GREMLIN Database
IADA - Isoaspartyl dipeptidase
UniProt: P39377 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12567
Length: 390 (342)
Sequences: 34882 (28054)
Seq/√Len: 1517.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
369_Y374_L4.8281.00
347_E352_N4.4831.00
12_L55_L4.1021.00
58_Q366_E3.8791.00
31_A36_I3.6921.00
367_Q374_L3.6421.00
61_C359_M3.3551.00
55_L358_V3.3271.00
15_A55_L3.1431.00
345_K353_D3.1211.00
324_S327_D3.1201.00
349_L352_N2.9821.00
63_G98_T2.7431.00
13_Q52_V2.7051.00
268_A272_Q2.7051.00
37_A350_P2.6291.00
353_D371_R2.5091.00
342_L345_K2.5091.00
61_C357_L2.4401.00
33_G353_D2.3551.00
11_L29_L2.3531.00
39_A42_I2.1491.00
51_T377_K2.1071.00
330_R334_S2.0911.00
28_V60_L2.0891.00
348_I356_L2.0671.00
34_K353_D2.0201.00
60_L358_V1.9831.00
327_D330_R1.9791.00
58_Q360_T1.9751.00
356_L369_Y1.9671.00
279_R338_G1.9511.00
10_T369_Y1.9481.00
30_V356_L1.9451.00
360_T366_E1.9161.00
27_D42_I1.8931.00
368_V376_V1.8891.00
60_L356_L1.8751.00
94_E376_V1.8481.00
58_Q358_V1.8371.00
33_G371_R1.8351.00
15_A60_L1.8041.00
93_T375_M1.7861.00
14_G54_D1.7521.00
17_L26_C1.7401.00
334_S347_E1.7391.00
254_T257_I1.7121.00
29_L50_C1.7041.00
374_L377_K1.6911.00
357_L365_I1.6841.00
338_G343_T1.6751.00
21_E349_L1.6721.00
13_Q27_D1.6601.00
151_D154_I1.5831.00
61_C64_F1.5821.00
225_K249_G1.5701.00
232_N235_V1.5541.00
330_R335_S1.5271.00
23_R26_C1.5191.00
35_I348_I1.5151.00
12_L30_V1.5041.00
163_C168_H1.4961.00
28_V348_I1.4921.00
27_D44_S1.4811.00
29_L37_A1.4761.00
329_L333_T1.4691.00
334_S338_G1.4571.00
155_I159_I1.4531.00
10_T30_V1.4321.00
11_L27_D1.4201.00
270_A275_I1.4141.00
344_G352_N1.4101.00
335_S338_G1.4051.00
367_Q377_K1.4001.00
184_E193_G1.3821.00
28_V356_L1.3761.00
233_R236_P1.3701.00
155_I158_V1.3591.00
254_T258_D1.3521.00
266_G269_R1.3501.00
240_Q243_E1.3471.00
117_L121_R1.3421.00
282_L285_D1.3371.00
358_V369_Y1.3261.00
281_T284_S1.3251.00
252_D256_S1.3201.00
14_G57_G1.3181.00
38_V350_P1.3131.00
118_A121_R1.3071.00
180_N183_A1.2951.00
27_D41_N1.2881.00
318_V328_A1.2871.00
338_G347_E1.2801.00
55_L60_L1.2661.00
163_C167_D1.2601.00
26_C40_S1.2541.00
175_V179_A1.2471.00
67_Q336_V1.2411.00
213_Y217_E1.2291.00
231_V234_N1.2221.00
232_N236_P1.2191.00
241_A245_A1.2151.00
359_M365_I1.2011.00
253_I257_I1.2011.00
208_A211_P1.2001.00
20_P334_S1.1941.00
271_V327_D1.1841.00
253_I256_S1.1841.00
154_I157_R1.1831.00
243_E246_R1.1811.00
65_I99_S1.1761.00
16_H24_G1.1751.00
19_A22_D1.1701.00
358_V367_Q1.1621.00
61_C329_L1.1601.00
12_L356_L1.1561.00
15_A358_V1.1541.00
243_E273_A1.1511.00
92_L100_V1.1481.00
239_E243_E1.1471.00
17_L28_V1.1441.00
26_C39_A1.1431.00
29_L36_I1.1361.00
65_I336_V1.1351.00
14_G25_I1.1351.00
269_R273_A1.1331.00
239_E269_R1.1321.00
174_D177_H1.1321.00
370_A375_M1.1321.00
14_G56_S1.1301.00
207_K211_P1.1261.00
252_D255_S1.1251.00
151_D155_I1.1161.00
360_T364_R1.1141.00
306_G309_T1.1121.00
16_H23_R1.1121.00
30_V369_Y1.0991.00
101_V340_L1.0961.00
16_H25_I1.0931.00
59_I361_P1.0921.00
281_T339_F1.0881.00
211_P214_D1.0871.00
150_K153_A1.0821.00
269_R272_Q1.0821.00
51_T374_L1.0801.00
67_Q340_L1.0751.00
250_T254_T1.0621.00
129_S132_M1.0591.00
152_V155_I1.0581.00
12_L369_Y1.0521.00
308_E313_T1.0481.00
250_T257_I1.0461.00
239_E242_L1.0431.00
36_I350_P1.0421.00
176_Y179_A1.0381.00
306_G313_T1.0351.00
89_L93_T1.0331.00
246_R273_A1.0311.00
343_T352_N1.0301.00
27_D43_P1.0281.00
331_P335_S1.0271.00
67_Q281_T1.0161.00
18_Y329_L1.0151.00
173_P177_H1.0151.00
27_D39_A1.0131.00
275_I279_R1.0111.00
150_K154_I1.0101.00
250_T256_S1.0091.00
252_D257_I1.0061.00
255_S258_D1.0051.00
178_L181_M1.0041.00
158_V161_V1.0031.00
210_Q214_D0.9991.00
248_G254_T0.9981.00
168_H171_A0.9971.00
121_R125_E0.9961.00
127_G130_A0.9961.00
39_A43_P0.9941.00
26_C38_V0.9931.00
260_P263_P0.9891.00
145_T149_E0.9871.00
205_S209_L0.9861.00
304_V309_T0.9841.00
242_L246_R0.9831.00
99_S345_K0.9811.00
261_V265_E0.9791.00
177_H180_N0.9781.00
309_T313_T0.9731.00
153_A156_D0.9731.00
154_I158_V0.9701.00
10_T51_T0.9701.00
53_V369_Y0.9651.00
334_S352_N0.9591.00
65_I345_K0.9551.00
35_I356_L0.9541.00
281_T336_V0.9541.00
279_R282_L0.9531.00
238_F241_A0.9521.00
251_I254_T0.9521.00
306_G310_L0.9521.00
305_A308_E0.9511.00
156_D160_G0.9451.00
323_F331_P0.9451.00
179_A183_A0.9411.00
261_V264_A0.9311.00
241_A244_F0.9281.00
65_I340_L0.9141.00
118_A122_A0.9121.00
153_A157_R0.9111.00
307_F311_L0.9071.00
279_R284_S0.9061.00
151_D158_V0.9051.00
307_F310_L0.9021.00
232_N237_L0.9001.00
357_L368_V0.8961.00
157_R160_G0.8961.00
332_L336_V0.8961.00
37_A44_S0.8941.00
37_A43_P0.8901.00
250_T253_I0.8881.00
16_H59_I0.8861.00
156_D159_I0.8821.00
201_H204_D0.8811.00
65_I337_A0.8801.00
10_T53_V0.8791.00
12_L53_V0.8781.00
140_P143_T0.8761.00
53_V367_Q0.8761.00
205_S208_A0.8741.00
345_K355_D0.8731.00
197_V341_N0.8681.00
176_Y180_N0.8661.00
154_I159_I0.8651.00
249_G254_T0.8641.00
82_T86_E0.8611.00
49_N52_V0.8601.00
29_L49_N0.8581.00
12_L60_L0.8561.00
157_R161_V0.8521.00
316_V319_K0.8521.00
122_A125_E0.8481.00
93_T370_A0.8471.00
242_L245_A0.8431.00
175_V181_M0.8421.00
308_E311_L0.8411.00
93_T368_V0.8411.00
40_S43_P0.8411.00
310_L332_L0.8381.00
166_S170_S0.8371.00
304_V307_F0.8371.00
222_P226_L0.8361.00
151_D156_D0.8351.00
91_R94_E0.8351.00
311_L315_Q0.8291.00
163_C169_R0.8291.00
197_V201_H0.8261.00
304_V308_E0.8241.00
13_Q54_D0.8241.00
155_I160_G0.8231.00
251_I256_S0.8221.00
145_T148_V0.8171.00
167_D171_A0.8141.00
248_G257_I0.8131.00
281_T335_S0.8111.00
69_V92_L0.8091.00
71_L88_A0.8081.00
143_T146_G0.8071.00
253_I258_D0.8051.00
18_Y59_I0.7981.00
252_D339_F0.7971.00
29_L39_A0.7971.00
249_G253_I0.7961.00
41_N44_S0.7941.00
90_S94_E0.7941.00
123_L126_E0.7941.00
206_K210_Q0.7941.00
98_T355_D0.7901.00
151_D157_R0.7871.00
10_T50_C0.7841.00
269_R321_Y0.7831.00
175_V178_L0.7811.00
165_I169_R0.7801.00
114_E117_L0.7801.00
251_I257_I0.7781.00
152_V158_V0.7751.00
169_R172_A0.7751.00
177_H181_M0.7721.00
365_I368_V0.7711.00
86_E90_S0.7711.00
249_G252_D0.7711.00
64_F332_L0.7691.00
310_L314_V0.7671.00
209_L213_Y0.7661.00
174_D181_M0.7631.00
208_A212_I0.7611.00
70_H235_V0.7591.00
93_T376_V0.7591.00
14_G55_L0.7581.00
42_I45_D0.7551.00
251_I255_S0.7551.00
308_E314_V0.7521.00
134_T137_Y0.7521.00
173_P181_M0.7511.00
237_L242_L0.7491.00
249_G257_I0.7491.00
163_C166_S0.7451.00
228_P235_V0.7421.00
305_A309_T0.7411.00
228_P233_R0.7411.00
71_L100_V0.7381.00
280_V284_S0.7381.00
311_L314_V0.7381.00
316_V320_D0.7361.00
168_H172_A0.7321.00
262_A265_E0.7311.00
98_T368_V0.7291.00
223_I226_L0.7291.00
355_D371_R0.7281.00
166_S171_A0.7281.00
218_N226_L0.7261.00
200_F203_G0.7231.00
58_Q367_Q0.7221.00
309_T312_E0.7221.00
136_A140_P0.7221.00
239_E245_A0.7211.00
173_P176_Y0.7211.00
156_D161_V0.7211.00
18_Y23_R0.7181.00
305_A311_L0.7171.00
166_S169_R0.7161.00
212_I216_L0.7141.00
20_P329_L0.7091.00
279_R285_D0.7081.00
123_L130_A0.7051.00
246_R275_I0.7031.00
237_L240_Q0.7011.00
99_S355_D0.7001.00
155_I161_V0.7001.00
242_L273_A0.6981.00
281_T285_D0.6941.00
16_H362_E0.6921.00
146_G149_E0.6911.00
55_L58_Q0.6891.00
306_G311_L0.6891.00
39_A44_S0.6841.00
141_S144_I0.6831.00
304_V313_T0.6791.00
337_A346_G0.6791.00
259_E262_A0.6781.00
71_L89_L0.6761.00
26_C348_I0.6751.00
21_E347_E0.6751.00
151_D159_I0.6741.00
264_A268_A0.6741.00
127_G131_W0.6741.00
196_G201_H0.6741.00
134_T138_H0.6691.00
209_L212_I0.6681.00
29_L42_I0.6671.00
23_R326_S0.6621.00
177_H182_A0.6621.00
326_S330_R0.6621.00
25_I56_S0.6611.00
211_P215_L0.6591.00
279_R335_S0.6571.00
66_D69_V0.6561.00
315_Q319_K0.6561.00
249_G256_S0.6561.00
128_I131_W0.6561.00
237_L241_A0.6551.00
313_T317_L0.6531.00
252_D258_D0.6531.00
234_N237_L0.6521.00
25_I41_N0.6501.00
207_K210_Q0.6501.00
307_F313_T0.6491.00
93_T129_S0.6481.00
133_L137_Y0.6451.00
28_V38_V0.6451.00
15_A57_G0.6431.00
70_H201_H0.6431.00
185_S198_T0.6431.00
123_L128_I0.6421.00
182_A186_R0.6421.00
347_E350_P0.6401.00
87_V90_S0.6371.00
20_P347_E0.6361.00
97_V310_L0.6361.00
249_G255_S0.6351.00
268_A271_V0.6331.00
305_A310_L0.6331.00
314_V332_L0.6291.00
221_V224_S0.6281.00
27_D37_A0.6281.00
334_S343_T0.6271.00
230_H233_R0.6261.00
305_A312_E0.6261.00
17_L24_G0.6251.00
163_C171_A0.6241.00
247_K250_T0.6241.00
125_E128_I0.6241.00
127_G132_M0.6211.00
313_T316_V0.6201.00
210_Q213_Y0.6191.00
310_L313_T0.6171.00
220_D224_S0.6161.00
283_S286_G0.6151.00
115_S119_K0.6131.00
20_P326_S0.6121.00
164_A168_H0.6101.00
345_K352_N0.6101.00
229_T235_V0.6101.00
138_H141_S0.6071.00
150_K155_I0.6071.00
308_E312_E0.6031.00
231_V235_V0.6031.00
81_T84_T0.6011.00
70_H285_D0.6001.00
30_V36_I0.6001.00
162_K167_D0.5961.00
174_D180_N0.5931.00
232_N254_T0.5931.00
304_V311_L0.5921.00
241_A246_R0.5921.00
130_A133_L0.5911.00
176_Y181_M0.5891.00
129_S133_L0.5861.00
64_F329_L0.5851.00
309_T314_V0.5841.00
163_C170_S0.5831.00
239_E266_G0.5821.00
248_G252_D0.5811.00
11_L44_S0.5781.00
214_D217_E0.5771.00
26_C41_N0.5771.00
19_A23_R0.5751.00
129_S345_K0.5751.00
186_R221_V0.5741.00
15_A356_L0.5741.00
13_Q41_N0.5721.00
314_V328_A0.5721.00
271_V274_G0.5721.00
152_V156_D0.5711.00
11_L50_C0.5691.00
223_I227_L0.5691.00
165_I171_A0.5681.00
250_T255_S0.5681.00
260_P264_A0.5671.00
184_E194_K0.5671.00
114_E118_A0.5671.00
141_S145_T0.5661.00
35_I352_N0.5641.00
37_A42_I0.5631.00
233_R237_L0.5591.00
306_G312_E0.5581.00
286_G289_S0.5561.00
219_C225_K0.5551.00
113_P117_L0.5501.00
315_Q318_V0.5481.00
121_R124_N0.5481.00
248_G256_S0.5461.00
167_D170_S0.5451.00
117_L120_T0.5441.00
247_K279_R0.5441.00
228_P232_N0.5421.00
247_K257_I0.5401.00
68_H201_H0.5391.00
16_H361_P0.5371.00
11_L52_V0.5371.00
20_P330_R0.5351.00
371_R374_L0.5351.00
133_L136_A0.5321.00
229_T233_R0.5311.00
226_L229_T0.5301.00
175_V182_A0.5301.00
307_F312_E0.5291.00
82_T118_A0.5291.00
205_S212_I0.5281.00
343_T347_E0.5271.00
220_D226_L0.5271.00
174_D178_L0.5261.00
137_Y140_P0.5251.00
174_D184_E0.5241.00
250_T279_R0.5241.00
103_L199_V0.5241.00
68_H235_V0.5221.00
242_L270_A0.5221.00
304_V310_L0.5211.00
11_L49_N0.5211.00
134_T140_P0.5211.00
229_T232_N0.5211.00
162_K168_H0.5161.00
353_D370_A0.5141.00
67_Q339_F0.5111.00
28_V35_I0.5111.00
142_R146_G0.5091.00
323_F328_A0.5091.00
64_F357_L0.5091.00
256_S259_E0.5091.00
261_V266_G0.5061.00
218_N222_P0.5051.00
144_I148_V0.5051.00
367_Q376_V0.5051.00
163_C172_A0.5051.00
356_L374_L0.5031.00
22_D326_S0.5031.00
175_V180_N0.5031.00
120_T123_L0.5031.00
150_K159_I0.5021.00
135_G138_H0.5021.00
112_H115_S0.5011.00
224_S227_L0.5001.00
265_E269_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1onwA 5 0.9744 100 0.328 Contact Map
2pajA 2 0.8641 100 0.345 Contact Map
3ls9A 2 0.9051 100 0.346 Contact Map
4dzhA 2 0.8949 100 0.35 Contact Map
3lnpA 2 0.9077 100 0.355 Contact Map
3hpaA 2 0.8744 100 0.362 Contact Map
4gbdA 2 0.8974 100 0.364 Contact Map
2ftwA 3 0.9487 100 0.37 Contact Map
4v1xA 5 0.8974 100 0.371 Contact Map
3griA 1 0.8974 100 0.371 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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