SGCQ - ECOLI - GREMLIN Contacts

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SGCQ - Putative sgc region protein SgcQ

UniProt:	P39364	Sequences: MSWLKEVIGTEKAVIAMCHLRALPGDPSFDAQLGMNWVIDKAWDDLMALQNGGVDAVMFSNEFSLPYLTKVRPETTAAMARIIGQLMSDIRIPFGVNVLWDPVASFDLAMATGAKFIREIFTGAYASDFGVWDTNVGETIRHQHRIGAGEVKTLFNIVPEAAVYLGNRDICSIAKSTVFNNHPDALCVSGLTAGTRTDSALLKRVKETVPDTVVLANTGVCLENVEEQLSIADGCVTATTFKKDGVFANFVDQARVSQFMEKVHHIRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12555
Length:	268 (253)
Sequences:	559 (368)
Seq/√Len:	23.1

ECOLI - SGCQ
HALSA - Q9HMJ2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
52_G	256_V	4.381	1.00
206_K	214_V	3.298	1.00
171_C	204_R	3.260	1.00
83_I	96_V	3.259	1.00
206_K	233_D	3.235	1.00
260_M	263_V	3.164	1.00
155_F	183_P	3.035	1.00
14_V	54_V	2.828	0.99
244_D	249_N	2.679	0.99
35_M	78_A	2.677	0.99
107_D	142_H	2.632	0.99
8_I	13_A	2.545	0.99
85_Q	88_S	2.504	0.98
174_A	209_V	2.438	0.98
14_V	235_C	2.383	0.98
45_D	251_V	2.373	0.98
21_R	42_A	2.369	0.98
81_R	85_Q	2.320	0.97
187_C	217_N	2.311	0.97
54_V	256_V	2.244	0.97
157_I	174_A	2.243	0.97
216_A	220_V	2.199	0.96
54_V	241_F	2.196	0.96
154_L	185_A	2.178	0.96
20_L	42_A	2.171	0.96
60_S	160_E	2.139	0.96
160_E	218_T	2.057	0.95
60_S	218_T	2.040	0.94
14_V	260_M	2.025	0.94
69_T	133_D	2.008	0.94
48_A	52_G	1.971	0.93
36_N	40_D	1.929	0.92
222_L	240_T	1.923	0.92
100_W	127_S	1.826	0.90
59_F	94_F	1.760	0.88
121_F	139_T	1.755	0.88
99_L	119_E	1.693	0.86
40_D	44_D	1.681	0.86
148_A	151_V	1.667	0.85
119_E	159_P	1.635	0.84
146_I	151_V	1.627	0.84
245_G	255_R	1.601	0.83
135_N	138_E	1.590	0.83
98_V	108_L	1.582	0.82
46_L	86_L	1.578	0.82
41_K	44_D	1.555	0.81
226_E	262_K	1.548	0.81
101_D	104_A	1.504	0.79
58_M	116_F	1.483	0.78
59_F	83_I	1.479	0.78
77_A	111_A	1.469	0.77
26_D	64_S	1.466	0.77
122_T	177_T	1.454	0.76
28_S	182_H	1.452	0.76
60_S	193_A	1.441	0.76
100_W	119_E	1.435	0.75
21_R	41_K	1.418	0.75
51_N	253_Q	1.400	0.74
60_S	159_P	1.397	0.73
44_D	250_F	1.397	0.73
46_L	57_V	1.388	0.73
100_W	129_F	1.388	0.73
30_D	37_W	1.382	0.73
45_D	48_A	1.381	0.73
45_D	63_F	1.359	0.71
246_V	249_N	1.358	0.71
60_S	161_A	1.348	0.71
43_W	86_L	1.333	0.70
125_Y	162_A	1.333	0.70
87_M	94_F	1.330	0.70
81_R	84_G	1.322	0.69
110_M	147_G	1.315	0.69
56_A	116_F	1.312	0.69
159_P	193_A	1.303	0.68
203_K	207_E	1.303	0.68
175_K	254_A	1.302	0.68
17_M	49_L	1.291	0.67
241_F	260_M	1.283	0.67
43_W	90_I	1.281	0.67
67_Y	119_E	1.278	0.66
174_A	205_V	1.239	0.64
129_F	180_N	1.235	0.64
159_P	218_T	1.233	0.64
17_M	58_M	1.224	0.63
214_V	232_A	1.208	0.62
110_M	148_A	1.199	0.61
64_S	107_D	1.192	0.61
209_V	212_T	1.183	0.60
44_D	47_M	1.181	0.60
98_V	101_D	1.175	0.60
257_S	261_E	1.162	0.59
27_P	141_R	1.154	0.58
156_N	218_T	1.143	0.58
161_A	218_T	1.140	0.57
160_E	193_A	1.133	0.57
83_I	112_T	1.132	0.57
243_K	249_N	1.130	0.57
19_H	24_P	1.130	0.57
76_T	80_A	1.127	0.57
15_I	56_A	1.124	0.56
100_W	180_N	1.114	0.56
154_L	236_V	1.102	0.55
251_V	256_V	1.100	0.55
97_N	119_E	1.093	0.54
42_A	82_I	1.079	0.53
25_G	74_E	1.067	0.52
170_I	174_A	1.064	0.52
45_D	244_D	1.057	0.52
156_N	217_N	1.056	0.52
174_A	208_T	1.048	0.51
101_D	120_I	1.045	0.51
220_V	225_V	1.045	0.51
119_E	129_F	1.038	0.50
103_V	138_E	1.036	0.50
196_R	224_N	1.031	0.50
16_A	19_H	1.028	0.50
25_G	238_A	1.028	0.50
243_K	250_F	1.018	0.49
156_N	161_A	1.007	0.48
54_V	260_M	1.007	0.48
125_Y	158_V	1.007	0.48
118_R	130_G	1.006	0.48
47_M	51_N	1.001	0.48
80_A	84_G	0.999	0.48
243_K	252_D	0.997	0.47
99_L	128_D	0.992	0.47
17_M	232_A	0.989	0.47
137_G	141_R	0.988	0.47
60_S	156_N	0.976	0.46
124_A	134_T	0.967	0.45
50_Q	92_I	0.966	0.45
64_S	161_A	0.956	0.45
241_F	256_V	0.955	0.45
60_S	187_C	0.953	0.44
161_A	193_A	0.950	0.44
237_T	259_F	0.949	0.44
158_V	162_A	0.945	0.44
85_Q	240_T	0.941	0.44
61_N	66_P	0.939	0.43
132_W	155_F	0.939	0.43
120_I	129_F	0.934	0.43
82_I	263_V	0.932	0.43
257_S	264_H	0.923	0.42
12_K	233_D	0.914	0.42
29_F	147_G	0.914	0.42
124_A	131_V	0.913	0.42
40_D	47_M	0.909	0.41
119_E	127_S	0.909	0.41
123_G	173_I	0.903	0.41
197_T	228_Q	0.900	0.41
185_A	228_Q	0.899	0.41
160_E	187_C	0.894	0.40
153_T	237_T	0.891	0.40
249_N	255_R	0.888	0.40
68_L	72_R	0.884	0.40
88_S	215_L	0.884	0.40
170_I	205_V	0.883	0.40
50_Q	90_I	0.878	0.39
39_I	85_Q	0.878	0.39
12_K	29_F	0.878	0.39
96_V	109_A	0.877	0.39
43_W	89_D	0.875	0.39
222_L	262_K	0.874	0.39
49_L	232_A	0.873	0.39
18_C	42_A	0.858	0.38
63_F	247_F	0.857	0.38
21_R	59_F	0.857	0.38
86_L	89_D	0.854	0.38
191_L	205_V	0.852	0.38
205_V	238_A	0.851	0.38
42_A	59_F	0.847	0.37
102_P	165_L	0.846	0.37
220_V	235_C	0.844	0.37
258_Q	261_E	0.843	0.37
108_L	237_T	0.842	0.37
228_Q	235_C	0.841	0.37
51_N	152_K	0.838	0.37
47_M	90_I	0.831	0.36
215_L	239_T	0.828	0.36
47_M	57_V	0.828	0.36
99_L	193_A	0.825	0.36
12_K	15_I	0.823	0.36
143_Q	239_T	0.823	0.36
120_I	127_S	0.822	0.36
15_I	93_P	0.821	0.36
62_E	125_Y	0.820	0.36
226_E	257_S	0.818	0.35
178_V	212_T	0.811	0.35
45_D	52_G	0.807	0.35
254_A	258_Q	0.807	0.35
99_L	202_L	0.802	0.34
91_R	117_I	0.797	0.34
115_K	150_E	0.796	0.34
21_R	38_V	0.796	0.34
102_P	139_T	0.795	0.34
50_Q	206_K	0.788	0.34
17_M	236_V	0.785	0.33
97_N	100_W	0.784	0.33
101_D	124_A	0.782	0.33
142_H	146_I	0.779	0.33
193_A	218_T	0.778	0.33
164_Y	247_F	0.775	0.33
77_A	106_F	0.774	0.33
156_N	160_E	0.774	0.33
140_I	153_T	0.770	0.32
99_L	236_V	0.770	0.32
109_A	151_V	0.769	0.32
14_V	39_I	0.767	0.32
110_M	150_E	0.766	0.32
97_N	159_P	0.765	0.32
73_P	76_T	0.763	0.32
12_K	263_V	0.763	0.32
17_M	189_S	0.757	0.32
156_N	187_C	0.757	0.32
43_W	46_L	0.756	0.32
225_V	229_L	0.756	0.32
144_H	147_G	0.750	0.31
13_A	233_D	0.748	0.31
196_R	227_E	0.745	0.31
57_V	92_I	0.745	0.31
44_D	87_M	0.744	0.31
73_P	104_A	0.744	0.31
226_E	261_E	0.743	0.31
67_Y	159_P	0.742	0.31
117_I	236_V	0.740	0.31
40_D	207_E	0.738	0.31
87_M	225_V	0.738	0.31
57_V	257_S	0.735	0.30
208_T	215_L	0.733	0.30
7_V	224_N	0.729	0.30
227_E	261_E	0.729	0.30
252_D	259_F	0.727	0.30
49_L	241_F	0.724	0.30
47_M	87_M	0.724	0.30
60_S	119_E	0.724	0.30
119_E	160_E	0.720	0.29
81_R	111_A	0.716	0.29
197_T	220_V	0.715	0.29
55_D	233_D	0.713	0.29
7_V	22_A	0.712	0.29
119_E	155_F	0.712	0.29
35_M	82_I	0.707	0.29
223_E	258_Q	0.706	0.29
120_I	123_G	0.705	0.29
122_T	189_S	0.704	0.29
189_S	220_V	0.703	0.28
30_D	58_M	0.700	0.28
83_I	94_F	0.700	0.28
173_I	177_T	0.695	0.28
119_E	134_T	0.693	0.28
10_T	13_A	0.693	0.28
45_D	111_A	0.692	0.28
123_G	128_D	0.691	0.28
54_V	57_V	0.689	0.28
16_A	49_L	0.687	0.28
70_K	117_I	0.686	0.28
129_F	164_Y	0.685	0.27
13_A	246_V	0.684	0.27
60_S	105_S	0.684	0.27
22_A	145_R	0.680	0.27
170_I	213_V	0.678	0.27
39_I	82_I	0.677	0.27
60_S	217_N	0.676	0.27
75_T	185_A	0.674	0.27
58_M	230_S	0.672	0.27
159_P	176_S	0.671	0.27
160_E	217_N	0.671	0.27
22_A	28_S	0.671	0.27
222_L	258_Q	0.670	0.27
99_L	129_F	0.667	0.26
14_V	241_F	0.665	0.26
72_R	164_Y	0.665	0.26
32_Q	37_W	0.662	0.26
108_L	171_C	0.656	0.26
163_V	169_D	0.654	0.26
14_V	185_A	0.653	0.26
156_N	159_P	0.649	0.26
215_L	234_G	0.647	0.25
61_N	242_K	0.645	0.25
119_E	218_T	0.645	0.25
174_A	188_V	0.642	0.25
199_S	223_E	0.641	0.25
123_G	129_F	0.641	0.25
252_D	256_V	0.639	0.25
17_M	25_G	0.638	0.25
220_V	228_Q	0.638	0.25
14_V	246_V	0.636	0.25
127_S	180_N	0.635	0.25
41_K	177_T	0.634	0.25
126_A	162_A	0.633	0.25
15_I	58_M	0.633	0.25
100_W	159_P	0.632	0.25
229_L	235_C	0.629	0.24
178_V	211_D	0.624	0.24
45_D	249_N	0.623	0.24
164_Y	180_N	0.623	0.24
9_G	56_A	0.621	0.24
194_G	218_T	0.620	0.24
13_A	20_L	0.617	0.24
222_L	259_F	0.616	0.24
119_E	128_D	0.615	0.24
17_M	238_A	0.613	0.24
43_W	117_I	0.612	0.24
45_D	224_N	0.605	0.23
72_R	142_H	0.602	0.23
38_V	82_I	0.601	0.23
155_F	218_T	0.600	0.23
166_G	176_S	0.598	0.23
140_I	241_F	0.598	0.23
11_E	51_N	0.587	0.22
189_S	217_N	0.586	0.22
50_Q	91_R	0.586	0.22
123_G	164_Y	0.586	0.22
222_L	226_E	0.584	0.22
119_E	156_N	0.583	0.22
134_T	164_Y	0.582	0.22
112_T	188_V	0.580	0.22
74_E	107_D	0.579	0.22
18_C	88_S	0.579	0.22
66_P	190_G	0.579	0.22
86_L	113_G	0.579	0.22
24_P	245_G	0.578	0.22
22_A	42_A	0.577	0.22
129_F	161_A	0.576	0.22
58_M	136_V	0.574	0.22
120_I	134_T	0.573	0.22
49_L	54_V	0.569	0.22
117_I	139_T	0.565	0.21
88_S	186_L	0.561	0.21
58_M	135_N	0.561	0.21
159_P	187_C	0.559	0.21
126_A	153_T	0.558	0.21
94_F	222_L	0.557	0.21
58_M	120_I	0.556	0.21
22_A	191_L	0.555	0.21
62_E	180_N	0.554	0.21
47_M	261_E	0.551	0.21
207_E	254_A	0.551	0.21
69_T	119_E	0.550	0.21
239_T	247_F	0.546	0.20
199_S	233_D	0.544	0.20
22_A	214_V	0.543	0.20
176_S	180_N	0.543	0.20
119_E	180_N	0.542	0.20
198_D	233_D	0.541	0.20
131_V	196_R	0.535	0.20
17_M	119_E	0.533	0.20
196_R	254_A	0.531	0.20
185_A	206_K	0.531	0.20
113_G	143_Q	0.530	0.20
57_V	90_I	0.529	0.20
197_T	202_L	0.526	0.20
78_A	253_Q	0.525	0.20
73_P	192_T	0.525	0.20
70_K	264_H	0.524	0.19
13_A	93_P	0.522	0.19
42_A	94_F	0.521	0.19
24_P	242_K	0.521	0.19
71_V	76_T	0.517	0.19
128_D	139_T	0.515	0.19
161_A	180_N	0.515	0.19
100_W	156_N	0.514	0.19
127_S	134_T	0.513	0.19
62_E	120_I	0.512	0.19
58_M	222_L	0.511	0.19
64_S	193_A	0.511	0.19
119_E	136_V	0.511	0.19
143_Q	257_S	0.510	0.19
92_I	216_A	0.510	0.19
109_A	236_V	0.509	0.19
76_T	213_V	0.508	0.19
198_D	244_D	0.508	0.19
19_H	27_P	0.506	0.19
105_S	177_T	0.505	0.19
96_V	240_T	0.504	0.19
99_L	180_N	0.504	0.19
70_K	73_P	0.503	0.19
26_D	75_T	0.503	0.19
62_E	97_N	0.501	0.18
205_V	214_V	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ekcA	1	0.8507	99.8	0.793	Contact Map
1ujpA	1	0.7761	99.8	0.793	Contact Map
3thaA	2	0.8321	99.8	0.798	Contact Map
3vndA	3	0.8321	99.8	0.798	Contact Map
3navA	2	0.8433	99.8	0.799	Contact Map
4ht3A	1	0.8657	99.8	0.8	Contact Map
4r9xA	2	0.7761	99.8	0.805	Contact Map
1geqA	1	0.8172	99.7	0.813	Contact Map
2yw3A	4	0.7351	99.7	0.815	Contact Map
1rd5A	6	0.8657	99.7	0.817	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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