GREMLIN Database
SGCX - Putative aminopeptidase SgcX
UniProt: P39366 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12557
Length: 373 (338)
Sequences: 2608 (1717)
Seq/√Len: 93.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_K150_I4.9981.00
15_H28_V3.5721.00
173_L336_S3.2271.00
342_D345_R2.8671.00
86_F139_I2.8451.00
10_F14_Q2.7311.00
18_I89_V2.7071.00
279_L319_A2.6091.00
13_L176_S2.6051.00
143_A149_A2.5921.00
190_G193_D2.5491.00
105_T161_T2.5311.00
65_F209_S2.5211.00
289_E353_M2.5151.00
290_H349_A2.4771.00
79_E85_R2.4371.00
62_L351_A2.3471.00
30_L34_R2.3281.00
252_R255_Q2.2921.00
84_L104_L2.2731.00
61_R205_Y2.2491.00
293_P342_D2.2341.00
30_L42_R2.1791.00
51_R203_A2.1691.00
285_Q289_E2.1421.00
19_S89_V2.0951.00
84_L160_V2.0921.00
113_G139_I2.0611.00
194_A348_T2.0591.00
70_E177_K2.0431.00
283_L319_A2.0251.00
80_P146_K2.0221.00
341_T345_R2.0201.00
31_C34_R2.0141.00
29_M185_C1.9861.00
283_L350_L1.9831.00
349_A352_G1.9721.00
198_M352_G1.9551.00
11_S32_E1.9341.00
227_K313_Q1.9301.00
147_D150_I1.9291.00
141_I154_I1.9291.00
172_D338_R1.9251.00
147_D151_R1.9221.00
21_H159_P1.9151.00
11_S28_V1.9131.00
192_A206_L1.8831.00
75_V160_V1.8641.00
51_R205_Y1.8451.00
104_L139_I1.8401.00
224_R313_Q1.7571.00
102_V139_I1.7491.00
17_A25_V1.7411.00
61_R203_A1.7291.00
11_S31_C1.7151.00
66_A188_L1.7141.00
335_A340_L1.6891.00
118_K127_E1.6761.00
141_I149_A1.6731.00
53_G203_A1.6701.00
79_E83_F1.6661.00
143_A152_M1.6511.00
183_L340_L1.6481.00
26_A68_M1.5901.00
30_L48_V1.5781.00
39_E51_R1.5741.00
47_N221_P1.5381.00
257_V342_D1.5311.00
37_A50_A1.5231.00
54_S203_A1.5011.00
63_M309_I1.4971.00
220_V308_Y1.4881.00
155_Q288_L1.4871.00
155_Q158_T1.4851.00
194_A345_R1.4801.00
261_C296_R1.4761.00
65_F305_E1.4761.00
106_G109_G1.4741.00
17_A182_R1.4511.00
32_E35_R1.4461.00
112_M167_Q1.4411.00
286_T290_H1.4381.00
40_V48_V1.4290.99
32_E193_D1.4280.99
74_M87_E1.4160.99
86_F137_L1.4050.99
33_F189_L1.4010.99
64_I351_A1.3940.99
185_C208_A1.3880.99
7_E10_F1.3810.99
282_M353_M1.3720.99
92_P162_L1.3690.99
86_F160_V1.3630.99
56_K59_A1.3600.99
78_I149_A1.3510.99
63_M222_V1.3460.99
6_Q168_L1.3420.99
8_T28_V1.3380.99
55_D201_D1.3280.99
10_F166_P1.3270.99
7_E11_S1.3240.99
212_E329_H1.3220.99
63_M207_V1.3180.99
284_E294_V1.3140.99
29_M189_L1.3040.99
325_C328_T1.2920.99
174_V179_L1.2900.99
172_D336_S1.2890.99
168_L337_L1.2800.99
187_A343_C1.2770.99
18_I72_G1.2690.99
75_V84_L1.2690.99
191_V347_L1.2690.99
29_M208_A1.2480.99
259_I294_V1.2430.99
193_D197_T1.2280.98
231_A309_I1.2280.98
282_M350_L1.2260.98
102_V115_I1.2190.98
73_F97_M1.2130.98
150_I155_Q1.2110.98
63_M228_P1.2020.98
16_N103_T1.2010.98
233_G306_T1.2000.98
191_V348_T1.2000.98
213_E329_H1.1970.98
27_D31_C1.1960.98
19_S72_G1.1880.98
145_D148_D1.1730.98
344_I348_T1.1610.98
144_K148_D1.1570.98
13_L166_P1.1560.98
148_D151_R1.1510.98
183_L335_A1.1360.97
306_T318_C1.1340.97
41_W225_R1.1330.97
84_L141_I1.1280.97
284_E296_R1.1280.97
16_N105_T1.1250.97
77_K85_R1.1200.97
26_A42_R1.1190.97
104_L160_V1.1190.97
88_R94_Q1.1130.97
205_Y226_V1.1110.97
55_D199_E1.1090.97
191_V344_I1.1090.97
125_G128_R1.0940.97
232_I283_L1.0930.97
188_L234_I1.0860.97
8_T189_L1.0840.96
321_L343_C1.0780.96
33_F50_A1.0680.96
282_M286_T1.0650.96
89_V159_P1.0640.96
207_V222_V1.0590.96
107_D158_T1.0590.96
8_T32_E1.0530.96
68_M185_C1.0490.96
236_I328_T1.0490.96
39_E53_G1.0490.96
280_I284_E1.0470.96
190_G194_A1.0460.96
86_F115_I1.0440.96
104_L158_T1.0420.96
36_Q193_D1.0390.96
251_V258_G1.0330.95
288_L294_V1.0310.95
254_N257_V1.0240.95
101_I167_Q1.0210.95
101_I163_Y1.0190.95
15_H24_A1.0160.95
186_T340_L1.0150.95
272_G307_G1.0110.95
260_T263_N1.0080.95
107_D281_R1.0080.95
28_V32_E1.0080.95
129_T133_S1.0040.95
27_D30_L1.0020.95
49_V207_V0.9900.94
186_T344_I0.9820.94
233_G309_I0.9810.94
273_L320_S0.9790.94
223_L309_I0.9760.94
338_R341_T0.9760.94
281_R285_Q0.9730.94
103_T163_Y0.9730.94
276_P317_P0.9720.94
237_T297_E0.9690.94
237_T322_S0.9660.93
33_F192_A0.9640.93
149_A154_I0.9610.93
180_D329_H0.9580.93
227_K314_D0.9560.93
23_N278_R0.9520.93
290_H353_M0.9470.93
195_I200_L0.9390.92
63_M226_V0.9360.92
126_D130_Q0.9360.92
254_N336_S0.9290.92
292_I346_L0.9270.92
62_L202_I0.9200.92
348_T352_G0.9200.92
241_D326_R0.9180.92
126_D129_T0.9130.91
102_V113_G0.9110.91
255_Q293_P0.9090.91
61_R229_D0.9040.91
112_M163_Y0.9040.91
188_L206_L0.9030.91
29_M68_M0.8970.91
55_D203_A0.8910.90
260_T297_E0.8850.90
46_G210_V0.8830.90
97_M115_I0.8810.90
190_G340_L0.8800.90
50_A208_A0.8790.90
60_L202_I0.8780.90
187_A344_I0.8770.90
179_L335_A0.8770.90
14_Q166_P0.8760.90
33_F208_A0.8750.89
180_D212_E0.8710.89
259_I263_N0.8700.89
26_A48_V0.8690.89
70_E178_A0.8690.89
24_A110_P0.8680.89
21_H105_T0.8660.89
38_K50_A0.8640.89
175_C334_V0.8630.89
307_G310_Q0.8630.89
24_A105_T0.8600.89
18_I159_P0.8600.89
43_D47_N0.8590.89
251_V257_V0.8590.89
278_R317_P0.8550.88
181_D184_G0.8510.88
30_L40_V0.8480.88
237_T258_G0.8460.88
236_I325_C0.8460.88
56_K203_A0.8450.88
124_K127_E0.8390.87
349_A353_M0.8320.87
133_S136_K0.8280.87
256_G339_D0.8240.86
101_I332_A0.8240.86
68_M208_A0.8240.86
40_V50_A0.8220.86
94_Q97_M0.8220.86
257_V343_C0.8220.86
169_L175_C0.8210.86
41_W51_R0.8190.86
190_G344_I0.8190.86
216_I308_Y0.8190.86
104_L141_I0.8160.86
233_G236_I0.8160.86
87_E262_L0.8150.86
111_V154_I0.8100.86
286_T353_M0.8080.85
54_S59_A0.8070.85
91_G329_H0.8070.85
23_N27_D0.8060.85
73_F160_V0.8030.85
211_Q216_I0.8000.85
56_K60_L0.7990.85
194_A344_I0.7980.85
174_V337_L0.7960.85
275_T320_S0.7950.84
233_G237_T0.7950.84
84_L149_A0.7950.84
62_L204_V0.7930.84
60_L229_D0.7920.84
6_Q166_P0.7870.84
15_H25_V0.7870.84
216_I307_G0.7840.84
51_R61_R0.7840.84
238_P328_T0.7820.83
9_L186_T0.7820.83
272_G303_I0.7820.83
103_T110_P0.7810.83
181_D236_I0.7760.83
284_E288_L0.7750.83
180_D213_E0.7730.83
111_V141_I0.7730.83
52_Y192_A0.7690.82
312_E316_I0.7670.82
275_T280_I0.7660.82
257_V346_L0.7630.82
345_R349_A0.7620.82
232_I347_L0.7590.82
98_A137_L0.7580.82
256_G295_Q0.7540.81
323_I343_C0.7530.81
254_N259_I0.7510.81
233_G318_C0.7490.81
66_A181_D0.7490.81
76_R87_E0.7470.81
234_I347_L0.7460.80
91_G212_E0.7460.80
10_F168_L0.7450.80
283_L321_L0.7430.80
303_I307_G0.7360.80
150_I288_L0.7320.79
15_H32_E0.7310.79
187_A191_V0.7310.79
84_L111_V0.7300.79
54_S200_L0.7300.79
187_A340_L0.7290.79
257_V321_L0.7290.79
59_A203_A0.7220.78
6_Q176_S0.7210.78
235_D297_E0.7210.78
297_E322_S0.7210.78
225_R314_D0.7190.78
166_P176_S0.7170.78
240_C250_E0.7150.78
173_L177_K0.7140.78
9_L179_L0.7130.77
25_V68_M0.7110.77
338_R342_D0.7070.77
187_A234_I0.7060.77
172_D177_K0.7060.77
204_V351_A0.7030.76
103_T112_M0.7030.76
258_G261_C0.7010.76
231_A316_I0.7000.76
309_I316_I0.6970.76
271_A303_I0.6960.76
93_A96_T0.6900.75
215_N303_I0.6890.75
91_G303_I0.6880.75
99_G331_P0.6860.75
67_H212_E0.6860.75
191_V351_A0.6860.75
219_I223_L0.6830.74
302_V328_T0.6820.74
62_L230_L0.6810.74
113_G141_I0.6780.74
200_L204_V0.6780.74
232_I319_A0.6760.74
169_L334_V0.6760.74
6_Q10_F0.6740.73
83_F243_P0.6710.73
141_I152_M0.6700.73
325_C335_A0.6690.73
42_R48_V0.6680.73
80_P126_D0.6680.73
223_L312_E0.6670.73
186_T190_G0.6630.72
155_Q284_E0.6630.72
340_L344_I0.6630.72
263_N302_V0.6600.72
286_T349_A0.6580.72
285_Q288_L0.6560.71
199_E291_N0.6550.71
249_S252_R0.6540.71
255_Q259_I0.6540.71
73_F86_F0.6530.71
38_K196_S0.6530.71
328_T333_E0.6520.71
211_Q214_F0.6510.71
110_P170_A0.6490.71
28_V31_C0.6460.70
55_D58_D0.6430.70
286_T292_I0.6420.70
257_V261_C0.6420.70
74_M300_P0.6390.69
287_A346_L0.6360.69
33_F37_A0.6340.69
277_P281_R0.6330.69
215_N263_N0.6330.69
254_N258_G0.6330.69
37_A192_A0.6310.68
124_K128_R0.6290.68
237_T251_V0.6270.68
106_G111_V0.6250.68
29_M48_V0.6250.68
275_T302_V0.6240.68
106_G153_G0.6220.67
111_V143_A0.6190.67
277_P317_P0.6180.67
224_R314_D0.6160.67
168_L172_D0.6150.66
44_R317_P0.6140.66
304_T329_H0.6130.66
258_G263_N0.6120.66
37_A40_V0.6120.66
83_F138_W0.6110.66
13_L177_K0.6110.66
116_G327_Y0.6110.66
47_N207_V0.6100.66
106_G158_T0.6080.66
91_G213_E0.6070.65
79_E138_W0.6070.65
9_L174_V0.6060.65
36_Q196_S0.6060.65
282_M285_Q0.6040.65
24_A31_C0.6030.65
12_L25_V0.6020.65
74_M89_V0.6010.65
290_H345_R0.6010.65
286_T350_L0.5990.64
260_T299_A0.5980.64
53_G58_D0.5960.64
33_F40_V0.5940.64
188_L191_V0.5920.64
104_L154_I0.5920.64
236_I240_C0.5890.63
234_I237_T0.5890.63
107_D285_Q0.5870.63
288_L291_N0.5850.63
38_K52_Y0.5850.63
21_H24_A0.5840.62
65_F233_G0.5810.62
49_V205_Y0.5810.62
194_A198_M0.5800.62
211_Q217_R0.5800.62
64_I347_L0.5770.62
259_I319_A0.5770.62
23_N26_A0.5760.61
263_N307_G0.5750.61
105_T160_V0.5740.61
176_S179_L0.5730.61
16_N24_A0.5690.60
253_I256_G0.5690.60
64_I234_I0.5680.60
18_I161_T0.5670.60
183_L344_I0.5660.60
9_L13_L0.5660.60
38_K51_R0.5620.60
58_D203_A0.5610.59
49_V222_V0.5610.59
94_Q132_P0.5600.59
125_G129_T0.5590.59
253_I324_P0.5580.59
197_T291_N0.5580.59
259_I280_I0.5550.59
115_I137_L0.5540.58
195_I204_V0.5540.58
44_R229_D0.5540.58
176_S334_V0.5530.58
16_N161_T0.5520.58
67_H329_H0.5510.58
238_P297_E0.5500.58
41_W205_Y0.5500.58
71_V333_E0.5490.58
246_H249_S0.5480.58
320_S328_T0.5480.58
230_L350_L0.5470.57
92_P120_Y0.5450.57
236_I297_E0.5420.57
88_R134_V0.5420.57
196_S199_E0.5410.57
302_V320_S0.5400.57
181_D212_E0.5340.56
38_K192_A0.5340.56
102_V162_L0.5340.56
179_L340_L0.5340.56
94_Q134_V0.5330.56
303_I329_H0.5320.55
32_E189_L0.5300.55
162_L331_P0.5300.55
216_I303_I0.5300.55
73_F92_P0.5280.55
258_G322_S0.5270.55
302_V307_G0.5260.55
195_I351_A0.5240.54
207_V231_A0.5240.54
260_T320_S0.5240.54
299_A302_V0.5230.54
144_K338_R0.5220.54
48_V74_M0.5210.54
230_L279_L0.5210.54
67_H213_E0.5200.54
26_A46_G0.5190.54
209_S222_V0.5190.54
281_R284_E0.5180.53
11_S14_Q0.5170.53
92_P123_A0.5160.53
88_R92_P0.5150.53
20_G159_P0.5150.53
34_R40_V0.5140.53
310_Q318_C0.5140.53
295_Q339_D0.5130.53
235_D304_T0.5130.53
230_L317_P0.5120.53
222_V309_I0.5110.53
256_G326_R0.5110.53
29_M50_A0.5110.53
70_E116_G0.5100.52
8_T190_G0.5100.52
14_Q165_P0.5080.52
77_K80_P0.5080.52
262_L275_T0.5080.52
233_G347_L0.5070.52
183_L323_I0.5070.52
218_G221_P0.5060.52
13_L179_L0.5060.52
72_G89_V0.5050.52
73_F162_L0.5040.52
125_G131_S0.5040.52
155_Q296_R0.5030.51
55_D290_H0.5030.51
212_E304_T0.5030.51
181_D235_D0.5030.51
62_L232_I0.5010.51
194_A341_T0.5010.51
280_I319_A0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wwvA 4 0.9598 100 0.423 Contact Map
1y0yA 5 0.8901 100 0.441 Contact Map
2wyrA 4 0.874 100 0.446 Contact Map
2wznA 4 0.9008 100 0.446 Contact Map
3wt4A 4 0.9062 100 0.448 Contact Map
3vatA 4 0.9517 100 0.451 Contact Map
2fvgA 1 0.8311 100 0.456 Contact Map
2gljA 6 0.9249 100 0.466 Contact Map
2glfA 4 0.9223 100 0.47 Contact Map
1y7eA 4 0.8177 100 0.482 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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