GREMLIN Database
YJIM - Uncharacterized protein YjiM
UniProt: P39384 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12574
Length: 383 (357)
Sequences: 1080 (824)
Seq/√Len: 43.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_R220_D6.9711.00
182_N227_R6.8091.00
143_K291_D4.7221.00
243_L324_V4.4091.00
179_A220_D3.9731.00
165_A168_D3.6111.00
139_R295_D3.4991.00
320_E353_H3.3071.00
228_Q232_E3.2951.00
143_K147_L3.2451.00
317_Q321_E3.2171.00
78_C335_C3.2131.00
78_C108_C3.1471.00
150_Q161_I3.1231.00
172_L213_E3.1111.00
103_V149_L2.9961.00
319_V355_I2.8021.00
108_C335_C2.7961.00
52_G165_A2.7771.00
51_A161_I2.7531.00
188_Q321_E2.6471.00
27_D31_R2.5291.00
175_R178_R2.5141.00
348_H352_Q2.3671.00
269_G324_V2.3641.00
140_A291_D2.3471.00
29_K100_D2.2541.00
49_M169_A2.2301.00
220_D224_A2.1991.00
48_P53_A2.1761.00
150_Q154_E2.1160.99
265_G380_I2.0620.99
120_E347_R2.0500.99
358_I376_V2.0470.99
68_E71_K2.0380.99
375_R378_A1.9940.99
179_A223_T1.9710.99
190_N323_Q1.9600.99
152_T155_E1.9570.99
313_K317_Q1.9360.99
28_L33_I1.9060.99
370_G373_S1.9050.99
136_D140_A1.8900.99
316_S353_H1.8820.99
40_C273_C1.8630.99
178_R282_C1.8620.99
260_I328_V1.8520.99
150_Q290_Y1.8050.98
16_E20_T1.8030.98
168_D171_A1.7880.98
348_H353_H1.7570.98
170_I289_V1.7390.98
170_I174_N1.7370.98
188_Q322_Y1.7360.98
218_E221_A1.7350.98
223_T227_R1.7260.98
242_I326_G1.7260.98
172_L216_I1.6970.98
179_A216_I1.6960.98
371_Q374_T1.6890.97
26_M30_E1.6840.97
81_I110_G1.6780.97
175_R216_I1.6760.97
319_V327_V1.6710.97
314_M317_Q1.6620.97
23_L27_D1.6520.97
182_N220_D1.6500.97
143_K290_Y1.6490.97
36_V101_L1.6470.97
327_V349_V1.6280.97
47_I153_V1.6190.97
123_P156_R1.6070.97
182_N223_T1.5860.96
213_E217_N1.5860.96
27_D30_E1.5840.96
182_N224_A1.5640.96
346_K350_R1.5380.96
150_Q163_E1.5270.95
312_L348_H1.4860.95
258_R262_E1.4770.94
316_S348_H1.4700.94
70_E82_K1.4680.94
187_G270_Y1.4290.93
349_V355_I1.4290.93
316_S320_E1.4190.93
128_Q141_L1.3950.93
168_D172_L1.3850.92
328_V376_V1.3730.92
151_K155_E1.3710.92
48_P55_V1.3620.92
374_T378_A1.3540.91
168_D213_E1.3510.91
49_M173_K1.3500.91
154_E160_E1.3350.91
72_D89_K1.3300.91
185_H188_Q1.3240.90
285_E289_V1.3190.90
269_G322_Y1.3180.90
196_G261_E1.3180.90
45_Q212_K1.3080.90
375_R381_E1.3040.90
140_A144_A1.2980.90
273_C302_C1.2910.89
163_E167_R1.2820.89
101_L152_T1.2730.89
326_G379_F1.2670.88
40_C302_C1.2600.88
142_W146_M1.2550.88
49_M55_V1.2550.88
170_I285_E1.2440.87
374_T377_A1.2330.87
181_A282_C1.2280.87
50_A161_I1.2250.87
260_I265_G1.2230.86
68_E90_T1.2220.86
125_H152_T1.2180.86
309_D313_K1.2180.86
185_H322_Y1.2170.86
370_G374_T1.2060.86
342_S359_A1.1970.85
143_K294_A1.1930.85
152_T156_R1.1760.84
127_M142_W1.1620.84
176_E216_I1.1540.83
245_T315_L1.1470.83
269_G318_M1.1420.82
289_V292_A1.1400.82
64_E92_K1.1350.82
179_A182_N1.1350.82
43_M48_P1.1330.82
181_A185_H1.1330.82
202_V222_M1.1290.82
288_D291_D1.1290.82
137_A148_R1.1170.81
79_P381_E1.1140.81
47_I146_M1.1140.81
191_P266_W1.1100.81
146_M293_L1.1080.80
187_G192_P1.0890.79
186_L223_T1.0740.78
36_V153_V1.0690.78
147_L151_K1.0680.78
147_L150_Q1.0680.78
125_H149_L1.0640.78
243_L327_V1.0620.78
315_L345_I1.0530.77
175_R179_A1.0430.76
167_R288_D1.0270.75
183_F223_T1.0230.75
189_L230_W1.0210.75
144_A147_L1.0180.74
76_N334_A1.0130.74
371_Q381_E1.0060.74
217_N221_A1.0050.74
311_R341_E1.0050.74
224_A228_Q1.0030.73
170_I293_L1.0000.73
248_P368_D0.9990.73
34_P159_H0.9990.73
40_C111_K0.9960.73
72_D85_Y0.9950.73
74_P113_K0.9940.73
37_G297_Y0.9940.73
130_P335_C0.9930.73
179_A219_L0.9930.73
217_N256_V0.9870.72
28_L54_V0.9800.72
303_S337_T0.9790.72
162_S165_A0.9790.72
241_R325_D0.9760.71
66_I69_A0.9700.71
83_S87_F0.9690.71
197_S229_Q0.9650.70
178_R182_N0.9600.70
241_R268_V0.9550.70
147_L290_Y0.9540.70
242_I260_I0.9460.69
216_I220_D0.9450.69
139_R291_D0.9410.68
113_K116_E0.9400.68
378_A381_E0.9380.68
261_E268_V0.9360.68
144_A299_A0.9350.68
166_L290_Y0.9350.68
225_R229_Q0.9330.68
255_K368_D0.9330.68
139_R143_K0.9320.68
132_S135_D0.9310.68
209_R218_E0.9230.67
53_A157_F0.9210.67
17_A21_G0.9200.67
336_H339_A0.9150.66
316_S319_V0.9100.66
315_L319_V0.9090.66
23_L26_M0.9070.66
228_Q231_E0.9060.66
195_S198_D0.9040.65
33_I52_G0.9040.65
68_E89_K0.9010.65
107_T368_D0.9000.65
176_E212_K0.8960.65
54_V172_L0.8880.64
249_I330_V0.8840.64
78_C130_P0.8830.64
243_L269_G0.8820.63
295_D299_A0.8790.63
241_R323_Q0.8780.63
336_H363_D0.8760.63
349_V357_Y0.8730.63
190_N238_P0.8730.63
361_E375_R0.8720.63
172_L175_R0.8720.63
161_I166_L0.8680.62
230_W233_G0.8680.62
318_M321_E0.8670.62
102_V118_M0.8660.62
175_R224_A0.8640.62
164_D168_D0.8620.62
330_V362_T0.8590.61
50_A166_L0.8580.61
182_N186_L0.8580.61
150_Q160_E0.8580.61
360_I372_L0.8550.61
227_R231_E0.8540.61
319_V324_V0.8470.60
37_G99_S0.8450.60
162_S166_L0.8400.60
49_M226_V0.8370.59
113_K248_P0.8320.59
154_E161_I0.8310.59
46_E177_R0.8210.58
59_C80_L0.8160.57
189_L227_R0.8160.57
162_S168_D0.8120.57
21_G187_G0.8120.57
139_R294_A0.8070.57
189_L193_A0.8040.56
168_D220_D0.8020.56
319_V349_V0.7970.56
312_L345_I0.7970.56
172_L288_D0.7950.55
182_N185_H0.7950.55
59_C271_E0.7940.55
211_D362_T0.7910.55
16_E19_Q0.7880.55
163_E289_V0.7800.54
112_K131_N0.7760.54
39_Y84_S0.7760.54
79_P363_D0.7750.54
316_S328_V0.7740.53
160_E165_A0.7740.53
166_L289_V0.7710.53
16_E22_F0.7680.53
226_V349_V0.7670.53
123_P152_T0.7650.53
20_T24_T0.7630.52
277_K314_M0.7620.52
42_F302_C0.7610.52
39_Y43_M0.7590.52
374_T381_E0.7590.52
77_L110_G0.7580.52
36_V53_A0.7540.52
333_Q361_E0.7540.52
290_Y320_E0.7490.51
326_G378_A0.7470.51
73_L79_P0.7440.51
309_D344_A0.7440.51
329_D342_S0.7430.50
144_A228_Q0.7410.50
115_Y293_L0.7390.50
214_A218_E0.7370.50
171_A217_N0.7360.50
130_P142_W0.7340.50
316_S352_Q0.7340.50
75_R327_V0.7340.50
176_E215_L0.7330.49
167_R171_A0.7310.49
140_A151_K0.7300.49
215_L219_L0.7300.49
274_T355_I0.7280.49
171_A285_E0.7250.49
116_E246_G0.7250.49
21_G270_Y0.7220.48
189_L323_Q0.7180.48
349_V353_H0.7180.48
320_E380_I0.7180.48
18_R21_G0.7150.48
220_D228_Q0.7150.48
286_T289_V0.7140.48
85_Y122_K0.7130.48
258_R293_L0.7100.47
358_I381_E0.7090.47
79_P114_M0.7090.47
127_M149_L0.7080.47
102_V125_H0.7060.47
319_V353_H0.7050.47
263_N373_S0.7020.47
79_P110_G0.7020.47
39_Y42_F0.6980.46
259_A373_S0.6930.46
224_A229_Q0.6920.46
28_L31_R0.6920.46
135_D138_S0.6920.46
22_F26_M0.6890.45
262_E373_S0.6860.45
231_E376_V0.6840.45
178_R354_N0.6840.45
342_S346_K0.6830.45
273_C371_Q0.6830.45
128_Q145_E0.6820.45
265_G268_V0.6820.45
206_A215_L0.6810.45
279_T360_I0.6790.44
172_L212_K0.6780.44
216_I224_A0.6760.44
304_C329_D0.6760.44
232_E323_Q0.6750.44
26_M98_F0.6750.44
46_E296_K0.6740.44
107_T302_C0.6740.44
172_L237_D0.6730.44
326_G382_M0.6720.44
29_K98_F0.6710.44
37_G48_P0.6710.44
328_V358_I0.6700.44
73_L114_M0.6690.43
24_T27_D0.6680.43
202_V219_L0.6670.43
240_P264_G0.6670.43
155_E197_S0.6660.43
281_Q299_A0.6640.43
40_C297_Y0.6580.42
193_A230_W0.6580.42
160_E163_E0.6570.42
280_E376_V0.6570.42
222_M226_V0.6570.42
163_E320_E0.6560.42
242_I265_G0.6560.42
124_V179_A0.6550.42
212_K215_L0.6540.42
159_H231_E0.6540.42
333_Q340_V0.6530.42
130_P375_R0.6530.42
336_H365_S0.6480.41
371_Q378_A0.6480.41
164_D313_K0.6460.41
153_V162_S0.6450.41
40_C59_C0.6440.41
24_T36_V0.6430.41
271_E342_S0.6410.41
181_A280_E0.6400.41
109_D130_P0.6400.41
153_V158_G0.6400.41
303_S336_H0.6390.41
165_A169_A0.6380.41
213_E224_A0.6370.40
277_K338_Y0.6360.40
36_V48_P0.6360.40
232_E317_Q0.6340.40
113_K364_Y0.6340.40
370_G381_E0.6340.40
47_I201_K0.6330.40
19_Q26_M0.6330.40
48_P242_I0.6320.40
136_D295_D0.6320.40
132_S138_S0.6290.40
70_E363_D0.6290.40
24_T214_A0.6270.40
193_A241_R0.6260.39
81_I116_E0.6230.39
112_K368_D0.6220.39
272_N315_L0.6220.39
149_L238_P0.6220.39
118_M186_L0.6200.39
24_T28_L0.6200.39
51_A150_Q0.6200.39
34_P128_Q0.6200.39
319_V352_Q0.6190.39
343_L347_R0.6180.39
19_Q22_F0.6180.39
261_E264_G0.6170.39
256_V260_I0.6170.39
207_T334_A0.6170.39
84_S114_M0.6130.38
146_M242_I0.6110.38
168_D232_E0.6110.38
25_V200_L0.6110.38
17_A27_D0.6090.38
171_A221_A0.6090.38
54_V71_K0.6090.38
178_R352_Q0.6070.38
170_I283_V0.6060.38
283_V293_L0.6060.38
18_R22_F0.6050.38
123_P171_A0.6040.37
82_K248_P0.6020.37
141_L146_M0.6010.37
225_R380_I0.6010.37
40_C107_T0.5990.37
171_A323_Q0.5980.37
51_A177_R0.5960.37
319_V325_D0.5960.37
125_H145_E0.5960.37
131_N307_P0.5940.37
360_I377_A0.5930.36
219_L226_V0.5920.36
158_G356_P0.5910.36
329_D345_I0.5910.36
342_S357_Y0.5910.36
356_P379_F0.5910.36
242_I267_V0.5900.36
47_I150_Q0.5890.36
47_I166_L0.5890.36
320_E347_R0.5880.36
146_M290_Y0.5870.36
311_R375_R0.5870.36
315_L361_E0.5870.36
371_Q375_R0.5870.36
177_R297_Y0.5860.36
378_A383_L0.5840.36
192_P266_W0.5830.36
221_A376_V0.5820.35
237_D313_K0.5800.35
64_E190_N0.5800.35
25_V28_L0.5800.35
65_T92_K0.5790.35
73_L117_Y0.5790.35
57_S300_I0.5790.35
243_L318_M0.5770.35
37_G53_A0.5770.35
302_C338_Y0.5760.35
228_Q320_E0.5760.35
74_P80_L0.5760.35
301_G310_Q0.5740.35
281_Q296_K0.5730.35
313_K383_L0.5730.35
214_A317_Q0.5720.35
329_D357_Y0.5720.35
175_R213_E0.5710.35
37_G347_R0.5700.34
86_G113_K0.5670.34
31_R323_Q0.5670.34
191_P238_P0.5650.34
161_I165_A0.5650.34
187_G199_I0.5650.34
150_Q166_L0.5640.34
49_M212_K0.5630.34
267_V314_M0.5620.34
39_Y118_M0.5600.34
218_E225_R0.5580.33
33_I383_L0.5580.33
71_K167_R0.5580.33
34_P53_A0.5580.33
260_I358_I0.5580.33
119_A323_Q0.5570.33
96_F339_A0.5570.33
42_F303_S0.5560.33
276_A279_T0.5560.33
46_E297_Y0.5550.33
280_E317_Q0.5540.33
107_T273_C0.5520.33
113_K341_E0.5510.33
326_G375_R0.5480.33
52_G213_E0.5480.33
272_N277_K0.5470.32
106_T297_Y0.5460.32
144_A290_Y0.5460.32
50_A177_R0.5440.32
80_L362_T0.5430.32
52_G67_E0.5430.32
192_P196_G0.5420.32
179_A227_R0.5420.32
104_G341_E0.5420.32
281_Q295_D0.5410.32
320_E324_V0.5400.32
183_F226_V0.5390.32
123_P180_L0.5370.32
19_Q358_I0.5350.31
99_S211_D0.5340.31
287_G292_A0.5340.31
59_C338_Y0.5330.31
186_L228_Q0.5320.31
161_I170_I0.5310.31
147_L167_R0.5310.31
136_D171_A0.5310.31
36_V343_L0.5300.31
191_P230_W0.5290.31
30_E151_K0.5280.31
59_C82_K0.5280.31
232_E287_G0.5270.31
302_C335_C0.5270.31
30_E197_S0.5270.31
184_Y322_Y0.5260.31
82_K375_R0.5250.31
160_E239_R0.5250.31
135_D299_A0.5230.30
24_T155_E0.5230.30
165_A350_R0.5220.30
239_R266_W0.5220.30
105_E127_M0.5210.30
89_K121_F0.5210.30
15_S19_Q0.5200.30
153_V161_I0.5200.30
168_D321_E0.5180.30
323_Q360_I0.5160.30
59_C111_K0.5150.30
284_A287_G0.5140.30
52_G159_H0.5140.30
260_I267_V0.5140.30
166_L269_G0.5130.30
171_A284_A0.5130.30
255_K308_N0.5130.30
224_A317_Q0.5120.30
101_L153_V0.5110.30
165_A237_D0.5110.30
149_L279_T0.5110.30
82_K116_E0.5100.29
56_V293_L0.5090.29
229_Q328_V0.5090.29
49_M215_L0.5090.29
155_E160_E0.5070.29
278_A281_Q0.5050.29
181_A328_V0.5050.29
74_P107_T0.5050.29
106_T128_Q0.5050.29
217_N228_Q0.5050.29
284_A292_A0.5040.29
67_E71_K0.5040.29
171_A228_Q0.5020.29
313_K316_S0.5020.29
246_G302_C0.5020.29
185_H313_K0.5020.29
84_S99_S0.5010.29
232_E290_Y0.5010.29
105_E336_H0.5010.29
104_G118_M0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o3mA 1 0.9634 100 0.302 Contact Map
3o3mB 1 0.9556 100 0.312 Contact Map
3wnzA 2 0.3525 86.5 0.948 Contact Map
1w96A 1 0.47 85.1 0.949 Contact Map
2vpqA 2 0.329 84.2 0.95 Contact Map
3va7A 1 0.2898 82.6 0.951 Contact Map
4h4dA 1 0.4204 82.5 0.951 Contact Map
1ulzA 2 0.3316 81 0.952 Contact Map
3ouzA 2 0.3316 79 0.952 Contact Map
3glkA 1 0.3786 78.4 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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