GREMLIN Database
YJHF - Uncharacterized permease YjhF
UniProt: P39357 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12548
Length: 449 (421)
Sequences: 5467 (3634)
Seq/√Len: 177.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
304_K307_A3.4951.00
294_T297_D3.3731.00
237_L282_F3.2361.00
12_L34_A3.2171.00
9_G322_F3.2071.00
324_Q328_D3.1191.00
272_S276_M3.0761.00
196_F200_I3.0391.00
9_G35_V2.9791.00
180_I184_P2.9671.00
333_Q337_T2.9081.00
77_D301_S2.9041.00
87_T228_F2.8511.00
228_F232_F2.8191.00
419_T422_E2.8111.00
87_T91_Y2.7901.00
272_S275_A2.7641.00
11_A15_L2.5861.00
183_I187_I2.5591.00
49_S328_D2.5511.00
234_T238_P2.5441.00
351_W435_S2.5041.00
343_D346_P2.4061.00
177_Y180_I2.3731.00
227_G230_I2.3581.00
182_G185_T2.3491.00
42_D45_K2.3261.00
48_T52_S2.3211.00
337_T340_S2.2841.00
15_L19_K2.2571.00
440_I444_L2.2551.00
436_I440_I2.2441.00
432_T436_I2.2371.00
87_T90_N2.2361.00
342_M348_L2.2301.00
345_N348_L2.1841.00
201_I205_F2.1751.00
229_G233_L2.1571.00
82_Q86_L2.0511.00
200_I204_A2.0231.00
52_S56_G1.9971.00
193_L197_C1.9911.00
354_A371_T1.9731.00
167_Y394_T1.9681.00
77_D297_D1.9401.00
343_D348_L1.8901.00
42_D46_V1.8661.00
176_I179_I1.8521.00
334_Y338_L1.8211.00
12_L31_V1.8091.00
355_A400_I1.7871.00
197_C200_I1.7661.00
182_G186_F1.7561.00
359_I401_C1.7531.00
350_A394_T1.7451.00
193_L196_F1.7351.00
231_S234_T1.7331.00
379_L390_I1.7031.00
178_G181_V1.7031.00
163_I368_A1.6981.00
114_F117_G1.6881.00
197_C201_I1.6731.00
342_M345_N1.6701.00
152_G399_C1.6581.00
5_I38_A1.6561.00
281_L285_Y1.6541.00
425_L429_L1.6541.00
73_R77_D1.6501.00
197_C204_A1.6341.00
45_K48_T1.6111.00
204_A207_K1.6011.00
174_V177_Y1.5911.00
246_T250_M1.5771.00
22_L27_S1.5571.00
238_P242_M1.5531.00
175_L179_I1.5511.00
245_V249_Q1.5471.00
105_A108_V1.5271.00
140_C416_F1.5191.00
177_Y181_V1.5081.00
241_L278_I1.5071.00
297_D300_D1.5061.00
201_I204_A1.4991.00
96_K108_V1.4901.00
83_R87_T1.4871.00
54_L62_G1.4861.00
113_F116_V1.4811.00
94_K131_E1.4791.00
198_Q201_I1.4711.00
13_L31_V1.4701.00
192_V196_F1.4691.00
275_A280_L1.4631.00
180_I183_I1.4471.00
400_I435_S1.4471.00
429_L433_L1.4441.00
443_L446_S1.4301.00
69_V302_C1.4121.00
172_G175_L1.4081.00
99_W191_P1.4061.00
233_L237_L1.4021.00
176_I180_I1.4001.00
181_V184_P1.3971.00
228_F231_S1.3941.00
193_L201_I1.3881.00
192_V195_K1.3791.00
204_A208_E1.3731.00
174_V391_T1.3621.00
175_L178_G1.3501.00
49_S324_Q1.3441.00
179_I183_I1.3441.00
229_G232_F1.3301.00
276_M279_S1.3231.00
246_T249_Q1.3211.00
323_K327_I1.3151.00
161_T164_A1.3151.00
181_V185_T1.3141.00
200_I203_D1.3111.00
380_A387_L1.3091.00
190_G193_L1.3071.00
247_I250_M1.3041.00
316_I407_A1.2971.00
72_G301_S1.2951.00
199_R203_D1.2931.00
202_P205_F1.2851.00
300_D304_K1.2851.00
166_E372_A1.2781.00
180_I187_I1.2751.00
109_G113_F1.2711.00
115_E407_A1.2701.00
183_I186_F1.2701.00
81_A85_A1.2611.00
113_F117_G1.2551.00
230_I233_L1.2551.00
170_D173_L1.2531.00
296_P300_D1.2401.00
205_F208_E1.2381.00
384_N387_L1.2371.00
194_N198_Q1.2371.00
70_M302_C1.2361.00
396_A438_G1.2361.00
193_L200_I1.2351.00
12_L16_L1.2291.00
181_V445_A1.2261.00
195_K198_Q1.2191.00
282_F286_T1.2191.00
96_K107_I1.2161.00
173_L176_I1.2131.00
78_A287_M1.2041.00
114_F408_S1.2041.00
242_M246_T1.2001.00
430_M434_L1.1961.00
190_G194_N1.1951.00
133_K204_A1.1921.00
198_Q202_P1.1871.00
421_K425_L1.1821.00
386_N389_L1.1791.00
396_A442_I1.1761.00
382_H385_T1.1701.00
101_V105_A1.1661.00
184_P187_I1.1611.00
226_P231_S1.1601.00
74_L283_A1.1601.00
86_L131_E1.1531.00
82_Q223_S1.1481.00
180_I185_T1.1481.00
234_T242_M1.1481.00
101_V104_S1.1481.00
53_G324_Q1.1411.00
400_I432_T1.1401.00
250_M253_A1.1371.00
171_V175_L1.1331.00
273_T277_L1.1291.00
201_I208_E1.1281.00
34_A38_A1.1271.00
6_V10_I1.1261.00
363_S366_V1.1231.00
39_S42_D1.1201.00
441_F445_A1.1151.00
25_F314_L1.1111.00
115_E316_I1.1101.00
178_G184_P1.0991.00
104_S108_V1.0961.00
276_M280_L1.0881.00
245_V250_M1.0741.00
342_M346_P1.0691.00
214_L217_T1.0671.00
275_A283_A1.0611.00
229_G234_T1.0611.00
172_G176_I1.0601.00
359_I400_I1.0571.00
230_I234_T1.0561.00
402_S406_D1.0541.00
80_G231_S1.0521.00
174_V179_I1.0501.00
145_S190_G1.0491.00
194_N197_C1.0491.00
351_W439_L1.0491.00
239_V243_A1.0481.00
191_P194_N1.0451.00
344_I348_L1.0441.00
279_S283_A1.0441.00
77_D304_K1.0431.00
86_L90_N1.0360.99
420_T424_L1.0330.99
57_T320_G1.0320.99
191_P195_K1.0310.99
118_L415_F1.0300.99
248_I252_H1.0290.99
40_G45_K1.0270.99
197_C203_D1.0260.99
177_Y183_I1.0240.99
110_I113_F1.0240.99
231_S238_P1.0140.99
235_A242_M1.0130.99
249_Q252_H1.0130.99
238_P241_L1.0070.99
171_V174_V1.0060.99
422_E425_L1.0010.99
237_L279_S0.9890.99
175_L180_I0.9870.99
247_I251_T0.9850.99
330_G333_Q0.9850.99
392_L442_I0.9830.99
130_R136_P0.9800.99
83_R228_F0.9790.99
102_V186_F0.9790.99
171_V176_I0.9780.99
101_V108_V0.9740.99
196_F204_A0.9720.99
413_K423_T0.9720.99
268_F271_N0.9700.99
41_M49_S0.9670.99
244_V248_I0.9650.99
50_V321_A0.9610.99
35_V322_F0.9600.99
84_I231_S0.9600.99
190_G197_C0.9600.99
109_G117_G0.9590.99
324_Q327_I0.9580.99
274_I278_I0.9560.99
27_S31_V0.9530.99
63_L67_F0.9510.99
272_S277_L0.9460.99
177_Y392_L0.9430.99
40_G43_L0.9430.99
189_C193_L0.9410.99
267_L270_G0.9410.99
64_I316_I0.9400.99
364_A402_S0.9380.99
368_A398_S0.9380.99
150_A157_H0.9360.99
214_L218_R0.9340.99
233_L240_I0.9330.99
171_V178_G0.9320.99
9_G34_A0.9320.99
96_K106_F0.9300.99
180_I186_F0.9290.99
266_I271_N0.9250.99
48_T51_E0.9220.99
438_G442_I0.9210.99
237_L241_L0.9210.99
249_Q253_A0.9210.99
309_I313_L0.9210.99
234_T241_L0.9160.99
178_G182_G0.9150.99
402_S427_W0.9120.99
284_I287_M0.9110.99
116_V119_I0.9070.99
181_V441_F0.9060.99
358_R406_D0.9050.99
408_S412_I0.9020.99
172_G179_I0.9020.99
160_P164_A0.9010.99
273_T276_M0.8990.99
233_L286_T0.8970.99
227_G231_S0.8960.99
217_T221_S0.8910.98
173_L177_Y0.8860.98
16_L22_L0.8860.98
220_F224_E0.8840.98
106_F110_I0.8810.98
16_L27_S0.8770.98
96_K100_A0.8750.98
293_K298_L0.8750.98
49_S53_G0.8730.98
104_S107_I0.8730.98
144_L409_F0.8690.98
182_G187_I0.8630.98
358_R364_A0.8620.98
248_I251_T0.8610.98
401_C428_T0.8560.98
31_V34_A0.8550.98
248_I253_A0.8540.98
267_L271_N0.8520.98
109_G112_L0.8510.98
270_G283_A0.8490.98
235_A238_P0.8480.98
109_G115_E0.8470.98
439_L443_L0.8460.98
428_T432_T0.8460.98
110_I114_F0.8450.98
189_C194_N0.8440.98
102_V105_A0.8430.98
194_N200_I0.8430.98
169_A174_V0.8430.98
32_S36_A0.8420.98
111_A114_F0.8410.98
213_S216_A0.8400.98
272_S283_A0.8390.98
249_Q267_L0.8390.98
198_Q204_A0.8380.98
193_L433_L0.8370.98
376_I380_A0.8370.98
172_G177_Y0.8370.98
111_A116_V0.8340.98
200_I205_F0.8320.98
44_S48_T0.8310.98
111_A117_G0.8310.98
367_A406_D0.8300.98
200_I207_K0.8280.98
7_V11_A0.8280.98
190_G196_F0.8280.98
47_V51_E0.8260.98
103_C107_I0.8240.97
96_K99_W0.8190.97
377_P381_V0.8190.97
437_S441_F0.8130.97
348_L439_L0.8100.97
196_F199_R0.8090.97
134_I138_F0.8050.97
203_D206_K0.8050.97
195_K199_R0.8050.97
112_L115_E0.8040.97
389_L442_I0.8010.97
224_E228_F0.7970.97
150_A154_L0.7970.97
226_P230_I0.7950.97
194_N201_I0.7910.97
39_S329_S0.7900.97
228_F234_T0.7900.97
200_I208_E0.7900.97
101_V107_I0.7880.97
243_A246_T0.7880.97
148_L431_S0.7860.97
94_K132_A0.7840.97
389_L445_A0.7830.97
284_I288_G0.7800.96
192_V200_I0.7780.96
431_S434_L0.7770.96
103_C106_F0.7760.96
275_A286_T0.7740.96
171_V179_I0.7740.96
177_Y388_A0.7730.96
281_L286_T0.7710.96
149_V182_G0.7710.96
10_I13_L0.7680.96
192_V197_C0.7650.96
109_G150_A0.7640.96
364_A407_A0.7640.96
187_I192_V0.7620.96
222_E225_M0.7620.96
91_Y95_N0.7610.96
189_C196_F0.7600.96
5_I31_V0.7590.96
162_V166_E0.7590.96
193_L429_L0.7590.96
389_L446_S0.7570.96
364_A398_S0.7530.96
197_C433_L0.7510.96
423_T427_W0.7480.96
174_V388_A0.7480.96
176_I181_V0.7450.95
358_R367_A0.7400.95
426_S429_L0.7390.95
86_L225_M0.7380.95
35_V325_V0.7370.95
275_A279_S0.7360.95
271_N275_A0.7320.95
354_A398_S0.7310.95
350_A375_V0.7300.95
202_P206_K0.7290.95
115_E119_I0.7290.95
266_I270_G0.7250.95
190_G195_K0.7240.95
361_L370_S0.7210.95
173_L388_A0.7210.95
185_T189_C0.7190.94
173_L179_I0.7190.94
237_L240_I0.7170.94
109_G114_F0.7150.94
8_A12_L0.7150.94
141_V145_S0.7150.94
169_A172_G0.7120.94
5_I39_S0.7100.94
162_V369_I0.7090.94
129_A134_I0.7060.94
245_V252_H0.7060.94
16_L30_I0.7050.94
5_I9_G0.7040.94
140_C418_L0.7040.94
125_L143_M0.7030.94
270_G275_A0.7020.94
273_T283_A0.7010.94
427_W431_S0.6990.94
245_V251_T0.6980.94
193_L198_Q0.6980.94
377_P382_H0.6970.94
339_V353_V0.6970.94
199_R207_K0.6960.93
201_I206_K0.6950.93
52_S55_G0.6940.93
112_L117_G0.6930.93
392_L396_A0.6920.93
111_A115_E0.6900.93
227_G233_L0.6890.93
177_Y184_P0.6880.93
442_I446_S0.6870.93
116_V159_G0.6870.93
234_T286_T0.6860.93
229_G251_T0.6860.93
102_V106_F0.6850.93
428_T435_S0.6840.93
284_I302_C0.6840.93
58_L317_G0.6830.93
45_K49_S0.6830.93
179_I182_G0.6830.93
117_G157_H0.6830.93
225_M229_G0.6820.93
348_L443_L0.6790.93
404_V424_L0.6780.93
41_M46_V0.6780.93
230_I238_P0.6770.93
285_Y288_G0.6710.92
228_F233_L0.6700.92
354_A367_A0.6700.92
125_L129_A0.6680.92
137_M203_D0.6660.92
110_I117_G0.6650.92
23_N26_V0.6630.92
245_V248_I0.6630.92
199_R202_P0.6600.92
232_F236_M0.6580.91
189_C200_I0.6560.91
109_G116_V0.6550.91
41_M329_S0.6550.91
52_S328_D0.6530.91
409_F413_K0.6520.91
388_A392_L0.6510.91
393_A397_G0.6500.91
96_K104_S0.6490.91
283_A287_M0.6460.91
220_F223_S0.6450.91
12_L15_L0.6450.91
358_R402_S0.6440.91
266_I269_L0.6430.90
117_G147_L0.6430.90
67_F158_P0.6420.90
152_G364_A0.6390.90
189_C192_V0.6380.90
342_M347_I0.6380.90
226_P240_I0.6340.90
222_E227_G0.6330.90
234_T250_M0.6330.90
80_G83_R0.6320.90
367_A371_T0.6300.90
293_K297_D0.6300.90
218_R221_S0.6280.89
198_Q205_F0.6280.89
240_I244_V0.6260.89
280_L286_T0.6260.89
271_N274_I0.6250.89
98_D101_V0.6240.89
271_N280_L0.6240.89
200_I206_K0.6240.89
277_L281_L0.6220.89
294_T298_L0.6220.89
38_A45_K0.6220.89
70_M279_S0.6200.89
33_I274_I0.6190.89
275_A278_I0.6180.89
83_R231_S0.6160.89
138_F142_P0.6140.88
34_A37_I0.6140.88
213_S217_T0.6130.88
175_L184_P0.6130.88
361_L366_V0.6120.88
36_A46_V0.6120.88
191_P198_Q0.6120.88
49_S52_S0.6110.88
163_I167_Y0.6110.88
284_I298_L0.6100.88
99_W103_C0.6100.88
214_L222_E0.6100.88
366_V370_S0.6080.88
26_V280_L0.6080.88
418_L422_E0.6070.88
129_A139_M0.6070.88
349_M379_L0.6070.88
217_T223_S0.6070.88
185_T437_S0.6060.88
441_F444_L0.6050.88
172_G180_I0.6050.88
174_V178_G0.6040.88
224_E227_G0.6000.87
5_I8_A0.5990.87
153_F438_G0.5990.87
73_R304_K0.5970.87
355_A435_S0.5950.87
135_S198_Q0.5950.87
343_D347_I0.5950.87
112_L276_M0.5940.87
166_E373_G0.5930.87
225_M228_F0.5930.87
403_H431_S0.5910.86
44_S47_V0.5910.86
303_G307_A0.5910.86
228_F235_A0.5900.86
407_A410_W0.5890.86
230_I286_T0.5880.86
235_A241_L0.5880.86
229_G240_I0.5880.86
359_I428_T0.5870.86
194_N204_A0.5870.86
232_F238_P0.5850.86
153_F396_A0.5850.86
214_L219_R0.5850.86
280_L284_I0.5850.86
203_D207_K0.5840.86
434_L438_G0.5830.86
148_L399_C0.5820.86
402_S431_S0.5810.85
368_A371_T0.5810.85
112_L323_K0.5780.85
196_F207_K0.5760.85
246_T251_T0.5760.85
300_D307_A0.5740.85
224_E232_F0.5730.85
225_M231_S0.5730.85
238_P246_T0.5720.85
216_A227_G0.5720.85
100_A107_I0.5720.85
37_I43_L0.5720.85
300_D303_G0.5710.85
112_L116_V0.5690.84
315_I369_I0.5680.84
101_V139_M0.5680.84
382_H386_N0.5670.84
106_F149_V0.5660.84
146_G150_A0.5650.84
399_C408_S0.5650.84
350_A390_I0.5640.84
334_Y337_T0.5640.84
189_C434_L0.5640.84
145_S430_M0.5640.84
214_L220_F0.5640.84
358_R398_S0.5630.84
38_A43_L0.5620.84
93_G96_K0.5610.83
243_A247_I0.5600.83
151_H157_H0.5590.83
357_L371_T0.5590.83
47_V274_I0.5580.83
108_V117_G0.5580.83
391_T434_L0.5570.83
97_L103_C0.5560.83
288_G292_G0.5540.83
29_I67_F0.5530.83
75_L287_M0.5530.83
350_A354_A0.5520.82
437_S440_I0.5520.82
52_S324_Q0.5500.82
219_R222_E0.5490.82
63_L66_G0.5490.82
355_A401_C0.5480.82
99_W102_V0.5470.82
192_V201_I0.5450.82
13_L360_C0.5440.82
80_G287_M0.5440.82
46_V50_V0.5440.82
426_S430_M0.5410.81
275_A281_L0.5400.81
244_V250_M0.5400.81
184_P441_F0.5380.81
35_V38_A0.5370.81
122_V416_F0.5340.80
151_H155_P0.5340.80
41_M45_K0.5340.80
114_F118_L0.5330.80
215_G219_R0.5330.80
196_F208_E0.5320.80
154_L157_H0.5310.80
160_P364_A0.5310.80
157_H160_P0.5280.80
21_K27_S0.5280.80
226_P234_T0.5270.80
73_R76_A0.5270.80
108_V121_L0.5260.79
194_N205_F0.5260.79
41_M44_S0.5250.79
243_A250_M0.5240.79
337_T341_G0.5230.79
201_I207_K0.5230.79
109_G157_H0.5220.79
30_I34_A0.5220.79
332_G336_S0.5210.79
269_L273_T0.5200.79
196_F202_P0.5200.79
178_G183_I0.5190.78
335_I360_C0.5170.78
355_A359_I0.5160.78
242_M245_V0.5160.78
413_K416_F0.5150.78
6_V331_V0.5150.78
273_T287_M0.5120.78
226_P229_G0.5110.77
82_Q104_S0.5110.77
401_C432_T0.5110.77
276_M283_A0.5100.77
196_F201_I0.5090.77
213_S220_F0.5080.77
401_C424_L0.5080.77
162_V165_R0.5060.77
157_H368_A0.5060.77
149_V431_S0.5040.76
197_C207_K0.5040.76
173_L178_G0.5040.76
162_V167_Y0.5030.76
346_P390_I0.5020.76
12_L19_K0.5020.76
46_V51_E0.5010.76
105_A117_G0.5010.76
223_S226_P0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.9777 100 0.578 Contact Map
4r0cA 3 0.9599 100 0.599 Contact Map
4f35D 2 0.8797 100 0.647 Contact Map
2cfqA 1 0.8196 73.4 0.948 Contact Map
4pd6A 3 0.7283 67.2 0.95 Contact Map
4k0jA 3 0.3096 56.9 0.953 Contact Map
4dx5A 3 0.3497 53 0.954 Contact Map
3aqpA 1 0.3252 45.4 0.956 Contact Map
2nwlA 3 0.7372 43.9 0.957 Contact Map
3qe7A 2 0.4343 42.2 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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