GREMLIN Database
SGCC - Putative permease IIC component
UniProt: P39365 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12556
Length: 437 (427)
Sequences: 611 (388)
Seq/√Len: 18.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_P32_A5.3721.00
185_P189_L5.1201.00
203_R350_V4.8191.00
225_V250_A4.5131.00
101_L105_A4.4921.00
73_H324_K4.4841.00
229_L246_M4.2171.00
233_L242_C3.8611.00
238_G241_G3.6081.00
106_M111_L3.5721.00
320_L365_L3.4761.00
19_I29_W3.4611.00
309_L356_G3.4491.00
29_W33_I3.4161.00
192_A196_K3.3821.00
308_L353_L3.2821.00
19_I36_G3.2140.99
191_D195_E3.2040.99
34_K219_D3.1900.99
67_R236_G3.1500.99
189_L193_I3.1270.99
51_V55_D3.0500.99
325_V367_A2.8970.99
205_I350_V2.8460.99
194_Y200_M2.8120.98
191_D351_R2.6840.98
102_L147_I2.6830.98
60_P245_L2.6480.98
291_L295_V2.5900.97
22_G27_I2.5820.97
167_I299_H2.5750.97
312_I357_V2.5090.97
160_T174_S2.4340.96
114_T158_D2.4240.96
74_V368_T2.4050.96
74_V324_K2.3380.95
239_F243_A2.2510.94
44_V247_I2.2400.94
86_G92_G2.2240.94
161_A165_Q2.2170.94
316_L365_L2.1630.93
386_A389_S2.0940.91
313_M360_M2.0830.91
110_R285_R2.0740.91
37_V247_I2.0610.91
345_H355_S2.0540.91
113_K286_E2.0320.90
325_V393_S2.0300.90
132_V145_G1.9940.89
369_Q403_W1.9810.89
376_E379_L1.9670.89
95_I146_A1.9300.88
107_L287_V1.9250.87
106_M109_T1.9220.87
116_N176_P1.9040.87
26_R213_R1.8950.87
105_A108_V1.8590.85
41_I221_V1.8470.85
140_I144_L1.8310.85
62_K66_E1.8210.84
232_G245_L1.8030.84
87_Y90_A1.7950.83
85_V378_A1.7730.83
87_Y92_G1.7580.82
106_M151_A1.7060.80
64_M136_T1.6570.78
33_I225_V1.6510.78
200_M354_I1.6360.77
104_V108_V1.6360.77
64_M234_A1.6340.77
48_L274_A1.6220.76
353_L357_V1.6160.76
20_V24_I1.6110.76
64_M231_F1.6050.76
185_P193_I1.5970.75
107_L201_K1.5950.75
191_D355_S1.5910.75
195_E201_K1.5880.75
116_N154_L1.5870.75
157_A247_I1.5760.74
317_A327_P1.5670.74
128_T149_H1.5640.74
98_V193_I1.5630.74
37_V250_A1.5550.73
58_S328_L1.5480.73
113_K285_R1.5330.72
125_Y153_S1.5320.72
204_N209_E1.5310.72
121_N154_L1.5280.72
312_I353_L1.5130.71
305_V352_T1.5100.71
26_R280_K1.5040.71
21_I25_F1.4920.70
116_N295_V1.4900.70
324_K368_T1.4880.70
192_A195_E1.4840.70
30_L216_M1.4820.69
161_A288_Y1.4730.69
88_A130_T1.4680.69
175_I295_V1.4610.68
47_G51_V1.4480.68
207_A301_T1.4320.67
200_M350_V1.4190.66
418_V421_G1.4100.66
122_Y164_V1.4070.65
39_V46_M1.3980.65
75_F381_G1.3830.64
104_V186_L1.3800.64
156_M284_G1.3740.63
166_N346_R1.3730.63
2_F6_L1.3550.62
142_G145_G1.3460.62
378_A392_I1.3420.62
33_I250_A1.3400.61
193_I315_I1.3340.61
263_I345_H1.3280.61
31_Q250_A1.3210.60
27_I32_A1.3060.59
23_L29_W1.2920.59
26_R36_G1.2890.58
417_V421_G1.2730.57
341_A358_I1.2730.57
110_R131_V1.2700.57
258_R261_R1.2530.56
190_L194_Y1.2500.56
364_L368_T1.2490.56
19_I33_I1.2450.56
87_Y177_Q1.2440.56
258_R262_L1.2350.55
152_L156_M1.2320.55
49_V57_L1.2180.54
77_V117_V1.2040.53
157_A174_S1.2020.53
86_G155_K1.1860.52
225_V246_M1.1840.52
105_A166_N1.1840.52
194_Y358_I1.1820.52
39_V266_G1.1790.52
129_G146_A1.1750.51
407_E410_S1.1650.51
10_G32_A1.1610.50
266_G332_P1.1610.50
96_I126_A1.1610.50
37_V225_V1.1610.50
66_E216_M1.1510.50
194_Y351_R1.1440.49
33_I344_I1.1420.49
20_V379_L1.1420.49
26_R277_F1.1400.49
19_I23_L1.1390.49
120_Y264_V1.1380.49
132_V141_Y1.1340.49
207_A210_I1.1280.48
92_G126_A1.1250.48
13_F115_M1.1230.48
144_L147_I1.1200.48
180_G184_V1.1170.48
15_P40_G1.1080.47
189_L192_A1.1080.47
194_Y354_I1.0980.46
194_Y345_H1.0960.46
74_V391_Q1.0930.46
102_L108_V1.0870.46
414_I417_V1.0850.46
28_P31_Q1.0820.45
329_A333_V1.0810.45
14_V329_A1.0660.44
342_T352_T1.0630.44
368_T393_S1.0620.44
102_L151_A1.0610.44
19_I22_G1.0580.44
363_V398_G1.0480.43
74_V354_I1.0460.43
229_L242_C1.0400.43
48_L315_I1.0380.43
413_I416_V1.0320.42
191_D345_H1.0230.42
92_G97_P1.0150.41
328_L367_A1.0110.41
48_L328_L1.0090.41
204_N416_V1.0070.41
101_L104_V1.0050.41
306_G346_R1.0050.41
404_S408_L1.0020.41
171_E392_I1.0010.40
57_L328_L0.9960.40
98_V147_I0.9950.40
120_Y347_G0.9910.40
16_I380_K0.9910.40
195_E351_R0.9830.39
369_Q407_E0.9760.39
116_N174_S0.9760.39
314_L326_L0.9750.39
256_F283_K0.9710.39
14_V256_F0.9630.38
89_T394_A0.9630.38
282_F378_A0.9580.38
56_S248_T0.9510.37
5_I240_K0.9450.37
70_L82_A0.9430.37
217_V310_I0.9400.37
165_Q286_E0.9370.37
157_A160_T0.9350.37
329_A398_G0.9230.36
179_Y302_T0.9210.36
265_E273_G0.9170.36
173_I176_P0.9130.35
113_K173_I0.9120.35
89_T130_T0.9070.35
125_Y185_P0.9020.35
136_T203_R0.9010.35
244_S248_T0.8990.34
190_L318_S0.8980.34
346_R357_V0.8970.34
14_V92_G0.8940.34
20_V286_E0.8920.34
48_L52_M0.8910.34
77_V392_I0.8890.34
96_I398_G0.8870.34
13_F18_M0.8860.34
87_Y303_I0.8860.34
321_P365_L0.8850.34
414_I418_V0.8840.34
227_L231_F0.8840.34
46_M256_F0.8840.34
29_W83_S0.8810.33
72_L326_L0.8800.33
33_I338_I0.8780.33
10_G80_G0.8760.33
116_N175_I0.8760.33
162_K376_E0.8760.33
100_F104_V0.8740.33
86_G150_A0.8740.33
135_M376_E0.8730.33
16_I36_G0.8730.33
370_F377_M0.8730.33
39_V52_M0.8720.33
19_I26_R0.8660.33
206_D350_V0.8640.33
138_S422_I0.8640.33
256_F262_L0.8640.33
234_A318_S0.8610.32
239_F242_C0.8610.32
246_M408_L0.8600.32
171_E355_S0.8590.32
328_L336_F0.8570.32
239_F346_R0.8560.32
26_R273_G0.8560.32
190_L358_I0.8530.32
60_P235_A0.8520.32
3_D7_S0.8490.32
8_L50_I0.8480.32
144_L151_A0.8470.32
50_I283_K0.8470.32
66_E236_G0.8400.31
64_M235_A0.8380.31
49_V246_M0.8350.31
132_V378_A0.8330.31
117_V291_L0.8320.31
271_S295_V0.8300.31
322_G365_L0.8300.31
256_F296_T0.8300.31
22_G36_G0.8280.31
284_G314_L0.8270.31
266_G294_A0.8240.30
5_I36_G0.8240.30
57_L393_S0.8230.30
312_I316_L0.8190.30
227_L330_D0.8190.30
194_Y355_S0.8180.30
14_V274_A0.8180.30
7_S202_G0.8130.30
235_A326_L0.8110.30
263_I266_G0.8100.30
333_V402_G0.8090.30
177_Q290_G0.8070.29
191_D227_L0.8050.29
8_L380_K0.8040.29
3_D53_A0.8000.29
53_A141_Y0.8000.29
200_M203_R0.7980.29
200_M407_E0.7970.29
341_A345_H0.7890.29
229_L387_G0.7890.29
22_G270_I0.7880.28
168_V286_E0.7880.28
376_E380_K0.7870.28
304_A342_T0.7860.28
149_H178_G0.7860.28
21_I391_Q0.7860.28
281_Y315_I0.7830.28
325_V368_T0.7810.28
62_K223_I0.7800.28
210_I304_A0.7780.28
117_V306_G0.7770.28
284_G287_V0.7760.28
104_V226_V0.7730.28
89_T303_I0.7720.28
361_I365_L0.7720.28
259_M263_I0.7700.28
320_L364_L0.7700.28
89_T129_G0.7660.27
83_S320_L0.7650.27
181_S346_R0.7620.27
174_S295_V0.7620.27
142_G340_M0.7600.27
115_M285_R0.7580.27
140_I247_I0.7570.27
46_M177_Q0.7560.27
259_M383_F0.7560.27
66_E241_G0.7550.27
238_G242_C0.7550.27
86_G134_L0.7540.27
117_V165_Q0.7510.27
186_L190_L0.7510.27
189_L223_I0.7490.27
57_L75_F0.7470.26
35_A73_H0.7460.26
41_I405_I0.7450.26
414_I424_A0.7440.26
30_L223_I0.7440.26
185_P354_I0.7420.26
7_S241_G0.7420.26
138_S142_G0.7420.26
104_V200_M0.7400.26
327_P364_L0.7400.26
106_M155_K0.7390.26
236_G287_V0.7370.26
106_M301_T0.7360.26
20_V246_M0.7350.26
168_V301_T0.7340.26
175_I283_K0.7330.26
330_D339_C0.7330.26
132_V282_F0.7330.26
177_Q398_G0.7330.26
89_T219_D0.7320.26
223_I227_L0.7310.26
414_I421_G0.7300.26
81_P92_G0.7250.25
14_V46_M0.7240.25
86_G120_Y0.7220.25
85_V123_W0.7210.25
310_I335_P0.7190.25
263_I293_T0.7170.25
168_V303_I0.7170.25
101_L193_I0.7160.25
239_F358_I0.7160.25
13_F256_F0.7140.25
334_A338_I0.7140.25
16_I24_I0.7120.25
306_G330_D0.7110.25
213_R233_L0.7110.25
177_Q336_F0.7100.25
82_A374_F0.7070.25
323_N326_L0.7070.25
294_A297_L0.7070.25
158_D271_S0.7050.24
5_I26_R0.7050.24
94_M143_V0.7040.24
42_G266_G0.7010.24
407_E420_V0.7000.24
412_G415_G0.6990.24
124_H383_F0.6980.24
43_F80_G0.6980.24
227_L291_L0.6970.24
110_R113_K0.6960.24
44_V51_V0.6950.24
324_K371_A0.6930.24
259_M309_L0.6930.24
233_L404_S0.6920.24
417_V425_S0.6920.24
154_L370_F0.6900.24
253_M275_R0.6900.24
85_V351_R0.6890.24
392_I405_I0.6880.24
259_M393_S0.6850.24
416_V420_V0.6840.23
134_L315_I0.6830.23
60_P237_E0.6830.23
20_V400_M0.6820.23
102_L242_C0.6820.23
16_I214_Y0.6810.23
263_I297_L0.6800.23
58_S83_S0.6800.23
24_I353_L0.6800.23
391_Q409_M0.6790.23
13_F17_I0.6790.23
35_A351_R0.6790.23
116_N121_N0.6750.23
135_M373_Y0.6720.23
326_L368_T0.6720.23
158_D323_N0.6720.23
186_L417_V0.6720.23
370_F373_Y0.6710.23
43_F267_L0.6710.23
119_I154_L0.6700.23
196_K354_I0.6670.23
258_R304_A0.6670.23
100_F341_A0.6670.23
23_L66_E0.6660.23
46_M61_I0.6660.23
33_I58_S0.6650.23
130_T143_V0.6650.23
96_I266_G0.6650.23
142_G165_Q0.6630.23
35_A272_D0.6630.23
317_A364_L0.6600.22
236_G317_A0.6570.22
77_V365_L0.6570.22
49_V300_P0.6560.22
63_V281_Y0.6560.22
26_R417_V0.6560.22
168_V349_L0.6560.22
330_D342_T0.6560.22
148_C193_I0.6550.22
124_H177_Q0.6550.22
5_I35_A0.6540.22
54_I247_I0.6530.22
110_R407_E0.6520.22
103_N118_D0.6520.22
424_A428_L0.6510.22
271_S290_G0.6500.22
161_A221_V0.6490.22
34_K246_M0.6490.22
221_V253_M0.6480.22
69_G278_F0.6470.22
148_C420_V0.6460.22
283_K287_V0.6460.22
101_L213_R0.6460.22
418_V422_I0.6450.22
177_Q395_L0.6450.22
163_R343_V0.6430.22
315_I417_V0.6430.22
18_M426_V0.6420.22
168_V270_I0.6380.21
72_L364_L0.6380.21
115_M130_T0.6370.21
191_D398_G0.6370.21
138_S151_A0.6370.21
293_T336_F0.6360.21
53_A306_G0.6360.21
345_H353_L0.6350.21
155_K377_M0.6310.21
133_Q142_G0.6310.21
226_V241_G0.6300.21
193_I354_I0.6300.21
85_V392_I0.6300.21
87_Y388_E0.6300.21
186_L291_L0.6270.21
7_S358_I0.6270.21
116_N343_V0.6270.21
108_V281_Y0.6270.21
333_V398_G0.6260.21
393_S398_G0.6250.21
227_L304_A0.6240.21
129_G232_G0.6240.21
254_V258_R0.6230.21
279_Q283_K0.6210.21
67_R100_F0.6210.21
405_I409_M0.6180.21
217_V308_L0.6150.20
79_A83_S0.6140.20
310_I351_R0.6140.20
93_A303_I0.6140.20
20_V29_W0.6130.20
210_I250_A0.6120.20
88_A131_V0.6120.20
64_M330_D0.6090.20
232_G252_I0.6070.20
142_G397_V0.6050.20
168_V343_V0.6040.20
13_F79_A0.6020.20
286_E319_I0.6000.20
199_F202_G0.5990.20
61_I328_L0.5990.20
247_I262_L0.5980.20
206_D275_R0.5970.20
256_F260_I0.5970.20
403_W407_E0.5950.20
174_S222_I0.5950.20
160_T184_V0.5930.20
32_A104_V0.5930.20
104_V197_I0.5930.20
83_S403_W0.5930.20
39_V291_L0.5910.20
89_T92_G0.5910.20
36_G210_I0.5890.19
33_I105_A0.5880.19
10_G24_I0.5880.19
21_I56_S0.5870.19
210_I214_Y0.5860.19
66_E71_A0.5860.19
24_I115_M0.5860.19
245_L284_G0.5850.19
25_F34_K0.5850.19
371_A391_Q0.5850.19
10_G180_G0.5820.19
144_L419_A0.5820.19
230_I253_M0.5810.19
122_Y175_I0.5790.19
114_T174_S0.5790.19
166_N354_I0.5780.19
57_L86_G0.5770.19
275_R279_Q0.5770.19
16_I127_I0.5760.19
129_G195_E0.5760.19
13_F335_P0.5750.19
37_V195_E0.5750.19
103_N292_D0.5750.19
18_M348_D0.5750.19
30_L158_D0.5740.19
26_R317_A0.5730.19
129_G184_V0.5720.19
201_K242_C0.5720.19
127_I397_V0.5720.19
41_I223_I0.5690.19
166_N319_I0.5680.19
133_Q349_L0.5670.19
33_I247_I0.5660.19
111_L288_Y0.5660.19
305_V339_C0.5650.19
42_G220_P0.5640.18
38_T277_F0.5630.18
35_A56_S0.5630.18
293_T335_P0.5620.18
107_L200_M0.5620.18
333_V336_F0.5580.18
139_L143_V0.5570.18
107_L378_A0.5570.18
119_I349_L0.5560.18
83_S107_L0.5560.18
160_T403_W0.5550.18
309_L405_I0.5550.18
419_A422_I0.5550.18
64_M326_L0.5550.18
106_M110_R0.5550.18
123_W173_I0.5540.18
263_I303_I0.5540.18
122_Y297_L0.5530.18
122_Y299_H0.5530.18
111_L147_I0.5520.18
227_L394_A0.5510.18
124_H332_P0.5510.18
92_G344_I0.5510.18
55_D59_P0.5500.18
113_K260_I0.5490.18
107_L282_F0.5490.18
29_W105_A0.5490.18
125_Y220_P0.5490.18
365_L369_Q0.5490.18
85_V370_F0.5480.18
80_G263_I0.5470.18
252_I376_E0.5460.18
416_V424_A0.5460.18
107_L367_A0.5440.18
20_V104_V0.5430.18
225_V405_I0.5420.18
12_V243_A0.5410.18
99_I335_P0.5400.18
175_I248_T0.5400.18
26_R122_Y0.5390.18
59_P317_A0.5380.18
264_V290_G0.5370.17
232_G246_M0.5370.17
139_L185_P0.5360.17
198_P267_L0.5360.17
173_I235_A0.5340.17
291_L298_G0.5330.17
116_N142_G0.5330.17
247_I392_I0.5310.17
18_M313_M0.5310.17
46_M87_Y0.5300.17
228_G311_P0.5300.17
41_I357_V0.5290.17
71_A241_G0.5280.17
230_I242_C0.5280.17
254_V262_L0.5280.17
158_D290_G0.5270.17
315_I318_S0.5270.17
62_K196_K0.5270.17
29_W32_A0.5270.17
166_N428_L0.5260.17
312_I328_L0.5250.17
354_I408_L0.5250.17
96_I399_N0.5250.17
123_W127_I0.5250.17
144_L305_V0.5240.17
105_A316_L0.5240.17
25_F324_K0.5220.17
5_I354_I0.5210.17
59_P288_Y0.5210.17
164_V173_I0.5210.17
67_R350_V0.5210.17
167_I347_G0.5190.17
223_I325_V0.5190.17
199_F350_V0.5180.17
421_G428_L0.5180.17
83_S253_M0.5180.17
169_G334_A0.5170.17
42_G168_V0.5160.17
9_G40_G0.5160.17
66_E425_S0.5150.17
94_M309_L0.5150.17
100_F393_S0.5140.17
83_S353_L0.5140.17
212_K421_G0.5140.17
205_I414_I0.5140.17
86_G91_I0.5140.17
356_G394_A0.5130.17
320_L323_N0.5120.17
93_A352_T0.5110.17
268_L272_D0.5110.17
204_N346_R0.5100.17
43_F199_F0.5090.16
173_I284_G0.5090.16
260_I263_I0.5090.16
187_F344_I0.5080.16
173_I326_L0.5080.16
216_M402_G0.5080.16
364_L393_S0.5070.16
30_L102_L0.5070.16
162_K210_I0.5070.16
191_D196_K0.5060.16
134_L302_T0.5060.16
46_M306_G0.5060.16
35_A109_T0.5060.16
212_K242_C0.5060.16
214_Y366_I0.5050.16
20_V98_V0.5050.16
205_I308_L0.5050.16
276_K280_K0.5050.16
229_L245_L0.5040.16
5_I369_Q0.5040.16
241_G382_G0.5040.16
104_V390_A0.5040.16
104_V282_F0.5030.16
329_A335_P0.5010.16
20_V226_V0.5000.16
14_V334_A0.5000.16
405_I408_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rp9A 2 0.9039 100 0.467 Contact Map
2m20A 2 0.0778 15.7 0.982 Contact Map
2l2tA 2 0.0938 12 0.983 Contact Map
1yg0A 1 0.151 7.4 0.984 Contact Map
2l3mA 1 0.1579 5.9 0.985 Contact Map
2xmmA 2 0.1396 5.9 0.985 Contact Map
1cpzA 1 0.151 5.8 0.985 Contact Map
2ks1B 1 0.0961 5.5 0.985 Contact Map
2mfrA 1 0.1098 5.5 0.985 Contact Map
4lz6A 1 0.4805 5.3 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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