GREMLIN Database
FHUF - Ferric iron reductase protein FhuF
UniProt: P39405 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12595
Length: 262 (219)
Sequences: 740 (569)
Seq/√Len: 38.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_Y164_A6.3281.00
71_A88_N4.9721.00
93_S186_N4.3961.00
190_L193_W3.3901.00
87_E249_R3.0781.00
214_L218_K2.8881.00
119_D124_H2.8491.00
178_I183_I2.6961.00
169_V184_W2.3841.00
170_Q180_G2.2981.00
232_V239_L2.2430.99
173_E180_G2.1720.99
58_A123_E2.1380.99
215_F218_K2.1200.99
179_N182_L2.0520.99
165_L187_T2.0290.99
184_W227_P2.0270.99
228_L231_T2.0020.99
185_S243_T1.9870.99
244_C259_C1.9460.98
245_C256_C1.9460.98
244_C256_C1.9460.98
245_C259_C1.9460.98
256_C259_C1.9460.98
66_L171_A1.9370.98
192_N239_L1.8730.98
247_R253_V1.7970.97
192_N234_L1.6200.95
72_V85_I1.5920.95
62_S65_V1.5870.95
74_S85_I1.5550.94
189_Y258_D1.5490.94
99_Y135_V1.5360.94
95_W260_T1.5340.94
210_L228_L1.5340.94
68_S72_V1.5320.94
138_F181_K1.5150.93
129_F132_T1.5050.93
97_Q101_G1.4830.92
94_L97_Q1.4690.92
107_L156_R1.4630.92
67_S175_T1.4440.91
93_S241_R1.4380.91
212_H216_F1.4250.91
85_I91_L1.4210.91
106_P109_L1.4210.91
119_D144_E1.4210.91
207_V218_K1.4120.90
186_N241_R1.4090.90
108_M241_R1.4070.90
182_L186_N1.3990.90
188_G242_R1.3990.90
97_Q194_Y1.3920.90
207_V214_L1.3890.90
112_L210_L1.3710.89
194_Y248_Y1.3670.89
121_S209_S1.3660.89
185_S189_Y1.3580.89
210_L214_L1.3460.88
164_A167_P1.3320.88
93_S182_L1.3300.87
185_S246_Q1.3180.87
96_A186_N1.2890.86
74_S88_N1.2880.86
67_S71_A1.2840.86
103_M138_F1.2730.85
149_T153_P1.2680.85
89_K93_S1.2610.84
107_L120_V1.2550.84
101_G129_F1.2440.84
192_N232_V1.2370.83
72_V76_H1.2310.83
59_Q62_S1.2130.82
64_N209_S1.1900.81
90_P249_R1.1900.81
126_H141_D1.1880.81
87_E179_N1.1870.81
182_L185_S1.1830.80
95_W247_R1.1810.80
97_Q185_S1.1790.80
49_P52_L1.1710.80
60_W172_L1.1670.80
218_K228_L1.1660.79
241_R245_C1.1550.79
241_R256_C1.1550.79
241_R244_C1.1550.79
241_R259_C1.1550.79
70_L250_L1.1460.78
155_H174_A1.1450.78
180_G261_L1.1430.78
97_Q195_L1.1330.77
56_T171_A1.1290.77
234_L239_L1.1240.77
42_E45_R1.1220.77
89_K187_T1.1210.77
158_E162_S1.1190.77
185_S231_T1.1160.76
98_W134_R1.1000.75
90_P243_T1.0930.75
173_E176_G1.0780.74
98_W185_S1.0730.73
78_Y85_I1.0730.73
193_W197_E1.0590.72
184_W260_T1.0560.72
110_A114_Q1.0520.72
42_E46_L1.0500.72
207_V217_E1.0330.71
208_E212_H1.0300.70
105_P255_Q1.0260.70
154_Q158_E1.0230.70
87_E125_F1.0200.70
96_A110_A1.0190.70
73_Y95_W1.0130.69
120_V250_L1.0060.69
104_V243_T1.0030.68
103_M251_P0.9920.67
178_I181_K0.9870.67
185_S247_R0.9720.66
102_L258_D0.9590.65
153_P213_A0.9500.64
240_V257_G0.9480.64
46_L128_E0.9460.64
191_I215_F0.9410.63
70_L92_I0.9320.63
161_I208_E0.9320.63
149_T210_L0.9250.62
220_L223_G0.9230.62
149_T220_L0.9190.61
127_A131_E0.9180.61
40_L255_Q0.9140.61
66_L190_L0.9090.61
58_A122_P0.9040.60
97_Q186_N0.9000.60
57_L67_S0.8960.59
105_P193_W0.8960.59
41_L44_I0.8950.59
74_S86_R0.8930.59
103_M112_L0.8920.59
210_L213_A0.8900.59
97_Q182_L0.8830.58
117_A155_H0.8800.58
227_P260_T0.8750.58
49_P203_G0.8740.58
96_A100_I0.8640.57
102_L194_Y0.8630.57
185_S188_G0.8620.56
161_I175_T0.8590.56
100_I135_V0.8500.55
210_L218_K0.8400.55
177_E180_G0.8400.55
67_S170_Q0.8330.54
184_W226_N0.8300.54
70_L176_G0.8290.54
251_P257_G0.8240.53
97_Q190_L0.8220.53
164_A168_V0.8190.53
120_V167_P0.8170.52
121_S152_S0.8160.52
69_L167_P0.8150.52
130_H165_L0.8120.52
66_L92_I0.8100.52
206_T209_S0.8090.52
112_L152_S0.8080.52
153_P163_Q0.8020.51
108_M195_L0.7980.51
95_W160_L0.7950.50
168_V255_Q0.7930.50
97_Q241_R0.7910.50
242_R261_L0.7910.50
95_W116_K0.7900.50
108_M249_R0.7880.50
193_W254_Q0.7870.50
247_R255_Q0.7830.49
73_Y90_P0.7790.49
214_L226_N0.7770.49
93_S258_D0.7750.49
38_E42_E0.7750.49
93_S108_M0.7720.48
71_A174_A0.7710.48
189_Y241_R0.7710.48
110_A118_L0.7670.48
93_S188_G0.7650.48
101_G185_S0.7620.48
155_H209_S0.7610.47
98_W190_L0.7580.47
186_N242_R0.7570.47
189_Y239_L0.7570.47
149_T152_S0.7560.47
118_L189_Y0.7540.47
105_P190_L0.7530.47
77_I191_I0.7430.46
193_W248_Y0.7400.46
106_P229_W0.7400.46
190_L194_Y0.7380.45
188_G241_R0.7290.45
100_I185_S0.7250.44
101_G195_L0.7220.44
62_S174_A0.7170.44
214_L247_R0.7160.43
55_M60_W0.7150.43
91_L112_L0.7130.43
135_V185_S0.7110.43
73_Y98_W0.7100.43
64_N168_V0.7040.42
169_V187_T0.7020.42
40_L45_R0.7020.42
71_A76_H0.7010.42
178_I193_W0.7000.42
64_N158_E0.6930.41
178_I199_K0.6890.41
96_A169_V0.6870.41
95_W100_I0.6850.41
213_A217_E0.6840.41
57_L99_Y0.6770.40
40_L188_G0.6750.40
122_P128_E0.6750.40
252_D258_D0.6720.40
37_R142_V0.6720.40
206_T212_H0.6710.40
57_L126_H0.6690.39
146_K155_H0.6680.39
54_A227_P0.6650.39
104_V120_V0.6640.39
130_H211_R0.6630.39
111_L156_R0.6590.38
58_A61_S0.6590.38
186_N257_G0.6580.38
179_N260_T0.6570.38
61_S170_Q0.6570.38
115_E149_T0.6550.38
138_F193_W0.6520.38
108_M115_E0.6490.38
247_R261_L0.6480.38
189_Y192_N0.6480.38
125_F208_E0.6470.37
189_Y232_V0.6460.37
100_I247_R0.6440.37
174_A179_N0.6430.37
128_E137_C0.6410.37
121_S124_H0.6410.37
90_P223_G0.6340.36
244_C260_T0.6320.36
256_C260_T0.6320.36
245_C260_T0.6320.36
186_N228_L0.6290.36
119_D164_A0.6290.36
173_E257_G0.6280.36
107_L209_S0.6280.36
125_F198_M0.6260.36
179_N186_N0.6230.35
124_H210_L0.6220.35
51_P161_I0.6210.35
70_L170_Q0.6190.35
165_L169_V0.6190.35
158_E163_Q0.6170.35
193_W258_D0.6170.35
74_S91_L0.6160.35
61_S70_L0.6150.35
63_P203_G0.6140.35
50_A72_V0.6130.35
254_Q258_D0.6130.35
69_L127_A0.6120.35
98_W255_Q0.6120.35
122_P173_E0.6090.34
93_S97_Q0.6080.34
77_I85_I0.6080.34
193_W247_R0.6050.34
99_Y130_H0.6020.34
127_A179_N0.6000.34
74_S78_Y0.5990.34
137_C160_L0.5940.33
142_V217_E0.5910.33
132_T177_E0.5900.33
146_K217_E0.5880.33
97_Q135_V0.5850.32
112_L146_K0.5840.32
146_K151_H0.5830.32
52_L219_T0.5820.32
71_A133_G0.5820.32
56_T251_P0.5810.32
104_V191_I0.5780.32
58_A168_V0.5720.31
174_A177_E0.5720.31
199_K211_R0.5710.31
190_L247_R0.5710.31
233_V236_D0.5670.31
87_E138_F0.5660.31
193_W196_T0.5650.31
71_A75_D0.5640.31
101_G109_L0.5600.30
36_H39_H0.5600.30
124_H142_V0.5560.30
89_K246_Q0.5540.30
56_T59_Q0.5540.30
89_K186_N0.5530.30
151_H206_T0.5530.30
150_P161_I0.5500.30
116_K145_D0.5450.29
230_R242_R0.5450.29
49_P59_Q0.5440.29
222_N225_D0.5400.29
98_W101_G0.5390.29
94_L247_R0.5380.29
117_A191_I0.5370.29
186_N189_Y0.5330.28
223_G247_R0.5330.28
214_L217_E0.5330.28
110_A255_Q0.5320.28
182_L241_R0.5280.28
95_W99_Y0.5250.28
103_M113_T0.5240.28
168_V218_K0.5220.28
108_M111_L0.5220.28
188_G246_Q0.5210.28
87_E237_G0.5200.28
102_L189_Y0.5190.27
210_L215_F0.5190.27
124_H144_E0.5180.27
55_M61_S0.5160.27
190_L243_T0.5150.27
119_D243_T0.5110.27
48_E52_L0.5110.27
96_A178_I0.5090.27
133_G138_F0.5050.26
176_G199_K0.5050.26
166_V170_Q0.5020.26
104_V122_P0.5000.26
51_P54_A0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x3jA 2 0.8244 97.7 0.871 Contact Map
3to3A 2 0.8359 96.7 0.891 Contact Map
2x0qA 2 0.8282 95.9 0.899 Contact Map
1ornA 1 0.6794 20.3 0.954 Contact Map
2abkA 1 0.6756 7.9 0.961 Contact Map
3fq3A 6 0.2977 4.6 0.966 Contact Map
3d53A 5 0.2939 4.6 0.966 Contact Map
4xelA 3 0.2939 4.5 0.966 Contact Map
1q16A 2 0.2176 3.9 0.967 Contact Map
3gvfA 5 0.3015 3.8 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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