GREMLIN Database
YJIE - HTH-type transcriptional regulator YjiE
UniProt: P39376 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12566
Length: 303 (281)
Sequences: 79234 (57698)
Seq/√Len: 3442.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_H84_Q3.7641.00
25_C34_S3.4191.00
21_T34_S2.7441.00
77_Q91_E2.6161.00
167_I296_R2.6021.00
168_R274_Q2.4811.00
55_V70_Q2.3601.00
20_L79_R2.3171.00
106_A148_S2.3121.00
168_R171_E2.2681.00
175_F249_E2.2651.00
171_E274_Q2.2521.00
20_L24_K2.2211.00
102_K130_A2.2201.00
18_D45_R2.1771.00
77_Q84_Q2.1691.00
21_T25_C2.1351.00
102_K128_T2.0371.00
239_L260_K2.0141.00
238_A245_A2.0111.00
175_F263_V2.0041.00
171_E272_P1.9971.00
104_K130_A1.9821.00
122_Q294_E1.9741.00
173_Q249_E1.9591.00
182_E195_F1.9521.00
23_E67_L1.9441.00
21_T24_K1.9111.00
81_L85_L1.8931.00
75_H79_R1.8921.00
18_D42_F1.8611.00
23_E75_H1.8591.00
235_K255_E1.8431.00
30_Q33_V1.8311.00
239_L255_E1.8281.00
20_L75_H1.8181.00
77_Q80_H1.7681.00
24_K79_R1.7681.00
73_I91_E1.7571.00
196_P225_F1.7551.00
166_H276_Y1.7351.00
178_C264_L1.7311.00
25_C30_Q1.6951.00
142_K147_Q1.6891.00
198_L243_G1.6631.00
59_N66_Q1.6481.00
27_N30_Q1.6421.00
167_I279_R1.5941.00
74_F88_N1.5891.00
279_R292_W1.5841.00
15_W52_A1.5481.00
113_L232_E1.5441.00
165_D281_N1.5431.00
84_Q87_S1.5421.00
61_Q66_Q1.5361.00
20_L78_I1.5281.00
77_Q87_S1.5101.00
15_W48_A1.5051.00
15_W45_R1.4881.00
141_D145_E1.4791.00
292_W296_R1.4771.00
38_S41_A1.4711.00
24_K34_S1.4691.00
165_D279_R1.4661.00
21_T35_R1.4601.00
139_A151_I1.4491.00
142_K148_S1.4371.00
28_F46_I1.4241.00
153_S278_Y1.4211.00
76_S80_H1.4131.00
56_E59_N1.4001.00
207_G211_N1.3971.00
104_K132_E1.3931.00
81_L88_N1.3751.00
155_H276_Y1.3701.00
123_M291_F1.3701.00
284_M288_A1.3631.00
12_E15_W1.3631.00
143_L151_I1.3441.00
29_S39_Q1.3401.00
277_A292_W1.3381.00
77_Q88_N1.3371.00
172_S250_Y1.3361.00
74_F89_L1.3321.00
98_Y126_L1.3311.00
236_Q239_L1.3261.00
168_R276_Y1.3231.00
37_V41_A1.3141.00
255_E260_K1.3121.00
19_F75_H1.3111.00
234_L245_A1.3081.00
290_R293_R1.3061.00
13_T85_L1.2991.00
180_S262_V1.2911.00
100_Q126_L1.2901.00
73_I77_Q1.2851.00
20_L82_L1.2831.00
44_R48_A1.2821.00
150_C277_A1.2821.00
18_D37_V1.2801.00
123_M127_F1.2801.00
144_R163_P1.2641.00
69_E72_K1.2621.00
73_I76_S1.2381.00
195_F244_I1.2331.00
124_P225_F1.2311.00
178_C244_I1.2281.00
118_S240_D1.2241.00
121_S240_D1.2191.00
249_E263_V1.2151.00
187_L192_Q1.2121.00
150_C288_A1.2091.00
180_S260_K1.1981.00
263_V266_R1.1931.00
80_H87_S1.1771.00
19_F23_E1.1741.00
249_E253_Q1.1691.00
167_I292_W1.1621.00
166_H278_Y1.1611.00
124_P196_P1.1541.00
16_L78_I1.1541.00
19_F58_F1.1491.00
52_A89_L1.1491.00
236_Q240_D1.1351.00
44_R47_R1.1291.00
21_T31_A1.1171.00
72_K76_S1.1161.00
132_E142_K1.1161.00
183_H195_F1.1101.00
81_L84_Q1.1031.00
208_R211_N1.1021.00
45_R48_A1.1001.00
235_K239_L1.0811.00
85_L89_L1.0781.00
144_R161_E1.0761.00
196_P223_S1.0751.00
189_N267_D1.0711.00
173_Q272_P1.0631.00
83_Q87_S1.0541.00
177_V263_V1.0531.00
28_F65_L1.0511.00
254_Q258_S1.0481.00
289_E293_R1.0451.00
47_R51_Q1.0401.00
89_L93_R1.0381.00
179_A241_G1.0361.00
199_N224_T1.0301.00
130_A227_V1.0221.00
123_M294_E1.0121.00
103_I291_F1.0111.00
43_S47_R1.0071.00
293_R296_R1.0041.00
70_Q73_I1.0011.00
80_H83_Q0.9991.00
253_Q257_R0.9981.00
208_R212_R0.9891.00
74_F78_I0.9851.00
294_E297_E0.9811.00
48_A51_Q0.9771.00
280_M283_R0.9741.00
165_D168_R0.9711.00
14_K17_Y0.9651.00
182_E185_E0.9631.00
30_Q34_S0.9631.00
31_A42_F0.9601.00
22_L31_A0.9591.00
22_L28_F0.9581.00
26_R66_Q0.9461.00
188_F262_V0.9441.00
239_L258_S0.9411.00
73_I95_G0.9411.00
198_L234_L0.9381.00
19_F49_L0.9331.00
142_K145_E0.9331.00
86_E89_L0.9251.00
17_Y86_E0.9231.00
228_S234_L0.9221.00
23_E58_F0.9211.00
67_L71_G0.9191.00
286_P290_R0.9141.00
119_I295_L0.9111.00
87_S91_E0.9101.00
177_V252_I0.9091.00
19_F57_L0.9061.00
176_P244_I0.9051.00
178_C182_E0.9011.00
37_V42_F0.8991.00
121_S242_C0.8971.00
14_K45_R0.8961.00
285_N288_A0.8931.00
18_D35_R0.8921.00
61_Q64_P0.8901.00
85_L88_N0.8871.00
109_H230_M0.8841.00
29_S33_V0.8821.00
76_S79_R0.8791.00
119_I294_E0.8781.00
25_C31_A0.8781.00
17_Y21_T0.8751.00
157_E161_E0.8731.00
155_H274_Q0.8721.00
19_F67_L0.8711.00
124_P242_C0.8691.00
101_R287_V0.8671.00
228_S237_V0.8671.00
72_K75_H0.8581.00
84_Q88_N0.8581.00
26_R64_P0.8571.00
24_K75_H0.8551.00
255_E258_S0.8531.00
55_V92_L0.8491.00
70_Q95_G0.8471.00
23_E26_R0.8471.00
86_E90_A0.8431.00
17_Y20_L0.8411.00
58_F65_L0.8381.00
209_L213_T0.8341.00
237_V242_C0.8321.00
181_D241_G0.8261.00
22_L58_F0.8251.00
290_R294_E0.8251.00
284_M289_E0.8241.00
70_Q92_L0.8231.00
252_I255_E0.8201.00
35_R42_F0.8191.00
39_Q43_S0.8121.00
140_V144_R0.8091.00
132_E148_S0.8081.00
88_N92_L0.8071.00
184_G195_F0.8071.00
148_S151_I0.8061.00
105_I150_C0.8021.00
79_R83_Q0.8021.00
138_E141_D0.7981.00
212_R216_R0.7971.00
196_P224_T0.7951.00
107_A112_S0.7931.00
106_A151_I0.7921.00
106_A153_S0.7921.00
22_L42_F0.7911.00
206_M210_I0.7891.00
173_Q270_V0.7881.00
146_G280_M0.7831.00
230_M233_L0.7801.00
185_E262_V0.7801.00
213_T216_R0.7781.00
211_N215_T0.7781.00
13_T82_L0.7751.00
22_L46_I0.7731.00
113_L236_Q0.7731.00
28_F42_F0.7711.00
78_I81_L0.7711.00
19_F74_F0.7641.00
178_C262_V0.7611.00
47_R56_E0.7581.00
17_Y82_L0.7571.00
128_T223_S0.7571.00
123_M290_R0.7541.00
19_F71_G0.7511.00
69_E73_I0.7501.00
127_F287_V0.7491.00
118_S121_S0.7451.00
26_R72_K0.7451.00
59_N68_S0.7441.00
178_C183_H0.7441.00
15_W18_D0.7431.00
179_A182_E0.7421.00
164_F278_Y0.7401.00
144_R164_F0.7391.00
214_L220_L0.7391.00
179_A242_C0.7371.00
186_A196_P0.7371.00
176_P246_W0.7361.00
183_H188_F0.7331.00
149_D288_A0.7311.00
177_V247_L0.7271.00
138_E142_K0.7181.00
209_L212_R0.7161.00
116_L119_I0.7141.00
173_Q265_N0.7141.00
213_T218_S0.7121.00
77_Q81_L0.7111.00
23_E71_G0.7081.00
201_S227_V0.7081.00
104_K149_D0.7061.00
150_C291_F0.7011.00
191_A267_D0.6991.00
67_L72_K0.6961.00
23_E72_K0.6931.00
188_F191_A0.6931.00
210_I213_T0.6891.00
177_V245_A0.6861.00
33_V36_N0.6861.00
74_F92_L0.6861.00
252_I256_I0.6841.00
93_R96_S0.6811.00
70_Q74_F0.6801.00
256_I259_G0.6791.00
177_V256_I0.6721.00
193_P220_L0.6701.00
14_K48_A0.6681.00
41_A45_R0.6651.00
82_L86_E0.6641.00
286_P289_E0.6591.00
163_P281_N0.6511.00
59_N64_P0.6501.00
226_F237_V0.6491.00
248_P251_A0.6441.00
210_I214_L0.6421.00
106_A139_A0.6421.00
154_F273_I0.6421.00
53_I74_F0.6401.00
293_R297_E0.6391.00
66_Q72_K0.6391.00
205_Y208_R0.6381.00
182_E186_A0.6341.00
87_S90_A0.6331.00
104_K148_S0.6321.00
197_L222_F0.6261.00
128_T227_V0.6261.00
228_S233_L0.6221.00
178_C184_G0.6211.00
287_V290_R0.6181.00
200_Y234_L0.6171.00
197_L244_I0.6151.00
12_E52_A0.6151.00
50_E60_R0.6131.00
256_I263_V0.6121.00
181_D184_G0.6091.00
191_A268_E0.6051.00
133_A229_S0.6051.00
101_R127_F0.6041.00
207_G213_T0.6031.00
150_C292_W0.6021.00
181_D185_E0.6011.00
121_S124_P0.6001.00
14_K18_D0.5971.00
187_L190_L0.5911.00
117_P121_S0.5911.00
83_Q86_E0.5891.00
279_R289_E0.5871.00
254_Q257_R0.5861.00
143_L164_F0.5861.00
91_E94_G0.5861.00
144_R147_Q0.5861.00
212_R215_T0.5851.00
103_I150_C0.5831.00
22_L27_N0.5821.00
100_Q128_T0.5811.00
155_H166_H0.5781.00
137_D141_D0.5781.00
211_N214_L0.5781.00
182_E196_P0.5781.00
90_A94_G0.5771.00
107_A131_I0.5771.00
180_S259_G0.5751.00
53_I56_E0.5751.00
115_L119_I0.5751.00
55_V59_N0.5711.00
73_I92_L0.5711.00
118_S122_Q0.5711.00
28_F39_Q0.5691.00
184_G187_L0.5691.00
201_S229_S0.5671.00
31_A35_R0.5671.00
186_A189_N0.5661.00
291_F295_L0.5631.00
208_R213_T0.5611.00
207_G227_V0.5611.00
206_M209_L0.5591.00
26_R65_L0.5581.00
214_L222_F0.5501.00
288_A292_W0.5491.00
174_L246_W0.5471.00
53_I92_L0.5471.00
99_A126_L0.5461.00
20_L86_E0.5451.00
88_N91_E0.5451.00
279_R284_M0.5431.00
56_E70_Q0.5431.00
90_A93_R0.5421.00
58_F67_L0.5421.00
183_H187_L0.5411.00
289_E292_W0.5411.00
181_D262_V0.5401.00
232_E236_Q0.5381.00
260_K263_V0.5371.00
169_L277_A0.5331.00
247_L252_I0.5331.00
94_G99_A0.5301.00
48_A52_A0.5301.00
172_S273_I0.5301.00
46_I50_E0.5301.00
16_L74_F0.5301.00
234_L238_A0.5291.00
40_P43_S0.5281.00
78_I82_L0.5261.00
40_P44_R0.5261.00
37_V45_R0.5261.00
178_C185_E0.5251.00
107_A116_L0.5251.00
53_I89_L0.5241.00
182_E244_I0.5241.00
143_L278_Y0.5221.00
172_S248_P0.5211.00
41_A44_R0.5211.00
12_E48_A0.5201.00
101_R126_L0.5181.00
106_A132_E0.5121.00
55_V96_S0.5111.00
113_L230_M0.5101.00
231_S248_P0.5091.00
118_S236_Q0.5081.00
128_T225_F0.5081.00
193_P221_S0.5071.00
111_L115_L0.5061.00
141_D147_Q0.5051.00
157_E160_L0.5021.00
81_L89_L0.5011.00
18_D46_I0.5011.00
183_H186_A0.5011.00
38_S44_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fxqA 3 0.9571 100 0.14 Contact Map
2esnA 3 0.9703 100 0.146 Contact Map
1uthA 2 0.7195 100 0.15 Contact Map
3fzvA 4 0.9307 100 0.152 Contact Map
2h98A 2 0.6568 100 0.154 Contact Map
1ixcA 4 0.9439 100 0.156 Contact Map
2h9bA 2 0.6568 100 0.159 Contact Map
4x6gA 4 0.9736 100 0.16 Contact Map
1al3A 1 0.6766 100 0.166 Contact Map
3szpA 3 0.934 100 0.182 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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