GREMLIN Database
KPTA - RNA 2'-phosphotransferase
UniProt: P39380 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12570
Length: 184 (174)
Sequences: 1154 (850)
Seq/√Len: 64.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_R181_F4.0611.00
71_S82_V3.9531.00
9_L60_T3.7021.00
39_I72_Y3.2521.00
108_A144_H3.2081.00
55_R59_D3.0711.00
31_L37_A2.7641.00
54_T57_L2.7571.00
18_F23_K2.7461.00
39_I58_L2.7381.00
153_K156_E2.6961.00
155_Q159_K2.5951.00
118_Q121_I2.5411.00
60_T64_T2.5291.00
65_S68_K2.4591.00
101_Q155_Q2.3121.00
82_V167_A2.1431.00
108_A111_F2.0731.00
16_L42_L2.0021.00
112_L150_L1.9451.00
10_A14_K1.9331.00
23_K26_A1.9141.00
65_S70_F1.8681.00
38_D41_K1.8261.00
59_D72_Y1.8041.00
152_V182_L1.7581.00
18_F26_A1.7340.99
13_S70_F1.7200.99
160_R180_E1.7120.99
157_M164_F1.6670.99
19_V27_I1.6580.99
150_L182_L1.6450.99
127_Y165_W1.6320.99
59_D63_A1.5900.99
83_Q169_N1.5850.99
68_K82_V1.5780.99
43_I53_L1.5540.99
17_S70_F1.5500.99
120_L176_T1.5320.99
122_A175_S1.5080.99
98_T101_Q1.5040.99
162_L178_A1.4970.98
114_E118_Q1.4970.98
96_E163_P1.4950.98
103_L130_L1.4690.98
156_E160_R1.4460.98
71_S168_E1.4300.98
13_S17_S1.3780.97
34_E93_S1.3670.97
8_E57_L1.3610.97
86_S124_E1.3490.97
73_S77_R1.3200.97
152_V164_F1.3160.97
12_T51_K1.2740.96
112_L116_K1.2680.96
156_E159_K1.2560.95
55_R77_R1.2530.95
141_G145_G1.2350.95
73_S76_G1.2210.95
92_I127_Y1.2040.94
99_P164_F1.1920.94
105_H115_I1.1900.94
177_V180_E1.1870.94
102_F153_K1.1730.94
16_L61_V1.1590.93
37_A42_L1.1570.93
99_P172_W1.1390.92
12_T53_L1.1160.92
133_D136_T1.1130.92
82_V168_E1.0830.90
66_D144_H1.0800.90
139_K142_A1.0770.90
15_F46_A1.0680.90
63_A68_K1.0660.90
163_P175_S1.0630.90
43_I58_L1.0290.88
46_A53_L1.0220.88
101_Q153_K1.0130.87
57_L60_T1.0120.87
58_L72_Y1.0050.87
15_F19_V1.0000.87
174_T177_V0.9950.86
164_F172_W0.9930.86
61_V70_F0.9920.86
108_A146_S0.9900.86
134_E151_T0.9860.86
105_H125_R0.9780.85
122_A127_Y0.9610.84
130_L152_V0.9550.84
32_D78_C0.9500.84
130_L174_T0.9430.83
100_P172_W0.9260.82
120_L141_G0.9190.82
90_V94_F0.9170.81
62_V65_S0.9130.81
62_V67_K0.9060.81
157_M177_V0.8930.80
132_A166_Q0.8830.79
166_Q172_W0.8710.78
36_W71_S0.8690.78
10_A40_D0.8670.78
39_I55_R0.8660.78
102_F151_T0.8630.77
83_Q167_A0.8600.77
43_I57_L0.8590.77
121_I128_V0.8490.76
107_T143_R0.8480.76
29_I37_A0.8480.76
138_R149_I0.8420.76
10_A96_E0.8400.75
15_F27_I0.8310.75
62_V79_I0.8300.74
72_Y77_R0.8270.74
30_V41_K0.8260.74
114_E123_G0.8260.74
92_I130_L0.8220.74
40_D55_R0.8160.73
120_L182_L0.8050.72
103_L172_W0.7880.71
105_H123_G0.7840.70
41_K45_C0.7820.70
135_A138_R0.7800.70
154_A158_A0.7780.70
104_Y133_D0.7710.69
103_L154_A0.7680.69
100_P103_L0.7670.69
53_L58_L0.7560.67
64_T68_K0.7530.67
161_G164_F0.7530.67
169_N173_L0.7530.67
29_I45_C0.7530.67
94_F126_H0.7510.67
31_L87_T0.7440.66
144_H149_I0.7440.66
94_F167_A0.7430.66
37_A41_K0.7400.66
95_A98_T0.7370.65
45_C48_K0.7360.65
55_R58_L0.7350.65
116_K150_L0.7300.65
156_E175_S0.7280.64
134_E182_L0.7250.64
43_I46_A0.7240.64
9_L53_L0.7220.64
176_T180_E0.7220.64
27_I45_C0.7200.64
141_G171_V0.7190.63
62_V169_N0.7160.63
127_Y167_A0.7090.62
13_S61_V0.7080.62
38_D77_R0.7020.62
70_F127_Y0.6960.61
156_E181_F0.6950.61
136_T172_W0.6940.61
108_A147_P0.6820.59
37_A45_C0.6810.59
25_E30_V0.6810.59
19_V42_L0.6790.59
126_H167_A0.6740.59
166_Q170_G0.6710.58
131_S136_T0.6680.58
8_E11_D0.6680.58
45_C49_A0.6620.57
39_I76_G0.6580.57
112_L148_V0.6560.56
127_Y175_S0.6520.56
108_A112_L0.6520.56
115_I143_R0.6500.56
107_T115_I0.6480.56
82_V94_F0.6470.55
90_V126_H0.6400.55
29_I46_A0.6390.55
73_S110_R0.6370.54
131_S149_I0.6320.54
29_I117_K0.6320.54
47_Q176_T0.6310.54
29_I41_K0.6290.53
60_T63_A0.6270.53
106_G140_V0.6260.53
138_R142_A0.6250.53
128_V162_L0.6240.53
12_T57_L0.6220.53
72_Y82_V0.6200.52
96_E166_Q0.6200.52
56_A59_D0.6200.52
120_L143_R0.6180.52
136_T140_V0.6150.52
83_Q171_V0.6150.52
125_R143_R0.6130.51
98_T158_A0.6020.50
114_E121_I0.6020.50
105_H143_R0.6000.50
19_V45_C0.5970.50
174_T182_L0.5970.50
71_S167_A0.5970.50
92_I126_H0.5960.50
61_V65_S0.5910.49
42_L103_L0.5910.49
14_K18_F0.5870.48
157_M172_W0.5860.48
104_Y149_I0.5810.48
40_D44_L0.5800.48
38_D78_C0.5740.47
31_L90_V0.5710.47
88_S118_Q0.5710.47
106_G125_R0.5700.46
84_G143_R0.5690.46
83_Q170_G0.5680.46
100_P130_L0.5670.46
133_D142_A0.5660.46
44_L98_T0.5660.46
167_A170_G0.5650.46
18_F25_E0.5630.46
16_L46_A0.5620.46
167_A173_L0.5610.45
14_K27_I0.5570.45
73_S78_C0.5560.45
58_L136_T0.5560.45
25_E28_G0.5560.45
34_E92_I0.5550.45
94_F173_L0.5510.44
8_E15_F0.5500.44
116_K121_I0.5490.44
56_A148_V0.5480.44
121_I179_V0.5470.44
165_W173_L0.5460.44
62_V171_V0.5450.44
12_T50_G0.5420.43
59_D77_R0.5400.43
34_E91_A0.5400.43
131_S140_V0.5390.43
110_R114_E0.5380.43
33_R87_T0.5350.42
66_D70_F0.5330.42
10_A66_D0.5330.42
109_S112_L0.5320.42
131_S144_H0.5320.42
111_F114_E0.5320.42
83_Q127_Y0.5310.42
8_E19_V0.5310.42
68_K71_S0.5310.42
92_I168_E0.5300.42
65_S127_Y0.5280.42
68_K79_I0.5260.41
11_D34_E0.5250.41
54_T180_E0.5230.41
145_G157_M0.5220.41
13_S105_H0.5220.41
47_Q50_G0.5210.41
55_R76_G0.5190.41
117_K155_Q0.5180.41
106_G115_I0.5160.40
164_F169_N0.5150.40
97_K100_P0.5150.40
16_L58_L0.5140.40
132_A138_R0.5070.39
66_D139_K0.5040.39
97_K166_Q0.5030.39
62_V145_G0.5010.39
142_A148_V0.5010.39
9_L64_T0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wfxA 3 0.9348 100 0.111 Contact Map
4f0dA 1 0.75 90.4 0.923 Contact Map
2cqkA 1 0.4511 85.9 0.929 Contact Map
1efyA 1 0.8261 84.5 0.93 Contact Map
3smjA 2 0.788 84 0.93 Contact Map
3kjdA 1 0.8261 81.1 0.933 Contact Map
3bljA 1 0.8315 79.9 0.933 Contact Map
2pqfA 2 0.7935 79 0.934 Contact Map
3hkvA 2 0.7717 79 0.934 Contact Map
2mtfA 1 0.4728 75.5 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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