GREMLIN Database
YJHH - Uncharacterized lyase YjhH
UniProt: P39359 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12550
Length: 301 (285)
Sequences: 10370 (6828)
Seq/√Len: 404.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_D234_T3.8261.00
31_D68_I3.3341.00
16_H20_T3.1971.00
118_D152_R3.1211.00
265_C290_H2.9181.00
27_R68_I2.8131.00
23_K60_A2.7381.00
23_K64_E2.6391.00
95_Q129_T2.6331.00
27_R64_E2.5601.00
79_V91_A2.5441.00
200_T205_G2.5161.00
59_M93_H2.4841.00
226_A234_T2.4841.00
91_A102_I2.2771.00
234_T237_T2.1661.00
31_D72_R2.1051.00
226_A231_D2.0241.00
201_M227_W2.0211.00
8_I40_G2.0161.00
114_P149_T2.0111.00
122_Q157_N2.0021.00
114_P146_T1.9991.00
225_R229_E1.9991.00
126_R157_N1.9921.00
221_V225_R1.9771.00
32_F36_K1.9731.00
84_T120_Y1.9601.00
39_D225_R1.8981.00
60_A63_E1.8841.00
290_H294_T1.8821.00
122_Q126_R1.8721.00
115_R119_D1.8711.00
115_R152_R1.8631.00
144_D172_H1.8621.00
27_R67_T1.8501.00
22_D25_A1.8471.00
31_D35_N1.8461.00
55_T86_E1.8291.00
261_Y286_K1.8221.00
219_L241_K1.7921.00
30_A65_A1.7461.00
118_D122_Q1.7331.00
36_K218_E1.7261.00
60_A64_E1.6841.00
63_E67_T1.6841.00
26_M65_A1.6831.00
133_I162_G1.6811.00
66_V75_V1.6761.00
9_P213_A1.6751.00
125_A157_N1.6581.00
57_Q275_L1.6171.00
119_D122_Q1.6141.00
287_D290_H1.6131.00
104_A124_I1.5821.00
146_T149_T1.5611.00
25_A28_E1.5541.00
43_Y65_A1.5501.00
64_E68_I1.5361.00
91_A128_V1.5291.00
150_V163_I1.5261.00
237_T241_K1.5201.00
62_A77_I1.5051.00
14_T26_M1.4951.00
26_M61_L1.4681.00
152_R156_Q1.4511.00
34_I73_V1.4491.00
95_Q128_V1.4031.00
87_A124_I1.3891.00
222_G226_A1.3861.00
283_E286_K1.3621.00
119_D123_Q1.3531.00
12_S263_M1.3411.00
283_E287_D1.3371.00
222_G234_T1.3361.00
8_I42_F1.3361.00
261_Y265_C1.3341.00
39_D221_V1.3321.00
264_Q271_E1.3231.00
95_Q130_L1.3201.00
81_S87_A1.3161.00
122_Q156_Q1.3151.00
93_H96_A1.3121.00
287_D291_V1.3091.00
251_L288_K1.3061.00
264_Q269_P1.2901.00
102_I128_V1.2891.00
55_T89_K1.2871.00
177_I189_V1.2761.00
218_E222_G1.2671.00
88_V123_Q1.2661.00
59_M89_K1.2631.00
282_S285_A1.2611.00
133_I209_I1.2591.00
7_I38_V1.2581.00
64_E67_T1.2541.00
32_F268_L1.2541.00
291_V295_A1.2511.00
5_S228_R1.2431.00
83_S86_E1.2321.00
76_L101_G1.2321.00
49_E260_K1.2281.00
59_M63_E1.2111.00
198_L235_A1.2081.00
227_W232_L1.2061.00
34_I72_R1.2021.00
55_T93_H1.1941.00
62_A94_A1.1921.00
56_A60_A1.1911.00
44_L61_L1.1871.00
232_L236_A1.1601.00
30_A69_V1.1561.00
66_V100_D1.1511.00
125_A159_N1.1421.00
123_Q276_P1.1421.00
92_Q96_A1.1351.00
63_E93_H1.1291.00
20_T85_D1.1291.00
262_S293_L1.1201.00
16_H22_D1.1161.00
233_A236_A1.1121.00
224_Y228_R1.1101.00
222_G225_R1.1091.00
69_V75_V1.1071.00
24_K27_R1.0981.00
123_Q126_R1.0971.00
188_S206_D1.0971.00
25_A270_V1.0881.00
15_F53_M1.0811.00
291_V294_T1.0791.00
261_Y264_Q1.0761.00
123_Q127_S1.0731.00
76_L133_I1.0731.00
261_Y290_H1.0681.00
59_M96_A1.0631.00
23_K27_R1.0621.00
92_Q127_S1.0501.00
30_A68_I1.0441.00
79_V94_A1.0431.00
9_P33_L1.0421.00
63_E97_Y1.0371.00
115_R282_S1.0241.00
115_R118_D1.0191.00
88_V92_Q1.0171.00
7_I221_V1.0161.00
102_I130_L1.0141.00
5_S206_D1.0121.00
77_I99_A1.0111.00
42_F103_V1.0091.00
175_T247_A1.0081.00
234_T238_L1.0071.00
153_L160_I1.0071.00
93_H97_Y1.0051.00
281_A289_V0.9961.00
9_P38_V0.9931.00
281_A285_A0.9911.00
134_L150_V0.9831.00
55_T90_L0.9821.00
27_R31_D0.9751.00
102_I132_V0.9751.00
154_A187_F0.9731.00
80_G105_I0.9651.00
248_I292_L0.9651.00
286_K290_H0.9621.00
173_L200_T0.9561.00
118_D156_Q0.9561.00
29_V263_M0.9491.00
202_L232_L0.9491.00
11_V33_L0.9471.00
236_A240_K0.9431.00
19_G85_D0.9431.00
264_Q286_K0.9411.00
66_V99_A0.9411.00
288_K291_V0.9381.00
226_A238_L0.9381.00
151_T183_V0.9371.00
58_R90_L0.9311.00
136_N144_D0.9291.00
125_A132_V0.9241.00
118_D149_T0.9221.00
114_P152_R0.9201.00
88_V127_S0.9191.00
56_A89_K0.9171.00
285_A288_K0.9141.00
79_V102_I0.9101.00
39_D224_Y0.9091.00
15_F275_L0.9051.00
272_T280_E0.9031.00
81_S86_E0.9021.00
34_I69_V0.9011.00
89_K93_H0.8971.00
106_N143_Q0.8961.00
43_Y61_L0.8941.00
66_V97_Y0.8911.00
30_A64_E0.8901.00
284_E287_D0.8891.00
119_D279_L0.8891.00
212_S246_P0.8881.00
75_V99_A0.8881.00
89_K92_Q0.8881.00
117_L143_Q0.8871.00
216_A245_L0.8771.00
202_L227_W0.8681.00
197_L208_A0.8641.00
19_G276_P0.8551.00
25_A269_P0.8551.00
223_I238_L0.8541.00
265_C294_T0.8531.00
244_Q295_A0.8531.00
201_M224_Y0.8501.00
7_I224_Y0.8491.00
190_F207_G0.8481.00
233_A237_T0.8461.00
92_Q95_Q0.8461.00
157_N160_I0.8441.00
84_T88_V0.8401.00
125_A160_I0.8391.00
22_D269_P0.8351.00
202_L236_A0.8301.00
38_V217_P0.8281.00
284_E288_K0.8261.00
292_L295_A0.8251.00
147_P151_T0.8241.00
44_L77_I0.8221.00
210_T213_A0.8191.00
11_V41_L0.8171.00
104_A132_V0.8161.00
28_E268_L0.8091.00
7_I208_A0.8021.00
191_C200_T0.8001.00
7_I213_A0.7971.00
46_T109_Y0.7931.00
62_A97_Y0.7921.00
265_C286_K0.7841.00
11_V26_M0.7841.00
69_V72_R0.7821.00
230_G233_A0.7811.00
118_D157_N0.7791.00
36_K217_P0.7761.00
94_A99_A0.7741.00
62_A99_A0.7731.00
24_K28_E0.7711.00
56_A59_M0.7691.00
243_L247_A0.7651.00
216_A242_L0.7551.00
184_R187_F0.7531.00
175_T178_N0.7511.00
53_M61_L0.7481.00
137_F141_T0.7471.00
26_M30_A0.7471.00
147_P175_T0.7461.00
239_N243_L0.7451.00
216_A219_L0.7441.00
171_G195_D0.7441.00
150_V176_M0.7371.00
264_Q272_T0.7341.00
85_D89_K0.7331.00
74_P100_D0.7291.00
183_V186_S0.7281.00
87_A104_A0.7281.00
222_G238_L0.7281.00
34_I68_I0.7271.00
147_P172_H0.7261.00
98_G130_L0.7241.00
264_Q270_V0.7221.00
257_S274_C0.7211.00
114_P148_E0.7201.00
16_H24_K0.7191.00
30_A41_L0.7161.00
106_N145_L0.7111.00
40_G76_L0.7071.00
198_L227_W0.7071.00
17_R272_T0.7061.00
271_E274_C0.7031.00
219_L222_G0.6991.00
122_Q152_R0.6961.00
199_N202_L0.6951.00
135_Y164_K0.6941.00
59_M90_L0.6911.00
144_D169_S0.6891.00
119_D276_P0.6891.00
251_L285_A0.6881.00
79_V104_A0.6871.00
218_E266_V0.6861.00
174_R178_N0.6851.00
223_I227_W0.6841.00
33_L38_V0.6831.00
84_T123_Q0.6811.00
21_L26_M0.6790.99
62_A66_V0.6780.99
41_L69_V0.6760.99
136_N165_D0.6760.99
229_E234_T0.6750.99
274_C278_I0.6740.99
21_L61_L0.6730.99
50_F78_G0.6680.99
59_M97_Y0.6670.99
44_L53_M0.6670.99
199_N203_L0.6660.99
116_N279_L0.6640.99
133_I161_V0.6630.99
145_L150_V0.6620.99
198_L232_L0.6620.99
173_L189_V0.6590.99
178_N240_K0.6590.99
113_A257_S0.6580.99
59_M94_A0.6570.99
134_L145_L0.6560.99
16_H19_G0.6550.99
32_F266_V0.6540.99
177_I183_V0.6530.99
263_M268_L0.6510.99
257_S281_A0.6490.99
263_M266_V0.6480.99
33_L36_K0.6460.99
55_T59_M0.6450.99
8_I76_L0.6430.99
69_V73_V0.6430.99
43_Y75_V0.6420.99
63_E96_A0.6400.99
287_D294_T0.6390.99
173_L177_I0.6370.99
11_V65_A0.6370.99
199_N239_N0.6370.99
174_R199_N0.6360.99
281_A286_K0.6350.99
197_L223_I0.6340.99
29_V33_L0.6250.99
288_K292_L0.6250.99
148_E175_T0.6240.99
129_T159_N0.6230.99
31_D34_I0.6180.99
51_S110_W0.6130.99
265_C293_L0.6120.99
174_R203_L0.6100.99
274_C279_L0.6090.99
54_N85_D0.6070.99
226_A229_E0.6050.99
161_V188_S0.6050.99
4_F101_G0.6030.99
165_D173_L0.5980.99
113_A116_N0.5960.99
23_K68_I0.5950.99
126_R159_N0.5950.99
149_T152_R0.5950.99
113_A253_T0.5920.99
17_R271_E0.5910.99
174_R239_N0.5910.99
86_E89_K0.5900.99
225_R228_R0.5850.98
46_T135_Y0.5830.98
44_L58_R0.5830.98
198_L239_N0.5780.98
253_T285_A0.5760.98
21_L64_E0.5760.98
15_F57_Q0.5750.98
38_V221_V0.5720.98
99_A130_L0.5710.98
261_Y274_C0.5700.98
237_T240_K0.5700.98
169_S172_H0.5680.98
269_P272_T0.5660.98
172_H176_M0.5640.98
71_G100_D0.5630.98
106_N121_Y0.5590.98
17_R270_V0.5590.98
215_F262_S0.5580.98
42_F76_L0.5570.98
111_K139_D0.5570.98
12_S259_I0.5570.98
283_E290_H0.5530.98
120_Y123_Q0.5520.98
148_E151_T0.5500.98
253_T282_S0.5490.98
162_G188_S0.5490.98
271_E286_K0.5470.98
95_Q127_S0.5470.98
262_S265_C0.5460.98
197_L220_S0.5440.98
227_W235_A0.5420.98
176_M189_V0.5420.98
76_L103_V0.5410.98
67_T70_D0.5410.98
162_G187_F0.5410.98
151_T184_R0.5400.97
37_G221_V0.5390.97
10_P211_A0.5380.97
170_V196_H0.5370.97
215_F259_I0.5370.97
133_I188_S0.5330.97
145_L149_T0.5320.97
254_P258_L0.5310.97
177_I206_D0.5300.97
101_G161_V0.5280.97
121_Y160_I0.5270.97
88_V124_I0.5270.97
10_P210_T0.5260.97
178_N244_Q0.5260.97
154_A184_R0.5260.97
238_L241_K0.5250.97
56_A93_H0.5220.97
153_L157_N0.5220.97
226_A235_A0.5190.97
147_P176_M0.5190.97
104_A121_Y0.5180.97
245_L249_Y0.5160.97
197_L224_Y0.5160.97
211_A259_I0.5150.97
198_L202_L0.5150.97
77_I94_A0.5140.97
5_S39_D0.5140.97
65_A69_V0.5130.97
90_L94_A0.5130.97
32_F217_P0.5120.97
258_L281_A0.5110.96
52_Q84_T0.5110.96
87_A91_A0.5110.96
262_S289_V0.5100.96
44_L62_A0.5100.96
33_L213_A0.5100.96
29_V269_P0.5100.96
249_Y259_I0.5100.96
29_V32_F0.5090.96
29_V268_L0.5070.96
115_R279_L0.5070.96
201_M228_R0.5030.96
88_V128_V0.5020.96
214_N217_P0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oe7A 3 0.9867 100 0.026 Contact Map
4i7wA 3 0.9668 100 0.03 Contact Map
3qzeA 2 0.9635 100 0.036 Contact Map
3na8A 3 0.9635 100 0.037 Contact Map
3si9A 3 0.9767 100 0.037 Contact Map
3fluA 3 0.9734 100 0.038 Contact Map
3l21A 5 0.9668 100 0.038 Contact Map
3cprA 3 0.9635 100 0.039 Contact Map
2ojpA 2 0.9635 100 0.04 Contact Map
1xkyA 3 0.9701 100 0.04 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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