GREMLIN Database
BGLJ - Transcriptional activator protein BglJ
UniProt: P39404 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12594
Length: 225 (189)
Sequences: 72158 (50293)
Seq/√Len: 3658.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_S40_T3.6911.00
21_S42_T3.1081.00
25_E40_T2.9881.00
14_I47_F2.6651.00
45_E67_R2.5721.00
43_S67_R2.5071.00
39_H56_F2.4771.00
48_Q79_E2.3901.00
52_S83_K2.3381.00
44_Q68_S2.2921.00
68_S79_E2.2141.00
10_N35_P2.1441.00
27_L120_L2.0691.00
10_N39_H2.0291.00
102_I122_I2.0251.00
25_E29_R2.0071.00
182_K185_R1.9741.00
156_T159_E1.9161.00
31_F124_H1.8941.00
41_Y50_A1.8811.00
42_T46_S1.8611.00
39_H50_A1.8511.00
64_S95_D1.8151.00
61_F76_C1.7921.00
43_S46_S1.7821.00
99_A119_T1.7691.00
170_M185_R1.7471.00
77_L89_R1.7221.00
39_H54_I1.6951.00
91_V105_L1.6931.00
12_A41_Y1.6541.00
33_G128_F1.6401.00
91_V110_L1.6111.00
81_A111_D1.6061.00
28_F127_L1.5741.00
187_H190_N1.5711.00
72_E75_S1.5691.00
79_E83_K1.5311.00
162_R166_R1.5301.00
44_Q76_C1.5201.00
9_R131_L1.4771.00
68_S75_S1.4721.00
163_F176_Q1.4521.00
157_E194_K1.4311.00
79_E82_I1.4251.00
112_G126_E1.4181.00
50_A54_I1.4171.00
95_D101_L1.4161.00
58_A127_L1.4151.00
77_L91_V1.3891.00
48_Q76_C1.3821.00
168_Y176_Q1.3781.00
50_A53_R1.3631.00
59_V87_T1.3501.00
84_F87_T1.3481.00
169_S172_Q1.3451.00
90_L130_S1.3341.00
15_E21_S1.3321.00
75_S78_T1.3301.00
61_F77_L1.3231.00
63_F91_V1.3191.00
51_M80_L1.3131.00
18_V42_T1.3091.00
45_E68_S1.2921.00
14_I65_A1.2291.00
111_D133_G1.2281.00
49_D53_R1.2161.00
78_T108_S1.2061.00
63_F74_L1.2051.00
107_P128_F1.1981.00
31_F128_F1.1901.00
41_Y47_F1.1841.00
98_E101_L1.1781.00
48_Q68_S1.1671.00
10_N54_I1.1561.00
46_S49_D1.1511.00
50_A56_F1.1501.00
45_E49_D1.1481.00
16_K62_S1.1411.00
46_S50_A1.1371.00
12_A47_F1.1361.00
158_R162_R1.1011.00
12_A56_F1.0951.00
58_A131_L1.0841.00
124_H128_F1.0821.00
163_F167_G1.0691.00
74_L104_S1.0671.00
171_T181_I1.0611.00
186_A189_F1.0591.00
78_T104_S1.0441.00
163_F168_Y1.0371.00
172_Q176_Q1.0261.00
99_A103_G1.0111.00
122_I125_Q1.0051.00
74_L108_S1.0011.00
168_Y172_Q0.9911.00
14_I59_V0.9801.00
156_T178_K0.9791.00
182_K186_A0.9771.00
111_D130_S0.9771.00
104_S108_S0.9771.00
47_F51_M0.9731.00
159_E162_R0.9721.00
163_F173_I0.9561.00
61_F89_R0.9551.00
74_L105_L0.9541.00
100_R104_S0.9531.00
24_I92_I0.9521.00
12_A50_A0.9521.00
125_Q129_L0.9321.00
59_V80_L0.9291.00
41_Y46_S0.9241.00
18_V21_S0.9201.00
196_G199_S0.9171.00
35_P39_H0.9081.00
51_M84_F0.9061.00
18_V22_I0.9051.00
145_W150_S0.9001.00
102_I115_S0.8941.00
63_F72_E0.8901.00
47_F76_C0.8881.00
130_S133_G0.8831.00
103_G107_P0.8811.00
19_M23_G0.8791.00
10_N56_F0.8771.00
155_P159_E0.8751.00
183_T187_H0.8751.00
48_Q52_S0.8711.00
12_A51_M0.8711.00
65_A76_C0.8691.00
22_I40_T0.8691.00
13_L24_I0.8661.00
25_E36_Y0.8631.00
49_D52_S0.8551.00
24_I123_F0.8531.00
181_I185_R0.8521.00
14_I41_Y0.8511.00
77_L108_S0.8491.00
60_I123_F0.8461.00
154_S194_K0.8451.00
188_K192_M0.8431.00
99_A102_I0.8421.00
122_I126_E0.8411.00
13_L36_Y0.8411.00
104_S107_P0.8411.00
12_A39_H0.8361.00
77_L110_L0.8331.00
75_S79_E0.8261.00
61_F91_V0.8221.00
171_T175_E0.8211.00
103_G121_E0.8211.00
60_I92_I0.8131.00
26_S30_K0.8121.00
106_S126_E0.8031.00
64_S94_D0.8001.00
182_K189_F0.7991.00
10_N57_A0.7971.00
96_D115_S0.7961.00
190_N193_S0.7951.00
145_W148_N0.7881.00
201_A204_L0.7871.00
189_F193_S0.7761.00
22_I25_E0.7741.00
78_T82_I0.7731.00
101_L104_S0.7701.00
88_R111_D0.7701.00
44_Q48_Q0.7581.00
59_V89_R0.7581.00
129_L132_N0.7561.00
9_R135_R0.7541.00
172_Q175_E0.7531.00
63_F101_L0.7521.00
44_Q67_R0.7511.00
76_C80_L0.7501.00
164_M188_K0.7421.00
100_R121_E0.7401.00
129_L134_V0.7401.00
68_S76_C0.7391.00
90_L126_E0.7391.00
198_S201_A0.7351.00
185_R188_K0.7271.00
120_L124_H0.7241.00
51_M87_T0.7191.00
13_L25_E0.7181.00
20_S118_S0.7171.00
15_E65_A0.7121.00
14_I76_C0.7061.00
51_M56_F0.7051.00
80_L85_P0.7011.00
90_L112_G0.6991.00
199_S202_G0.6971.00
63_F95_D0.6951.00
198_S202_G0.6931.00
48_Q51_M0.6931.00
179_R184_I0.6921.00
22_I26_S0.6901.00
55_S84_F0.6871.00
36_Y39_H0.6821.00
166_R176_Q0.6811.00
197_V202_G0.6791.00
118_S123_F0.6691.00
99_A121_E0.6641.00
13_L40_T0.6631.00
36_Y40_T0.6611.00
107_P125_Q0.6601.00
196_G202_G0.6591.00
21_S25_E0.6581.00
186_A190_N0.6551.00
11_V58_A0.6521.00
188_K200_D0.6441.00
93_A102_I0.6431.00
11_V28_F0.6421.00
160_I164_M0.6411.00
192_M197_V0.6411.00
131_L134_V0.6391.00
17_C94_D0.6351.00
170_M174_A0.6341.00
92_I118_S0.6331.00
159_E163_F0.6331.00
80_L89_R0.6301.00
29_R36_Y0.6281.00
23_G27_L0.6271.00
52_S79_E0.6261.00
121_E125_Q0.6251.00
170_M181_I0.6251.00
154_S157_E0.6221.00
86_R136_Q0.6191.00
62_S116_K0.6181.00
60_I127_L0.6161.00
63_F105_L0.6161.00
156_T187_H0.6131.00
29_R35_P0.6121.00
51_M59_V0.6101.00
146_Y196_G0.6081.00
119_T122_I0.6061.00
93_A116_K0.6051.00
175_E178_K0.6031.00
88_R131_L0.6021.00
52_S84_F0.6021.00
105_L110_L0.6021.00
141_L144_Q0.6001.00
161_L203_L0.5981.00
61_F65_A0.5931.00
17_C20_S0.5911.00
102_I119_T0.5821.00
27_L124_H0.5811.00
126_E130_S0.5791.00
33_G124_H0.5741.00
16_K93_A0.5661.00
60_I90_L0.5651.00
44_Q65_A0.5651.00
179_R183_T0.5611.00
163_F166_R0.5601.00
157_E160_I0.5591.00
188_K203_L0.5571.00
100_R103_G0.5511.00
9_R57_A0.5501.00
174_A178_K0.5501.00
134_V138_T0.5491.00
11_V127_L0.5481.00
162_R165_S0.5451.00
81_A87_T0.5441.00
81_A88_R0.5431.00
23_G26_S0.5411.00
74_L101_L0.5391.00
146_Y149_Q0.5371.00
140_R144_Q0.5361.00
146_Y197_V0.5321.00
86_R137_A0.5291.00
93_A113_V0.5291.00
105_L113_V0.5171.00
58_A130_S0.5171.00
55_S85_P0.5151.00
20_S23_G0.5141.00
16_K116_K0.5101.00
180_N183_T0.5081.00
146_Y198_S0.5051.00
48_Q83_K0.5051.00
153_L157_E0.5041.00
27_L31_F0.5041.00
140_R143_N0.5021.00
118_S126_E0.5021.00
14_I61_F0.5011.00
161_L191_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gvpA 1 0.8978 100 0.249 Contact Map
3c3wA 2 0.8978 100 0.256 Contact Map
1a04A 1 0.8889 100 0.262 Contact Map
4ldzA 2 0.8756 100 0.271 Contact Map
1yioA 1 0.8756 100 0.278 Contact Map
3kloA 2 0.9067 100 0.293 Contact Map
4hyeA 2 0.8889 100 0.295 Contact Map
4b09A 2 0.8667 100 0.297 Contact Map
1ys7A 2 0.8978 100 0.303 Contact Map
3r0jA 2 0.8889 100 0.318 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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