FHUF - ECOLI - GREMLIN Contacts

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FHUF - Ferric iron reductase protein FhuF

UniProt:	P39405	Sequences: MAYRSAPLYEDVIWRTHLQPQDPTLAQAVRATIAKHREHLLEFIRLDEPAPLNAMTLAQWSSPNVLSSLLAVYSDHIYRNQPMMIRENKPLISLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHAEFHETGRVACFWVDVCEDKNATPHSPQHRMETLISQALVPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEATVESLRHALFFEKTLTNGEDNPLWRTVVLRDGLLVRRTCCQRYRLPDVQQCGDCTLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12595
Length:	262 (219)
Sequences:	740 (569)
Seq/√Len:	38.4

ECOLI - FHUF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
99_Y	164_A	6.328	1.00
71_A	88_N	4.972	1.00
93_S	186_N	4.396	1.00
190_L	193_W	3.390	1.00
87_E	249_R	3.078	1.00
214_L	218_K	2.888	1.00
119_D	124_H	2.849	1.00
178_I	183_I	2.696	1.00
169_V	184_W	2.384	1.00
170_Q	180_G	2.298	1.00
232_V	239_L	2.243	0.99
173_E	180_G	2.172	0.99
58_A	123_E	2.138	0.99
215_F	218_K	2.120	0.99
179_N	182_L	2.052	0.99
165_L	187_T	2.029	0.99
184_W	227_P	2.027	0.99
228_L	231_T	2.002	0.99
185_S	243_T	1.987	0.99
244_C	259_C	1.946	0.98
245_C	256_C	1.946	0.98
244_C	256_C	1.946	0.98
245_C	259_C	1.946	0.98
256_C	259_C	1.946	0.98
66_L	171_A	1.937	0.98
192_N	239_L	1.873	0.98
247_R	253_V	1.797	0.97
192_N	234_L	1.620	0.95
72_V	85_I	1.592	0.95
62_S	65_V	1.587	0.95
74_S	85_I	1.555	0.94
189_Y	258_D	1.549	0.94
99_Y	135_V	1.536	0.94
95_W	260_T	1.534	0.94
210_L	228_L	1.534	0.94
68_S	72_V	1.532	0.94
138_F	181_K	1.515	0.93
129_F	132_T	1.505	0.93
97_Q	101_G	1.483	0.92
94_L	97_Q	1.469	0.92
107_L	156_R	1.463	0.92
67_S	175_T	1.444	0.91
93_S	241_R	1.438	0.91
212_H	216_F	1.425	0.91
85_I	91_L	1.421	0.91
106_P	109_L	1.421	0.91
119_D	144_E	1.421	0.91
207_V	218_K	1.412	0.90
186_N	241_R	1.409	0.90
108_M	241_R	1.407	0.90
182_L	186_N	1.399	0.90
188_G	242_R	1.399	0.90
97_Q	194_Y	1.392	0.90
207_V	214_L	1.389	0.90
112_L	210_L	1.371	0.89
194_Y	248_Y	1.367	0.89
121_S	209_S	1.366	0.89
185_S	189_Y	1.358	0.89
210_L	214_L	1.346	0.88
164_A	167_P	1.332	0.88
93_S	182_L	1.330	0.87
185_S	246_Q	1.318	0.87
96_A	186_N	1.289	0.86
74_S	88_N	1.288	0.86
67_S	71_A	1.284	0.86
103_M	138_F	1.273	0.85
149_T	153_P	1.268	0.85
89_K	93_S	1.261	0.84
107_L	120_V	1.255	0.84
101_G	129_F	1.244	0.84
192_N	232_V	1.237	0.83
72_V	76_H	1.231	0.83
59_Q	62_S	1.213	0.82
64_N	209_S	1.190	0.81
90_P	249_R	1.190	0.81
126_H	141_D	1.188	0.81
87_E	179_N	1.187	0.81
182_L	185_S	1.183	0.80
95_W	247_R	1.181	0.80
97_Q	185_S	1.179	0.80
49_P	52_L	1.171	0.80
60_W	172_L	1.167	0.80
218_K	228_L	1.166	0.79
241_R	245_C	1.155	0.79
241_R	256_C	1.155	0.79
241_R	244_C	1.155	0.79
241_R	259_C	1.155	0.79
70_L	250_L	1.146	0.78
155_H	174_A	1.145	0.78
180_G	261_L	1.143	0.78
97_Q	195_L	1.133	0.77
56_T	171_A	1.129	0.77
234_L	239_L	1.124	0.77
42_E	45_R	1.122	0.77
89_K	187_T	1.121	0.77
158_E	162_S	1.119	0.77
185_S	231_T	1.116	0.76
98_W	134_R	1.100	0.75
90_P	243_T	1.093	0.75
173_E	176_G	1.078	0.74
98_W	185_S	1.073	0.73
78_Y	85_I	1.073	0.73
193_W	197_E	1.059	0.72
184_W	260_T	1.056	0.72
110_A	114_Q	1.052	0.72
42_E	46_L	1.050	0.72
207_V	217_E	1.033	0.71
208_E	212_H	1.030	0.70
105_P	255_Q	1.026	0.70
154_Q	158_E	1.023	0.70
87_E	125_F	1.020	0.70
96_A	110_A	1.019	0.70
73_Y	95_W	1.013	0.69
120_V	250_L	1.006	0.69
104_V	243_T	1.003	0.68
103_M	251_P	0.992	0.67
178_I	181_K	0.987	0.67
185_S	247_R	0.972	0.66
102_L	258_D	0.959	0.65
153_P	213_A	0.950	0.64
240_V	257_G	0.948	0.64
46_L	128_E	0.946	0.64
191_I	215_F	0.941	0.63
70_L	92_I	0.932	0.63
161_I	208_E	0.932	0.63
149_T	210_L	0.925	0.62
220_L	223_G	0.923	0.62
149_T	220_L	0.919	0.61
127_A	131_E	0.918	0.61
40_L	255_Q	0.914	0.61
66_L	190_L	0.909	0.61
58_A	122_P	0.904	0.60
97_Q	186_N	0.900	0.60
57_L	67_S	0.896	0.59
105_P	193_W	0.896	0.59
41_L	44_I	0.895	0.59
74_S	86_R	0.893	0.59
103_M	112_L	0.892	0.59
210_L	213_A	0.890	0.59
97_Q	182_L	0.883	0.58
117_A	155_H	0.880	0.58
227_P	260_T	0.875	0.58
49_P	203_G	0.874	0.58
96_A	100_I	0.864	0.57
102_L	194_Y	0.863	0.57
185_S	188_G	0.862	0.56
161_I	175_T	0.859	0.56
100_I	135_V	0.850	0.55
210_L	218_K	0.840	0.55
177_E	180_G	0.840	0.55
67_S	170_Q	0.833	0.54
184_W	226_N	0.830	0.54
70_L	176_G	0.829	0.54
251_P	257_G	0.824	0.53
97_Q	190_L	0.822	0.53
164_A	168_V	0.819	0.53
120_V	167_P	0.817	0.52
121_S	152_S	0.816	0.52
69_L	167_P	0.815	0.52
130_H	165_L	0.812	0.52
66_L	92_I	0.810	0.52
206_T	209_S	0.809	0.52
112_L	152_S	0.808	0.52
153_P	163_Q	0.802	0.51
108_M	195_L	0.798	0.51
95_W	160_L	0.795	0.50
168_V	255_Q	0.793	0.50
97_Q	241_R	0.791	0.50
242_R	261_L	0.791	0.50
95_W	116_K	0.790	0.50
108_M	249_R	0.788	0.50
193_W	254_Q	0.787	0.50
247_R	255_Q	0.783	0.49
73_Y	90_P	0.779	0.49
214_L	226_N	0.777	0.49
93_S	258_D	0.775	0.49
38_E	42_E	0.775	0.49
93_S	108_M	0.772	0.48
71_A	174_A	0.771	0.48
189_Y	241_R	0.771	0.48
110_A	118_L	0.767	0.48
93_S	188_G	0.765	0.48
101_G	185_S	0.762	0.48
155_H	209_S	0.761	0.47
98_W	190_L	0.758	0.47
186_N	242_R	0.757	0.47
189_Y	239_L	0.757	0.47
149_T	152_S	0.756	0.47
118_L	189_Y	0.754	0.47
105_P	190_L	0.753	0.47
77_I	191_I	0.743	0.46
193_W	248_Y	0.740	0.46
106_P	229_W	0.740	0.46
190_L	194_Y	0.738	0.45
188_G	241_R	0.729	0.45
100_I	185_S	0.725	0.44
101_G	195_L	0.722	0.44
62_S	174_A	0.717	0.44
214_L	247_R	0.716	0.43
55_M	60_W	0.715	0.43
91_L	112_L	0.713	0.43
135_V	185_S	0.711	0.43
73_Y	98_W	0.710	0.43
64_N	168_V	0.704	0.42
169_V	187_T	0.702	0.42
40_L	45_R	0.702	0.42
71_A	76_H	0.701	0.42
178_I	193_W	0.700	0.42
64_N	158_E	0.693	0.41
178_I	199_K	0.689	0.41
96_A	169_V	0.687	0.41
95_W	100_I	0.685	0.41
213_A	217_E	0.684	0.41
57_L	99_Y	0.677	0.40
40_L	188_G	0.675	0.40
122_P	128_E	0.675	0.40
252_D	258_D	0.672	0.40
37_R	142_V	0.672	0.40
206_T	212_H	0.671	0.40
57_L	126_H	0.669	0.39
146_K	155_H	0.668	0.39
54_A	227_P	0.665	0.39
104_V	120_V	0.664	0.39
130_H	211_R	0.663	0.39
111_L	156_R	0.659	0.38
58_A	61_S	0.659	0.38
186_N	257_G	0.658	0.38
179_N	260_T	0.657	0.38
61_S	170_Q	0.657	0.38
115_E	149_T	0.655	0.38
138_F	193_W	0.652	0.38
108_M	115_E	0.649	0.38
247_R	261_L	0.648	0.38
189_Y	192_N	0.648	0.38
125_F	208_E	0.647	0.37
189_Y	232_V	0.646	0.37
100_I	247_R	0.644	0.37
174_A	179_N	0.643	0.37
128_E	137_C	0.641	0.37
121_S	124_H	0.641	0.37
90_P	223_G	0.634	0.36
244_C	260_T	0.632	0.36
256_C	260_T	0.632	0.36
245_C	260_T	0.632	0.36
186_N	228_L	0.629	0.36
119_D	164_A	0.629	0.36
173_E	257_G	0.628	0.36
107_L	209_S	0.628	0.36
125_F	198_M	0.626	0.36
179_N	186_N	0.623	0.35
124_H	210_L	0.622	0.35
51_P	161_I	0.621	0.35
70_L	170_Q	0.619	0.35
165_L	169_V	0.619	0.35
158_E	163_Q	0.617	0.35
193_W	258_D	0.617	0.35
74_S	91_L	0.616	0.35
61_S	70_L	0.615	0.35
63_P	203_G	0.614	0.35
50_A	72_V	0.613	0.35
254_Q	258_D	0.613	0.35
69_L	127_A	0.612	0.35
98_W	255_Q	0.612	0.35
122_P	173_E	0.609	0.34
93_S	97_Q	0.608	0.34
77_I	85_I	0.608	0.34
193_W	247_R	0.605	0.34
99_Y	130_H	0.602	0.34
127_A	179_N	0.600	0.34
74_S	78_Y	0.599	0.34
137_C	160_L	0.594	0.33
142_V	217_E	0.591	0.33
132_T	177_E	0.590	0.33
146_K	217_E	0.588	0.33
97_Q	135_V	0.585	0.32
112_L	146_K	0.584	0.32
146_K	151_H	0.583	0.32
52_L	219_T	0.582	0.32
71_A	133_G	0.582	0.32
56_T	251_P	0.581	0.32
104_V	191_I	0.578	0.32
58_A	168_V	0.572	0.31
174_A	177_E	0.572	0.31
199_K	211_R	0.571	0.31
190_L	247_R	0.571	0.31
233_V	236_D	0.567	0.31
87_E	138_F	0.566	0.31
193_W	196_T	0.565	0.31
71_A	75_D	0.564	0.31
101_G	109_L	0.560	0.30
36_H	39_H	0.560	0.30
124_H	142_V	0.556	0.30
89_K	246_Q	0.554	0.30
56_T	59_Q	0.554	0.30
89_K	186_N	0.553	0.30
151_H	206_T	0.553	0.30
150_P	161_I	0.550	0.30
116_K	145_D	0.545	0.29
230_R	242_R	0.545	0.29
49_P	59_Q	0.544	0.29
222_N	225_D	0.540	0.29
98_W	101_G	0.539	0.29
94_L	247_R	0.538	0.29
117_A	191_I	0.537	0.29
186_N	189_Y	0.533	0.28
223_G	247_R	0.533	0.28
214_L	217_E	0.533	0.28
110_A	255_Q	0.532	0.28
182_L	241_R	0.528	0.28
95_W	99_Y	0.525	0.28
103_M	113_T	0.524	0.28
168_V	218_K	0.522	0.28
108_M	111_L	0.522	0.28
188_G	246_Q	0.521	0.28
87_E	237_G	0.520	0.28
102_L	189_Y	0.519	0.27
210_L	215_F	0.519	0.27
124_H	144_E	0.518	0.27
55_M	61_S	0.516	0.27
190_L	243_T	0.515	0.27
119_D	243_T	0.511	0.27
48_E	52_L	0.511	0.27
96_A	178_I	0.509	0.27
133_G	138_F	0.505	0.26
176_G	199_K	0.505	0.26
166_V	170_Q	0.502	0.26
104_V	122_P	0.500	0.26
51_P	54_A	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2x3jA	2	0.8244	97.7	0.871	Contact Map
3to3A	2	0.8359	96.7	0.891	Contact Map
2x0qA	2	0.8282	95.9	0.899	Contact Map
1ornA	1	0.6794	20.3	0.954	Contact Map
2abkA	1	0.6756	7.9	0.961	Contact Map
3fq3A	6	0.2977	4.6	0.966	Contact Map
3d53A	5	0.2939	4.6	0.966	Contact Map
4xelA	3	0.2939	4.5	0.966	Contact Map
1q16A	2	0.2176	3.9	0.967	Contact Map
3gvfA	5	0.3015	3.8	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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