GREMLIN Database
YJHI - Uncharacterized HTH-type transcriptional regulator YjhI
UniProt: P39360 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12551
Length: 262 (243)
Sequences: 12750 (9365)
Seq/√Len: 600.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_L12_A3.2291.00
95_K237_L3.1111.00
103_G140_L2.8341.00
10_V51_C2.8001.00
88_P241_C2.7951.00
182_K186_R2.5801.00
17_T67_K2.5681.00
86_K114_D2.4081.00
142_K179_E2.3851.00
13_E53_F2.3651.00
154_D177_L2.3301.00
142_K194_E2.2471.00
109_S132_K2.1821.00
88_P244_Q2.1241.00
98_L225_V2.1031.00
19_I54_L2.0751.00
148_K152_E2.0241.00
90_Q116_I2.0161.00
14_K51_C2.0111.00
147_W207_F1.9441.00
105_M135_L1.9011.00
204_M238_L1.8961.00
191_D201_C1.8681.00
192_N200_V1.8591.00
88_P248_G1.8451.00
204_M242_A1.8341.00
200_V223_P1.7671.00
235_L239_R1.7501.00
91_E244_Q1.7451.00
55_I63_S1.7431.00
17_T51_C1.7371.00
15_I30_L1.7171.00
91_E95_K1.7021.00
18_H34_F1.6871.00
172_D175_L1.6861.00
173_K177_L1.6851.00
85_T245_I1.6811.00
93_S100_C1.6751.00
18_H25_A1.6541.00
18_H30_L1.6341.00
18_H33_K1.6321.00
45_L54_L1.6311.00
204_M239_R1.6061.00
193_E223_P1.6001.00
221_G226_Y1.5941.00
230_K233_S1.5611.00
219_L234_Y1.5561.00
25_A33_K1.5431.00
45_L62_Y1.5411.00
179_E182_K1.5351.00
193_E198_G1.5181.00
26_S29_E1.5151.00
188_W235_L1.5071.00
153_L177_L1.5041.00
88_P91_E1.4971.00
24_M63_S1.4911.00
149_T152_E1.4901.00
237_L240_K1.4901.00
96_S237_L1.4781.00
183_T189_A1.4701.00
36_Y41_L1.4581.00
30_L41_L1.4511.00
24_M61_Y1.4451.00
110_A144_L1.4311.00
207_F246_S1.4271.00
67_K70_E1.4251.00
166_T169_T1.4171.00
154_D173_K1.3851.00
82_F114_D1.3581.00
110_A135_L1.3541.00
85_T102_L1.3431.00
17_T53_F1.3411.00
92_L237_L1.3401.00
49_V54_L1.3371.00
93_S116_I1.3371.00
57_N63_S1.3361.00
19_I25_A1.3281.00
242_A246_S1.3241.00
13_E51_C1.3221.00
117_E123_P1.3211.00
49_V56_K1.3031.00
108_I159_A1.3011.00
19_I24_M1.3011.00
22_V25_A1.2921.00
89_M102_L1.2681.00
240_K244_Q1.2601.00
150_R177_L1.2511.00
37_P40_S1.2431.00
22_V33_K1.2401.00
92_L241_C1.2261.00
86_K90_Q1.2261.00
42_L46_N1.2231.00
31_L41_L1.2121.00
180_L183_T1.2091.00
30_L45_L1.1981.00
158_E173_K1.1921.00
170_F179_E1.1741.00
207_F213_V1.1581.00
146_A183_T1.1551.00
105_M148_K1.1521.00
147_W205_P1.1511.00
96_S234_Y1.1321.00
150_R154_D1.1291.00
137_I169_T1.1221.00
103_G110_A1.1191.00
239_R243_E1.1151.00
204_M235_L1.1121.00
27_Y42_L1.1101.00
6_C47_V1.1081.00
168_N193_E1.1071.00
147_W213_V1.0961.00
28_M32_N1.0931.00
150_R153_L1.0911.00
26_S61_Y1.0871.00
10_V50_D1.0831.00
153_L184_R1.0811.00
137_I165_H1.0801.00
10_V47_V1.0771.00
90_Q94_L1.0741.00
102_L215_Y1.0621.00
68_N75_A1.0581.00
105_M108_I1.0561.00
96_S219_L1.0541.00
104_A215_Y1.0521.00
157_L173_K1.0521.00
232_D236_E1.0471.00
140_L216_A1.0451.00
227_S230_K1.0431.00
150_R181_Q1.0421.00
136_H169_T1.0391.00
236_E240_K1.0351.00
217_I245_I1.0311.00
27_Y31_L1.0241.00
106_E132_K1.0231.00
89_M100_C1.0181.00
29_E32_N1.0161.00
102_L206_V1.0141.00
53_F71_L1.0091.00
138_T141_G1.0041.00
244_Q248_G1.0041.00
154_D158_E0.9881.00
95_K240_K0.9821.00
164_P171_T0.9731.00
91_E241_C0.9731.00
243_E247_Y0.9721.00
208_N212_R0.9661.00
7_N11_R0.9591.00
28_M38_K0.9451.00
86_K116_I0.9441.00
167_R197_Y0.9431.00
205_P213_V0.9401.00
103_G112_Y0.9391.00
24_M57_N0.9381.00
111_I132_K0.9341.00
123_P126_K0.9341.00
152_E155_Y0.9281.00
139_A201_C0.9211.00
183_T186_R0.9201.00
81_I215_Y0.9081.00
19_I23_G0.9061.00
21_W33_K0.9041.00
84_V248_G0.9031.00
16_L68_N0.9021.00
178_E182_K0.9011.00
143_A147_W0.8981.00
178_E181_Q0.8871.00
152_E156_F0.8851.00
29_E33_K0.8831.00
82_F86_K0.8751.00
165_H169_T0.8741.00
15_I34_F0.8701.00
155_Y159_A0.8661.00
101_H220_S0.8641.00
145_L176_F0.8611.00
181_Q185_L0.8601.00
202_L235_L0.8601.00
177_L181_Q0.8581.00
89_M114_D0.8521.00
175_L179_E0.8501.00
39_S42_L0.8471.00
192_N223_P0.8451.00
100_C219_L0.8451.00
175_L178_E0.8431.00
165_H195_S0.8341.00
19_I22_V0.8341.00
186_R235_L0.8291.00
143_A213_V0.8281.00
143_A183_T0.8271.00
49_V62_Y0.8271.00
153_L180_L0.8261.00
11_R40_S0.8261.00
203_S218_S0.8221.00
140_L218_S0.8201.00
208_N214_N0.8171.00
238_L242_A0.8071.00
193_E197_Y0.8071.00
105_M152_E0.8061.00
89_M217_I0.7981.00
106_E111_I0.7981.00
98_L120_D0.7951.00
15_I44_L0.7841.00
182_K185_L0.7831.00
222_D225_V0.7831.00
179_E183_T0.7791.00
139_A203_S0.7761.00
241_C244_Q0.7751.00
170_F175_L0.7741.00
179_E186_R0.7731.00
88_P245_I0.7711.00
34_F41_L0.7691.00
8_S12_A0.7661.00
233_S237_L0.7651.00
27_Y45_L0.7601.00
56_K60_G0.7561.00
36_Y40_S0.7501.00
201_C220_S0.7491.00
46_N49_V0.7491.00
146_A180_L0.7461.00
16_L53_F0.7441.00
64_L68_N0.7381.00
236_E239_R0.7331.00
144_L216_A0.7291.00
137_I195_S0.7291.00
101_H115_K0.7271.00
46_N50_D0.7261.00
55_I65_G0.7221.00
89_M116_I0.7211.00
201_C218_S0.7201.00
81_I85_T0.7181.00
68_N71_L0.7151.00
68_N72_G0.7121.00
153_L156_F0.7111.00
101_H127_S0.7061.00
25_A30_L0.6981.00
27_Y41_L0.6971.00
56_K59_N0.6961.00
31_L34_F0.6891.00
108_I156_F0.6861.00
153_L181_Q0.6821.00
9_L44_L0.6791.00
27_Y38_K0.6791.00
142_K183_T0.6771.00
15_I41_L0.6761.00
170_F176_F0.6741.00
202_L231_I0.6741.00
93_S118_S0.6741.00
148_K153_L0.6721.00
120_D225_V0.6711.00
243_E246_S0.6711.00
233_S236_E0.6661.00
207_F214_N0.6661.00
105_M144_L0.6661.00
156_F160_L0.6651.00
91_E94_L0.6631.00
27_Y62_Y0.6621.00
80_N83_E0.6601.00
192_N228_G0.6601.00
153_L157_L0.6591.00
240_K243_E0.6551.00
181_Q184_R0.6541.00
231_I236_E0.6531.00
104_A113_L0.6521.00
166_T170_F0.6521.00
193_E200_V0.6491.00
55_I66_I0.6481.00
144_L148_K0.6461.00
231_I235_L0.6411.00
157_L161_T0.6411.00
150_R184_R0.6411.00
230_K234_Y0.6391.00
239_R242_A0.6391.00
171_T175_L0.6391.00
217_I242_A0.6391.00
101_H201_C0.6341.00
241_C245_I0.6291.00
145_L180_L0.6291.00
92_L96_S0.6271.00
72_G75_A0.6251.00
9_L13_E0.6231.00
17_T70_E0.6171.00
98_L221_G0.6161.00
217_I241_C0.6141.00
92_L219_L0.6131.00
84_V87_R0.6121.00
92_L100_C0.6101.00
190_I231_I0.6091.00
20_A71_L0.6091.00
244_Q247_Y0.6081.00
136_H162_L0.6071.00
56_K62_Y0.6041.00
204_M246_S0.6041.00
6_C44_L0.6031.00
145_L153_L0.6001.00
138_T201_C0.5961.00
53_F67_K0.5951.00
187_G207_F0.5951.00
8_S44_L0.5931.00
128_W131_K0.5901.00
112_Y127_S0.5891.00
94_L119_P0.5881.00
90_Q114_D0.5861.00
46_N56_K0.5851.00
29_E61_Y0.5851.00
52_G67_K0.5811.00
134_E137_I0.5801.00
11_R36_Y0.5791.00
14_K17_T0.5791.00
87_R248_G0.5741.00
143_A205_P0.5731.00
237_L241_C0.5701.00
143_A203_S0.5661.00
112_Y140_L0.5641.00
31_L38_K0.5631.00
206_V215_Y0.5621.00
217_I238_L0.5611.00
117_E128_W0.5611.00
14_K18_H0.5601.00
115_K127_S0.5591.00
24_M59_N0.5581.00
85_T89_M0.5560.99
101_H218_S0.5550.99
100_C116_I0.5540.99
110_A140_L0.5540.99
168_N197_Y0.5530.99
144_L215_Y0.5510.99
16_L71_L0.5510.99
142_K191_D0.5500.99
17_T71_L0.5490.99
188_W239_R0.5490.99
12_A44_L0.5490.99
115_K129_I0.5460.99
234_Y237_L0.5450.99
58_K61_Y0.5450.99
110_A138_T0.5450.99
99_V115_K0.5420.99
9_L47_V0.5420.99
98_L219_L0.5400.99
204_M217_I0.5400.99
18_H22_V0.5400.99
26_S38_K0.5380.99
110_A133_L0.5370.99
73_C76_L0.5370.99
97_G119_P0.5370.99
206_V246_S0.5360.99
20_A64_L0.5350.99
11_R44_L0.5340.99
69_Y76_L0.5320.99
57_N61_Y0.5310.99
174_K177_L0.5300.99
164_P167_R0.5240.99
103_G138_T0.5210.99
42_L56_K0.5160.99
206_V245_I0.5140.99
162_L166_T0.5110.99
207_F215_Y0.5090.99
108_I160_L0.5090.99
112_Y138_T0.5070.99
147_W184_R0.5060.99
143_A189_A0.5060.99
174_K178_E0.5050.99
176_F180_L0.5040.99
87_R91_E0.5020.99
7_N47_V0.5020.99
13_E47_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mq0A 2 0.9504 100 0.121 Contact Map
2ia2A 4 0.9466 100 0.122 Contact Map
2g7uA 6 0.9542 100 0.125 Contact Map
1mkmA 4 0.9389 100 0.127 Contact Map
3r4kA 2 0.9656 100 0.136 Contact Map
2xrnA 3 0.9122 100 0.154 Contact Map
2o0yA 4 0.9389 100 0.171 Contact Map
1ysqA 1 0.6794 100 0.418 Contact Map
1tf1A 1 0.7023 100 0.418 Contact Map
3obfA 1 0.6718 100 0.427 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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