GREMLIN Database
YJJJ - Putative kinase YjjJ
UniProt: P39410 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12342
Length: 443 (340)
Sequences: 2007 (1590)
Seq/√Len: 86.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_E277_E5.3911.00
326_A412_R4.9601.00
249_A262_S4.4011.00
77_A89_L3.9841.00
330_V419_A3.5471.00
246_S262_S3.4711.00
290_I349_S3.4001.00
250_Q253_R3.3131.00
290_I363_Y3.2971.00
253_R261_E3.2641.00
248_A338_I3.2471.00
330_V416_I3.0821.00
351_Y360_T3.0511.00
258_H327_Q3.0501.00
324_S358_A2.9711.00
334_F338_I2.9021.00
257_I362_V2.7581.00
246_S250_Q2.7501.00
318_Q324_S2.5621.00
293_L310_A2.5451.00
292_S363_Y2.5381.00
75_K92_G2.5061.00
329_E413_D2.4661.00
315_C325_V2.4241.00
110_L159_V2.3991.00
254_D430_K2.3961.00
362_V365_M2.3941.00
282_K285_D2.3371.00
403_A413_D2.3251.00
260_I276_A2.3091.00
396_W418_E2.3021.00
321_T324_S2.2851.00
349_S363_Y2.2701.00
265_L275_E2.2621.00
252_L365_M2.2321.00
426_E429_E2.2301.00
79_I107_L2.1931.00
243_I272_V2.1921.00
353_S358_A2.1851.00
331_I362_V2.1391.00
177_P180_Q2.1031.00
182_L270_R2.0961.00
182_L269_N2.0641.00
158_L287_R2.0161.00
290_I351_Y2.0041.00
214_Q218_G1.9931.00
251_I427_M1.9931.00
294_E345_A1.9801.00
117_G121_G1.9551.00
388_D398_T1.9201.00
255_G423_I1.8891.00
327_Q331_I1.8691.00
400_I414_P1.8671.00
249_A259_A1.8651.00
352_L355_P1.8191.00
141_D144_Y1.7671.00
224_V275_E1.7501.00
118_R122_R1.7251.00
69_D73_A1.7241.00
113_Q205_E1.7161.00
68_D163_N1.7131.00
174_A180_Q1.6981.00
249_A260_I1.6921.00
311_M406_F1.6671.00
222_V277_E1.6321.00
327_Q330_V1.6281.00
310_A328_T1.6271.00
242_L264_V1.6231.00
262_S276_A1.6101.00
400_I413_D1.5961.00
255_G424_A1.5721.00
414_P418_E1.5601.00
81_L141_D1.5531.00
418_E421_R1.5491.00
320_V323_Q1.5411.00
250_Q433_Q1.5261.00
336_R399_A1.5121.00
267_T270_R1.4960.99
336_R387_F1.4930.99
258_H358_A1.4570.99
288_L351_Y1.4570.99
252_L334_F1.4400.99
156_G289_P1.4270.99
244_A367_P1.4130.99
311_M325_V1.4100.99
291_V295_A1.4090.99
249_A274_L1.4000.99
68_D75_K1.3900.99
415_R419_A1.3800.99
331_I348_L1.3760.99
314_L328_T1.3730.99
333_A416_I1.3710.99
400_I403_A1.3320.99
251_I338_I1.3180.99
337_L421_R1.3150.99
307_W332_W1.2970.99
246_S264_V1.2930.99
255_G420_F1.2810.98
383_I394_S1.2610.98
260_I274_L1.2480.98
430_K433_Q1.2450.98
213_A263_T1.2360.98
390_N398_T1.1980.98
425_Q429_E1.1950.98
203_G292_S1.1900.97
70_T160_G1.1850.97
267_T272_V1.1840.97
75_K78_D1.1830.97
296_V350_F1.1830.97
81_L87_S1.1780.97
254_D426_E1.1770.97
222_V275_E1.1730.97
416_I419_A1.1570.97
402_L406_F1.1560.97
343_M348_L1.1520.97
250_Q262_S1.1440.97
410_V414_P1.1440.97
139_E144_Y1.1370.97
247_I430_K1.1320.97
255_G334_F1.1310.97
254_D434_I1.1300.96
305_G345_A1.1200.96
396_W414_P1.1190.96
80_R88_C1.1170.96
311_M328_T1.0990.96
78_D90_V1.0940.96
67_V71_G1.0920.96
257_I330_V1.0810.95
425_Q428_P1.0760.95
326_A330_V1.0700.95
73_A158_L1.0610.95
337_L420_F1.0440.95
430_K434_I1.0400.94
202_A223_L1.0380.94
220_K277_E1.0360.94
246_S274_L1.0320.94
145_A148_V1.0310.94
341_S368_M1.0310.94
176_I184_H1.0270.94
390_N393_K1.0220.94
180_Q183_T1.0150.94
138_Q141_D1.0130.94
182_L186_E1.0080.93
182_L185_Y1.0080.93
318_Q321_T1.0040.93
296_V313_R1.0040.93
285_D420_F0.9990.93
253_R259_A0.9950.93
412_R416_I0.9890.93
250_Q254_D0.9850.93
202_A210_T0.9840.93
244_A248_A0.9820.93
314_L324_S0.9820.93
109_D292_S0.9710.92
110_L295_A0.9700.92
291_V352_L0.9690.92
80_R90_V0.9600.92
209_F226_F0.9540.91
329_E333_A0.9520.91
106_Y291_V0.9440.91
78_D92_G0.9380.91
314_L318_Q0.9320.90
332_W402_L0.9310.90
426_E430_K0.9300.90
111_R346_G0.9300.90
412_R415_R0.9260.90
301_I346_G0.9250.90
206_Q343_M0.9250.90
279_F290_I0.9240.90
335_G343_M0.9210.90
341_S366_L0.9210.90
107_L159_V0.9140.90
344_H364_D0.9090.89
259_A262_S0.9060.89
257_I331_I0.9060.89
400_I417_S0.9030.89
265_L268_S0.9030.89
211_Y224_V0.9020.89
109_D343_M0.8990.89
109_D295_A0.8990.89
297_Q313_R0.8960.89
225_K245_E0.8950.89
69_D89_L0.8850.88
310_A348_L0.8810.88
423_I430_K0.8810.88
306_S385_V0.8780.88
332_W406_F0.8740.87
343_M357_F0.8740.87
313_R316_E0.8600.87
324_S327_Q0.8600.87
427_M431_I0.8570.86
90_V93_A0.8560.86
329_E417_S0.8530.86
175_E182_L0.8510.86
210_T223_L0.8490.86
429_E433_Q0.8460.86
314_L350_F0.8440.86
342_D364_D0.8370.85
77_A92_G0.8330.85
87_S102_G0.8330.85
109_D279_F0.8300.85
224_V273_F0.8260.84
307_W328_T0.8210.84
70_T75_K0.8200.84
338_I365_M0.8180.84
311_M402_L0.8170.84
320_V358_A0.8170.84
225_K347_N0.8160.84
417_S421_R0.8160.84
106_Y295_A0.8160.84
208_K344_H0.8160.84
292_S346_G0.8160.84
225_K344_H0.8150.83
82_C88_C0.8130.83
384_E387_F0.8120.83
291_V350_F0.8100.83
177_P181_K0.8070.83
282_K288_L0.8070.83
337_L418_E0.8050.83
108_T301_I0.8050.83
388_D401_P0.8040.83
245_E347_N0.8040.83
205_E292_S0.7980.82
179_D184_H0.7980.82
294_E301_I0.7980.82
77_A107_L0.7970.82
251_I430_K0.7960.82
241_L366_L0.7950.82
411_A426_E0.7930.82
199_G226_F0.7930.82
337_L424_A0.7920.82
249_A276_A0.7920.82
416_I420_F0.7920.82
255_G333_A0.7910.82
292_S349_S0.7910.82
174_A178_L0.7880.81
428_P431_I0.7850.81
335_G365_M0.7820.81
245_E344_H0.7810.81
422_H429_E0.7810.81
307_W343_M0.7800.81
403_A410_V0.7790.81
274_L338_I0.7780.81
160_G166_R0.7770.80
152_E281_C0.7760.80
248_A367_P0.7750.80
314_L325_V0.7750.80
109_D203_G0.7720.80
259_A276_A0.7690.80
335_G340_N0.7650.79
257_I334_F0.7640.79
246_S249_A0.7630.79
420_F423_I0.7620.79
176_I285_D0.7600.79
428_P433_Q0.7560.79
114_G302_S0.7560.79
107_L205_E0.7550.79
281_C295_A0.7530.78
396_W417_S0.7530.78
175_E179_D0.7520.78
323_Q358_A0.7500.78
414_P417_S0.7490.78
404_Q410_V0.7490.78
183_T186_E0.7480.78
109_D207_P0.7470.78
71_G76_F0.7410.77
330_V423_I0.7400.77
324_S328_T0.7390.77
177_P218_G0.7370.77
243_I264_V0.7330.76
329_E403_A0.7320.76
332_W335_G0.7320.76
351_Y357_F0.7300.76
393_K396_W0.7290.76
347_N364_D0.7250.76
334_F365_M0.7250.76
251_I334_F0.7210.75
344_H347_N0.7210.75
227_T232_T0.7150.75
180_Q184_H0.7140.75
337_L396_W0.7140.75
292_S295_A0.7140.75
252_L259_A0.7130.74
308_P405_Q0.7120.74
386_K391_V0.7100.74
201_S281_C0.7090.74
195_G199_G0.7090.74
414_P429_E0.7000.73
181_K185_Y0.7000.73
115_F343_M0.6980.73
153_Y295_A0.6950.73
214_Q220_K0.6930.72
199_G203_G0.6930.72
403_A408_Q0.6930.72
144_Y147_T0.6910.72
108_T117_G0.6910.72
289_P335_G0.6910.72
290_I360_T0.6900.72
420_F424_A0.6880.72
205_E346_G0.6870.72
141_D223_L0.6850.71
288_L360_T0.6850.71
67_V292_S0.6840.71
248_A365_M0.6830.71
307_W340_N0.6820.71
103_L108_T0.6820.71
338_I424_A0.6810.71
115_F207_P0.6810.71
314_L319_L0.6780.71
186_E190_S0.6780.71
428_P432_R0.6780.71
327_Q359_L0.6770.71
85_Q139_E0.6760.70
202_A351_Y0.6740.70
113_Q346_G0.6740.70
333_A399_A0.6730.70
333_A417_S0.6730.70
113_Q343_M0.6720.70
208_K225_K0.6710.70
324_S359_L0.6680.70
208_K245_E0.6670.69
176_I232_T0.6630.69
221_H290_I0.6620.69
345_A385_V0.6610.69
203_G244_A0.6590.69
74_H92_G0.6590.69
293_L350_F0.6570.68
117_G120_W0.6570.68
203_G343_M0.6570.68
109_D113_Q0.6560.68
84_P220_K0.6540.68
323_Q426_E0.6540.68
139_E143_L0.6530.68
154_T279_F0.6520.68
109_D206_Q0.6500.67
329_E399_A0.6440.67
89_L107_L0.6440.67
283_G286_G0.6440.67
429_E432_R0.6420.67
70_T166_R0.6420.67
181_K187_Q0.6400.66
95_G99_W0.6400.66
407_W419_A0.6390.66
176_I181_K0.6390.66
419_A426_E0.6380.66
253_R258_H0.6370.66
326_A416_I0.6360.66
219_N315_C0.6360.66
228_V241_L0.6350.66
106_Y157_W0.6340.66
260_I290_I0.6340.66
334_F420_F0.6340.66
421_R425_Q0.6330.65
109_D331_I0.6320.65
220_K263_T0.6320.65
207_P340_N0.6320.65
310_A314_L0.6300.65
91_T108_T0.6300.65
109_D357_F0.6290.65
367_P370_Y0.6260.65
284_N358_A0.6250.64
208_K279_F0.6240.64
292_S367_P0.6200.64
175_E178_L0.6190.64
395_A398_T0.6190.64
399_A406_F0.6180.64
111_R149_F0.6180.64
247_I427_M0.6170.63
208_K347_N0.6160.63
419_A423_I0.6150.63
352_L357_F0.6150.63
106_Y159_V0.6150.63
259_A327_Q0.6100.63
291_V357_F0.6100.63
417_S420_F0.6090.62
83_W157_W0.6070.62
337_L414_P0.6070.62
113_Q203_G0.6040.62
200_S399_A0.6030.62
340_N343_M0.6030.62
208_K364_D0.6020.62
153_Y343_M0.6020.62
248_A366_L0.6000.61
323_Q326_A0.6000.61
173_P176_I0.5980.61
330_V420_F0.5970.61
106_Y222_V0.5970.61
319_L358_A0.5950.61
70_T73_A0.5940.61
113_Q292_S0.5900.60
332_W343_M0.5890.60
294_E346_G0.5880.60
178_L181_K0.5870.60
69_D159_V0.5870.60
253_R263_T0.5860.60
314_L359_L0.5850.59
140_E348_L0.5820.59
391_V398_T0.5820.59
328_T359_L0.5820.59
274_L279_F0.5810.59
383_I389_L0.5800.59
388_D402_L0.5800.59
322_H412_R0.5790.59
120_W145_A0.5780.58
200_S203_G0.5760.58
353_S356_P0.5760.58
225_K364_D0.5750.58
160_G163_N0.5750.58
245_E364_D0.5740.58
119_A122_R0.5740.58
312_R316_E0.5730.58
222_V274_L0.5720.58
423_I427_M0.5710.58
202_A293_L0.5700.57
354_E432_R0.5700.57
99_W294_E0.5700.57
154_T289_P0.5670.57
260_I362_V0.5660.57
271_Q408_Q0.5660.57
113_Q206_Q0.5650.57
383_I387_F0.5650.57
193_L363_Y0.5650.57
109_D231_Q0.5640.57
140_E145_A0.5630.57
331_I335_G0.5620.56
96_D142_V0.5620.56
177_P185_Y0.5610.56
195_G206_Q0.5600.56
111_R150_N0.5600.56
137_W148_V0.5590.56
252_L335_G0.5570.56
259_A362_V0.5570.56
138_Q337_L0.5550.55
254_D433_Q0.5530.55
201_S205_E0.5510.55
93_A183_T0.5470.54
115_F118_R0.5470.54
341_S381_A0.5460.54
110_L145_A0.5460.54
225_K363_Y0.5440.54
252_L257_I0.5410.54
156_G201_S0.5410.54
400_I411_A0.5410.54
208_K342_D0.5400.53
312_R400_I0.5390.53
225_K342_D0.5390.53
145_A383_I0.5390.53
310_A313_R0.5390.53
327_Q419_A0.5380.53
185_Y189_A0.5380.53
94_D171_Q0.5370.53
401_P405_Q0.5350.53
307_W329_E0.5340.53
179_D185_Y0.5340.53
279_F344_H0.5340.53
293_L328_T0.5330.53
299_E309_Q0.5320.52
179_D183_T0.5290.52
209_F340_N0.5290.52
117_G122_R0.5280.52
113_Q348_L0.5280.52
114_G340_N0.5280.52
188_L191_D0.5260.52
386_K392_S0.5250.51
122_R408_Q0.5250.51
114_G209_F0.5250.51
173_P179_D0.5250.51
333_A411_A0.5250.51
107_L146_L0.5240.51
231_Q371_A0.5240.51
245_E342_D0.5230.51
300_F303_S0.5230.51
387_F430_K0.5220.51
415_R426_E0.5220.51
286_G419_A0.5210.51
91_T113_Q0.5200.51
207_P279_F0.5190.51
244_A371_A0.5180.50
157_W226_F0.5160.50
143_L147_T0.5140.50
200_S226_F0.5140.50
243_I360_T0.5130.50
245_E363_Y0.5130.50
157_W227_T0.5120.50
243_I247_I0.5120.50
206_Q241_L0.5110.50
200_S207_P0.5100.49
203_G331_I0.5090.49
390_N395_A0.5090.49
418_E423_I0.5090.49
188_L223_L0.5080.49
382_A391_V0.5080.49
202_A296_V0.5070.49
176_I185_Y0.5070.49
117_G292_S0.5070.49
96_D257_I0.5050.49
150_N289_P0.5050.49
325_V407_W0.5050.49
169_T172_H0.5050.49
150_N295_A0.5040.49
322_H409_T0.5030.48
288_L433_Q0.5030.48
247_I434_I0.5030.48
91_T385_V0.5020.48
164_Y263_T0.5020.48
178_L188_L0.5010.48
219_N415_R0.5010.48
67_V70_T0.5010.48
210_T221_H0.5010.48
81_L85_Q0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tpdA 1 0.7449 100 0.462 Contact Map
4pu5A 1 0.8081 100 0.465 Contact Map
3akjA 2 0.4966 100 0.669 Contact Map
1cjaA 1 0.6005 97.1 0.936 Contact Map
4hneA 6 0.6253 96.8 0.939 Contact Map
4wtvA 1 0.7652 95.7 0.945 Contact Map
2zkzA 2 0.1512 95.7 0.945 Contact Map
3lmmA 1 0.1219 95.3 0.946 Contact Map
1r1uA 2 0.1625 94.7 0.948 Contact Map
1xmkA 1 0.14 94.7 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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