YJJJ - ECOLI - GREMLIN Contacts

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YJJJ - Putative kinase YjjJ

UniProt:	P39410	Sequences: MSELTDLLLQGPRSAPELRQRLAISQATFSRLVAREDRVIRFGKARATRYALLRPYRGIERIPVWRVDDTGKAHKFADIRLCWPQGSCLVTGADGDEQWFDGLPWYLTDLRPQGFLGRAWGRKLAAQLNLTDDIRLWQEEDVLYALTVFNGEYTGGWLVGEGNYQRWITAQHPAEIPLDQKLTHYEQLASDALAGEIVGSSAGGEQPKFTYYAQTPSGNKHVLVKFTVPQQTAVSQRWGDLLIAESIAAQILRDGGIHAIESTVLVTSNRQVFLEAERFDCKGNDGRLPIVSLEAVQSEFISSPGSWPQAMRRLCEQQLVTHQSVAQTEVIWAFGRLIANSDMHAGNLSFYLSEPPFALTPVYDMLPMVYAPNSAGMLRDAAIEVKFDLNVSKSAWLTAIPLAQQFWQTVARDPRISEAFRHIAQEMPEKIRQIEEKVARMGG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12342
Length:	443 (340)
Sequences:	2007 (1590)
Seq/√Len:	86.3

ECOLI - YJJJ HIPA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
261_E	277_E	5.391	1.00
326_A	412_R	4.960	1.00
249_A	262_S	4.401	1.00
77_A	89_L	3.984	1.00
330_V	419_A	3.547	1.00
246_S	262_S	3.471	1.00
290_I	349_S	3.400	1.00
250_Q	253_R	3.313	1.00
290_I	363_Y	3.297	1.00
253_R	261_E	3.264	1.00
248_A	338_I	3.247	1.00
330_V	416_I	3.082	1.00
351_Y	360_T	3.051	1.00
258_H	327_Q	3.050	1.00
324_S	358_A	2.971	1.00
334_F	338_I	2.902	1.00
257_I	362_V	2.758	1.00
246_S	250_Q	2.750	1.00
318_Q	324_S	2.562	1.00
293_L	310_A	2.545	1.00
292_S	363_Y	2.538	1.00
75_K	92_G	2.506	1.00
329_E	413_D	2.466	1.00
315_C	325_V	2.424	1.00
110_L	159_V	2.399	1.00
254_D	430_K	2.396	1.00
362_V	365_M	2.394	1.00
282_K	285_D	2.337	1.00
403_A	413_D	2.325	1.00
260_I	276_A	2.309	1.00
396_W	418_E	2.302	1.00
321_T	324_S	2.285	1.00
349_S	363_Y	2.270	1.00
265_L	275_E	2.262	1.00
252_L	365_M	2.232	1.00
426_E	429_E	2.230	1.00
79_I	107_L	2.193	1.00
243_I	272_V	2.192	1.00
353_S	358_A	2.185	1.00
331_I	362_V	2.139	1.00
177_P	180_Q	2.103	1.00
182_L	270_R	2.096	1.00
182_L	269_N	2.064	1.00
158_L	287_R	2.016	1.00
290_I	351_Y	2.004	1.00
214_Q	218_G	1.993	1.00
251_I	427_M	1.993	1.00
294_E	345_A	1.980	1.00
117_G	121_G	1.955	1.00
388_D	398_T	1.920	1.00
255_G	423_I	1.889	1.00
327_Q	331_I	1.869	1.00
400_I	414_P	1.867	1.00
249_A	259_A	1.865	1.00
352_L	355_P	1.819	1.00
141_D	144_Y	1.767	1.00
224_V	275_E	1.750	1.00
118_R	122_R	1.725	1.00
69_D	73_A	1.724	1.00
113_Q	205_E	1.716	1.00
68_D	163_N	1.713	1.00
174_A	180_Q	1.698	1.00
249_A	260_I	1.692	1.00
311_M	406_F	1.667	1.00
222_V	277_E	1.632	1.00
327_Q	330_V	1.628	1.00
310_A	328_T	1.627	1.00
242_L	264_V	1.623	1.00
262_S	276_A	1.610	1.00
400_I	413_D	1.596	1.00
255_G	424_A	1.572	1.00
414_P	418_E	1.560	1.00
81_L	141_D	1.553	1.00
418_E	421_R	1.549	1.00
320_V	323_Q	1.541	1.00
250_Q	433_Q	1.526	1.00
336_R	399_A	1.512	1.00
267_T	270_R	1.496	0.99
336_R	387_F	1.493	0.99
258_H	358_A	1.457	0.99
288_L	351_Y	1.457	0.99
252_L	334_F	1.440	0.99
156_G	289_P	1.427	0.99
244_A	367_P	1.413	0.99
311_M	325_V	1.410	0.99
291_V	295_A	1.409	0.99
249_A	274_L	1.400	0.99
68_D	75_K	1.390	0.99
415_R	419_A	1.380	0.99
331_I	348_L	1.376	0.99
314_L	328_T	1.373	0.99
333_A	416_I	1.371	0.99
400_I	403_A	1.332	0.99
251_I	338_I	1.318	0.99
337_L	421_R	1.315	0.99
307_W	332_W	1.297	0.99
246_S	264_V	1.293	0.99
255_G	420_F	1.281	0.98
383_I	394_S	1.261	0.98
260_I	274_L	1.248	0.98
430_K	433_Q	1.245	0.98
213_A	263_T	1.236	0.98
390_N	398_T	1.198	0.98
425_Q	429_E	1.195	0.98
203_G	292_S	1.190	0.97
70_T	160_G	1.185	0.97
267_T	272_V	1.184	0.97
75_K	78_D	1.183	0.97
296_V	350_F	1.183	0.97
81_L	87_S	1.178	0.97
254_D	426_E	1.177	0.97
222_V	275_E	1.173	0.97
416_I	419_A	1.157	0.97
402_L	406_F	1.156	0.97
343_M	348_L	1.152	0.97
250_Q	262_S	1.144	0.97
410_V	414_P	1.144	0.97
139_E	144_Y	1.137	0.97
247_I	430_K	1.132	0.97
255_G	334_F	1.131	0.97
254_D	434_I	1.130	0.96
305_G	345_A	1.120	0.96
396_W	414_P	1.119	0.96
80_R	88_C	1.117	0.96
311_M	328_T	1.099	0.96
78_D	90_V	1.094	0.96
67_V	71_G	1.092	0.96
257_I	330_V	1.081	0.95
425_Q	428_P	1.076	0.95
326_A	330_V	1.070	0.95
73_A	158_L	1.061	0.95
337_L	420_F	1.044	0.95
430_K	434_I	1.040	0.94
202_A	223_L	1.038	0.94
220_K	277_E	1.036	0.94
246_S	274_L	1.032	0.94
145_A	148_V	1.031	0.94
341_S	368_M	1.031	0.94
176_I	184_H	1.027	0.94
390_N	393_K	1.022	0.94
180_Q	183_T	1.015	0.94
138_Q	141_D	1.013	0.94
182_L	186_E	1.008	0.93
182_L	185_Y	1.008	0.93
318_Q	321_T	1.004	0.93
296_V	313_R	1.004	0.93
285_D	420_F	0.999	0.93
253_R	259_A	0.995	0.93
412_R	416_I	0.989	0.93
250_Q	254_D	0.985	0.93
202_A	210_T	0.984	0.93
244_A	248_A	0.982	0.93
314_L	324_S	0.982	0.93
109_D	292_S	0.971	0.92
110_L	295_A	0.970	0.92
291_V	352_L	0.969	0.92
80_R	90_V	0.960	0.92
209_F	226_F	0.954	0.91
329_E	333_A	0.952	0.91
106_Y	291_V	0.944	0.91
78_D	92_G	0.938	0.91
314_L	318_Q	0.932	0.90
332_W	402_L	0.931	0.90
426_E	430_K	0.930	0.90
111_R	346_G	0.930	0.90
412_R	415_R	0.926	0.90
301_I	346_G	0.925	0.90
206_Q	343_M	0.925	0.90
279_F	290_I	0.924	0.90
335_G	343_M	0.921	0.90
341_S	366_L	0.921	0.90
107_L	159_V	0.914	0.90
344_H	364_D	0.909	0.89
259_A	262_S	0.906	0.89
257_I	331_I	0.906	0.89
400_I	417_S	0.903	0.89
265_L	268_S	0.903	0.89
211_Y	224_V	0.902	0.89
109_D	343_M	0.899	0.89
109_D	295_A	0.899	0.89
297_Q	313_R	0.896	0.89
225_K	245_E	0.895	0.89
69_D	89_L	0.885	0.88
310_A	348_L	0.881	0.88
423_I	430_K	0.881	0.88
306_S	385_V	0.878	0.88
332_W	406_F	0.874	0.87
343_M	357_F	0.874	0.87
313_R	316_E	0.860	0.87
324_S	327_Q	0.860	0.87
427_M	431_I	0.857	0.86
90_V	93_A	0.856	0.86
329_E	417_S	0.853	0.86
175_E	182_L	0.851	0.86
210_T	223_L	0.849	0.86
429_E	433_Q	0.846	0.86
314_L	350_F	0.844	0.86
342_D	364_D	0.837	0.85
77_A	92_G	0.833	0.85
87_S	102_G	0.833	0.85
109_D	279_F	0.830	0.85
224_V	273_F	0.826	0.84
307_W	328_T	0.821	0.84
70_T	75_K	0.820	0.84
338_I	365_M	0.818	0.84
311_M	402_L	0.817	0.84
320_V	358_A	0.817	0.84
225_K	347_N	0.816	0.84
417_S	421_R	0.816	0.84
106_Y	295_A	0.816	0.84
208_K	344_H	0.816	0.84
292_S	346_G	0.816	0.84
225_K	344_H	0.815	0.83
82_C	88_C	0.813	0.83
384_E	387_F	0.812	0.83
291_V	350_F	0.810	0.83
177_P	181_K	0.807	0.83
282_K	288_L	0.807	0.83
337_L	418_E	0.805	0.83
108_T	301_I	0.805	0.83
388_D	401_P	0.804	0.83
245_E	347_N	0.804	0.83
205_E	292_S	0.798	0.82
179_D	184_H	0.798	0.82
294_E	301_I	0.798	0.82
77_A	107_L	0.797	0.82
251_I	430_K	0.796	0.82
241_L	366_L	0.795	0.82
411_A	426_E	0.793	0.82
199_G	226_F	0.793	0.82
337_L	424_A	0.792	0.82
249_A	276_A	0.792	0.82
416_I	420_F	0.792	0.82
255_G	333_A	0.791	0.82
292_S	349_S	0.791	0.82
174_A	178_L	0.788	0.81
428_P	431_I	0.785	0.81
335_G	365_M	0.782	0.81
245_E	344_H	0.781	0.81
422_H	429_E	0.781	0.81
307_W	343_M	0.780	0.81
403_A	410_V	0.779	0.81
274_L	338_I	0.778	0.81
160_G	166_R	0.777	0.80
152_E	281_C	0.776	0.80
248_A	367_P	0.775	0.80
314_L	325_V	0.775	0.80
109_D	203_G	0.772	0.80
259_A	276_A	0.769	0.80
335_G	340_N	0.765	0.79
257_I	334_F	0.764	0.79
246_S	249_A	0.763	0.79
420_F	423_I	0.762	0.79
176_I	285_D	0.760	0.79
428_P	433_Q	0.756	0.79
114_G	302_S	0.756	0.79
107_L	205_E	0.755	0.79
281_C	295_A	0.753	0.78
396_W	417_S	0.753	0.78
175_E	179_D	0.752	0.78
323_Q	358_A	0.750	0.78
414_P	417_S	0.749	0.78
404_Q	410_V	0.749	0.78
183_T	186_E	0.748	0.78
109_D	207_P	0.747	0.78
71_G	76_F	0.741	0.77
330_V	423_I	0.740	0.77
324_S	328_T	0.739	0.77
177_P	218_G	0.737	0.77
243_I	264_V	0.733	0.76
329_E	403_A	0.732	0.76
332_W	335_G	0.732	0.76
351_Y	357_F	0.730	0.76
393_K	396_W	0.729	0.76
347_N	364_D	0.725	0.76
334_F	365_M	0.725	0.76
251_I	334_F	0.721	0.75
344_H	347_N	0.721	0.75
227_T	232_T	0.715	0.75
180_Q	184_H	0.714	0.75
337_L	396_W	0.714	0.75
292_S	295_A	0.714	0.75
252_L	259_A	0.713	0.74
308_P	405_Q	0.712	0.74
386_K	391_V	0.710	0.74
201_S	281_C	0.709	0.74
195_G	199_G	0.709	0.74
414_P	429_E	0.700	0.73
181_K	185_Y	0.700	0.73
115_F	343_M	0.698	0.73
153_Y	295_A	0.695	0.73
214_Q	220_K	0.693	0.72
199_G	203_G	0.693	0.72
403_A	408_Q	0.693	0.72
144_Y	147_T	0.691	0.72
108_T	117_G	0.691	0.72
289_P	335_G	0.691	0.72
290_I	360_T	0.690	0.72
420_F	424_A	0.688	0.72
205_E	346_G	0.687	0.72
141_D	223_L	0.685	0.71
288_L	360_T	0.685	0.71
67_V	292_S	0.684	0.71
248_A	365_M	0.683	0.71
307_W	340_N	0.682	0.71
103_L	108_T	0.682	0.71
338_I	424_A	0.681	0.71
115_F	207_P	0.681	0.71
314_L	319_L	0.678	0.71
186_E	190_S	0.678	0.71
428_P	432_R	0.678	0.71
327_Q	359_L	0.677	0.71
85_Q	139_E	0.676	0.70
202_A	351_Y	0.674	0.70
113_Q	346_G	0.674	0.70
333_A	399_A	0.673	0.70
333_A	417_S	0.673	0.70
113_Q	343_M	0.672	0.70
208_K	225_K	0.671	0.70
324_S	359_L	0.668	0.70
208_K	245_E	0.667	0.69
176_I	232_T	0.663	0.69
221_H	290_I	0.662	0.69
345_A	385_V	0.661	0.69
203_G	244_A	0.659	0.69
74_H	92_G	0.659	0.69
293_L	350_F	0.657	0.68
117_G	120_W	0.657	0.68
203_G	343_M	0.657	0.68
109_D	113_Q	0.656	0.68
84_P	220_K	0.654	0.68
323_Q	426_E	0.654	0.68
139_E	143_L	0.653	0.68
154_T	279_F	0.652	0.68
109_D	206_Q	0.650	0.67
329_E	399_A	0.644	0.67
89_L	107_L	0.644	0.67
283_G	286_G	0.644	0.67
429_E	432_R	0.642	0.67
70_T	166_R	0.642	0.67
181_K	187_Q	0.640	0.66
95_G	99_W	0.640	0.66
407_W	419_A	0.639	0.66
176_I	181_K	0.639	0.66
419_A	426_E	0.638	0.66
253_R	258_H	0.637	0.66
326_A	416_I	0.636	0.66
219_N	315_C	0.636	0.66
228_V	241_L	0.635	0.66
106_Y	157_W	0.634	0.66
260_I	290_I	0.634	0.66
334_F	420_F	0.634	0.66
421_R	425_Q	0.633	0.65
109_D	331_I	0.632	0.65
220_K	263_T	0.632	0.65
207_P	340_N	0.632	0.65
310_A	314_L	0.630	0.65
91_T	108_T	0.630	0.65
109_D	357_F	0.629	0.65
367_P	370_Y	0.626	0.65
284_N	358_A	0.625	0.64
208_K	279_F	0.624	0.64
292_S	367_P	0.620	0.64
175_E	178_L	0.619	0.64
395_A	398_T	0.619	0.64
399_A	406_F	0.618	0.64
111_R	149_F	0.618	0.64
247_I	427_M	0.617	0.63
208_K	347_N	0.616	0.63
419_A	423_I	0.615	0.63
352_L	357_F	0.615	0.63
106_Y	159_V	0.615	0.63
259_A	327_Q	0.610	0.63
291_V	357_F	0.610	0.63
417_S	420_F	0.609	0.62
83_W	157_W	0.607	0.62
337_L	414_P	0.607	0.62
113_Q	203_G	0.604	0.62
200_S	399_A	0.603	0.62
340_N	343_M	0.603	0.62
208_K	364_D	0.602	0.62
153_Y	343_M	0.602	0.62
248_A	366_L	0.600	0.61
323_Q	326_A	0.600	0.61
173_P	176_I	0.598	0.61
330_V	420_F	0.597	0.61
106_Y	222_V	0.597	0.61
319_L	358_A	0.595	0.61
70_T	73_A	0.594	0.61
113_Q	292_S	0.590	0.60
332_W	343_M	0.589	0.60
294_E	346_G	0.588	0.60
178_L	181_K	0.587	0.60
69_D	159_V	0.587	0.60
253_R	263_T	0.586	0.60
314_L	359_L	0.585	0.59
140_E	348_L	0.582	0.59
391_V	398_T	0.582	0.59
328_T	359_L	0.582	0.59
274_L	279_F	0.581	0.59
383_I	389_L	0.580	0.59
388_D	402_L	0.580	0.59
322_H	412_R	0.579	0.59
120_W	145_A	0.578	0.58
200_S	203_G	0.576	0.58
353_S	356_P	0.576	0.58
225_K	364_D	0.575	0.58
160_G	163_N	0.575	0.58
245_E	364_D	0.574	0.58
119_A	122_R	0.574	0.58
312_R	316_E	0.573	0.58
222_V	274_L	0.572	0.58
423_I	427_M	0.571	0.58
202_A	293_L	0.570	0.57
354_E	432_R	0.570	0.57
99_W	294_E	0.570	0.57
154_T	289_P	0.567	0.57
260_I	362_V	0.566	0.57
271_Q	408_Q	0.566	0.57
113_Q	206_Q	0.565	0.57
383_I	387_F	0.565	0.57
193_L	363_Y	0.565	0.57
109_D	231_Q	0.564	0.57
140_E	145_A	0.563	0.57
331_I	335_G	0.562	0.56
96_D	142_V	0.562	0.56
177_P	185_Y	0.561	0.56
195_G	206_Q	0.560	0.56
111_R	150_N	0.560	0.56
137_W	148_V	0.559	0.56
252_L	335_G	0.557	0.56
259_A	362_V	0.557	0.56
138_Q	337_L	0.555	0.55
254_D	433_Q	0.553	0.55
201_S	205_E	0.551	0.55
93_A	183_T	0.547	0.54
115_F	118_R	0.547	0.54
341_S	381_A	0.546	0.54
110_L	145_A	0.546	0.54
225_K	363_Y	0.544	0.54
252_L	257_I	0.541	0.54
156_G	201_S	0.541	0.54
400_I	411_A	0.541	0.54
208_K	342_D	0.540	0.53
312_R	400_I	0.539	0.53
225_K	342_D	0.539	0.53
145_A	383_I	0.539	0.53
310_A	313_R	0.539	0.53
327_Q	419_A	0.538	0.53
185_Y	189_A	0.538	0.53
94_D	171_Q	0.537	0.53
401_P	405_Q	0.535	0.53
307_W	329_E	0.534	0.53
179_D	185_Y	0.534	0.53
279_F	344_H	0.534	0.53
293_L	328_T	0.533	0.53
299_E	309_Q	0.532	0.52
179_D	183_T	0.529	0.52
209_F	340_N	0.529	0.52
117_G	122_R	0.528	0.52
113_Q	348_L	0.528	0.52
114_G	340_N	0.528	0.52
188_L	191_D	0.526	0.52
386_K	392_S	0.525	0.51
122_R	408_Q	0.525	0.51
114_G	209_F	0.525	0.51
173_P	179_D	0.525	0.51
333_A	411_A	0.525	0.51
107_L	146_L	0.524	0.51
231_Q	371_A	0.524	0.51
245_E	342_D	0.523	0.51
300_F	303_S	0.523	0.51
387_F	430_K	0.522	0.51
415_R	426_E	0.522	0.51
286_G	419_A	0.521	0.51
91_T	113_Q	0.520	0.51
207_P	279_F	0.519	0.51
244_A	371_A	0.518	0.50
157_W	226_F	0.516	0.50
143_L	147_T	0.514	0.50
200_S	226_F	0.514	0.50
243_I	360_T	0.513	0.50
245_E	363_Y	0.513	0.50
157_W	227_T	0.512	0.50
243_I	247_I	0.512	0.50
206_Q	241_L	0.511	0.50
200_S	207_P	0.510	0.49
203_G	331_I	0.509	0.49
390_N	395_A	0.509	0.49
418_E	423_I	0.509	0.49
188_L	223_L	0.508	0.49
382_A	391_V	0.508	0.49
202_A	296_V	0.507	0.49
176_I	185_Y	0.507	0.49
117_G	292_S	0.507	0.49
96_D	257_I	0.505	0.49
150_N	289_P	0.505	0.49
325_V	407_W	0.505	0.49
169_T	172_H	0.505	0.49
150_N	295_A	0.504	0.49
322_H	409_T	0.503	0.48
288_L	433_Q	0.503	0.48
247_I	434_I	0.503	0.48
91_T	385_V	0.502	0.48
164_Y	263_T	0.502	0.48
178_L	188_L	0.501	0.48
219_N	415_R	0.501	0.48
67_V	70_T	0.501	0.48
210_T	221_H	0.501	0.48
81_L	85_Q	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tpdA	1	0.7449	100	0.462	Contact Map
4pu5A	1	0.8081	100	0.465	Contact Map
3akjA	2	0.4966	100	0.669	Contact Map
1cjaA	1	0.6005	97.1	0.936	Contact Map
4hneA	6	0.6253	96.8	0.939	Contact Map
4wtvA	1	0.7652	95.7	0.945	Contact Map
2zkzA	2	0.1512	95.7	0.945	Contact Map
3lmmA	1	0.1219	95.3	0.946	Contact Map
1r1uA	2	0.1625	94.7	0.948	Contact Map
1xmkA	1	0.14	94.7	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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