GREMLIN Database
SGCE - Protein SgcE
UniProt: P39362 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12553
Length: 210 (207)
Sequences: 4304 (2561)
Seq/√Len: 178.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_F164_T3.5051.00
14_H17_R3.2691.00
177_A188_M2.6741.00
165_E186_Q2.5061.00
172_I180_L2.3331.00
85_I107_A2.1951.00
38_S68_A2.1751.00
63_F82_P2.1681.00
23_D59_H2.1321.00
158_R162_P2.0891.00
146_F151_C2.0811.00
120_D123_R2.0631.00
132_V157_V2.0531.00
69_R72_R2.0331.00
75_N101_E2.0251.00
148_P179_Q1.9811.00
197_S203_T1.9751.00
86_F112_V1.9301.00
96_S128_E1.9141.00
32_L50_V1.8651.00
110_G131_G1.8591.00
199_D202_A1.8291.00
123_R156_K1.8051.00
78_A107_A1.7841.00
178_Q182_A1.7711.00
116_A138_E1.7531.00
134_V150_M1.7401.00
152_E155_Q1.7401.00
89_A121_A1.7191.00
21_A200_Y1.6911.00
71_Q92_L1.6911.00
201_R205_A1.6871.00
60_P84_W1.6861.00
75_N105_T1.6621.00
75_N79_E1.6531.00
2_I165_E1.6331.00
181_A188_M1.6311.00
87_V95_P1.6221.00
136_T150_M1.6171.00
101_E104_H1.6031.00
90_E117_T1.5881.00
86_F131_G1.5801.00
119_I157_V1.5661.00
159_T163_Q1.5611.00
103_R109_A1.5381.00
158_R161_F1.5131.00
16_G20_T1.5031.00
173_T176_A1.4971.00
123_R160_A1.4921.00
114_N138_E1.4851.00
71_Q98_T1.4481.00
32_L61_L1.4301.00
134_V157_V1.4191.00
176_A180_L1.4111.00
23_D58_P1.3871.00
29_S187_H1.3861.00
94_Y97_E1.3811.00
68_A93_D1.3781.00
51_Q79_E1.3561.00
28_G208_A1.3441.00
13_L16_G1.3431.00
22_L30_L1.3321.00
165_E187_H1.3281.00
20_T24_N1.3271.00
103_R130_D1.3261.00
38_S69_R1.3031.00
174_L193_A1.2901.00
151_C179_Q1.2811.00
54_A61_L1.2801.00
84_W108_R1.2761.00
18_E21_A1.2731.00
50_V61_L1.2721.00
202_A206_Q1.2651.00
54_A83_A1.2621.00
4_H187_H1.2601.00
100_T104_H1.2601.00
13_L56_Q1.2521.00
111_L129_L1.2311.00
18_E200_Y1.2191.00
120_D156_K1.2091.00
4_H29_S1.2011.00
95_P125_L1.2011.00
100_T128_E1.1911.00
2_I29_S1.1741.00
119_I124_Y1.1691.00
19_L53_V1.1691.00
167_W189_V1.1681.00
109_A130_D1.1661.00
161_F186_Q1.1621.00
20_T23_D1.1411.00
95_P111_L1.1371.00
78_A105_T1.1231.00
99_L129_L1.1161.00
35_E40_I1.1121.00
87_V98_T1.1111.00
179_Q182_A1.0981.00
102_I109_A1.0971.00
84_W131_G1.0961.00
39_F90_E1.0941.00
2_I187_H1.0901.00
74_F105_T1.0841.00
8_A142_Q1.0641.00
7_L30_L1.0601.00
29_S84_W1.0591.00
98_T101_E1.0561.00
101_E105_T1.0511.00
29_S165_E1.0501.00
30_L59_H1.0210.99
11_N14_H1.0200.99
7_L32_L1.0180.99
62_S86_F1.0170.99
45_F49_T1.0120.99
79_E105_T0.9950.99
95_P116_A0.9880.99
174_L206_Q0.9860.99
99_L128_E0.9820.99
2_I28_G0.9800.99
124_Y156_K0.9740.99
71_Q101_E0.9630.99
203_T206_Q0.9620.99
89_A95_P0.9590.99
129_L132_V0.9570.99
99_L103_R0.9540.99
99_L109_A0.9530.99
47_M76_A0.9510.99
136_T146_F0.9500.99
99_L125_L0.9470.99
111_L125_L0.9460.99
161_F166_C0.9410.99
24_N201_R0.9390.99
17_R21_A0.9330.99
48_K51_Q0.9330.99
155_Q182_A0.9310.99
155_Q159_T0.9250.99
48_K52_A0.9180.99
57_T61_L0.9170.99
23_D57_T0.9070.99
32_L45_F0.9020.99
86_F110_G0.9010.99
76_A79_E0.9010.99
190_I193_A0.9010.99
108_R165_E0.9000.99
168_A185_A0.8980.99
13_L52_A0.8970.99
190_I194_L0.8950.99
167_W187_H0.8890.98
151_C183_A0.8890.98
96_S149_S0.8890.98
87_V99_L0.8870.98
180_L188_M0.8850.98
94_Y138_E0.8840.98
54_A57_T0.8840.98
89_A122_W0.8800.98
15_Y49_T0.8790.98
39_F117_T0.8750.98
89_A119_I0.8700.98
200_Y203_T0.8650.98
177_A181_A0.8620.98
156_K160_A0.8610.98
158_R164_T0.8590.98
154_I168_A0.8580.98
28_G60_P0.8570.98
78_A85_I0.8540.98
19_L30_L0.8490.98
202_A205_A0.8470.98
67_L73_W0.8440.98
185_A188_M0.8440.98
119_I160_A0.8390.98
119_I134_V0.8380.98
9_S44_T0.8370.98
72_R76_A0.8280.98
159_T162_P0.8230.97
157_V161_F0.8220.97
53_V61_L0.8180.97
43_I77_L0.8120.97
34_I77_L0.8100.97
3_L204_L0.8090.97
42_N141_G0.8070.97
127_S149_S0.8060.97
10_A15_Y0.8040.97
115_P137_S0.8000.97
155_Q183_A0.7900.97
51_Q55_R0.7870.97
65_F77_L0.7850.97
92_L98_T0.7810.97
17_R20_T0.7730.96
38_S72_R0.7680.96
9_S192_R0.7560.96
96_S100_T0.7560.96
124_Y127_S0.7530.96
87_V92_L0.7520.96
126_A164_T0.7510.96
157_V166_C0.7480.96
152_E156_K0.7450.95
119_I156_K0.7420.95
160_A163_Q0.7370.95
154_I166_C0.7340.95
14_H18_E0.7330.95
34_I50_V0.7320.95
25_L200_Y0.7290.95
150_M153_K0.7270.95
193_A203_T0.7190.95
151_C180_L0.7170.94
117_T121_A0.7150.94
44_T47_M0.7140.94
122_W132_V0.7110.94
10_A18_E0.7070.94
5_P27_F0.6990.94
23_D26_D0.6990.94
142_Q171_G0.6920.93
142_Q191_G0.6920.93
129_L164_T0.6910.93
102_I107_A0.6900.93
76_A80_I0.6860.93
131_G187_H0.6830.93
19_L23_D0.6800.93
168_A172_I0.6660.92
194_L200_Y0.6640.92
52_A55_R0.6640.92
111_L122_W0.6620.92
154_I185_A0.6610.92
174_L203_T0.6590.92
89_A113_F0.6500.91
8_A171_G0.6470.91
194_L204_L0.6460.91
29_S131_G0.6450.91
100_T103_R0.6440.91
126_A161_F0.6410.90
148_P152_E0.6400.90
74_F98_T0.6400.90
197_S200_Y0.6390.90
66_M88_H0.6370.90
147_I150_M0.6360.90
156_K159_T0.6280.90
174_L207_F0.6270.89
65_F85_I0.6250.89
95_P98_T0.6250.89
11_N18_E0.6240.89
145_R175_A0.6220.89
22_L27_F0.6100.88
60_P83_A0.6090.88
173_T193_A0.6070.88
94_Y116_A0.6070.88
51_Q76_A0.6020.88
19_L59_H0.6020.88
47_M80_I0.6010.87
115_P139_P0.5950.87
74_F78_A0.5900.86
87_V111_L0.5890.86
193_A207_F0.5820.86
122_W125_L0.5800.86
43_I67_L0.5780.85
75_N104_H0.5780.85
22_L200_Y0.5770.85
9_S22_L0.5740.85
67_L77_L0.5700.85
193_A206_Q0.5690.84
119_I123_R0.5670.84
16_G56_Q0.5660.84
83_A107_A0.5620.84
103_R128_E0.5570.83
113_F134_V0.5560.83
126_A132_V0.5550.83
20_T56_Q0.5550.83
94_Y125_L0.5530.83
176_A207_F0.5510.83
74_F102_I0.5490.82
137_S144_Q0.5480.82
44_T48_K0.5470.82
145_R173_T0.5470.82
151_C176_A0.5440.82
199_D203_T0.5430.82
126_A157_V0.5430.82
74_F101_E0.5410.81
43_I46_G0.5410.81
142_Q190_I0.5390.81
128_E149_S0.5390.81
177_A207_F0.5390.81
22_L195_F0.5380.81
44_T50_V0.5360.81
132_V164_T0.5330.80
96_S138_E0.5330.80
32_L63_F0.5310.80
136_T168_A0.5290.80
4_H167_W0.5280.80
42_N144_Q0.5270.80
69_R93_D0.5270.80
121_A124_Y0.5270.80
37_S73_W0.5220.79
172_I188_M0.5220.79
45_F48_K0.5220.79
3_L207_F0.5220.79
30_L57_T0.5210.79
137_S142_Q0.5200.79
9_S18_E0.5190.79
119_I153_K0.5180.79
94_Y114_N0.5170.78
120_D124_Y0.5140.78
141_G144_Q0.5130.78
83_A108_R0.5110.78
56_Q60_P0.5110.78
11_N56_Q0.5110.78
74_F85_I0.5100.77
32_L53_V0.5080.77
38_S47_M0.5070.77
100_T138_E0.5070.77
166_C187_H0.5060.77
155_Q158_R0.5040.77
27_F204_L0.5020.76
12_P49_T0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cu2A 2 0.981 100 0.328 Contact Map
3ctlA 4 0.9952 100 0.424 Contact Map
4muzA 2 0.9619 100 0.44 Contact Map
4df0A 2 0.9 100 0.44 Contact Map
3inpA 6 0.9905 100 0.443 Contact Map
1rpxA 4 1 100 0.451 Contact Map
2yyuA 2 0.9571 100 0.454 Contact Map
1dbtA 2 0.9667 100 0.456 Contact Map
1eixA 2 0.9476 100 0.456 Contact Map
1tqxA 2 0.9905 100 0.457 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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