GREMLIN Database
YJJV - Uncharacterized deoxyribonuclease YjjV
UniProt: P39408 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12598
Length: 259 (251)
Sequences: 7120 (4998)
Seq/√Len: 315.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_Q125_R3.4591.00
117_D147_R3.0901.00
232_V235_E2.7611.00
163_L196_K2.6471.00
102_L140_K2.6421.00
54_E89_P2.5281.00
27_R222_R2.4971.00
154_G174_Y2.2911.00
120_L130_V2.2621.00
250_N254_T2.2001.00
146_K168_R2.1611.00
191_R232_V2.1021.00
231_A241_A2.0901.00
113_Q140_K2.0241.00
85_L95_V1.9841.00
134_S141_L1.9431.00
121_K148_H1.8531.00
199_L237_R1.8511.00
10_C36_I1.8481.00
62_A94_A1.8431.00
26_Q30_Q1.8421.00
18_S21_E1.8321.00
246_Q250_N1.8311.00
199_L247_A1.8221.00
239_E244_I1.8171.00
194_I233_L1.7871.00
102_L109_F1.7661.00
29_A58_P1.7551.00
117_D148_H1.7491.00
139_D143_M1.7411.00
230_F241_A1.7381.00
20_D220_P1.7371.00
62_A131_I1.7191.00
53_A61_A1.7101.00
146_K172_L1.6761.00
35_K60_Y1.6651.00
114_W118_E1.6621.00
98_I119_Q1.6611.00
163_L167_E1.6611.00
199_L239_E1.6571.00
158_G179_G1.6511.00
61_A92_V1.6441.00
47_A80_Q1.6431.00
168_R171_Q1.6271.00
8_T252_T1.6271.00
35_K253_Y1.6221.00
156_V169_F1.6121.00
98_I130_V1.5991.00
22_E55_N1.5981.00
204_L230_F1.5861.00
167_E171_Q1.5421.00
118_E121_K1.5301.00
82_Q126_Y1.5101.00
134_S138_H1.5011.00
178_V194_I1.4901.00
113_Q143_M1.4881.00
182_I233_L1.4671.00
51_A55_N1.4521.00
167_E196_K1.4511.00
231_A235_E1.4471.00
143_M147_R1.4461.00
155_V255_L1.4391.00
116_L132_L1.4341.00
6_I35_K1.4341.00
175_K201_S1.4241.00
166_A176_I1.4201.00
78_L118_E1.4131.00
85_L126_Y1.3961.00
188_S192_D1.3881.00
175_K254_T1.3861.00
192_D195_A1.3831.00
227_A231_A1.3701.00
162_S165_Q1.3651.00
188_S191_R1.3541.00
127_D153_T1.3381.00
42_E45_N1.3371.00
142_A168_R1.3301.00
113_Q117_D1.3271.00
80_Q83_Q1.3261.00
13_D45_N1.3241.00
6_I37_I1.3111.00
116_L141_L1.2911.00
249_L253_Y1.2761.00
124_K148_H1.2691.00
228_R231_A1.2681.00
49_V61_A1.2641.00
117_D144_H1.2641.00
176_I197_L1.2611.00
28_A36_I1.2541.00
51_A54_E1.2521.00
191_R236_L1.2461.00
68_G104_G1.2451.00
37_I93_V1.2451.00
102_L113_Q1.2361.00
6_I249_L1.2311.00
40_A46_F1.2251.00
216_F228_R1.2231.00
5_F245_A1.2171.00
243_E246_Q1.2141.00
10_C208_A1.2131.00
198_P201_S1.2041.00
233_L244_I1.2011.00
5_F230_F1.2011.00
240_P243_E1.2001.00
216_F225_Q1.1931.00
178_V202_L1.1801.00
249_L252_T1.1801.00
203_L255_L1.1781.00
108_Q111_R1.1771.00
230_F248_L1.1701.00
113_Q144_H1.1691.00
43_A46_F1.1651.00
109_F113_Q1.1641.00
50_L61_A1.1631.00
239_E243_E1.1571.00
38_V49_V1.1461.00
170_V201_S1.1421.00
74_S77_S1.1151.00
164_Q167_E1.1151.00
39_P131_I1.1111.00
248_L252_T1.1061.00
23_A27_R1.0821.00
194_I237_R1.0811.00
20_D23_A1.0741.00
232_V236_L1.0721.00
22_E26_Q1.0721.00
68_G107_P1.0711.00
17_F220_P1.0701.00
36_I59_L1.0671.00
5_F226_A1.0631.00
204_L226_A1.0501.00
54_E91_K1.0461.00
105_D109_F1.0461.00
83_Q86_E1.0451.00
70_L115_L1.0431.00
216_F219_Q1.0381.00
82_Q86_E1.0361.00
139_D165_Q1.0361.00
43_A77_S1.0361.00
110_E114_W1.0321.00
110_E113_Q1.0311.00
221_N225_Q1.0301.00
47_A51_A1.0251.00
138_H165_Q1.0191.00
121_K125_R1.0161.00
139_D168_R1.0111.00
6_I252_T1.0061.00
38_V59_L0.9891.00
163_L193_V0.9881.00
175_K255_L0.9851.00
161_G165_Q0.9851.00
184_Y212_P0.9811.00
192_D196_K0.9791.00
204_L233_L0.9761.00
69_M72_K0.9751.00
27_R224_E0.9661.00
111_R114_W0.9631.00
185_P214_N0.9621.00
50_L89_P0.9581.00
50_L63_L0.9501.00
154_G255_L0.9461.00
82_Q122_L0.9411.00
48_R51_A0.9391.00
230_F245_A0.9321.00
53_A59_L0.9261.00
23_A26_Q0.9251.00
73_H78_L0.9251.00
182_I194_I0.9161.00
178_V197_L0.9141.00
222_R225_Q0.9091.00
247_A250_N0.9011.00
37_I252_T0.8991.00
177_G203_L0.8991.00
43_A80_Q0.8961.00
47_A84_A0.8961.00
244_I248_L0.8881.00
12_F223_P0.8871.00
230_F244_I0.8841.00
204_L248_L0.8811.00
8_T203_L0.8781.00
22_E56_Y0.8741.00
25_L56_Y0.8681.00
245_A249_L0.8661.00
86_E126_Y0.8631.00
199_L244_I0.8621.00
163_L192_D0.8611.00
149_D152_R0.8601.00
70_L111_R0.8591.00
103_F136_R0.8591.00
124_K151_P0.8591.00
194_I236_L0.8581.00
142_A169_F0.8501.00
50_L54_E0.8471.00
243_E247_A0.8451.00
155_V256_F0.8411.00
73_H115_L0.8391.00
49_V53_A0.8381.00
237_R244_I0.8331.00
79_E83_Q0.8321.00
132_L156_V0.8301.00
170_V198_P0.8261.00
134_S161_G0.8261.00
227_A241_A0.8251.00
79_E82_Q0.8211.00
127_D152_R0.8171.00
78_L82_Q0.8151.00
109_F140_K0.8131.00
120_L124_K0.8081.00
17_F20_D0.8081.00
77_S80_Q0.8051.00
138_H161_G0.7941.00
92_V128_L0.7891.00
124_K152_R0.7881.00
80_Q84_A0.7851.00
39_P62_A0.7831.00
41_T45_N0.7821.00
132_L141_L0.7781.00
65_L73_H0.7731.00
63_L92_V0.7690.99
68_G106_D0.7680.99
140_K143_M0.7660.99
230_F234_C0.7650.99
241_A245_A0.7640.99
75_D118_E0.7630.99
122_L126_Y0.7620.99
17_F21_E0.7600.99
226_A229_V0.7590.99
8_T155_V0.7570.99
170_V176_I0.7530.99
142_A165_Q0.7530.99
138_H169_F0.7470.99
195_A236_L0.7440.99
25_L36_I0.7440.99
233_L237_R0.7440.99
5_F227_A0.7410.99
150_L153_T0.7400.99
31_A227_A0.7400.99
34_G249_L0.7360.99
124_K149_D0.7280.99
242_D246_Q0.7260.99
146_K171_Q0.7210.99
13_D48_R0.7210.99
73_H77_S0.7200.99
153_T257_N0.7170.99
27_R30_Q0.7170.99
175_K203_L0.7130.99
105_D108_Q0.7100.99
250_N253_Y0.7040.99
95_V98_I0.7000.99
181_T184_Y0.6990.99
5_F249_L0.6970.99
37_I62_A0.6970.99
202_L244_I0.6960.99
144_H147_R0.6920.99
46_F84_A0.6920.99
45_N49_V0.6920.99
26_Q29_A0.6890.99
111_R115_L0.6880.99
124_K150_L0.6860.99
144_H148_H0.6850.99
117_D121_K0.6820.99
239_E247_A0.6790.99
8_T131_I0.6780.99
188_S195_A0.6780.99
14_F210_D0.6770.99
120_L144_H0.6730.99
155_V177_G0.6720.99
184_Y215_G0.6690.99
60_Y91_K0.6690.99
195_A238_R0.6660.99
202_L237_R0.6650.99
198_P237_R0.6550.98
63_L84_A0.6540.98
190_T193_V0.6530.98
25_L29_A0.6500.98
106_D109_F0.6500.98
42_E72_K0.6480.98
5_F241_A0.6450.98
181_T211_M0.6450.98
40_A49_V0.6450.98
5_F204_L0.6410.98
18_S48_R0.6410.98
100_L137_T0.6330.98
46_F63_L0.6320.98
98_I115_L0.6320.98
169_F176_I0.6310.98
134_S169_F0.6270.98
78_L122_L0.6270.98
20_D24_S0.6250.98
94_A131_I0.6210.98
170_V197_L0.6110.97
21_E24_S0.6100.97
46_F49_V0.6100.97
166_A193_V0.6090.97
60_Y93_V0.6090.97
120_L148_H0.6070.97
166_A170_V0.6060.97
212_P225_Q0.6040.97
15_P18_S0.6040.97
166_A197_L0.6030.97
46_F81_L0.5970.97
127_D257_N0.5970.97
70_L107_P0.5960.97
247_A254_T0.5950.97
71_E108_Q0.5920.97
127_D151_P0.5880.97
159_F165_Q0.5860.97
202_L248_L0.5840.97
197_L202_L0.5830.97
37_I256_F0.5820.97
184_Y218_G0.5770.96
181_T190_T0.5760.96
138_H142_A0.5760.96
203_L252_T0.5750.96
46_F61_A0.5740.96
237_R247_A0.5720.96
83_Q89_P0.5720.96
28_A222_R0.5710.96
189_K192_D0.5700.96
131_I256_F0.5700.96
170_V196_K0.5660.96
142_A146_K0.5620.96
156_V177_G0.5590.96
71_E107_P0.5580.96
155_V203_L0.5570.96
200_A254_T0.5560.96
142_A172_L0.5560.96
28_A33_V0.5550.95
234_C241_A0.5530.95
175_K251_N0.5490.95
24_S220_P0.5490.95
191_R195_A0.5480.95
103_F135_R0.5470.95
168_R172_L0.5470.95
13_D38_V0.5470.95
76_V79_E0.5450.95
179_G211_M0.5410.95
247_A251_N0.5400.95
251_N254_T0.5390.95
13_D41_T0.5350.95
138_H141_L0.5350.95
115_L119_Q0.5340.94
28_A32_G0.5310.94
182_I190_T0.5310.94
132_L154_G0.5300.94
71_E111_R0.5300.94
190_T194_I0.5290.94
159_F169_F0.5270.94
6_I253_Y0.5270.94
179_G204_L0.5270.94
29_A34_G0.5260.94
68_G105_D0.5250.94
158_G211_M0.5240.94
182_I244_I0.5220.94
119_Q123_A0.5210.94
122_L125_R0.5200.94
200_A247_A0.5130.93
121_K124_K0.5110.93
25_L59_L0.5110.93
242_D245_A0.5110.93
8_T177_G0.5100.93
178_V181_T0.5080.93
31_A224_E0.5070.93
21_E220_P0.5070.93
41_T69_M0.5060.93
16_P220_P0.5060.93
225_Q228_R0.5060.93
64_G119_Q0.5060.93
75_D114_W0.5050.93
93_V252_T0.5050.93
85_L92_V0.5040.93
9_H131_I0.5040.93
25_L58_P0.5030.93
123_A130_V0.5020.92
154_G176_I0.5020.92
52_L59_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e2vA 1 0.973 100 0.191 Contact Map
3ipwA 1 0.9923 100 0.245 Contact Map
2xioA 1 0.9846 100 0.318 Contact Map
1j6oA 1 0.9923 100 0.334 Contact Map
3gg7A 1 0.9305 100 0.346 Contact Map
3rcmA 1 0.9846 100 0.373 Contact Map
1xwyA 1 0.9768 100 0.373 Contact Map
1zzmA 1 1 100 0.377 Contact Map
2y1hA 2 0.9768 100 0.387 Contact Map
2gzxA 1 0.9691 100 0.396 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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