GREMLIN Database
SGCR - Putative sgc region transcriptional regulator
UniProt: P39361 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12552
Length: 260 (246)
Sequences: 7677 (5623)
Seq/√Len: 358.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_D171_R3.3241.00
89_L92_T3.0421.00
111_L209_M2.9341.00
140_E147_L2.7191.00
172_A203_S2.6151.00
103_D196_K2.4361.00
15_Y30_L2.3301.00
212_H235_D2.2531.00
113_K132_E2.2101.00
200_I224_A2.1971.00
95_K98_D2.1031.00
231_T254_F2.0961.00
207_I231_T2.0851.00
171_R207_I2.0411.00
165_N198_R2.0331.00
11_Q14_H2.0181.00
101_F169_V2.0011.00
15_Y19_H1.9881.00
88_A114_C1.9731.00
84_R110_E1.9691.00
222_A225_T1.9561.00
200_I206_V1.9541.00
102_L108_C1.9001.00
238_L243_A1.8951.00
162_E165_N1.8941.00
171_R205_E1.8751.00
96_D118_A1.8351.00
101_F199_I1.8241.00
123_I169_V1.7861.00
110_E113_K1.7751.00
243_A247_Q1.7611.00
205_E231_T1.7571.00
90_A173_F1.7141.00
169_V199_I1.6921.00
225_T228_C1.6791.00
89_L254_F1.6571.00
162_E166_A1.6401.00
90_A209_M1.6161.00
48_Q51_G1.5631.00
161_L194_G1.5601.00
143_I155_V1.5601.00
198_R201_Q1.5541.00
79_Q213_S1.5391.00
111_L173_F1.5371.00
144_I163_M1.5361.00
170_E204_R1.5281.00
130_A143_I1.5231.00
185_I229_I1.5221.00
185_I208_L1.5191.00
33_Y38_V1.5041.00
165_N201_Q1.4961.00
244_Q248_R1.4841.00
91_R114_C1.4801.00
27_A38_V1.4801.00
21_H60_D1.4771.00
9_I48_Q1.4581.00
87_A114_C1.4361.00
239_P242_I1.4231.00
144_I155_V1.4201.00
42_F59_L1.4131.00
12_M27_A1.4091.00
84_R114_C1.4051.00
160_A195_V1.4011.00
10_K14_H1.3901.00
11_Q15_Y1.3831.00
19_H26_Q1.3801.00
15_Y22_L1.3791.00
122_V133_L1.3751.00
198_R202_R1.3751.00
79_Q82_A1.3671.00
212_H237_G1.3641.00
148_I155_V1.3561.00
104_S154_S1.3551.00
17_W61_F1.3541.00
208_L229_I1.3521.00
93_M207_I1.3491.00
93_M233_I1.3481.00
98_D170_E1.3371.00
147_L191_F1.3231.00
53_I62_D1.3221.00
25_Q35_E1.3201.00
96_D119_R1.3191.00
122_V139_V1.3001.00
55_G58_C1.2871.00
80_S110_E1.2871.00
82_A235_D1.2861.00
36_A40_R1.2821.00
9_I44_Y1.2811.00
83_K106_S1.2681.00
144_I160_A1.2611.00
13_L51_G1.2591.00
179_L215_F1.2441.00
94_I115_L1.2431.00
23_S26_Q1.2431.00
240_E244_Q1.2381.00
97_G119_R1.2351.00
224_A228_C1.2301.00
89_L93_M1.2271.00
205_E230_K1.2191.00
84_R113_K1.2011.00
11_Q30_L1.1951.00
121_K142_Y1.1901.00
244_Q247_Q1.1771.00
201_Q228_C1.1751.00
112_A133_L1.1731.00
11_Q31_F1.1671.00
93_M254_F1.1671.00
176_C210_A1.1541.00
43_Q47_N1.1481.00
180_S183_T1.1421.00
101_F202_R1.1411.00
16_L52_M1.1371.00
14_H18_Q1.1311.00
81_V84_R1.1291.00
173_F207_I1.1281.00
82_A212_H1.1011.00
161_L195_V1.0991.00
80_S84_R1.0961.00
215_F238_L1.0951.00
121_K140_E1.0931.00
178_A186_T1.0911.00
95_K171_R1.0861.00
206_V229_I1.0801.00
19_H30_L1.0791.00
13_L16_L1.0711.00
16_L61_F1.0651.00
159_L163_M1.0601.00
52_M59_L1.0591.00
53_I60_D1.0531.00
207_I233_I1.0531.00
231_T252_Q1.0471.00
176_C223_V1.0401.00
24_T42_F1.0291.00
91_R94_I1.0171.00
142_Y147_L1.0101.00
91_R111_L1.0081.00
123_I167_F1.0011.00
44_Y48_Q1.0001.00
102_L111_L0.9921.00
94_I173_F0.9801.00
90_A111_L0.9801.00
7_D11_Q0.9791.00
28_M35_E0.9771.00
159_L167_F0.9761.00
144_I164_I0.9721.00
177_D187_N0.9621.00
112_A132_E0.9581.00
242_I245_R0.9581.00
82_A86_I0.9571.00
215_F232_I0.9461.00
87_A91_R0.9461.00
72_F106_S0.9401.00
179_L210_A0.9381.00
108_C129_I0.9301.00
93_M231_T0.9291.00
83_K107_T0.9281.00
84_R88_A0.9271.00
44_Y47_N0.9261.00
172_A199_I0.9221.00
15_Y18_Q0.9221.00
194_G197_T0.9221.00
161_L198_R0.9211.00
227_S249_A0.9201.00
105_G108_C0.9161.00
111_L114_C0.9151.00
83_K214_K0.9141.00
107_T211_D0.9141.00
176_C208_L0.9121.00
43_Q46_V0.9051.00
193_V221_H0.9031.00
168_S204_R0.8961.00
243_A253_L0.8921.00
180_S218_V0.8921.00
26_Q30_L0.8901.00
86_I107_T0.8891.00
166_A197_T0.8891.00
79_Q211_D0.8881.00
107_T214_K0.8851.00
168_S183_T0.8811.00
128_K153_F0.8791.00
87_A111_L0.8791.00
108_C111_L0.8741.00
28_M38_V0.8631.00
87_A110_E0.8621.00
116_A136_F0.8611.00
22_L59_L0.8591.00
22_L27_A0.8491.00
134_G153_F0.8481.00
141_S148_I0.8421.00
126_D129_I0.8361.00
112_A129_I0.8351.00
116_A132_E0.8271.00
204_R218_V0.8261.00
167_F190_M0.8231.00
45_I51_G0.8201.00
152_Y177_D0.8181.00
164_I199_I0.8171.00
173_F209_M0.8101.00
7_D10_K0.8101.00
245_R248_R0.8051.00
159_L166_A0.8051.00
168_S222_A0.8031.00
90_A233_I0.8021.00
187_N193_V0.8011.00
14_H17_W0.7991.00
119_R138_H0.7961.00
206_V230_K0.7961.00
13_L17_W0.7951.00
168_S218_V0.7931.00
26_Q29_E0.7841.00
85_E88_A0.7841.00
79_Q212_H0.7811.00
179_L185_I0.7811.00
75_K177_D0.7801.00
43_Q54_R0.7781.00
132_E135_C0.7751.00
101_F164_I0.7691.00
7_D21_H0.7661.00
164_I198_R0.7661.00
190_M221_H0.7651.00
108_C209_M0.7621.00
238_L242_I0.7611.00
183_T218_V0.7571.00
176_C185_I0.7511.00
168_S202_R0.7401.00
149_R192_E0.7361.00
102_L122_V0.7331.00
186_T218_V0.7331.00
130_A155_V0.7321.00
106_S214_K0.7311.00
238_L253_L0.7311.00
71_V74_V0.7301.00
102_L112_A0.7271.00
109_L132_E0.7271.00
166_A222_A0.7261.00
131_N153_F0.7230.99
81_V85_E0.7160.99
145_G160_A0.7090.99
20_R61_F0.7050.99
9_I13_L0.7050.99
200_I223_V0.6950.99
33_Y36_A0.6920.99
104_S152_Y0.6900.99
130_A148_I0.6890.99
169_V203_S0.6890.99
187_N223_V0.6890.99
179_L226_L0.6870.99
210_A232_I0.6870.99
172_A206_V0.6860.99
69_E75_K0.6840.99
117_D136_F0.6820.99
25_Q29_E0.6800.99
185_I223_V0.6780.99
187_N192_E0.6780.99
125_N199_I0.6770.99
110_E114_C0.6770.99
88_A92_T0.6760.99
42_F54_R0.6750.99
99_C123_I0.6740.99
145_G163_M0.6730.99
211_D214_K0.6690.99
149_R156_G0.6680.99
136_F139_V0.6680.99
157_E160_A0.6650.99
55_G60_D0.6610.99
127_I155_V0.6600.99
13_L45_I0.6550.99
76_R109_L0.6520.99
27_A42_F0.6520.99
6_P9_I0.6520.99
174_I203_S0.6490.99
165_N202_R0.6430.99
212_H238_L0.6410.99
24_T38_V0.6410.99
240_E243_A0.6410.99
100_F171_R0.6410.99
100_F122_V0.6400.99
207_I230_K0.6390.99
197_T201_Q0.6370.99
245_R249_A0.6370.99
46_V54_R0.6370.99
135_C153_F0.6360.99
85_E89_L0.6350.99
205_E252_Q0.6340.99
109_L128_K0.6340.99
16_L22_L0.6320.99
162_E194_G0.6320.99
36_A126_D0.6300.99
167_F221_H0.6290.99
86_I209_M0.6270.99
241_T245_R0.6270.99
177_D219_E0.6250.99
158_S162_E0.6240.99
124_C130_A0.6210.98
8_R41_D0.6200.98
31_F38_V0.6190.98
242_I246_Y0.6160.98
224_A229_I0.6160.98
158_S194_G0.6120.98
46_V52_M0.6100.98
215_F242_I0.6020.98
188_A219_E0.6010.98
123_I220_P0.5990.98
105_G175_S0.5960.98
69_E149_R0.5950.98
203_S206_V0.5940.98
103_D108_C0.5910.98
126_D192_E0.5910.98
177_D192_E0.5880.98
193_V223_V0.5870.98
127_I143_I0.5820.98
82_A237_G0.5800.98
158_S161_L0.5780.98
94_I111_L0.5770.98
75_K192_E0.5770.98
160_A163_M0.5760.98
149_R189_T0.5720.97
174_I223_V0.5720.97
175_S187_N0.5690.97
161_L165_N0.5690.97
36_A177_D0.5670.97
191_F194_G0.5670.97
105_G177_D0.5660.97
100_F173_F0.5620.97
181_L242_I0.5620.97
76_R110_E0.5620.97
119_R140_E0.5610.97
83_K211_D0.5580.97
128_K131_N0.5560.97
127_I131_N0.5550.97
180_S186_T0.5550.97
196_K223_V0.5540.97
215_F234_S0.5530.97
99_C220_P0.5530.97
100_F111_L0.5510.97
195_V198_R0.5510.97
177_D188_A0.5500.97
12_M31_F0.5480.97
177_D196_K0.5460.97
154_S192_E0.5440.97
123_I142_Y0.5430.96
206_V228_C0.5410.96
29_E32_G0.5410.96
187_N196_K0.5380.96
85_E236_S0.5380.96
40_R179_L0.5370.96
174_I200_I0.5360.96
185_I224_A0.5330.96
181_L245_R0.5320.96
158_S191_F0.5320.96
75_K106_S0.5320.96
174_I206_V0.5260.96
237_G243_A0.5190.95
162_E197_T0.5190.95
240_E247_Q0.5170.95
101_F172_A0.5150.95
102_L129_I0.5130.95
22_L55_G0.5130.95
24_T28_M0.5120.95
178_A219_E0.5110.95
178_A217_A0.5090.95
120_V139_V0.5090.95
101_F123_I0.5070.95
216_D242_I0.5050.95
105_G126_D0.5020.95
73_D76_R0.5020.95
24_T56_H0.5020.95
140_E150_P0.5010.95
117_D138_H0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9385 100 0.517 Contact Map
3rrlB 1 0.6654 100 0.533 Contact Map
2w48A 3 0.9 100 0.587 Contact Map
3l7oA 2 0.5885 100 0.617 Contact Map
1o8bA 2 0.5808 100 0.621 Contact Map
2o0mA 1 0.6769 100 0.628 Contact Map
1m0sA 2 0.6038 100 0.63 Contact Map
1uj6A 2 0.5962 100 0.63 Contact Map
1lk5A 4 0.6 100 0.631 Contact Map
4io1A 2 0.6038 100 0.635 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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