GREMLIN Database
YJJN - Putative L-galactonate oxidoreductase
UniProt: P39400 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12590
Length: 340 (303)
Sequences: 52900 (36504)
Seq/√Len: 2097.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
318_T321_E2.9781.00
35_K139_P2.9531.00
33_K69_V2.8301.00
35_K67_E2.7491.00
10_Q18_K2.6701.00
31_L69_V2.6671.00
183_K208_L2.5401.00
165_Q188_Q2.5291.00
30_A131_I2.5251.00
138_D141_A2.5191.00
82_Q133_P2.3621.00
79_K82_Q2.3611.00
314_Y325_R2.3411.00
221_Q224_A2.3401.00
33_K67_E2.2501.00
22_I123_Y2.2261.00
171_A191_V2.1951.00
33_K123_Y2.1801.00
64_I119_G2.1771.00
200_E204_T2.1761.00
140_Q313_R2.1401.00
10_Q16_V2.1311.00
188_Q209_P2.0931.00
166_V182_A2.0901.00
297_R301_E2.0651.00
77_D128_V2.0601.00
312_H325_R2.0591.00
199_R203_A2.0541.00
161_A164_E2.0541.00
83_Q139_P2.0161.00
8_I18_K2.0081.00
27_D73_K1.9921.00
28_N74_N1.9901.00
65_C139_P1.9901.00
179_A207_E1.9831.00
136_G300_A1.9591.00
26_G29_E1.9541.00
64_I86_V1.9411.00
315_P318_T1.9281.00
27_D74_N1.9141.00
200_E203_A1.8571.00
24_I70_G1.8451.00
148_F177_G1.8261.00
167_L231_A1.7911.00
167_L192_A1.7751.00
31_L125_S1.7701.00
324_E329_N1.7651.00
164_E256_T1.7601.00
321_E324_E1.7591.00
69_V123_Y1.7541.00
196_P200_E1.7461.00
314_Y322_T1.7291.00
184_A303_K1.6931.00
190_V231_A1.6911.00
199_R210_L1.6911.00
232_Q252_R1.6721.00
193_D199_R1.6601.00
72_G75_I1.6521.00
48_G328_I1.6491.00
256_T280_T1.6161.00
321_E325_R1.6121.00
196_P212_D1.6111.00
251_I257_V1.6021.00
169_V247_T1.5971.00
158_A233_K1.5941.00
325_R331_R1.5931.00
209_P225_Q1.5391.00
216_E221_Q1.5381.00
83_Q135_D1.5341.00
78_L133_P1.5281.00
251_I279_T1.5201.00
201_H204_T1.5191.00
7_L319_L1.5171.00
25_P125_S1.5171.00
188_Q208_L1.5131.00
212_D215_A1.5031.00
256_T282_M1.5021.00
29_E127_P1.4981.00
217_D220_A1.4931.00
71_L80_N1.4911.00
196_P215_A1.4821.00
120_F323_Y1.4711.00
31_L123_Y1.4641.00
5_N19_Q1.4631.00
70_G80_N1.4491.00
251_I255_G1.4481.00
34_I64_I1.4411.00
78_L82_Q1.4401.00
67_E83_Q1.4071.00
25_P31_L1.4021.00
28_N127_P1.3811.00
47_W323_Y1.3751.00
179_A191_V1.3721.00
5_N122_E1.3701.00
36_S140_Q1.3601.00
29_E125_S1.3541.00
234_V247_T1.3331.00
320_A324_E1.3291.00
68_I78_L1.3281.00
234_V251_I1.3281.00
5_N317_A1.3041.00
220_A224_A1.2951.00
165_Q190_V1.2921.00
31_L70_G1.2911.00
311_T325_R1.2871.00
30_A78_L1.2851.00
194_T213_P1.2591.00
67_E139_P1.2591.00
156_R294_K1.2461.00
6_V20_R1.2401.00
169_V192_A1.2391.00
297_R300_A1.2371.00
7_L17_W1.2281.00
178_A235_I1.2281.00
35_K83_Q1.2201.00
156_R291_D1.2161.00
184_A298_L1.2091.00
145_I299_M1.2021.00
199_R212_D1.1791.00
160_I187_A1.1741.00
78_L131_I1.1611.00
22_I31_L1.1491.00
25_P29_E1.1441.00
180_A305_T1.1301.00
165_Q232_Q1.1291.00
196_P199_R1.1211.00
191_V207_E1.1171.00
203_A210_L1.1131.00
28_N128_V1.1081.00
221_Q225_Q1.1001.00
69_V80_N1.0811.00
34_I124_L1.0751.00
158_A258_V1.0741.00
11_Q14_E1.0721.00
7_L316_F1.0651.00
294_K297_R1.0601.00
289_P293_A1.0511.00
126_V131_I1.0501.00
164_E232_Q1.0491.00
141_A305_T1.0471.00
32_I66_G1.0441.00
39_I322_T1.0431.00
36_S139_P1.0391.00
201_H333_L1.0301.00
47_W328_I1.0281.00
157_R280_T1.0271.00
153_H291_D1.0241.00
217_D221_Q1.0211.00
249_N273_E1.0191.00
35_K65_C1.0181.00
298_L303_K1.0151.00
151_S181_I1.0041.00
160_I164_E1.0011.00
17_W317_A0.9931.00
226_F230_L0.9901.00
32_I84_V0.9881.00
40_C63_E0.9861.00
40_C62_H0.9851.00
238_T243_A0.9841.00
37_V120_F0.9791.00
319_L338_I0.9791.00
293_A297_R0.9751.00
151_S178_A0.9711.00
120_F319_L0.9701.00
203_A209_P0.9681.00
215_A221_Q0.9601.00
37_V119_G0.9561.00
219_D249_N0.9561.00
324_E328_I0.9551.00
182_A187_A0.9471.00
148_F295_V0.9461.00
194_T199_R0.9451.00
194_T214_S0.9431.00
71_L75_I0.9401.00
171_A193_D0.9391.00
154_A260_V0.9341.00
137_I142_A0.9311.00
168_V178_A0.9231.00
325_R336_G0.9231.00
236_D239_G0.9211.00
190_V209_P0.9121.00
22_I70_G0.9101.00
179_A189_V0.9011.00
273_E277_K0.9011.00
8_I59_V0.8981.00
75_I128_V0.8971.00
168_V182_A0.8921.00
245_N249_N0.8891.00
169_V234_V0.8861.00
28_N72_G0.8851.00
193_D210_L0.8831.00
222_L231_A0.8811.00
176_L201_H0.8801.00
192_A213_P0.8791.00
195_S198_R0.8751.00
8_I20_R0.8751.00
58_R117_D0.8731.00
219_D246_N0.8731.00
33_K122_E0.8731.00
152_A294_K0.8721.00
24_I31_L0.8711.00
79_K133_P0.8691.00
44_I327_V0.8691.00
171_A179_A0.8681.00
167_L250_L0.8671.00
181_I295_V0.8641.00
171_A202_V0.8641.00
38_G63_E0.8611.00
246_N249_N0.8591.00
165_Q231_A0.8591.00
120_F338_I0.8581.00
20_R117_D0.8571.00
36_S337_V0.8551.00
190_V211_L0.8541.00
197_A200_E0.8521.00
10_Q14_E0.8501.00
135_D300_A0.8471.00
195_S212_D0.8471.00
154_A235_I0.8411.00
22_I69_V0.8371.00
6_V59_V0.8371.00
191_V202_V0.8371.00
64_I124_L0.8351.00
76_A128_V0.8331.00
85_A296_G0.8281.00
274_F281_M0.8211.00
219_D223_R0.8171.00
157_R282_M0.8141.00
314_Y318_T0.8131.00
254_G278_E0.8101.00
198_R333_L0.8101.00
164_E233_K0.8091.00
294_K298_L0.8041.00
40_C43_D0.7961.00
28_N73_K0.7951.00
202_V207_E0.7931.00
155_V182_A0.7891.00
290_E294_K0.7861.00
151_S177_G0.7841.00
181_I298_L0.7811.00
7_L320_A0.7801.00
220_A223_R0.7771.00
151_S174_I0.7751.00
5_N17_W0.7741.00
154_A178_A0.7721.00
39_I327_V0.7711.00
227_G230_L0.7701.00
327_V336_G0.7701.00
149_A291_D0.7691.00
137_I299_M0.7661.00
166_V187_A0.7661.00
190_V222_L0.7661.00
7_L15_L0.7591.00
245_N266_E0.7581.00
26_G125_S0.7561.00
182_A189_V0.7561.00
219_D250_L0.7511.00
39_I120_F0.7491.00
189_V208_L0.7471.00
218_F246_N0.7411.00
17_W316_F0.7411.00
25_P70_G0.7391.00
153_H278_E0.7391.00
234_V257_V0.7381.00
42_T62_H0.7371.00
190_V225_Q0.7361.00
86_V126_V0.7361.00
247_T257_V0.7361.00
298_L302_G0.7341.00
290_E293_A0.7321.00
204_T305_T0.7311.00
160_I233_K0.7311.00
298_L301_E0.7311.00
217_D246_N0.7311.00
185_D294_K0.7301.00
40_C146_E0.7281.00
270_S273_E0.7281.00
138_D142_A0.7251.00
71_L79_K0.7191.00
84_V131_I0.7181.00
30_A128_V0.7181.00
168_V191_V0.7151.00
169_V243_A0.7131.00
65_C143_A0.7131.00
63_E146_E0.7111.00
237_A260_V0.7091.00
65_C83_Q0.7061.00
134_A300_A0.7061.00
25_P72_G0.7041.00
314_Y338_I0.7041.00
274_F279_T0.7021.00
36_S313_R0.6971.00
274_F283_G0.6971.00
312_H321_E0.6961.00
20_R59_V0.6941.00
231_A234_V0.6911.00
259_F281_M0.6911.00
325_R329_N0.6891.00
152_A295_V0.6881.00
310_L313_R0.6861.00
181_I185_D0.6851.00
146_E150_I0.6851.00
139_P142_A0.6811.00
159_A256_T0.6801.00
151_S155_V0.6781.00
132_L293_A0.6781.00
193_D202_V0.6751.00
62_H146_E0.6721.00
233_K258_V0.6711.00
9_C14_E0.6681.00
119_G124_L0.6661.00
187_A233_K0.6641.00
147_P173_P0.6641.00
40_C147_P0.6611.00
199_R202_V0.6601.00
150_I174_I0.6591.00
222_L250_L0.6551.00
13_K324_E0.6531.00
296_G300_A0.6531.00
159_A282_M0.6521.00
41_G45_H0.6511.00
83_Q136_G0.6491.00
152_A298_L0.6471.00
193_D213_P0.6471.00
312_H336_G0.6451.00
314_Y336_G0.6441.00
57_P61_G0.6421.00
159_A280_T0.6421.00
30_A68_I0.6411.00
244_M257_V0.6401.00
253_H277_K0.6391.00
132_L292_F0.6391.00
82_Q135_D0.6371.00
223_R230_L0.6341.00
132_L296_G0.6331.00
36_S65_C0.6291.00
32_I86_V0.6261.00
180_A205_R0.6251.00
28_N129_A0.6241.00
77_D289_P0.6211.00
77_D133_P0.6201.00
23_P125_S0.6201.00
183_K189_V0.6191.00
34_I37_V0.6171.00
201_H205_R0.6151.00
209_P221_Q0.6131.00
179_A205_R0.6131.00
236_D257_V0.6121.00
145_I295_V0.6121.00
42_T46_A0.6121.00
323_Y328_I0.6121.00
223_R226_F0.6081.00
158_A256_T0.6071.00
240_N243_A0.6071.00
332_E336_G0.6061.00
178_A260_V0.6051.00
266_E270_S0.6031.00
218_F222_L0.6011.00
77_D80_N0.6011.00
245_N273_E0.6001.00
199_R213_P0.6001.00
156_R185_D0.5971.00
245_N268_Q0.5971.00
193_D212_D0.5961.00
234_V250_L0.5961.00
152_A291_D0.5951.00
192_A211_L0.5951.00
233_K256_T0.5951.00
231_A250_L0.5941.00
150_I260_V0.5921.00
278_E288_T0.5901.00
87_I132_L0.5871.00
25_P74_N0.5871.00
45_H50_N0.5861.00
23_P123_Y0.5841.00
241_Q245_N0.5821.00
132_L289_P0.5781.00
11_Q16_V0.5761.00
61_G120_F0.5731.00
41_G172_G0.5721.00
236_D261_G0.5691.00
76_A79_K0.5681.00
202_V210_L0.5671.00
147_P177_G0.5641.00
166_V233_K0.5631.00
211_L225_Q0.5631.00
44_I328_I0.5621.00
162_P185_D0.5611.00
243_A247_T0.5591.00
86_V131_I0.5591.00
23_P31_L0.5581.00
193_D198_R0.5541.00
32_I131_I0.5531.00
165_Q226_F0.5531.00
22_I25_P0.5531.00
325_R332_E0.5531.00
144_L337_V0.5521.00
167_L234_V0.5511.00
194_T212_D0.5501.00
156_R290_E0.5481.00
273_E276_K0.5461.00
42_T45_H0.5441.00
54_F58_R0.5431.00
155_V181_I0.5421.00
17_W319_L0.5421.00
71_L82_Q0.5421.00
211_L221_Q0.5411.00
179_A202_V0.5411.00
284_S287_A0.5391.00
152_A185_D0.5371.00
141_A145_I0.5371.00
22_I125_S0.5361.00
224_A227_G0.5341.00
154_A284_S0.5341.00
14_E320_A0.5331.00
299_M304_I0.5311.00
46_A51_Q0.5301.00
211_L216_E0.5301.00
65_C142_A0.5301.00
197_A331_R0.5291.00
134_A142_A0.5281.00
177_G181_I0.5271.00
14_E47_W0.5271.00
59_V118_G0.5271.00
144_L306_A0.5221.00
21_E24_I0.5221.00
40_C335_K0.5211.00
44_I48_G0.5211.00
34_I86_V0.5211.00
34_I119_G0.5201.00
23_P29_E0.5201.00
302_G305_T0.5191.00
292_F296_G0.5191.00
78_L128_V0.5181.00
159_A164_E0.5171.00
128_V131_I0.5171.00
312_H318_T0.5161.00
190_V226_F0.5151.00
15_L323_Y0.5151.00
138_D313_R0.5141.00
258_V284_S0.5141.00
83_Q142_A0.5141.00
183_K207_E0.5131.00
86_V119_G0.5121.00
127_P130_N0.5091.00
37_V338_I0.5061.00
46_A54_F0.5061.00
314_Y321_E0.5051.00
38_G143_A0.5031.00
86_V124_L0.5031.00
176_L205_R0.5031.00
299_M306_A0.5011.00
25_P28_N0.5011.00
169_V218_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ilkA 2 0.9824 100 0.149 Contact Map
4ej6A 1 0.9853 100 0.15 Contact Map
1h2bA 4 0.9735 100 0.162 Contact Map
2dq4A 4 0.9765 100 0.163 Contact Map
1e3iA 2 0.9853 100 0.167 Contact Map
3ukoA 4 0.9882 100 0.168 Contact Map
2h6eA 4 0.9206 100 0.169 Contact Map
1f8fA 4 0.9824 100 0.171 Contact Map
2d8aA 3 0.95 100 0.171 Contact Map
4oh1A 4 0.9647 100 0.171 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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