GREMLIN Database
NANM - N-acetylneuraminate epimerase
UniProt: P39371 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12562
Length: 368 (323)
Sequences: 105 (91)
Seq/√Len: 5.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_L295_Y3.2200.77
96_N99_G3.0140.72
289_Y294_N2.8940.68
91_G141_Y2.7090.63
93_I129_A2.6600.61
33_T80_S2.6130.60
268_G276_F2.5640.58
133_T139_K2.5250.57
76_D93_I2.4780.56
192_F197_Q2.4760.55
79_T133_T2.4580.55
64_W125_P2.3690.52
49_G88_Y2.3490.51
71_P106_D2.2640.49
75_R88_Y2.2140.47
257_S296_A2.1580.45
332_L339_L2.1470.45
228_E233_L2.0970.43
73_G104_F2.0680.42
41_V165_S2.0150.41
92_G145_G1.9920.40
261_G278_G1.9650.39
307_D331_S1.9350.38
335_N341_I1.9310.38
46_G92_G1.9310.38
155_F168_I1.9300.38
109_K143_T1.9300.38
199_W232_G1.9280.38
100_L103_V1.9100.37
227_G231_P1.9020.37
183_Y231_P1.8980.37
85_G110_Y1.8930.37
188_F240_E1.8740.36
176_F185_F1.8640.36
280_A328_Y1.8620.36
49_G80_S1.8470.35
104_F143_T1.8380.35
96_N319_S1.8280.35
25_T32_G1.8170.34
131_H142_V1.8150.34
87_L174_H1.8140.34
26_P46_G1.8120.34
86_N109_K1.7960.34
33_T216_V1.7380.32
228_E232_G1.7070.31
227_G232_G1.6930.31
58_Q315_K1.6900.31
38_N131_H1.6870.31
228_E234_R1.6770.30
212_G234_R1.6660.30
46_G145_G1.6530.30
256_V309_H1.6490.30
58_Q118_V1.6350.29
64_W90_F1.6280.29
75_R91_G1.6240.29
228_E261_G1.6180.29
25_T296_A1.6180.29
157_D256_V1.6120.29
51_A66_A1.6110.29
91_G294_N1.5990.28
259_P307_D1.5950.28
158_L298_E1.5930.28
230_K261_G1.5770.28
176_F211_A1.5630.27
129_A168_I1.5450.27
53_Y87_L1.5450.27
87_L262_V1.5400.27
195_S290_Q1.5280.27
23_P32_G1.5160.26
306_T321_E1.4880.26
247_N335_N1.4780.25
146_V176_F1.4760.25
183_Y234_R1.4720.25
99_G106_D1.4660.25
189_L213_A1.4610.25
319_S335_N1.4550.25
183_Y199_W1.4460.24
187_K204_E1.4320.24
28_P39_D1.4300.24
236_D289_Y1.4160.24
35_A80_S1.4160.24
58_Q334_W1.4050.23
340_I345_T1.4040.23
111_N120_L1.4040.23
261_G279_G1.4010.23
53_Y137_N1.3930.23
219_G223_W1.3740.23
101_T155_F1.3730.23
256_V281_G1.3550.22
199_W228_E1.3500.22
265_G272_D1.3460.22
176_F210_T1.3440.22
92_G144_G1.3410.22
92_G117_W1.3400.22
40_T110_Y1.3370.22
132_V149_N1.3200.22
108_H119_K1.3110.21
125_P130_G1.3090.21
222_T338_L1.3050.21
100_L104_F1.3020.21
336_N341_I1.3020.21
55_L296_A1.2990.21
278_G284_G1.2910.21
75_R106_D1.2830.21
32_G44_G1.2700.20
41_V65_T1.2660.20
86_N126_M1.2550.20
334_W337_S1.2540.20
36_I338_L1.2490.20
277_A322_L1.2450.20
92_G125_P1.2390.20
251_N255_P1.2380.20
59_A345_T1.2370.20
91_G205_S1.2330.20
199_W230_K1.2230.19
52_W76_D1.2220.19
52_W140_A1.2190.19
31_S321_E1.2110.19
87_L226_N1.2040.19
127_G328_Y1.2040.19
126_M186_N1.1910.19
199_W227_G1.1890.19
279_G284_G1.1890.19
292_G299_G1.1840.19
93_I103_V1.1820.19
43_I131_H1.1810.19
55_L257_S1.1740.19
26_P92_G1.1690.18
158_L220_D1.1640.18
123_H274_L1.1630.18
332_L341_I1.1590.18
171_I312_H1.1580.18
81_A165_S1.1510.18
226_N262_V1.1490.18
64_W130_G1.1430.18
128_M186_N1.1310.18
312_H315_K1.1300.18
105_N157_D1.1200.17
64_W92_G1.1130.17
227_G233_L1.1110.17
330_V341_I1.1010.17
232_G261_G1.1000.17
32_G78_A1.0990.17
199_W212_G1.0990.17
101_T158_L1.0970.17
110_Y115_N1.0950.17
175_Y250_W1.0920.17
188_F223_W1.0880.17
263_A279_G1.0870.17
235_T281_G1.0860.17
39_D58_Q1.0830.17
77_Q171_I1.0810.17
210_T239_F1.0780.17
70_F263_A1.0660.16
98_E139_K1.0640.16
308_I312_H1.0630.16
37_D84_D1.0620.16
327_A333_P1.0620.16
199_W233_L1.0610.16
31_S100_L1.0560.16
47_S331_S1.0550.16
96_N141_Y1.0530.16
183_Y230_K1.0480.16
84_D340_I1.0390.16
27_V203_G1.0320.16
69_A120_L1.0280.16
45_L128_M1.0230.16
24_E43_I1.0220.16
27_V58_Q1.0200.16
176_F209_G1.0190.16
232_G284_G1.0150.16
117_W145_G1.0130.16
80_S118_V1.0130.16
199_W261_G1.0080.15
257_S281_G1.0060.15
211_A226_N1.0040.15
98_E208_Y1.0040.15
223_W240_E1.0020.15
46_G117_W1.0010.15
83_I223_W0.9980.15
330_V345_T0.9980.15
40_T69_A0.9980.15
262_V295_Y0.9940.15
276_F280_A0.9900.15
165_S327_A0.9900.15
264_G284_G0.9890.15
131_H178_K0.9870.15
132_V247_N0.9830.15
206_P230_K0.9800.15
87_L337_S0.9780.15
183_Y233_L0.9780.15
69_A72_G0.9780.15
127_G148_Q0.9760.15
26_P64_W0.9720.15
213_A261_G0.9700.15
119_K317_D0.9670.15
50_T98_E0.9650.15
49_G158_L0.9640.15
46_G144_G0.9620.15
186_N231_P0.9610.15
100_L140_A0.9590.15
265_G275_I0.9510.15
150_I184_F0.9490.14
155_F176_F0.9480.14
73_G257_S0.9450.14
70_F279_G0.9440.14
29_F312_H0.9430.14
129_A146_V0.9420.14
146_V185_F0.9400.14
71_P262_V0.9320.14
87_L170_K0.9300.14
233_L284_G0.9250.14
90_F104_F0.9200.14
52_W210_T0.9180.14
306_T338_L0.9170.14
228_E268_G0.9130.14
199_W206_P0.9100.14
46_G125_P0.9020.14
125_P145_G0.9010.14
90_F145_G0.8980.14
32_G45_L0.8930.14
267_A287_E0.8910.14
216_V305_S0.8890.14
334_W340_I0.8880.14
185_F239_F0.8840.13
99_G137_N0.8800.13
167_A251_N0.8760.13
184_F211_A0.8760.13
315_K336_N0.8730.13
198_Q216_V0.8700.13
212_G235_T0.8700.13
113_K223_W0.8690.13
39_D83_I0.8690.13
88_Y213_A0.8670.13
330_V335_N0.8620.13
180_A238_V0.8610.13
59_A306_T0.8580.13
199_W234_R0.8570.13
231_P261_G0.8570.13
206_P233_L0.8570.13
35_A82_F0.8540.13
232_G235_T0.8530.13
155_F162_G0.8530.13
321_E341_I0.8490.13
212_G227_G0.8470.13
74_P91_G0.8460.13
113_K137_N0.8410.13
142_V241_L0.8400.13
28_P38_N0.8390.13
46_G91_G0.8380.13
196_T261_G0.8330.13
29_F251_N0.8310.13
109_K319_S0.8300.13
90_F125_P0.8300.13
185_F210_T0.8290.13
74_P118_V0.8280.13
37_D266_F0.8280.13
26_P55_L0.8280.13
30_K44_G0.8270.13
102_Q106_D0.8230.13
77_Q235_T0.8220.13
26_P145_G0.8180.12
206_P261_G0.8170.12
94_G127_G0.8160.12
227_G261_G0.8160.12
321_E336_N0.8160.12
221_K237_A0.8140.12
170_K174_H0.8130.12
330_V340_I0.8130.12
31_S336_N0.8130.12
71_P75_R0.8090.12
146_V211_A0.8050.12
105_N337_S0.8030.12
100_L335_N0.7930.12
319_S341_I0.7900.12
137_N334_W0.7890.12
278_G285_S0.7890.12
192_F224_L0.7870.12
137_N245_G0.7870.12
233_L261_G0.7860.12
82_F136_H0.7790.12
182_D192_F0.7740.12
305_S318_K0.7740.12
175_Y213_A0.7730.12
46_G64_W0.7720.12
64_W145_G0.7710.12
31_S140_A0.7710.12
151_F231_P0.7690.12
33_T220_D0.7680.12
212_G261_G0.7610.12
180_A214_A0.7590.12
62_K174_H0.7540.12
101_T104_F0.7490.12
281_G309_H0.7450.11
288_N306_T0.7430.11
206_P227_G0.7420.11
75_R117_W0.7410.11
77_Q150_I0.7390.11
143_T289_Y0.7330.11
147_N192_F0.7320.11
261_G284_G0.7320.11
41_V114_T0.7320.11
59_A293_K0.7320.11
134_F169_D0.7300.11
140_A161_A0.7260.11
198_Q315_K0.7260.11
227_G234_R0.7250.11
77_Q162_G0.7250.11
89_V291_N0.7220.11
228_E278_G0.7150.11
56_D64_W0.7140.11
105_N323_S0.7140.11
85_G164_D0.7130.11
234_R282_F0.7110.11
39_D76_D0.7110.11
50_T333_P0.7090.11
332_L337_S0.7070.11
55_L157_D0.7060.11
75_R142_V0.7060.11
70_F268_G0.7050.11
230_K234_R0.7040.11
297_H316_W0.7040.11
77_Q283_K0.7020.11
103_V158_L0.6960.11
320_G335_N0.6960.11
28_P131_H0.6930.11
137_N190_L0.6930.11
206_P212_G0.6910.11
153_G269_I0.6890.11
222_T240_E0.6890.11
228_E231_P0.6890.11
71_P179_K0.6880.11
82_F275_I0.6870.11
270_S275_I0.6860.11
173_A214_A0.6860.11
104_F339_L0.6850.11
25_T28_P0.6810.11
37_D111_N0.6810.11
68_A296_A0.6800.11
253_L319_S0.6790.11
212_G233_L0.6790.11
282_F292_G0.6790.11
236_D242_D0.6710.11
126_M146_V0.6710.11
275_I288_N0.6680.10
33_T43_I0.6670.10
135_V170_K0.6640.10
299_G316_W0.6630.10
67_L84_D0.6600.10
67_L110_Y0.6600.10
72_G131_H0.6590.10
110_Y203_G0.6580.10
278_G297_H0.6570.10
313_N333_P0.6560.10
49_G94_G0.6550.10
319_S333_P0.6510.10
66_A132_V0.6490.10
312_H324_Q0.6480.10
284_G297_H0.6450.10
101_T148_Q0.6450.10
287_E296_A0.6440.10
264_G278_G0.6440.10
81_A85_G0.6420.10
206_P232_G0.6410.10
185_F211_A0.6390.10
296_A338_L0.6390.10
79_T184_F0.6370.10
33_T131_H0.6370.10
53_Y295_Y0.6350.10
119_K252_K0.6350.10
153_G345_T0.6320.10
105_N326_R0.6320.10
237_A289_Y0.6260.10
193_D275_I0.6230.10
317_D334_W0.6230.10
84_D197_Q0.6220.10
51_A58_Q0.6220.10
75_R89_V0.6210.10
142_V236_D0.6200.10
227_G316_W0.6190.10
336_N345_T0.6190.10
320_G334_W0.6180.10
335_N340_I0.6180.10
226_N256_V0.6180.10
119_K221_K0.6160.10
114_T222_T0.6160.10
74_P312_H0.6160.10
171_I283_K0.6160.10
213_A230_K0.6150.10
59_A97_S0.6150.10
282_F297_H0.6140.10
297_H302_K0.6130.10
226_N235_T0.6110.10
301_K336_N0.6080.10
299_G302_K0.6070.10
176_F283_K0.6040.10
329_G342_G0.6040.10
329_G343_G0.6040.10
230_K233_L0.6030.10
304_Y320_G0.6030.10
192_F233_L0.6020.10
113_K143_T0.6010.10
321_E324_Q0.6000.10
39_D141_Y0.5970.10
54_K81_A0.5930.10
40_T82_F0.5920.10
59_A324_Q0.5920.10
260_D282_F0.5900.10
201_Y245_G0.5880.10
330_V339_L0.5850.10
73_G332_L0.5820.09
321_E345_T0.5820.09
27_V140_A0.5800.09
175_Y209_G0.5800.09
279_G299_G0.5790.09
51_A217_N0.5770.09
176_F184_F0.5760.09
192_F235_T0.5750.09
100_L111_N0.5750.09
97_S293_K0.5740.09
31_S103_V0.5730.09
177_D226_N0.5720.09
88_Y245_G0.5700.09
231_P268_G0.5700.09
40_T269_I0.5680.09
34_G77_Q0.5680.09
141_Y336_N0.5680.09
97_S336_N0.5670.09
54_K174_H0.5670.09
56_D277_A0.5660.09
214_A310_L0.5660.09
24_E140_A0.5630.09
38_N252_K0.5610.09
102_Q163_K0.5590.09
50_T59_A0.5580.09
99_G335_N0.5570.09
195_S249_K0.5570.09
100_L162_G0.5550.09
50_T141_Y0.5540.09
177_D252_K0.5540.09
96_N335_N0.5520.09
78_A224_L0.5510.09
188_F242_D0.5510.09
263_A278_G0.5500.09
74_P138_G0.5480.09
51_A59_A0.5480.09
206_P234_R0.5480.09
141_Y152_N0.5450.09
44_G53_Y0.5440.09
227_G282_F0.5420.09
271_N314_G0.5410.09
231_P279_G0.5360.09
313_N320_G0.5350.09
230_K297_H0.5340.09
321_E334_W0.5330.09
151_F183_Y0.5330.09
70_F261_G0.5290.09
233_L282_F0.5290.09
39_D113_K0.5280.09
70_F284_G0.5270.09
80_S120_L0.5270.09
59_A331_S0.5260.09
227_G278_G0.5260.09
262_V340_I0.5250.09
81_A195_S0.5250.09
94_G104_F0.5240.09
134_F318_K0.5230.09
206_P228_E0.5220.09
31_S162_G0.5180.09
32_G130_G0.5180.09
199_W278_G0.5160.09
213_A218_K0.5160.09
260_D284_G0.5150.09
231_P299_G0.5140.09
91_G150_I0.5130.09
91_G193_D0.5130.09
29_F318_K0.5130.09
183_Y212_G0.5120.09
332_L335_N0.5120.09
182_D224_L0.5100.09
318_K338_L0.5080.09
206_P299_G0.5030.09
186_N230_K0.5030.09
178_K294_N0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uvkA 2 0.9484 100 0.567 Contact Map
4chbA 1 0.7391 100 0.734 Contact Map
4yy8A 2 0.7337 100 0.736 Contact Map
3ii7A 1 0.7473 100 0.736 Contact Map
2vpjA 1 0.7337 100 0.739 Contact Map
1zgkA 1 0.7283 100 0.742 Contact Map
2zwaA 1 0.8234 100 0.749 Contact Map
1k3iA 1 0.856 100 0.754 Contact Map
4ascA 1 0.6332 100 0.757 Contact Map
2wozA 2 0.6223 100 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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