SGCX - ECOLI - GREMLIN Contacts

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SGCX - Putative aminopeptidase SgcX

UniProt:	P39366	Sequences: MSFSVQETLFSLLQHNAISGHENAVADVMLCEFRRQAKEVWRDRLGNVVARYGSDKPDALRLMIFAHMDEVGFMVRKIEPSGFLRFERVGGPAQVTMAGSIVTLTGDKGPVMGCIGIKSYHFAKGDERTQSPSVDKLWIDIGAKDKDDAIRMGIQVGTPVTLYNPPQLLANDLVCSKALDDRLGCTALLGVADAISTMELDIAVYLVASVQEEFNIRGIVPVLRRVKPDLAIGIDITPSCDTPDLHDYSEVRINQGVGITCLNYHGRGTLAGLITPPRLIRMLEQTALEHNIPVQREVAPGVITETGYIQVEQDGIPCASLSIPCRYTHSPAEVASLRDLTDCIRLLTALAGMSAAHFPVEPDSGTTQEAHPL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12557
Length:	373 (338)
Sequences:	2608 (1717)
Seq/√Len:	93.4

ECOLI - SGCX FRVX YPDE
BACSU - YSDC YTOP YHFE
HALSA - Q9HPS1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
146_K	150_I	4.998	1.00
15_H	28_V	3.572	1.00
173_L	336_S	3.227	1.00
342_D	345_R	2.867	1.00
86_F	139_I	2.845	1.00
10_F	14_Q	2.731	1.00
18_I	89_V	2.707	1.00
279_L	319_A	2.609	1.00
13_L	176_S	2.605	1.00
143_A	149_A	2.592	1.00
190_G	193_D	2.549	1.00
105_T	161_T	2.531	1.00
65_F	209_S	2.521	1.00
289_E	353_M	2.515	1.00
290_H	349_A	2.477	1.00
79_E	85_R	2.437	1.00
62_L	351_A	2.347	1.00
30_L	34_R	2.328	1.00
252_R	255_Q	2.292	1.00
84_L	104_L	2.273	1.00
61_R	205_Y	2.249	1.00
293_P	342_D	2.234	1.00
30_L	42_R	2.179	1.00
51_R	203_A	2.169	1.00
285_Q	289_E	2.142	1.00
19_S	89_V	2.095	1.00
84_L	160_V	2.092	1.00
113_G	139_I	2.061	1.00
194_A	348_T	2.059	1.00
70_E	177_K	2.043	1.00
283_L	319_A	2.025	1.00
80_P	146_K	2.022	1.00
341_T	345_R	2.020	1.00
31_C	34_R	2.014	1.00
29_M	185_C	1.986	1.00
283_L	350_L	1.983	1.00
349_A	352_G	1.972	1.00
198_M	352_G	1.955	1.00
11_S	32_E	1.934	1.00
227_K	313_Q	1.930	1.00
147_D	150_I	1.929	1.00
141_I	154_I	1.929	1.00
172_D	338_R	1.925	1.00
147_D	151_R	1.922	1.00
21_H	159_P	1.915	1.00
11_S	28_V	1.913	1.00
192_A	206_L	1.883	1.00
75_V	160_V	1.864	1.00
51_R	205_Y	1.845	1.00
104_L	139_I	1.840	1.00
224_R	313_Q	1.757	1.00
102_V	139_I	1.749	1.00
17_A	25_V	1.741	1.00
61_R	203_A	1.729	1.00
11_S	31_C	1.715	1.00
66_A	188_L	1.714	1.00
335_A	340_L	1.689	1.00
118_K	127_E	1.676	1.00
141_I	149_A	1.673	1.00
53_G	203_A	1.670	1.00
79_E	83_F	1.666	1.00
143_A	152_M	1.651	1.00
183_L	340_L	1.648	1.00
26_A	68_M	1.590	1.00
30_L	48_V	1.578	1.00
39_E	51_R	1.574	1.00
47_N	221_P	1.538	1.00
257_V	342_D	1.531	1.00
37_A	50_A	1.523	1.00
54_S	203_A	1.501	1.00
63_M	309_I	1.497	1.00
220_V	308_Y	1.488	1.00
155_Q	288_L	1.487	1.00
155_Q	158_T	1.485	1.00
194_A	345_R	1.480	1.00
261_C	296_R	1.476	1.00
65_F	305_E	1.476	1.00
106_G	109_G	1.474	1.00
17_A	182_R	1.451	1.00
32_E	35_R	1.446	1.00
112_M	167_Q	1.441	1.00
286_T	290_H	1.438	1.00
40_V	48_V	1.429	0.99
32_E	193_D	1.428	0.99
74_M	87_E	1.416	0.99
86_F	137_L	1.405	0.99
33_F	189_L	1.401	0.99
64_I	351_A	1.394	0.99
185_C	208_A	1.388	0.99
7_E	10_F	1.381	0.99
282_M	353_M	1.372	0.99
92_P	162_L	1.369	0.99
86_F	160_V	1.363	0.99
56_K	59_A	1.360	0.99
78_I	149_A	1.351	0.99
63_M	222_V	1.346	0.99
6_Q	168_L	1.342	0.99
8_T	28_V	1.338	0.99
55_D	201_D	1.328	0.99
10_F	166_P	1.327	0.99
7_E	11_S	1.324	0.99
212_E	329_H	1.322	0.99
63_M	207_V	1.318	0.99
284_E	294_V	1.314	0.99
29_M	189_L	1.304	0.99
325_C	328_T	1.292	0.99
174_V	179_L	1.290	0.99
172_D	336_S	1.289	0.99
168_L	337_L	1.280	0.99
187_A	343_C	1.277	0.99
18_I	72_G	1.269	0.99
75_V	84_L	1.269	0.99
191_V	347_L	1.269	0.99
29_M	208_A	1.248	0.99
259_I	294_V	1.243	0.99
193_D	197_T	1.228	0.98
231_A	309_I	1.228	0.98
282_M	350_L	1.226	0.98
102_V	115_I	1.219	0.98
73_F	97_M	1.213	0.98
150_I	155_Q	1.211	0.98
63_M	228_P	1.202	0.98
16_N	103_T	1.201	0.98
233_G	306_T	1.200	0.98
191_V	348_T	1.200	0.98
213_E	329_H	1.197	0.98
27_D	31_C	1.196	0.98
19_S	72_G	1.188	0.98
145_D	148_D	1.173	0.98
344_I	348_T	1.161	0.98
144_K	148_D	1.157	0.98
13_L	166_P	1.156	0.98
148_D	151_R	1.151	0.98
183_L	335_A	1.136	0.97
306_T	318_C	1.134	0.97
41_W	225_R	1.133	0.97
84_L	141_I	1.128	0.97
284_E	296_R	1.128	0.97
16_N	105_T	1.125	0.97
77_K	85_R	1.120	0.97
26_A	42_R	1.119	0.97
104_L	160_V	1.119	0.97
88_R	94_Q	1.113	0.97
205_Y	226_V	1.111	0.97
55_D	199_E	1.109	0.97
191_V	344_I	1.109	0.97
125_G	128_R	1.094	0.97
232_I	283_L	1.093	0.97
188_L	234_I	1.086	0.97
8_T	189_L	1.084	0.96
321_L	343_C	1.078	0.96
33_F	50_A	1.068	0.96
282_M	286_T	1.065	0.96
89_V	159_P	1.064	0.96
207_V	222_V	1.059	0.96
107_D	158_T	1.059	0.96
8_T	32_E	1.053	0.96
68_M	185_C	1.049	0.96
236_I	328_T	1.049	0.96
39_E	53_G	1.049	0.96
280_I	284_E	1.047	0.96
190_G	194_A	1.046	0.96
86_F	115_I	1.044	0.96
104_L	158_T	1.042	0.96
36_Q	193_D	1.039	0.96
251_V	258_G	1.033	0.95
288_L	294_V	1.031	0.95
254_N	257_V	1.024	0.95
101_I	167_Q	1.021	0.95
101_I	163_Y	1.019	0.95
15_H	24_A	1.016	0.95
186_T	340_L	1.015	0.95
272_G	307_G	1.011	0.95
260_T	263_N	1.008	0.95
107_D	281_R	1.008	0.95
28_V	32_E	1.008	0.95
129_T	133_S	1.004	0.95
27_D	30_L	1.002	0.95
49_V	207_V	0.990	0.94
186_T	344_I	0.982	0.94
233_G	309_I	0.981	0.94
273_L	320_S	0.979	0.94
223_L	309_I	0.976	0.94
338_R	341_T	0.976	0.94
281_R	285_Q	0.973	0.94
103_T	163_Y	0.973	0.94
276_P	317_P	0.972	0.94
237_T	297_E	0.969	0.94
237_T	322_S	0.966	0.93
33_F	192_A	0.964	0.93
149_A	154_I	0.961	0.93
180_D	329_H	0.958	0.93
227_K	314_D	0.956	0.93
23_N	278_R	0.952	0.93
290_H	353_M	0.947	0.93
195_I	200_L	0.939	0.92
63_M	226_V	0.936	0.92
126_D	130_Q	0.936	0.92
254_N	336_S	0.929	0.92
292_I	346_L	0.927	0.92
62_L	202_I	0.920	0.92
348_T	352_G	0.920	0.92
241_D	326_R	0.918	0.92
126_D	129_T	0.913	0.91
102_V	113_G	0.911	0.91
255_Q	293_P	0.909	0.91
61_R	229_D	0.904	0.91
112_M	163_Y	0.904	0.91
188_L	206_L	0.903	0.91
29_M	68_M	0.897	0.91
55_D	203_A	0.891	0.90
260_T	297_E	0.885	0.90
46_G	210_V	0.883	0.90
97_M	115_I	0.881	0.90
190_G	340_L	0.880	0.90
50_A	208_A	0.879	0.90
60_L	202_I	0.878	0.90
187_A	344_I	0.877	0.90
179_L	335_A	0.877	0.90
14_Q	166_P	0.876	0.90
33_F	208_A	0.875	0.89
180_D	212_E	0.871	0.89
259_I	263_N	0.870	0.89
26_A	48_V	0.869	0.89
70_E	178_A	0.869	0.89
24_A	110_P	0.868	0.89
21_H	105_T	0.866	0.89
38_K	50_A	0.864	0.89
175_C	334_V	0.863	0.89
307_G	310_Q	0.863	0.89
24_A	105_T	0.860	0.89
18_I	159_P	0.860	0.89
43_D	47_N	0.859	0.89
251_V	257_V	0.859	0.89
278_R	317_P	0.855	0.88
181_D	184_G	0.851	0.88
30_L	40_V	0.848	0.88
237_T	258_G	0.846	0.88
236_I	325_C	0.846	0.88
56_K	203_A	0.845	0.88
124_K	127_E	0.839	0.87
349_A	353_M	0.832	0.87
133_S	136_K	0.828	0.87
256_G	339_D	0.824	0.86
101_I	332_A	0.824	0.86
68_M	208_A	0.824	0.86
40_V	50_A	0.822	0.86
94_Q	97_M	0.822	0.86
257_V	343_C	0.822	0.86
169_L	175_C	0.821	0.86
41_W	51_R	0.819	0.86
190_G	344_I	0.819	0.86
216_I	308_Y	0.819	0.86
104_L	141_I	0.816	0.86
233_G	236_I	0.816	0.86
87_E	262_L	0.815	0.86
111_V	154_I	0.810	0.86
286_T	353_M	0.808	0.85
54_S	59_A	0.807	0.85
91_G	329_H	0.807	0.85
23_N	27_D	0.806	0.85
73_F	160_V	0.803	0.85
211_Q	216_I	0.800	0.85
56_K	60_L	0.799	0.85
194_A	344_I	0.798	0.85
174_V	337_L	0.796	0.85
275_T	320_S	0.795	0.84
233_G	237_T	0.795	0.84
84_L	149_A	0.795	0.84
62_L	204_V	0.793	0.84
60_L	229_D	0.792	0.84
6_Q	166_P	0.787	0.84
15_H	25_V	0.787	0.84
216_I	307_G	0.784	0.84
51_R	61_R	0.784	0.84
238_P	328_T	0.782	0.83
9_L	186_T	0.782	0.83
272_G	303_I	0.782	0.83
103_T	110_P	0.781	0.83
181_D	236_I	0.776	0.83
284_E	288_L	0.775	0.83
180_D	213_E	0.773	0.83
111_V	141_I	0.773	0.83
52_Y	192_A	0.769	0.82
312_E	316_I	0.767	0.82
275_T	280_I	0.766	0.82
257_V	346_L	0.763	0.82
345_R	349_A	0.762	0.82
232_I	347_L	0.759	0.82
98_A	137_L	0.758	0.82
256_G	295_Q	0.754	0.81
323_I	343_C	0.753	0.81
254_N	259_I	0.751	0.81
233_G	318_C	0.749	0.81
66_A	181_D	0.749	0.81
76_R	87_E	0.747	0.81
234_I	347_L	0.746	0.80
91_G	212_E	0.746	0.80
10_F	168_L	0.745	0.80
283_L	321_L	0.743	0.80
303_I	307_G	0.736	0.80
150_I	288_L	0.732	0.79
15_H	32_E	0.731	0.79
187_A	191_V	0.731	0.79
84_L	111_V	0.730	0.79
54_S	200_L	0.730	0.79
187_A	340_L	0.729	0.79
257_V	321_L	0.729	0.79
59_A	203_A	0.722	0.78
6_Q	176_S	0.721	0.78
235_D	297_E	0.721	0.78
297_E	322_S	0.721	0.78
225_R	314_D	0.719	0.78
166_P	176_S	0.717	0.78
240_C	250_E	0.715	0.78
173_L	177_K	0.714	0.78
9_L	179_L	0.713	0.77
25_V	68_M	0.711	0.77
338_R	342_D	0.707	0.77
187_A	234_I	0.706	0.77
172_D	177_K	0.706	0.77
204_V	351_A	0.703	0.76
103_T	112_M	0.703	0.76
258_G	261_C	0.701	0.76
231_A	316_I	0.700	0.76
309_I	316_I	0.697	0.76
271_A	303_I	0.696	0.76
93_A	96_T	0.690	0.75
215_N	303_I	0.689	0.75
91_G	303_I	0.688	0.75
99_G	331_P	0.686	0.75
67_H	212_E	0.686	0.75
191_V	351_A	0.686	0.75
219_I	223_L	0.683	0.74
302_V	328_T	0.682	0.74
62_L	230_L	0.681	0.74
113_G	141_I	0.678	0.74
200_L	204_V	0.678	0.74
232_I	319_A	0.676	0.74
169_L	334_V	0.676	0.74
6_Q	10_F	0.674	0.73
83_F	243_P	0.671	0.73
141_I	152_M	0.670	0.73
325_C	335_A	0.669	0.73
42_R	48_V	0.668	0.73
80_P	126_D	0.668	0.73
223_L	312_E	0.667	0.73
186_T	190_G	0.663	0.72
155_Q	284_E	0.663	0.72
340_L	344_I	0.663	0.72
263_N	302_V	0.660	0.72
286_T	349_A	0.658	0.72
285_Q	288_L	0.656	0.71
199_E	291_N	0.655	0.71
249_S	252_R	0.654	0.71
255_Q	259_I	0.654	0.71
73_F	86_F	0.653	0.71
38_K	196_S	0.653	0.71
328_T	333_E	0.652	0.71
211_Q	214_F	0.651	0.71
110_P	170_A	0.649	0.71
28_V	31_C	0.646	0.70
55_D	58_D	0.643	0.70
286_T	292_I	0.642	0.70
257_V	261_C	0.642	0.70
74_M	300_P	0.639	0.69
287_A	346_L	0.636	0.69
33_F	37_A	0.634	0.69
277_P	281_R	0.633	0.69
215_N	263_N	0.633	0.69
254_N	258_G	0.633	0.69
37_A	192_A	0.631	0.68
124_K	128_R	0.629	0.68
237_T	251_V	0.627	0.68
106_G	111_V	0.625	0.68
29_M	48_V	0.625	0.68
275_T	302_V	0.624	0.68
106_G	153_G	0.622	0.67
111_V	143_A	0.619	0.67
277_P	317_P	0.618	0.67
224_R	314_D	0.616	0.67
168_L	172_D	0.615	0.66
44_R	317_P	0.614	0.66
304_T	329_H	0.613	0.66
258_G	263_N	0.612	0.66
37_A	40_V	0.612	0.66
83_F	138_W	0.611	0.66
13_L	177_K	0.611	0.66
116_G	327_Y	0.611	0.66
47_N	207_V	0.610	0.66
106_G	158_T	0.608	0.66
91_G	213_E	0.607	0.65
79_E	138_W	0.607	0.65
9_L	174_V	0.606	0.65
36_Q	196_S	0.606	0.65
282_M	285_Q	0.604	0.65
24_A	31_C	0.603	0.65
12_L	25_V	0.602	0.65
74_M	89_V	0.601	0.65
290_H	345_R	0.601	0.65
286_T	350_L	0.599	0.64
260_T	299_A	0.598	0.64
53_G	58_D	0.596	0.64
33_F	40_V	0.594	0.64
188_L	191_V	0.592	0.64
104_L	154_I	0.592	0.64
236_I	240_C	0.589	0.63
234_I	237_T	0.589	0.63
107_D	285_Q	0.587	0.63
288_L	291_N	0.585	0.63
38_K	52_Y	0.585	0.63
21_H	24_A	0.584	0.62
65_F	233_G	0.581	0.62
49_V	205_Y	0.581	0.62
194_A	198_M	0.580	0.62
211_Q	217_R	0.580	0.62
64_I	347_L	0.577	0.62
259_I	319_A	0.577	0.62
23_N	26_A	0.576	0.61
263_N	307_G	0.575	0.61
105_T	160_V	0.574	0.61
176_S	179_L	0.573	0.61
16_N	24_A	0.569	0.60
253_I	256_G	0.569	0.60
64_I	234_I	0.568	0.60
18_I	161_T	0.567	0.60
183_L	344_I	0.566	0.60
9_L	13_L	0.566	0.60
38_K	51_R	0.562	0.60
58_D	203_A	0.561	0.59
49_V	222_V	0.561	0.59
94_Q	132_P	0.560	0.59
125_G	129_T	0.559	0.59
253_I	324_P	0.558	0.59
197_T	291_N	0.558	0.59
259_I	280_I	0.555	0.59
115_I	137_L	0.554	0.58
195_I	204_V	0.554	0.58
44_R	229_D	0.554	0.58
176_S	334_V	0.553	0.58
16_N	161_T	0.552	0.58
67_H	329_H	0.551	0.58
238_P	297_E	0.550	0.58
41_W	205_Y	0.550	0.58
71_V	333_E	0.549	0.58
246_H	249_S	0.548	0.58
320_S	328_T	0.548	0.58
230_L	350_L	0.547	0.57
92_P	120_Y	0.545	0.57
236_I	297_E	0.542	0.57
88_R	134_V	0.542	0.57
196_S	199_E	0.541	0.57
302_V	320_S	0.540	0.57
181_D	212_E	0.534	0.56
38_K	192_A	0.534	0.56
102_V	162_L	0.534	0.56
179_L	340_L	0.534	0.56
94_Q	134_V	0.533	0.56
303_I	329_H	0.532	0.55
32_E	189_L	0.530	0.55
162_L	331_P	0.530	0.55
216_I	303_I	0.530	0.55
73_F	92_P	0.528	0.55
258_G	322_S	0.527	0.55
302_V	307_G	0.526	0.55
195_I	351_A	0.524	0.54
207_V	231_A	0.524	0.54
260_T	320_S	0.524	0.54
299_A	302_V	0.523	0.54
144_K	338_R	0.522	0.54
48_V	74_M	0.521	0.54
230_L	279_L	0.521	0.54
67_H	213_E	0.520	0.54
26_A	46_G	0.519	0.54
209_S	222_V	0.519	0.54
281_R	284_E	0.518	0.53
11_S	14_Q	0.517	0.53
92_P	123_A	0.516	0.53
88_R	92_P	0.515	0.53
20_G	159_P	0.515	0.53
34_R	40_V	0.514	0.53
310_Q	318_C	0.514	0.53
295_Q	339_D	0.513	0.53
235_D	304_T	0.513	0.53
230_L	317_P	0.512	0.53
222_V	309_I	0.511	0.53
256_G	326_R	0.511	0.53
29_M	50_A	0.511	0.53
70_E	116_G	0.510	0.52
8_T	190_G	0.510	0.52
14_Q	165_P	0.508	0.52
77_K	80_P	0.508	0.52
262_L	275_T	0.508	0.52
233_G	347_L	0.507	0.52
183_L	323_I	0.507	0.52
218_G	221_P	0.506	0.52
13_L	179_L	0.506	0.52
72_G	89_V	0.505	0.52
73_F	162_L	0.504	0.52
125_G	131_S	0.504	0.52
155_Q	296_R	0.503	0.51
55_D	290_H	0.503	0.51
212_E	304_T	0.503	0.51
181_D	235_D	0.503	0.51
62_L	232_I	0.501	0.51
194_A	341_T	0.501	0.51
280_I	319_A	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wwvA	4	0.9598	100	0.423	Contact Map
1y0yA	5	0.8901	100	0.441	Contact Map
2wyrA	4	0.874	100	0.446	Contact Map
2wznA	4	0.9008	100	0.446	Contact Map
3wt4A	4	0.9062	100	0.448	Contact Map
3vatA	4	0.9517	100	0.451	Contact Map
2fvgA	1	0.8311	100	0.456	Contact Map
2gljA	6	0.9249	100	0.466	Contact Map
2glfA	4	0.9223	100	0.47	Contact Map
1y7eA	4	0.8177	100	0.482	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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