GREMLIN Database
ADHP - Alcohol dehydrogenase, propanol-preferring
UniProt: P39451 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12622
Length: 336 (300)
Sequences: 52882 (36830)
Seq/√Len: 2126.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_E137_S2.9801.00
30_K65_A2.9291.00
32_E63_V2.8551.00
313_D316_T2.8531.00
28_L65_A2.6231.00
7_T15_T2.5501.00
164_W188_K2.5481.00
75_K78_D2.4421.00
136_D139_A2.4201.00
27_A128_A2.4171.00
79_R131_V2.3931.00
309_R320_E2.3711.00
78_D130_K2.3621.00
170_L191_A2.3111.00
182_K208_D2.2841.00
19_L120_E2.2701.00
307_A320_E2.2221.00
30_K63_V2.2201.00
138_A308_L2.2151.00
221_I224_E2.1771.00
200_K204_E2.1761.00
7_T13_D2.1731.00
30_K120_E2.1651.00
165_I181_A2.1391.00
188_K209_L2.0771.00
199_L203_T2.0691.00
160_R163_Q2.0491.00
23_K26_E2.0391.00
5_V15_T2.0341.00
73_S125_A2.0321.00
24_H69_P2.0161.00
295_Q299_E2.0141.00
60_G116_G2.0121.00
60_G82_V2.0071.00
24_H70_G1.9961.00
134_G298_A1.9791.00
310_P313_D1.9611.00
178_L207_A1.9401.00
28_L122_I1.9111.00
319_T323_E1.9071.00
45_N322_E1.8781.00
65_A120_E1.8621.00
79_R137_S1.8241.00
61_I137_S1.8241.00
25_G70_G1.8161.00
199_L210_A1.8021.00
183_N301_K1.7921.00
200_K203_T1.7561.00
166_A192_I1.7441.00
254_R278_E1.7261.00
320_E325_K1.7221.00
166_A229_A1.6971.00
316_T319_T1.6891.00
230_H250_R1.6801.00
131_V137_S1.6741.00
21_S66_E1.6701.00
316_T320_E1.6381.00
190_I229_A1.6261.00
254_R280_V1.6241.00
147_G176_L1.6231.00
196_D200_K1.6041.00
193_D199_L1.6021.00
309_R317_I1.5951.00
131_V140_A1.5921.00
201_L204_E1.5711.00
196_D215_T1.5671.00
209_L225_K1.5521.00
168_Y245_A1.5411.00
188_K208_D1.5411.00
28_L120_E1.5341.00
4_A314_I1.5141.00
163_Q254_R1.4881.00
66_E76_P1.4871.00
67_V76_P1.4861.00
63_V79_R1.4791.00
157_S231_A1.4751.00
249_V277_I1.4741.00
196_D212_N1.4731.00
74_L130_K1.4721.00
68_G71_V1.4521.00
74_L78_D1.4501.00
22_L122_I1.4491.00
315_N319_T1.4451.00
249_V255_V1.4381.00
25_G124_V1.4381.00
31_M60_G1.4381.00
117_M318_F1.4281.00
216_E221_I1.4261.00
26_E124_V1.4181.00
232_A249_V1.4071.00
249_V253_G1.4001.00
28_L66_E1.3971.00
26_E122_I1.3851.00
22_L28_L1.3681.00
232_A245_A1.3591.00
33_C138_A1.3531.00
212_N215_T1.3451.00
217_D220_K1.3441.00
79_R133_D1.3341.00
295_Q298_A1.3041.00
64_V74_L1.3021.00
164_W190_I1.3021.00
183_N296_F1.3001.00
27_A74_L1.2911.00
168_Y192_I1.2901.00
63_V137_S1.2831.00
194_V213_S1.2641.00
177_A233_V1.2621.00
178_L191_A1.2611.00
44_K318_F1.2581.00
196_D199_L1.2341.00
32_E79_R1.2231.00
4_A14_V1.2001.00
220_K224_E1.1981.00
155_K289_D1.1981.00
143_I297_A1.1851.00
19_L28_L1.1761.00
31_M121_C1.1701.00
8_K11_H1.1691.00
203_T210_A1.1641.00
74_L128_A1.1621.00
221_I225_K1.1501.00
199_L212_N1.1481.00
25_G125_A1.1281.00
155_K292_E1.1231.00
164_W230_H1.1201.00
287_R291_T1.1161.00
179_Q303_V1.1161.00
163_Q230_H1.1141.00
201_L327_R1.1121.00
247_D271_R1.0901.00
292_E295_Q1.0851.00
123_V128_A1.0831.00
152_K289_D1.0811.00
217_D221_I1.0741.00
296_F301_K1.0741.00
186_N189_V1.0601.00
219_A247_D1.0551.00
5_V17_K1.0441.00
36_V317_I1.0361.00
14_V312_A1.0311.00
135_L140_A1.0301.00
203_T209_L1.0271.00
44_K322_E1.0271.00
34_C117_M1.0221.00
150_T177_A1.0181.00
29_L62_G1.0151.00
139_A303_V1.0141.00
157_S256_V1.0111.00
65_A76_P1.0081.00
236_A241_A1.0081.00
29_L80_A1.0031.00
291_T295_Q1.0021.00
4_A311_L0.9951.00
219_A244_S0.9901.00
244_S247_D0.9881.00
156_L278_E0.9881.00
314_I332_I0.9871.00
215_T221_I0.9871.00
33_C137_S0.9811.00
319_T322_E0.9691.00
194_V214_H0.9561.00
22_L26_E0.9521.00
159_I187_A0.9521.00
139_A305_K0.9521.00
320_E330_M0.9501.00
190_I209_L0.9491.00
71_V125_A0.9431.00
243_N247_D0.9421.00
170_L193_D0.9411.00
159_I163_Q0.9391.00
271_R275_D0.9391.00
153_A258_V0.9381.00
151_Y292_E0.9351.00
117_M314_I0.9351.00
191_A207_A0.9281.00
219_A223_Q0.9251.00
37_C59_E0.9241.00
72_T125_A0.9211.00
7_T11_H0.9171.00
54_V114_D0.9161.00
41_L321_M0.9121.00
178_L189_V0.9101.00
32_E61_I0.9101.00
150_T180_Y0.9071.00
234_V237_V0.9041.00
166_A248_A0.9031.00
153_A233_V0.9021.00
192_I213_S0.9011.00
163_Q231_A0.8981.00
175_N201_L0.8881.00
19_L66_E0.8871.00
309_R313_D0.8841.00
37_C58_H0.8781.00
81_S294_F0.8781.00
191_A202_A0.8771.00
170_L202_A0.8751.00
30_K119_E0.8741.00
195_N198_Q0.8731.00
34_C116_G0.8721.00
292_E296_F0.8691.00
167_I177_A0.8641.00
33_C331_V0.8621.00
193_D210_A0.8611.00
194_V199_L0.8611.00
170_L178_L0.8601.00
168_Y232_A0.8581.00
222_V229_A0.8571.00
197_E200_K0.8561.00
60_G121_C0.8481.00
67_V71_V0.8461.00
5_V55_I0.8401.00
180_Y293_A0.8401.00
167_I181_A0.8381.00
288_Q292_E0.8351.00
19_L65_A0.8351.00
25_G68_G0.8331.00
198_Q327_R0.8321.00
148_V289_D0.8311.00
4_A12_V0.8281.00
240_A244_S0.8281.00
190_I211_I0.8271.00
156_L280_V0.8231.00
67_V75_K0.8221.00
23_K122_I0.8211.00
252_G276_G0.8211.00
17_K114_D0.8191.00
35_G59_E0.8161.00
117_M332_I0.8151.00
158_K254_R0.8151.00
272_L279_V0.8041.00
75_K130_K0.8031.00
288_Q291_T0.8021.00
21_S28_L0.7981.00
220_K223_Q0.7961.00
164_W229_A0.7901.00
133_D298_A0.7881.00
218_A244_S0.7801.00
168_Y241_A0.7771.00
245_A255_V0.7771.00
326_I330_M0.7751.00
180_Y296_F0.7731.00
202_A207_A0.7711.00
129_V291_T0.7681.00
36_V321_M0.7681.00
150_T176_L0.7651.00
162_G187_A0.7631.00
14_V311_L0.7611.00
232_A255_V0.7571.00
116_G121_C0.7541.00
190_I222_V0.7541.00
39_T58_H0.7491.00
307_A316_T0.7491.00
81_S131_V0.7481.00
37_C40_D0.7471.00
307_A330_M0.7461.00
217_D244_S0.7451.00
82_V123_V0.7431.00
235_T258_V0.7421.00
219_A248_A0.7391.00
296_F299_E0.7371.00
268_D271_R0.7361.00
132_P298_A0.7321.00
61_I141_S0.7301.00
27_A125_A0.7291.00
320_E323_E0.7281.00
272_L281_G0.7261.00
195_N212_N0.7241.00
153_A177_A0.7231.00
154_V181_A0.7221.00
80_A128_A0.7201.00
321_M330_M0.7201.00
181_A189_V0.7171.00
257_A279_V0.7141.00
22_L66_E0.7141.00
17_K55_I0.7091.00
129_V290_L0.7061.00
309_R330_M0.7051.00
152_K276_G0.7051.00
167_I191_A0.7051.00
158_K278_E0.7021.00
135_L297_A0.7011.00
296_F300_G0.7001.00
33_C308_L0.6971.00
159_I231_A0.6971.00
158_K280_V0.6911.00
151_Y293_A0.6831.00
147_G293_A0.6821.00
193_D202_A0.6791.00
73_S287_R0.6771.00
25_G126_D0.6761.00
150_T154_V0.6751.00
22_L68_G0.6751.00
150_T173_L0.6701.00
25_G69_P0.6681.00
190_I225_K0.6681.00
231_A256_V0.6671.00
20_R122_I0.6641.00
81_S144_T0.6641.00
151_Y296_F0.6631.00
294_F298_A0.6601.00
181_A187_A0.6601.00
201_L305_K0.6591.00
229_A232_A0.6591.00
201_L205_M0.6571.00
243_N271_R0.6571.00
159_I186_N0.6571.00
242_F255_V0.6571.00
41_L322_E0.6551.00
175_N305_K0.6541.00
31_M34_C0.6531.00
9_D319_T0.6531.00
33_C61_I0.6491.00
264_S268_D0.6491.00
189_V208_D0.6461.00
151_Y289_D0.6461.00
251_A275_D0.6441.00
238_A241_A0.6441.00
144_T147_G0.6421.00
179_Q205_M0.6391.00
4_A315_N0.6381.00
234_V255_V0.6371.00
10_H319_T0.6371.00
58_H145_C0.6371.00
61_I131_V0.6361.00
272_L277_I0.6351.00
222_V248_A0.6341.00
27_A64_V0.6341.00
223_Q228_G0.6311.00
199_L202_A0.6301.00
39_T43_V0.6301.00
146_A176_L0.6281.00
6_V11_H0.6271.00
53_G57_G0.6261.00
271_R274_L0.6241.00
204_E303_V0.6241.00
309_R332_I0.6221.00
37_C145_C0.6201.00
143_I293_A0.6201.00
36_V117_M0.6171.00
79_R134_G0.6171.00
129_V294_F0.6161.00
145_C149_T0.6161.00
209_L221_I0.6151.00
229_A248_A0.6151.00
193_D213_S0.6151.00
157_S254_R0.6141.00
61_I79_R0.6121.00
223_Q226_T0.6111.00
78_D133_D0.6081.00
178_L205_M0.6071.00
276_G286_T0.6041.00
142_S331_V0.6031.00
29_L82_V0.6011.00
187_A231_A0.6001.00
8_K13_D0.5991.00
320_E326_I0.5991.00
73_S76_P0.5971.00
165_I187_A0.5961.00
177_A258_V0.5961.00
83_A129_V0.5961.00
164_W187_A0.5951.00
231_A254_R0.5931.00
164_W226_T0.5931.00
82_V128_A0.5901.00
155_K158_K0.5891.00
181_A186_N0.5881.00
42_H47_D0.5861.00
37_C146_A0.5851.00
51_K54_V0.5831.00
318_F322_E0.5831.00
74_L125_A0.5821.00
240_A243_N0.5801.00
57_G117_M0.5801.00
202_A210_A0.5791.00
38_H42_H0.5781.00
39_T42_H0.5761.00
162_G186_N0.5761.00
161_P185_F0.5741.00
125_A128_A0.5731.00
265_M269_I0.5701.00
265_M268_D0.5681.00
241_A245_A0.5681.00
192_I211_I0.5661.00
232_A248_A0.5641.00
165_I231_A0.5631.00
41_L45_N0.5631.00
61_I140_A0.5631.00
193_D212_N0.5621.00
211_I225_K0.5611.00
182_K185_F0.5611.00
211_I221_I0.5611.00
34_C332_I0.5601.00
185_F292_E0.5591.00
43_V48_F0.5581.00
142_S304_P0.5581.00
20_R120_E0.5571.00
243_N266_S0.5561.00
185_F189_V0.5561.00
129_V287_R0.5561.00
166_A232_A0.5551.00
73_S130_K0.5551.00
72_T75_K0.5541.00
178_L202_A0.5531.00
153_A282_S0.5531.00
218_A222_V0.5491.00
289_D292_E0.5491.00
155_K288_Q0.5481.00
18_T21_S0.5471.00
20_R26_E0.5461.00
146_A329_R0.5441.00
124_V127_Y0.5421.00
297_A304_P0.5421.00
67_V78_D0.5421.00
193_D198_Q0.5411.00
271_R277_I0.5411.00
176_L180_Y0.5391.00
182_K189_V0.5381.00
234_V259_G0.5351.00
164_W209_L0.5351.00
38_H171_G0.5351.00
175_N205_M0.5341.00
153_A256_V0.5301.00
36_V332_I0.5271.00
31_M82_V0.5261.00
37_C329_R0.5261.00
152_K156_L0.5251.00
165_I186_N0.5221.00
12_V318_F0.5221.00
136_D308_L0.5211.00
277_I281_G0.5211.00
59_E329_R0.5211.00
199_L213_S0.5211.00
243_N268_D0.5191.00
290_L294_F0.5181.00
59_E145_C0.5171.00
11_H315_N0.5161.00
176_L302_V0.5161.00
154_V180_Y0.5151.00
19_L122_I0.5141.00
29_L128_A0.5141.00
300_G303_V0.5121.00
149_T173_L0.5111.00
167_I178_L0.5081.00
146_A172_G0.5061.00
179_Q302_V0.5041.00
26_E113_V0.5021.00
20_R28_L0.5011.00
241_A244_S0.5011.00
55_I115_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gkvA 4 1 100 0.109 Contact Map
1rjwA 4 0.994 100 0.136 Contact Map
1h2bA 4 0.9851 100 0.142 Contact Map
3jv7A 4 0.9821 100 0.147 Contact Map
4ilkA 2 0.9821 100 0.151 Contact Map
4eezA 4 0.994 100 0.152 Contact Map
3s2eA 5 0.994 100 0.157 Contact Map
4oaqA 2 0.9881 100 0.158 Contact Map
2h6eA 4 0.9196 100 0.158 Contact Map
4ej6A 1 0.9821 100 0.16 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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