30
243_S	246_N	0.531	0.30
115_K	122_Y	0.530	0.30
204_G	223_R	0.530	0.30
204_G	228_S	0.530	0.30
198_L	237_M	0.530	0.30
498_F	653_A	0.530	0.30
88_L	96_G	0.530	0.30
272_T	286_L	0.529	0.30
522_G	525_Q	0.529	0.30
221_I	265_D	0.528	0.30
589_T	592_I	0.527	0.30
617_T	699_M	0.527	0.30
58_S	66_L	0.527	0.30
626_F	682_Y	0.527	0.30
36_K	39_Q	0.526	0.30
451_I	466_A	0.526	0.30
338_E	341_R	0.526	0.30
260_H	291_V	0.525	0.30
108_F	129_R	0.525	0.30
210_L	395_N	0.524	0.30
502_T	573_V	0.524	0.30
667_F	671_A	0.522	0.30
382_I	651_A	0.522	0.30
206_G	415_C	0.521	0.30
494_T	649_T	0.521	0.30
447_D	451_I	0.521	0.30
166_N	204_G	0.521	0.30
472_M	594_Y	0.520	0.29
182_R	213_N	0.520	0.29
178_C	693_Y	0.520	0.29
163_T	167_C	0.520	0.29
249_G	253_G	0.519	0.29
199_Q	250_A	0.519	0.29
62_R	397_A	0.519	0.29
304_A	575_R	0.519	0.29
45_I	49_V	0.518	0.29
669_D	697_R	0.518	0.29
536_Q	570_R	0.517	0.29
295_I	331_Y	0.517	0.29
380_G	526_S	0.517	0.29
439_V	505_A	0.517	0.29
475_H	593_S	0.517	0.29
388_C	662_S	0.517	0.29
443_T	580_N	0.516	0.29
531_G	566_W	0.516	0.29
89_F	131_T	0.516	0.29
54_V	74_E	0.515	0.29
98_R	428_S	0.514	0.29
518_E	578_I	0.514	0.29
305_Q	345_L	0.514	0.29
625_P	658_D	0.513	0.29
48_H	55_T	0.513	0.29
72_Y	79_R	0.513	0.29
417_L	588_P	0.513	0.29
147_Q	150_D	0.513	0.29
502_T	535_S	0.513	0.29
274_R	360_E	0.513	0.29
200_L	592_I	0.513	0.29
587_P	680_Q	0.512	0.29
261_A	266_I	0.512	0.29
351_F	355_A	0.512	0.29
130_V	164_F	0.511	0.29
74_E	170_Q	0.510	0.29
90_T	143_T	0.510	0.29
499_Y	566_W	0.509	0.29
472_M	598_A	0.508	0.29
351_F	613_K	0.508	0.29
309_F	334_L	0.507	0.28
498_F	501_I	0.507	0.28
45_I	98_R	0.507	0.28
262_H	309_F	0.507	0.28
180_L	384_M	0.507	0.28
82_R	437_T	0.507	0.28
35_D	53_S	0.506	0.28
251_R	417_L	0.506	0.28
376_N	582_N	0.505	0.28
254_A	421_N	0.505	0.28
255_G	286_L	0.505	0.28
44_F	109_Y	0.504	0.28
62_R	86_I	0.504	0.28
166_N	176_V	0.504	0.28
44_F	125_D	0.503	0.28
453_S	607_A	0.503	0.28
204_G	616_K	0.503	0.28
268_R	496_L	0.503	0.28
72_Y	77_L	0.502	0.28
436_E	440_R	0.502	0.28
372_V	659_Q	0.502	0.28
53_S	57_S	0.502	0.28
61_Q	86_I	0.502	0.28
70_G	429_P	0.502	0.28
463_A	514_R	0.501	0.28
154_S	430_D	0.501	0.28
624_A	628_T	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2xapA	4	0.937	100	0.108	Contact Map
3hncA	2	0.916	100	0.119	Contact Map
1peqA	2	0.9258	100	0.127	Contact Map
3k8tA	2	0.8361	100	0.128	Contact Map
2wghA	2	0.8613	100	0.16	Contact Map
3o0qA	2	0.7465	100	0.255	Contact Map
1l1lA	1	0.6891	100	0.444	Contact Map
4u3eA	2	0.7689	99.8	0.907	Contact Map
1h7bA	2	0.6036	91.3	0.977	Contact Map
3onoA	4	0.2647	24.1	0.986	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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