GREMLIN Database
TTDT - L-tartrate/succinate antiporter
UniProt: P39414 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12393
Length: 487 (412)
Sequences: 8858 (6015)
Seq/√Len: 296.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_S93_W4.8641.00
136_R139_F4.5751.00
361_S365_K4.4051.00
118_K330_D4.3391.00
296_A316_V3.6021.00
93_W356_N3.2161.00
128_I132_K3.2111.00
457_A461_R2.9471.00
209_L219_I2.9061.00
43_V61_G2.8341.00
128_I131_K2.8231.00
148_E166_I2.7731.00
231_S234_D2.7651.00
455_P458_D2.7421.00
327_S330_D2.7281.00
298_V302_F2.6391.00
275_E278_A2.5361.00
287_K291_G2.5351.00
107_F341_F2.5331.00
37_F359_F2.5211.00
138_L255_Y2.5151.00
191_S458_D2.4731.00
329_D334_N2.4641.00
115_G320_M2.3951.00
34_W38_A2.3901.00
302_F306_Y2.3621.00
375_S378_M2.3491.00
194_M448_Y2.3451.00
295_G299_L2.3381.00
292_L316_V2.3131.00
45_V49_L2.2911.00
458_D461_R2.2831.00
111_M317_V2.2431.00
290_L294_V2.2181.00
362_W366_L2.1911.00
149_L243_S2.1911.00
292_L319_L2.1811.00
284_S288_R2.1651.00
237_L241_P2.1301.00
39_V64_I2.1161.00
352_T356_N2.0421.00
195_W199_V2.0191.00
42_G46_G1.9551.00
386_V471_L1.9411.00
115_G289_M1.9361.00
112_F296_A1.8921.00
302_F305_D1.8831.00
233_G237_L1.8831.00
256_V259_P1.8821.00
366_L370_S1.8761.00
388_Y404_L1.8531.00
291_G295_G1.8491.00
389_L467_G1.8411.00
144_V170_I1.8311.00
236_F240_L1.8181.00
468_L472_V1.8131.00
170_I197_G1.8001.00
124_R128_I1.7981.00
62_I95_V1.7921.00
303_G306_Y1.7681.00
252_W256_V1.7601.00
476_I480_L1.7581.00
382_A475_V1.7461.00
282_L286_E1.7451.00
203_V246_L1.7391.00
46_G49_L1.7111.00
108_A317_V1.7061.00
207_I243_S1.6941.00
252_W255_Y1.6941.00
234_D237_L1.6721.00
150_I154_V1.6661.00
33_T359_F1.6571.00
108_A313_G1.6531.00
124_R286_E1.6531.00
39_V61_G1.6341.00
142_Y251_P1.6301.00
114_T117_E1.6221.00
46_G57_V1.6141.00
93_W96_S1.6131.00
292_L320_M1.6011.00
145_M200_A1.5831.00
249_L469_I1.5731.00
64_I68_L1.5701.00
98_F345_A1.5571.00
39_V65_I1.5491.00
148_E201_D1.5251.00
385_V430_A1.5231.00
426_M478_G1.5191.00
282_L285_R1.5151.00
274_T278_A1.5031.00
39_V68_L1.5021.00
35_L68_L1.5001.00
477_T481_W1.4931.00
244_I248_L1.4781.00
65_I353_G1.4741.00
107_F111_M1.4721.00
63_S318_A1.4621.00
276_L280_G1.4581.00
246_L470_F1.4471.00
200_A204_T1.4451.00
299_L306_Y1.4261.00
295_G319_L1.4241.00
52_V56_V1.4151.00
210_T232_W1.3991.00
374_Y378_M1.3981.00
43_V57_V1.3891.00
103_I341_F1.3891.00
253_L256_V1.3881.00
133_M143_A1.3841.00
365_K369_G1.3811.00
460_W464_A1.3721.00
354_L360_I1.3661.00
36_Y353_G1.3601.00
401_T431_I1.3591.00
392_Y397_A1.3431.00
52_V57_V1.3351.00
294_V298_V1.3261.00
35_L70_P1.3251.00
277_Q280_G1.3241.00
474_L478_G1.3211.00
281_P284_S1.3191.00
439_P449_Y1.3171.00
355_N361_S1.3101.00
33_T362_W1.3031.00
135_H139_F1.2991.00
152_A204_T1.2941.00
366_L369_G1.2901.00
55_A339_N1.2881.00
198_I448_Y1.2861.00
276_L282_L1.2761.00
37_F41_T1.2751.00
464_A468_L1.2721.00
253_L257_L1.2701.00
167_Y447_I1.2511.00
269_P273_E1.2371.00
240_L244_I1.2351.00
241_P477_T1.2341.00
390_L394_F1.2331.00
38_A42_G1.2251.00
437_L467_G1.2151.00
299_L312_V1.2101.00
270_R274_T1.2091.00
288_R291_G1.2091.00
476_I479_L1.2081.00
131_K273_E1.2081.00
204_T247_V1.2081.00
207_I240_L1.1891.00
134_G139_F1.1891.00
40_F354_L1.1841.00
144_V173_L1.1791.00
354_L359_F1.1791.00
292_L299_L1.1771.00
457_A460_W1.1771.00
114_T336_A1.1751.00
253_L469_I1.1731.00
393_F467_G1.1671.00
408_M427_V1.1611.00
117_E335_K1.1511.00
471_L475_V1.1481.00
145_M196_M1.1481.00
265_G268_V1.1461.00
371_L383_L1.1331.00
417_E423_F1.1321.00
283_C286_E1.1241.00
362_W365_K1.1221.00
234_D420_L1.1161.00
36_Y65_I1.1051.00
426_M430_A1.1021.00
62_I346_S1.1001.00
352_T355_N1.0991.00
245_L473_L1.0931.00
280_G283_C1.0921.00
58_A346_S1.0911.00
42_G64_I1.0821.00
137_T192_Y1.0821.00
289_M292_L1.0811.00
149_L247_V1.0741.00
157_S160_A1.0731.00
288_R323_L1.0711.00
108_A314_Y1.0701.00
123_R127_L1.0701.00
300_W303_G1.0701.00
145_M250_V1.0651.00
194_M454_L1.0581.00
222_M424_C1.0521.00
114_T335_K1.0481.00
405_A424_C1.0461.00
299_L303_G1.0441.00
292_L300_W1.0421.00
66_A94_A1.0421.00
278_A282_L1.0341.00
39_V43_V1.0311.00
124_R127_L1.0251.00
274_T277_Q1.0241.00
153_P207_I1.0171.00
285_R288_R1.0161.00
276_L279_M1.0141.00
96_S352_T1.0121.00
249_L473_L1.0111.00
409_I413_L1.0101.00
288_R292_L1.0091.00
386_V390_L1.0051.00
450_G453_Y1.0001.00
195_W462_L1.0001.00
396_S399_A0.9991.00
377_T479_L0.9981.00
344_L398_T0.9851.00
272_A276_L0.9831.00
59_M342_F0.9831.00
168_P172_N0.9791.00
60_V318_A0.9741.00
145_M247_V0.9731.00
376_P379_V0.9701.00
267_Q270_R0.9671.00
254_A258_Y0.9661.00
287_K290_L0.9661.00
43_V47_L0.9661.00
289_M293_M0.9651.00
282_L287_K0.9591.00
273_E276_L0.9581.00
97_G349_T0.9531.00
416_P419_P0.9501.00
53_P57_V0.9481.00
174_P193_I0.9401.00
327_S331_I0.9391.00
204_T211_A0.9381.00
284_S287_K0.9361.00
94_A349_T0.9341.00
373_G376_P0.9331.00
384_I427_V0.9271.00
47_L58_A0.9241.00
383_L387_F0.9221.00
393_F437_L0.9221.00
213_A398_T0.9191.00
91_L94_A0.9181.00
41_T45_V0.9121.00
158_N205_S0.9111.00
157_S398_T0.9031.00
116_Y121_L0.8991.00
162_G201_D0.8961.00
62_I66_A0.8961.00
172_N176_L0.8911.00
141_G193_I0.8901.00
280_G284_S0.8871.00
101_S310_A0.8851.00
270_R273_E0.8841.00
281_P285_R0.8831.00
278_A281_P0.8821.00
369_G372_S0.8801.00
337_A340_V0.8801.00
248_L252_W0.8791.00
138_L251_P0.8761.00
250_V254_A0.8731.00
274_T280_G0.8711.00
296_A299_L0.8711.00
472_V476_I0.8701.00
393_F441_A0.8681.00
437_L464_A0.8661.00
413_L419_P0.8641.00
205_S212_M0.8621.00
308_D311_M0.8611.00
385_V471_L0.8601.00
365_K368_A0.8521.00
393_F434_G0.8481.00
203_V250_V0.8471.00
90_S94_A0.8471.00
437_L460_W0.8471.00
281_P287_K0.8451.00
214_P432_G0.8441.00
239_M429_A0.8431.00
292_L303_G0.8431.00
277_Q282_L0.8421.00
106_I398_T0.8401.00
101_S308_D0.8391.00
272_A275_E0.8391.00
438_T441_A0.8361.00
205_S208_F0.8351.00
279_M282_L0.8351.00
315_S318_A0.8351.00
391_R400_Y0.8331.00
410_A413_L0.8331.00
151_L161_R0.8321.00
439_P446_P0.8311.00
242_L473_L0.8301.00
58_A62_I0.8291.00
147_S166_I0.8291.00
396_S434_G0.8291.00
258_Y462_L0.8281.00
218_L428_G0.8261.00
463_G466_F0.8241.00
299_L315_S0.8241.00
217_L405_A0.8221.00
232_W236_F0.8221.00
410_A414_A0.8211.00
288_R325_I0.8201.00
299_L302_F0.8161.00
418_I421_P0.8161.00
123_R275_E0.8141.00
280_G286_E0.8131.00
392_Y441_A0.8121.00
43_V350_L0.8121.00
92_S96_S0.8111.00
163_A447_I0.8111.00
293_M300_W0.8091.00
54_G57_V0.8081.00
275_E280_G0.8041.00
398_T401_T0.8011.00
397_A434_G0.8001.00
288_R300_W0.7991.00
65_I350_L0.7930.99
429_A474_L0.7910.99
296_A300_W0.7850.99
467_G470_F0.7800.99
300_W313_G0.7800.99
275_E279_M0.7760.99
381_V426_M0.7760.99
70_P353_G0.7750.99
206_A433_L0.7750.99
397_A441_A0.7730.99
206_A243_S0.7720.99
235_W425_L0.7720.99
55_A62_I0.7720.99
434_G441_A0.7680.99
458_D462_L0.7680.99
289_M300_W0.7680.99
212_M215_N0.7660.99
194_M197_G0.7650.99
208_F211_A0.7650.99
207_I236_F0.7630.99
265_G270_R0.7630.99
49_L52_V0.7630.99
275_E281_P0.7600.99
384_I408_M0.7530.99
100_N220_G0.7530.99
214_P398_T0.7530.99
179_S193_I0.7500.99
54_G58_A0.7500.99
109_A296_A0.7470.99
90_S356_N0.7470.99
214_P442_T0.7440.99
279_M283_C0.7430.99
218_L405_A0.7420.99
202_C435_S0.7400.99
465_I469_I0.7390.99
385_V426_M0.7380.99
247_V251_P0.7380.99
276_L284_S0.7360.99
60_V63_S0.7330.99
170_I193_I0.7330.99
40_F350_L0.7320.99
130_V173_L0.7280.99
272_A280_G0.7270.99
152_A211_A0.7260.99
280_G285_R0.7260.99
152_A158_N0.7250.99
297_L300_W0.7210.99
370_S373_G0.7160.99
55_A58_A0.7150.99
368_A372_S0.7150.99
292_L296_A0.7150.99
317_V321_L0.7110.99
159_S212_M0.7110.99
62_I349_T0.7100.99
161_R201_D0.7070.99
209_L236_F0.7070.99
398_T442_T0.7070.99
386_V475_V0.7060.99
104_W345_A0.7060.99
382_A471_L0.7050.99
398_T443_G0.7020.99
261_V264_S0.7020.99
65_I70_P0.6990.99
191_S195_W0.6980.99
264_S268_V0.6960.99
47_L57_V0.6960.99
152_A205_S0.6960.99
36_Y357_T0.6950.99
124_R280_G0.6950.99
249_L253_L0.6910.99
105_L313_G0.6890.99
212_M432_G0.6890.99
56_V60_V0.6890.99
158_N211_A0.6890.99
107_F336_A0.6860.98
379_V423_F0.6860.98
307_I312_V0.6860.98
273_E281_P0.6840.98
340_V398_T0.6830.98
442_T445_S0.6830.98
196_M200_A0.6830.98
71_W349_T0.6830.98
60_V64_I0.6830.98
279_M284_S0.6820.98
324_R327_S0.6820.98
276_L281_P0.6810.98
46_G60_V0.6810.98
198_I444_P0.6800.98
94_A97_G0.6780.98
250_V466_F0.6770.98
364_G368_A0.6770.98
268_V272_A0.6740.98
371_L374_Y0.6730.98
277_Q285_R0.6730.98
348_I402_S0.6730.98
406_P409_I0.6720.98
54_G396_S0.6710.98
59_M346_S0.6710.98
62_I65_I0.6700.98
94_A98_F0.6690.98
396_S400_Y0.6690.98
278_A284_S0.6660.98
392_Y434_G0.6650.98
103_I345_A0.6650.98
44_I47_L0.6650.98
301_I305_D0.6640.98
61_G65_I0.6630.98
390_L467_G0.6630.98
115_G325_I0.6620.98
300_W304_G0.6610.98
214_P401_T0.6610.98
409_I412_A0.6590.98
36_Y70_P0.6570.98
240_L243_S0.6560.98
146_F150_I0.6560.98
236_F241_P0.6540.98
392_Y396_S0.6540.98
262_L265_G0.6530.98
171_R175_P0.6530.98
245_L477_T0.6520.98
286_E299_L0.6510.98
45_V51_P0.6500.98
251_P255_Y0.6490.98
215_N432_G0.6480.98
114_T118_K0.6480.98
281_P286_E0.6450.98
46_G51_P0.6450.98
269_P272_A0.6430.98
50_E449_Y0.6420.98
221_L405_A0.6400.98
309_A313_G0.6350.98
325_I328_W0.6350.98
249_L252_W0.6340.97
167_Y194_M0.6340.97
342_F346_S0.6330.97
218_L401_T0.6310.97
242_L246_L0.6290.97
35_L39_V0.6280.97
388_Y431_I0.6260.97
214_P344_L0.6260.97
128_I276_L0.6240.97
222_M229_T0.6230.97
326_I331_I0.6230.97
215_N235_W0.6220.97
309_A312_V0.6220.97
103_I344_L0.6220.97
162_G448_Y0.6200.97
97_G352_T0.6170.97
106_I110_F0.6160.97
66_A311_M0.6160.97
42_G49_L0.6150.97
207_I211_A0.6130.97
217_L402_S0.6120.97
112_F320_M0.6110.97
271_W275_E0.6110.97
219_I229_T0.6100.97
119_T289_M0.6100.97
204_T208_F0.6090.97
238_G477_T0.6090.97
50_E54_G0.6070.97
91_L95_V0.6050.97
96_S99_S0.6040.97
69_S94_A0.6040.97
387_F391_R0.6030.97
209_L216_L0.6010.97
96_S100_N0.6000.97
345_A349_T0.5990.96
429_A433_L0.5990.96
44_I394_F0.5970.96
241_P245_L0.5970.96
382_A386_V0.5960.96
388_Y427_V0.5910.96
241_P244_I0.5900.96
131_K276_L0.5900.96
465_I468_L0.5900.96
389_L471_L0.5900.96
112_F316_V0.5890.96
48_I51_P0.5880.96
148_E161_R0.5880.96
330_D334_N0.5880.96
433_L470_F0.5860.96
106_I344_L0.5850.96
297_L301_I0.5840.96
413_L416_P0.5840.96
50_E53_P0.5830.96
198_I202_C0.5830.96
286_E290_L0.5820.96
202_C444_P0.5820.96
158_N210_T0.5800.96
159_S205_S0.5800.96
242_L477_T0.5790.96
286_E297_L0.5790.96
158_N201_D0.5770.96
161_R166_I0.5760.96
367_L387_F0.5740.96
289_M296_A0.5740.96
162_G444_P0.5740.96
440_Y456_T0.5730.95
263_K267_Q0.5710.95
105_L157_S0.5700.95
330_D335_K0.5700.95
268_V273_E0.5690.95
203_V247_V0.5680.95
38_A41_T0.5670.95
263_K266_D0.5660.95
180_Q191_S0.5650.95
434_G442_T0.5650.95
297_L303_G0.5640.95
118_K326_I0.5640.95
218_L424_C0.5640.95
301_I306_Y0.5630.95
199_V250_V0.5630.95
464_A467_G0.5620.95
157_S161_R0.5620.95
158_N212_M0.5610.95
196_M254_A0.5610.95
44_I395_A0.5590.95
123_R176_L0.5580.95
228_A234_D0.5580.95
375_S383_L0.5570.95
167_Y451_S0.5570.95
315_S319_L0.5570.95
284_S291_G0.5570.95
66_A69_S0.5560.95
145_M251_P0.5550.95
63_S314_Y0.5520.94
102_V106_I0.5520.94
388_Y400_Y0.5510.94
385_V474_L0.5500.94
159_S396_S0.5480.94
46_G52_V0.5480.94
328_W331_I0.5470.94
198_I445_S0.5460.94
370_S374_Y0.5460.94
288_R302_F0.5450.94
238_G482_M0.5440.94
417_E421_P0.5410.94
141_G192_Y0.5410.94
289_M299_L0.5400.94
462_L465_I0.5380.94
47_L347_L0.5380.94
114_T334_N0.5380.94
254_A462_L0.5380.94
217_L398_T0.5370.94
354_L357_T0.5370.94
266_D269_P0.5370.94
288_R303_G0.5350.94
212_M442_T0.5340.93
148_E200_A0.5340.93
425_L429_A0.5340.93
95_V99_S0.5330.93
222_M228_A0.5330.93
428_G432_G0.5320.93
235_W428_G0.5300.93
141_G251_P0.5300.93
377_T476_I0.5300.93
293_M299_L0.5290.93
354_L403_A0.5280.93
272_A277_Q0.5270.93
475_V479_L0.5270.93
219_I230_L0.5250.93
143_A220_G0.5240.93
351_A449_Y0.5240.93
32_H35_L0.5230.93
211_A214_P0.5230.93
152_A161_R0.5220.93
191_S258_Y0.5220.93
289_M298_V0.5220.93
232_W235_W0.5210.93
71_W94_A0.5210.93
160_A235_W0.5200.93
466_F469_I0.5200.93
138_L142_Y0.5190.92
142_Y146_F0.5190.92
148_E197_G0.5180.92
117_E122_G0.5160.92
293_M297_L0.5160.92
397_A400_Y0.5160.92
274_T284_S0.5150.92
467_G471_L0.5150.92
397_A442_T0.5150.92
275_E284_S0.5140.92
471_L474_L0.5130.92
105_L109_A0.5120.92
326_I329_D0.5120.92
71_W90_S0.5120.92
446_P449_Y0.5120.92
144_V148_E0.5110.92
287_K298_V0.5110.92
43_V46_G0.5100.92
277_Q283_C0.5100.92
241_P481_W0.5090.92
254_A257_L0.5080.92
246_L433_L0.5080.92
412_A415_M0.5070.92
245_L469_I0.5070.92
358_G361_S0.5060.92
274_T279_M0.5060.92
388_Y430_A0.5050.91
91_L311_M0.5050.91
36_Y354_L0.5040.91
158_N214_P0.5030.91
112_F317_V0.5030.91
401_T427_V0.5020.91
94_A99_S0.5010.91
152_A155_T0.5010.91
303_G308_D0.5000.91
442_T446_P0.5000.91
116_Y155_T0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8789 100 0.389 Contact Map
4r1iA 2 0.9097 100 0.662 Contact Map
4r0cA 3 0.8563 99.9 0.729 Contact Map
2m20A 2 0.1232 21 0.966 Contact Map
2ksfA 1 0.2197 15.8 0.968 Contact Map
4pd6A 3 0.7721 11.7 0.97 Contact Map
1ldfA 3 0.4517 8.6 0.972 Contact Map
3tdsE 3 0.4682 7.7 0.972 Contact Map
2rddB 1 0.0739 6.2 0.973 Contact Map
3l1lA 2 0.4066 5.9 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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