GREMLIN Database
RSMC - Ribosomal RNA small subunit methyltransferase C
UniProt: P39406 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12596
Length: 343 (321)
Sequences: 1795 (1230)
Seq/√Len: 68.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_F266_I5.9451.00
201_L262_F5.0041.00
321_E333_R4.5171.00
200_V214_F4.4591.00
263_D294_N3.9911.00
199_K222_R3.9761.00
298_E333_R3.9151.00
300_R323_I3.4251.00
211_S225_L3.2801.00
14_H17_D3.0371.00
199_K294_N2.9691.00
185_S210_L2.9551.00
222_R248_E2.8891.00
200_V264_M2.7821.00
199_K224_T2.7661.00
322_V325_Q2.7411.00
283_Q312_V2.7391.00
224_T262_F2.7351.00
234_E237_R2.7251.00
224_T250_F2.7141.00
240_L249_V2.6961.00
22_R78_D2.6751.00
310_P330_K2.6291.00
155_A158_F2.4561.00
225_L236_S2.4301.00
205_C211_S2.3391.00
289_A299_L2.3141.00
212_V239_T2.2811.00
187_L326_T2.2751.00
225_L249_V2.2631.00
183_V328_R2.2181.00
14_H18_F2.0421.00
205_C227_D1.9951.00
237_R241_A1.9751.00
171_T178_R1.9681.00
85_P91_A1.8971.00
160_G164_V1.8961.00
136_S140_C1.8931.00
198_G263_D1.8911.00
252_S257_E1.8771.00
102_L106_T1.8711.00
191_T324_A1.8371.00
267_S301_I1.8341.00
49_F53_Q1.8231.00
300_R333_R1.8211.00
282_A286_I1.7591.00
153_F157_K1.7441.00
190_S326_T1.7381.00
237_R249_V1.7371.00
153_F159_W1.7161.00
203_V254_V1.7161.00
308_P311_D1.6981.00
271_F304_N1.6941.00
44_A55_L1.6560.99
114_N117_G1.6240.99
159_W162_Y1.6210.99
154_D157_K1.5850.99
140_C143_Y1.5780.99
153_F158_F1.5720.99
187_L324_A1.5660.99
233_V249_V1.5460.99
185_S189_L1.5430.99
34_P44_A1.5400.99
238_A242_A1.5380.99
159_W164_V1.5080.99
169_V239_T1.4930.99
224_T248_E1.4920.99
113_E140_C1.4900.99
167_L212_V1.4830.99
236_S249_V1.4610.99
134_V141_G1.4470.98
155_A159_W1.4460.98
169_V207_A1.4140.98
114_N136_S1.4120.98
135_D138_R1.4120.98
134_V144_F1.3940.98
177_S180_G1.3910.98
137_A140_C1.3620.98
68_V71_A1.3430.98
52_W56_S1.3400.97
191_T331_V1.3360.97
15_S18_F1.3300.97
35_A39_T1.3240.97
74_V77_C1.3230.97
47_Q229_S1.3200.97
79_T107_D1.2940.97
170_K238_A1.2910.97
152_V157_K1.2770.97
313_L320_H1.2710.97
156_E159_W1.2620.96
151_P155_A1.2580.96
307_L313_L1.2520.96
136_S141_G1.2490.96
133_K137_A1.2450.96
177_S236_S1.2440.96
229_S272_H1.2120.95
200_V221_I1.2070.95
288_G291_R1.2070.95
125_L145_G1.2010.95
153_F156_E1.1960.95
106_T132_N1.1890.95
261_R294_N1.1830.95
147_L150_Q1.1820.95
253_N256_S1.1780.95
175_V207_A1.1780.95
201_L292_H1.1660.94
280_D284_T1.1480.94
160_G163_S1.1470.94
114_N119_R1.1440.94
215_A245_V1.1420.94
293_L297_G1.1400.94
138_R143_Y1.1230.93
152_V155_A1.1170.93
186_Q190_S1.1110.93
267_S299_L1.1100.93
272_H302_V1.1020.92
102_L134_V1.0940.92
154_D158_F1.0900.92
303_A307_L1.0890.92
305_A325_Q1.0870.92
213_A216_R1.0740.91
325_Q332_Y1.0720.91
79_T109_F1.0650.91
271_F307_L1.0650.91
161_E164_V1.0630.91
26_A94_Q1.0620.91
189_L213_A1.0600.91
283_Q287_R1.0580.91
234_E238_A1.0550.91
137_A142_L1.0490.90
197_K200_V1.0460.90
320_H332_Y1.0430.90
199_K221_I1.0420.90
156_E163_S1.0380.90
213_A217_H1.0370.90
305_A308_P1.0320.90
158_F162_Y1.0310.90
199_K263_D1.0300.90
303_A308_P1.0290.90
187_L190_S1.0280.90
298_E335_I1.0260.89
131_L143_Y1.0230.89
182_D185_S1.0220.89
175_V235_A1.0190.89
199_K261_R1.0140.89
210_L216_R1.0130.89
157_K164_V1.0110.89
197_K218_S1.0040.88
136_S139_R1.0020.88
171_T177_S0.9960.88
191_T323_I0.9900.88
148_E151_P0.9900.88
261_R292_H0.9890.88
93_F97_N0.9730.87
37_L42_S0.9710.87
184_G187_L0.9700.87
137_A143_Y0.9690.87
49_F257_E0.9690.87
174_G231_P0.9650.86
239_T243_N0.9640.86
119_R123_Q0.9640.86
206_G268_N0.9630.86
121_A125_L0.9630.86
262_F265_I0.9560.86
145_G148_E0.9510.86
260_G295_S0.9510.86
98_L102_L0.9490.85
27_G90_E0.9420.85
325_Q330_K0.9380.85
136_S144_F0.9340.85
35_A59_M0.9290.84
123_Q146_R0.9260.84
136_S143_Y0.9260.84
137_A141_G0.9240.84
23_I79_T0.9180.84
215_A240_L0.9180.84
122_E143_Y0.9170.83
157_K162_Y0.9150.83
212_V245_V0.9050.83
215_A244_G0.9040.83
189_L210_L0.8930.82
86_K275_M0.8900.82
38_D41_A0.8880.81
254_V284_T0.8870.81
103_P106_T0.8870.81
215_A223_L0.8860.81
83_Y111_V0.8830.81
262_F292_H0.8790.81
161_E168_T0.8780.81
95_L331_V0.8730.80
253_N284_T0.8710.80
259_K291_R0.8680.80
152_V156_E0.8670.80
312_V316_T0.8630.80
88_K120_S0.8500.79
141_G145_G0.8460.78
214_F221_I0.8450.78
187_L191_T0.8430.78
186_Q213_A0.8420.78
133_K204_G0.8410.78
135_D141_G0.8410.78
53_Q56_S0.8390.78
46_T52_W0.8370.77
138_R141_G0.8320.77
133_K144_F0.8320.77
117_G143_Y0.8230.76
228_V272_H0.8210.76
41_A53_Q0.8210.76
181_L209_V0.8180.76
313_L334_A0.8160.76
233_V237_R0.8150.76
87_N174_G0.8140.75
210_L266_I0.8110.75
110_V125_L0.8110.75
186_Q210_L0.7970.74
179_D183_V0.7960.74
310_P332_Y0.7940.74
217_H301_I0.7920.73
202_D206_G0.7910.73
102_L108_I0.7890.73
185_S188_L0.7890.73
114_N262_F0.7870.73
223_L240_L0.7840.73
109_F134_V0.7820.72
59_M62_N0.7820.72
153_F162_Y0.7760.72
131_L145_G0.7750.72
286_I299_L0.7750.72
114_N122_E0.7740.72
211_S223_L0.7740.72
276_Q285_L0.7720.72
323_I333_R0.7720.72
305_A330_K0.7710.71
56_S66_S0.7710.71
239_T242_A0.7690.71
258_V324_A0.7670.71
230_A251_A0.7660.71
47_Q58_Q0.7650.71
138_R181_L0.7640.71
80_L229_S0.7610.70
118_V121_A0.7600.70
86_K110_V0.7580.70
119_R122_E0.7580.70
167_L216_R0.7560.70
202_D268_N0.7550.70
158_F164_V0.7510.69
56_S61_D0.7510.69
171_T179_D0.7490.69
133_K141_G0.7460.69
200_V219_P0.7450.69
92_Q96_M0.7450.69
76_D79_T0.7440.69
192_L214_F0.7430.69
77_C106_T0.7420.69
306_F309_Y0.7420.69
171_T174_G0.7410.68
64_R67_L0.7410.68
28_D51_H0.7410.68
51_H54_V0.7390.68
304_N309_Y0.7380.68
84_W121_A0.7360.68
321_E325_Q0.7340.68
208_G268_N0.7310.67
73_D76_D0.7260.67
148_E152_V0.7230.66
267_S286_I0.7220.66
304_N307_L0.7210.66
155_A160_G0.7210.66
199_K295_S0.7200.66
90_E229_S0.7200.66
185_S209_V0.7200.66
52_W55_L0.7170.66
186_Q189_L0.7160.66
320_H334_A0.7150.66
188_L210_L0.7110.65
81_I111_V0.7090.65
250_F258_V0.7090.65
204_G226_C0.7080.65
138_R142_L0.7070.65
29_L83_Y0.7070.65
139_R143_Y0.7070.65
287_R316_T0.7030.64
222_R246_E0.7030.64
154_D159_W0.7010.64
134_V138_R0.7010.64
28_D34_P0.7010.64
125_L142_L0.7000.64
182_D272_H0.6990.64
312_V315_E0.6980.64
237_R248_E0.6980.64
135_D140_C0.6960.64
265_I289_A0.6950.63
184_G272_H0.6920.63
195_H218_S0.6920.63
177_S235_A0.6900.63
206_G232_A0.6890.63
217_H265_I0.6880.63
57_R61_D0.6870.63
204_G268_N0.6840.62
152_V159_W0.6830.62
172_L274_G0.6810.62
57_R237_R0.6790.62
273_D276_Q0.6780.62
145_G152_V0.6780.62
255_F292_H0.6770.61
243_N278_S0.6760.61
313_L317_F0.6750.61
224_T258_V0.6750.61
141_G144_F0.6730.61
153_F164_V0.6730.61
196_T263_D0.6720.61
272_H304_N0.6720.61
240_L245_V0.6710.61
139_R203_V0.6670.60
88_K92_Q0.6670.60
20_Q53_Q0.6650.60
33_L272_H0.6640.60
165_D217_H0.6640.60
18_F29_L0.6620.60
306_F310_P0.6620.60
26_A42_S0.6610.60
322_V332_Y0.6540.59
158_F161_E0.6530.59
289_A317_F0.6510.58
183_V326_T0.6500.58
212_V243_N0.6490.58
232_A268_N0.6490.58
109_F144_F0.6490.58
307_L310_P0.6470.58
314_D320_H0.6460.58
267_S285_L0.6440.58
56_S67_L0.6440.58
102_L132_N0.6430.57
118_V122_E0.6410.57
113_E117_G0.6390.57
114_N139_R0.6390.57
182_D302_V0.6380.57
25_F30_Q0.6380.57
184_G192_L0.6370.57
188_L266_I0.6360.57
181_L184_G0.6360.57
22_R39_T0.6350.57
32_D58_Q0.6320.56
215_A242_A0.6320.56
204_G255_F0.6300.56
271_F303_A0.6270.56
229_S328_R0.6250.55
133_K136_S0.6220.55
96_M128_Y0.6210.55
135_D139_R0.6180.55
40_A45_H0.6180.55
149_K177_S0.6170.54
22_R42_S0.6160.54
181_L185_S0.6160.54
151_P159_W0.6160.54
330_K333_R0.6160.54
109_F265_I0.6150.54
135_D143_Y0.6140.54
47_Q50_H0.6110.54
273_D278_S0.6070.53
86_K304_N0.6040.53
95_L121_A0.6020.53
155_A165_D0.6010.52
101_L110_V0.5950.52
267_S282_A0.5950.52
156_E162_Y0.5950.52
137_A144_F0.5940.52
157_K161_E0.5930.52
201_L258_V0.5920.51
220_K324_A0.5920.51
22_R75_A0.5910.51
26_A30_Q0.5910.51
95_L173_P0.5880.51
157_K160_G0.5870.51
185_S254_V0.5860.51
27_G48_Q0.5860.51
78_D105_G0.5850.51
314_D318_G0.5850.51
177_S307_L0.5840.50
47_Q55_L0.5840.50
97_N101_L0.5830.50
129_A145_G0.5820.50
252_S256_S0.5820.50
148_E163_S0.5810.50
200_V223_L0.5810.50
259_K327_G0.5800.50
254_V281_A0.5790.50
157_K165_D0.5780.50
93_F172_L0.5770.50
20_Q56_S0.5770.50
56_S60_G0.5760.49
103_P250_F0.5750.49
213_A265_I0.5750.49
90_E174_G0.5730.49
235_A273_D0.5720.49
279_L283_Q0.5710.49
202_D208_G0.5690.49
134_V137_A0.5690.49
171_T207_A0.5690.49
90_E175_V0.5670.48
49_F56_S0.5620.48
136_S142_L0.5610.48
299_L309_Y0.5600.48
112_G118_V0.5580.47
286_I301_I0.5560.47
112_G272_H0.5560.47
124_M127_D0.5560.47
198_G221_I0.5550.47
134_V142_L0.5520.47
24_L43_R0.5520.47
201_L226_C0.5520.47
151_P154_D0.5500.46
148_E157_K0.5490.46
72_D76_D0.5490.46
280_D283_Q0.5470.46
172_L234_E0.5470.46
210_L267_S0.5450.46
24_L77_C0.5440.46
22_R43_R0.5430.46
15_S40_A0.5420.45
188_L206_G0.5420.45
89_P150_Q0.5410.45
40_A43_R0.5400.45
303_A309_Y0.5400.45
92_Q124_M0.5390.45
184_G302_V0.5390.45
181_L266_I0.5390.45
170_K242_A0.5380.45
279_L303_A0.5370.45
184_G271_F0.5360.45
39_T42_S0.5360.45
266_I300_R0.5320.44
31_D54_V0.5320.44
25_F34_P0.5310.44
219_P263_D0.5290.44
189_L209_V0.5280.44
222_R287_R0.5270.44
308_P314_D0.5270.44
301_I332_Y0.5270.44
203_V273_D0.5270.44
83_Y113_E0.5220.43
286_I316_T0.5220.43
55_L66_S0.5220.43
140_C144_F0.5210.43
16_D20_Q0.5210.43
231_P282_A0.5210.43
211_S240_L0.5200.43
271_F309_Y0.5190.43
44_A57_R0.5180.43
187_L331_V0.5170.42
88_K114_N0.5160.42
22_R77_C0.5150.42
283_Q316_T0.5140.42
67_L72_D0.5140.42
148_E210_L0.5130.42
133_K140_C0.5130.42
116_S125_L0.5120.42
303_A312_V0.5120.42
143_Y176_F0.5100.42
95_L135_D0.5100.42
85_P306_F0.5100.42
28_D32_D0.5100.42
240_L247_G0.5090.42
286_I305_A0.5080.41
116_S275_M0.5070.41
105_G108_I0.5060.41
202_D272_H0.5050.41
169_V174_G0.5040.41
76_D248_E0.5040.41
205_C236_S0.5030.41
212_V215_A0.5030.41
201_L252_S0.5020.41
115_R235_A0.5020.41
79_T102_L0.5010.41
214_F218_S0.5010.41
255_F281_A0.5010.41
86_K277_T0.5010.41
288_G292_H0.5010.41
177_S207_A0.5010.41
110_V118_V0.5010.41
16_D22_R0.5000.40
47_Q51_H0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pjdA 1 0.9738 100 0.34 Contact Map
4dcmA 1 0.9534 100 0.37 Contact Map
3dmgA 1 0.9592 100 0.444 Contact Map
2b3tA 1 0.7114 100 0.684 Contact Map
1nv8A 1 0.6939 100 0.7 Contact Map
1dusA 1 0.5452 100 0.704 Contact Map
3evzA 1 0.5423 99.9 0.743 Contact Map
4mtlA 4 0.5569 99.9 0.748 Contact Map
3lpmA 2 0.5277 99.9 0.749 Contact Map
2ozvA 2 0.4461 99.9 0.754 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.