GREMLIN Database
NCPP - Non-canonical purine NTP phosphatase
UniProt: P39411 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12600
Length: 170 (161)
Sequences: 592 (430)
Seq/√Len: 33.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_K118_E3.6721.00
113_K126_R3.0381.00
15_Q18_L2.9311.00
6_C32_I2.8941.00
5_V69_A2.6811.00
4_V21_F2.5411.00
132_E135_R2.5211.00
113_K123_V2.4751.00
37_V61_N2.4371.00
124_M139_A2.3190.99
19_Q151_A2.2960.99
42_P50_E2.2680.99
84_T104_L2.1390.99
118_E126_R2.1060.99
19_Q155_H2.0730.98
18_L31_H2.0400.98
52_R98_E2.0100.98
86_S154_Y1.9530.98
56_R96_R1.9240.97
118_E122_P1.8260.96
110_I127_Y1.8140.96
151_A155_H1.7920.96
7_A59_V1.7870.96
17_I75_I1.7610.96
40_G61_N1.7570.96
59_V74_A1.7140.95
35_V62_A1.7090.95
12_A151_A1.6410.94
20_A159_I1.6130.93
43_E122_P1.6050.93
11_P135_R1.5940.93
5_V62_A1.5790.92
48_S87_W1.5480.91
128_T142_V1.5450.91
48_S103_T1.5370.91
23_E155_H1.5130.91
100_R103_T1.5070.90
130_I137_E1.4790.89
3_Q31_H1.4740.89
157_A161_A1.4590.89
39_S57_N1.4550.89
3_Q33_A1.4370.88
102_A156_Q1.4350.88
24_I73_V1.4300.88
56_R89_V1.4210.88
118_E123_V1.4190.87
81_G98_E1.3480.85
97_G165_F1.3320.84
130_I142_V1.3300.84
47_G114_V1.3270.84
125_S130_I1.3230.83
124_M133_I1.3090.83
21_F162_L1.3080.83
88_V158_V1.3050.83
83_S98_E1.3040.83
102_A160_L1.2980.82
11_P121_G1.2970.82
5_V34_S1.2800.81
14_I34_S1.2610.80
9_T36_A1.2350.79
49_E53_A1.1530.74
86_S157_A1.1490.74
41_V57_N1.1420.73
18_L22_H1.1390.73
140_I160_L1.1380.73
8_T12_A1.1360.73
12_A153_V1.1230.72
97_G161_A1.0950.70
82_D111_L1.0920.70
6_C17_I1.0910.70
9_T14_I1.0900.70
62_A74_A1.0860.69
106_L120_L1.0790.69
134_G154_Y1.0570.67
48_S100_R1.0530.67
15_Q151_A1.0380.66
24_I162_L1.0310.65
59_V72_W1.0260.65
7_A72_W1.0150.64
106_L139_A1.0130.64
6_C12_A1.0050.63
161_A164_P1.0040.63
77_A141_G0.9930.62
53_A56_R0.9890.62
108_A112_E0.9850.62
77_A140_I0.9680.60
36_A43_E0.9610.60
20_A162_L0.9520.59
125_S134_G0.9520.59
101_S153_V0.9350.58
21_F71_F0.9330.57
22_H29_S0.9330.57
8_T125_S0.9230.57
144_T163_S0.9200.56
86_S134_G0.9160.56
119_A125_S0.9060.55
77_A120_L0.9050.55
79_I82_D0.8860.54
8_T34_S0.8850.53
128_T133_I0.8790.53
42_P47_G0.8790.53
81_G114_V0.8730.52
11_P21_F0.8690.52
121_G135_R0.8680.52
63_R94_S0.8640.52
99_A106_L0.8630.52
60_A64_R0.8540.51
21_F25_F0.8530.51
112_E116_E0.8450.50
86_S101_S0.8450.50
52_R89_V0.8440.50
11_P132_E0.8430.50
116_E131_D0.8420.50
53_A60_A0.8260.48
99_A157_A0.8190.48
7_A98_E0.8150.48
71_F132_E0.8140.47
3_Q29_S0.8020.46
104_L153_V0.7990.46
59_V62_A0.7960.46
148_L156_Q0.7950.46
84_T154_Y0.7880.45
148_L160_L0.7860.45
55_A78_G0.7840.45
63_R72_W0.7820.45
15_Q19_Q0.7770.44
6_C34_S0.7700.44
125_S128_T0.7660.43
132_E144_T0.7630.43
149_T152_S0.7570.43
158_V165_F0.7540.42
5_V33_A0.7520.42
70_D146_G0.7520.42
113_K116_E0.7470.42
117_G121_G0.7470.42
18_L131_D0.7390.41
124_M153_V0.7330.41
86_S153_V0.7280.40
87_W148_L0.7260.40
7_A16_A0.7240.40
99_A156_Q0.7190.40
15_Q112_E0.7190.40
121_G124_M0.7180.40
24_I166_H0.7170.39
21_F73_V0.7140.39
46_F114_V0.7090.39
87_W99_A0.7070.39
99_A153_V0.7060.39
3_Q71_F0.7040.38
140_I153_V0.6970.38
10_N138_G0.6960.38
110_I137_E0.6930.38
77_A84_T0.6930.38
49_E116_E0.6930.38
46_F82_D0.6920.37
56_R123_V0.6890.37
63_R69_A0.6890.37
88_V161_A0.6790.36
17_I72_W0.6790.36
81_G105_P0.6690.36
86_S123_V0.6690.36
156_Q160_L0.6690.36
4_V64_R0.6660.35
41_V54_G0.6650.35
101_S124_M0.6620.35
11_P119_A0.6610.35
85_F154_Y0.6600.35
125_S132_E0.6580.35
123_V126_R0.6580.35
85_F100_R0.6560.35
44_Q139_A0.6520.34
40_G60_A0.6500.34
51_T139_A0.6470.34
43_E118_E0.6460.34
101_S154_Y0.6440.34
6_C14_I0.6430.34
90_I110_I0.6380.33
56_R60_A0.6360.33
26_G30_C0.6320.33
111_L115_R0.6300.33
97_G164_P0.6280.33
75_I154_Y0.6210.32
37_V40_G0.6190.32
148_L159_I0.6160.32
130_I133_I0.6160.32
41_V50_E0.6160.32
4_V111_L0.6150.32
38_E42_P0.6140.31
79_I110_I0.6110.31
77_A154_Y0.6110.31
19_Q22_H0.6090.31
48_S80_D0.6080.31
50_E90_I0.6070.31
157_A165_F0.6050.31
71_F147_K0.6000.30
99_A160_L0.6000.30
44_Q51_T0.5980.30
36_A61_N0.5980.30
38_E110_I0.5950.30
79_I98_E0.5950.30
70_D151_A0.5910.30
157_A164_P0.5870.30
109_V112_E0.5840.29
107_P121_G0.5840.29
4_V136_K0.5780.29
148_L153_V0.5780.29
51_T78_G0.5750.29
49_E68_E0.5720.29
47_G161_A0.5710.28
40_G57_N0.5700.28
59_V92_N0.5700.28
17_I23_E0.5700.28
87_W100_R0.5700.28
121_G160_L0.5680.28
52_R56_R0.5680.28
8_T17_I0.5640.28
124_M160_L0.5620.28
33_A63_R0.5500.27
9_T42_P0.5410.26
133_I142_V0.5330.26
51_T164_P0.5320.26
17_I32_I0.5310.26
59_V89_V0.5300.26
30_C36_A0.5300.26
82_D87_W0.5280.26
152_S159_I0.5270.26
125_S165_F0.5260.25
104_L163_S0.5250.25
52_R122_P0.5230.25
47_G89_V0.5210.25
84_T101_S0.5210.25
102_A148_L0.5200.25
51_T79_I0.5180.25
114_V155_H0.5180.25
128_T143_F0.5140.25
62_A72_W0.5130.25
72_W84_T0.5110.25
86_S128_T0.5100.24
48_S85_F0.5080.24
57_N125_S0.5060.24
121_G134_G0.5040.24
51_T86_S0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u14A 1 0.9882 100 0.042 Contact Map
1zwyA 4 1 100 0.07 Contact Map
3brcA 4 0.7 71.3 0.932 Contact Map
1k7kA 1 0.7588 61.8 0.936 Contact Map
3wb0A 4 0.7059 61.5 0.936 Contact Map
3tquA 2 0.7588 56.4 0.938 Contact Map
2carA 2 0.7118 53.4 0.939 Contact Map
4bnqA 2 0.7353 46.6 0.942 Contact Map
1b78A 2 0.6941 40.5 0.944 Contact Map
1vp2A 3 0.7294 40.1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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