GREMLIN Database
YJHU - Uncharacterized transcriptional regulator YjhU
UniProt: P39356 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12604
Length: 328 (305)
Sequences: 2211 (1719)
Seq/√Len: 98.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_D262_M7.0961.00
211_T279_Q4.1531.00
125_G213_C3.5231.00
106_L291_G3.2761.00
259_K297_D2.9511.00
299_T317_T2.9011.00
58_H62_D2.8631.00
79_F300_L2.8571.00
122_D214_T2.8531.00
79_F303_L2.7921.00
257_Y301_G2.7221.00
220_V288_F2.6831.00
300_L304_L2.6381.00
313_V317_T2.5461.00
288_F308_V2.5391.00
113_Y312_I2.5361.00
28_K36_I2.4971.00
194_A198_Q2.4761.00
110_G289_L2.4501.00
149_V175_L2.3581.00
320_F323_A2.2031.00
204_R208_D2.1941.00
74_Q77_D2.1581.00
250_G301_G2.1561.00
123_V209_V2.1421.00
87_V109_A2.1381.00
219_V288_F2.1291.00
214_T284_E2.1111.00
290_A299_T2.0671.00
49_Q53_E2.0611.00
285_R310_D2.0241.00
296_Y320_F2.0141.00
250_G257_Y1.9941.00
121_G146_N1.9801.00
296_Y321_L1.9581.00
110_G135_M1.9521.00
50_T54_N1.9351.00
85_I109_A1.9301.00
296_Y317_T1.8821.00
151_Q165_I1.8751.00
276_S279_Q1.8731.00
135_M289_L1.8491.00
188_V193_L1.8391.00
103_R130_R1.8131.00
136_S167_S1.8051.00
241_Q245_D1.8051.00
73_L76_R1.7801.00
191_A270_Q1.7791.00
75_I84_V1.7751.00
286_K309_T1.7621.00
300_L321_L1.7601.00
88_P315_E1.7461.00
123_V213_C1.7461.00
148_T180_A1.7411.00
215_K287_I1.7401.00
83_R310_D1.7121.00
210_L213_C1.7061.00
218_F286_K1.6721.00
213_C283_I1.6621.00
19_A39_V1.6611.00
152_M216_A1.6611.00
123_V212_R1.6521.00
191_A195_M1.6401.00
189_S201_P1.6351.00
257_Y298_A1.6231.00
218_F288_F1.6121.00
76_R84_V1.6051.00
82_Q285_R1.5991.00
139_M171_I1.5751.00
113_Y310_D1.5581.00
19_A33_V1.5561.00
118_I124_L1.5421.00
292_G314_D1.4861.00
104_T138_T1.4721.00
259_K301_G1.4681.00
16_V47_Y1.4591.00
236_N239_E1.4561.00
172_A179_V1.4531.00
127_A253_C1.4441.00
42_V45_V1.4351.00
260_E304_L1.4321.00
220_V298_A1.4321.00
107_S134_Q1.4291.00
239_E271_R1.4271.00
113_Y117_V1.4151.00
76_R83_R1.3920.99
124_L215_K1.3780.99
137_K170_Q1.3680.99
293_E320_F1.3560.99
315_E319_E1.3520.99
148_T209_V1.3280.99
266_A269_D1.3060.99
24_Y59_I1.2950.99
242_T246_L1.2880.99
125_G152_M1.2870.99
299_T313_V1.2820.99
124_L149_V1.2790.99
16_V56_L1.2690.99
207_F210_L1.2620.99
258_D264_V1.2570.99
19_A37_M1.2560.99
189_S200_E1.2480.99
111_G139_M1.2480.99
170_Q173_Y1.2320.99
28_K32_E1.2270.99
134_Q137_K1.2150.99
27_G52_R1.2140.99
216_A283_I1.2130.99
114_L215_K1.2130.99
180_A209_V1.2110.99
70_D74_Q1.2050.98
242_T245_D1.2040.98
136_S171_I1.1930.98
188_V197_L1.1870.98
78_K321_L1.1800.98
21_W25_Q1.1780.98
125_G128_W1.1730.98
208_D212_R1.1700.98
135_M217_F1.1650.98
123_V214_T1.1610.98
290_A313_V1.1540.98
19_A47_Y1.1460.98
15_P47_Y1.1330.98
203_I207_F1.1050.97
117_V285_R1.0980.97
16_V50_T1.0940.97
122_D215_K1.0920.97
155_S251_V1.0810.97
75_I86_I1.0790.97
114_L217_F1.0740.97
73_L77_D1.0690.97
120_N145_K1.0610.97
34_A44_V1.0560.97
74_Q78_K1.0540.96
255_R274_G1.0530.96
22_L36_I1.0520.96
17_L56_L1.0450.96
44_V48_L1.0340.96
241_Q244_R1.0320.96
303_L308_V1.0290.96
23_Y41_R1.0220.96
155_S163_T1.0150.96
136_S170_Q1.0130.96
148_T178_R1.0100.95
78_K322_L1.0070.95
75_I322_L1.0060.95
255_R269_D1.0040.95
220_V299_T1.0040.95
195_M199_A1.0020.95
193_L200_E1.0010.95
75_I321_L1.0010.95
208_D211_T0.9950.95
197_L273_L0.9850.95
13_D64_N0.9800.95
168_S179_V0.9800.95
257_Y302_A0.9730.94
151_Q163_T0.9710.94
222_N227_N0.9710.94
83_R116_Q0.9640.94
218_F308_V0.9640.94
259_K300_L0.9540.94
219_V290_A0.9500.94
216_A280_L0.9490.94
229_L232_V0.9410.93
79_F84_V0.9390.93
205_S208_D0.9340.93
85_I113_Y0.9330.93
319_E323_A0.9310.93
82_Q309_T0.9290.93
259_K304_L0.9280.93
265_V269_D0.9270.93
16_V19_A0.9250.93
29_S41_R0.9240.93
29_S32_E0.9190.93
124_L171_I0.9170.93
166_E169_S0.9150.92
106_L110_G0.9120.92
314_D317_T0.9110.92
127_A255_R0.9030.92
68_S72_A0.9000.92
277_L307_Y0.8970.92
128_W255_R0.8970.92
186_A254_G0.8930.92
123_V150_I0.8900.91
251_V254_G0.8880.91
128_W251_V0.8870.91
265_V270_Q0.8810.91
89_D316_G0.8800.91
119_E122_D0.8790.91
217_F287_I0.8710.90
302_A305_G0.8690.90
127_A151_Q0.8660.90
243_Y248_A0.8610.90
296_Y300_L0.8400.89
108_R138_T0.8360.89
237_K241_Q0.8350.89
126_V171_I0.8330.88
199_A204_R0.8270.88
45_V63_V0.8260.88
184_V273_L0.8250.88
42_V63_V0.8150.87
48_L52_R0.8120.87
74_Q319_E0.8100.87
157_P163_T0.8090.87
33_V61_L0.8070.87
19_A22_L0.8060.87
114_L135_M0.8030.87
165_I183_H0.7990.86
22_L30_Q0.7990.86
275_I283_I0.7960.86
149_V177_G0.7960.86
20_T48_L0.7960.86
196_E200_E0.7960.86
81_L311_L0.7910.86
248_A264_V0.7890.86
301_G304_L0.7890.86
219_V299_T0.7880.86
107_S291_G0.7880.86
106_L289_L0.7860.85
288_F299_T0.7850.85
168_S172_A0.7840.85
92_H316_G0.7820.85
219_V308_V0.7820.85
134_Q219_V0.7770.85
15_P18_H0.7750.85
21_W63_V0.7750.85
187_V272_I0.7740.84
31_T35_A0.7740.84
22_L33_V0.7730.84
19_A44_V0.7720.84
15_P39_V0.7690.84
13_D54_N0.7630.84
301_G305_G0.7620.84
68_S86_I0.7610.83
187_V271_R0.7600.83
126_V167_S0.7590.83
71_A86_I0.7580.83
188_V273_L0.7580.83
186_A223_A0.7530.83
198_Q207_F0.7480.82
113_Y287_I0.7450.82
118_I175_L0.7430.82
278_A281_R0.7410.82
79_F321_L0.7400.82
39_V44_V0.7390.82
71_A319_E0.7380.82
291_G299_T0.7360.81
306_G309_T0.7360.81
110_G219_V0.7300.81
21_W45_V0.7240.80
119_E214_T0.7240.80
128_W151_Q0.7230.80
152_M253_C0.7210.80
290_A295_G0.7190.80
106_L313_V0.7180.80
18_H21_W0.7180.80
24_Y48_L0.7170.80
75_I79_F0.7160.80
170_Q174_K0.7150.79
113_Y116_Q0.7130.79
33_V46_K0.7110.79
208_D297_D0.7100.79
30_Q45_V0.7090.79
291_G317_T0.7040.78
208_D323_A0.7020.78
117_V309_T0.7000.78
275_I279_Q0.7000.78
17_L63_V0.7000.78
115_N175_L0.6940.77
292_G295_G0.6930.77
205_S209_V0.6920.77
219_V272_I0.6920.77
22_L28_K0.6910.77
171_I298_A0.6890.77
117_V215_K0.6880.77
255_R272_I0.6820.76
182_L273_L0.6820.76
129_G315_E0.6800.76
188_V203_I0.6800.76
221_G251_V0.6800.76
120_N146_N0.6800.76
140_T174_K0.6790.76
68_S88_P0.6780.76
57_V61_L0.6780.76
110_G312_I0.6780.76
30_Q42_V0.6720.75
81_L309_T0.6710.75
31_T41_R0.6680.75
87_V106_L0.6660.75
124_L260_E0.6640.74
41_R52_R0.6590.74
151_Q183_H0.6560.73
84_V104_T0.6560.73
70_D284_E0.6540.73
20_T51_A0.6510.73
19_A43_T0.6450.72
47_Y179_V0.6420.72
118_I147_V0.6390.71
226_E229_L0.6370.71
151_Q200_E0.6350.71
185_P188_V0.6350.71
47_Y51_A0.6350.71
287_I309_T0.6330.71
192_R195_M0.6320.71
87_V102_M0.6300.70
73_L316_G0.6280.70
42_V186_A0.6280.70
149_V171_I0.6260.70
252_I302_A0.6260.70
280_L283_I0.6260.70
195_M269_D0.6250.70
18_H76_R0.6230.70
84_V303_L0.6230.70
242_T267_D0.6220.69
42_V153_L0.6200.69
14_D21_W0.6180.69
46_K271_R0.6170.69
45_V251_V0.6170.69
169_S183_H0.6170.69
193_L197_L0.6160.69
150_I206_N0.6130.68
44_V280_L0.6110.68
104_T134_Q0.6110.68
214_T283_I0.6110.68
299_T311_L0.6110.68
34_A141_P0.6100.68
117_V310_D0.6070.68
255_R276_S0.6060.67
151_Q224_L0.6060.67
46_K183_H0.6050.67
72_A84_V0.6030.67
263_P277_L0.6020.67
127_A180_A0.6000.67
269_D276_S0.6000.67
37_M109_A0.5980.66
23_Y30_Q0.5970.66
128_W152_M0.5950.66
80_N306_G0.5950.66
23_Y45_V0.5950.66
112_M115_N0.5950.66
222_N244_R0.5940.66
22_L26_E0.5940.66
104_T137_K0.5930.66
78_K304_L0.5930.66
153_L186_A0.5910.66
249_V301_G0.5910.66
226_E294_R0.5910.66
126_V164_I0.5900.65
211_T282_Q0.5900.65
249_V264_V0.5890.65
200_E254_G0.5880.65
132_I167_S0.5880.65
248_A256_F0.5870.65
33_V110_G0.5860.65
85_I310_D0.5840.65
223_A298_A0.5830.64
269_D272_I0.5810.64
15_P37_M0.5800.64
118_I144_C0.5800.64
207_F273_L0.5790.64
149_V168_S0.5790.64
122_D146_N0.5780.64
41_R186_A0.5780.64
15_P72_A0.5770.64
208_D242_T0.5770.64
291_G314_D0.5720.63
152_M210_L0.5720.63
155_S184_V0.5710.63
165_I219_V0.5710.63
14_D72_A0.5700.63
155_S165_I0.5700.63
25_Q127_A0.5700.63
73_L293_E0.5690.63
302_A306_G0.5680.62
48_L251_V0.5680.62
220_V308_V0.5670.62
42_V61_L0.5670.62
117_V287_I0.5660.62
143_S176_S0.5650.62
89_D314_D0.5640.62
136_S174_K0.5640.62
81_L310_D0.5640.62
308_V311_L0.5640.62
62_D200_E0.5610.62
193_L196_E0.5610.62
88_P109_A0.5610.62
48_L64_N0.5590.61
163_T254_G0.5550.61
16_V51_A0.5550.61
74_Q80_N0.5550.61
188_V280_L0.5530.60
133_H170_Q0.5510.60
87_V268_V0.5510.60
32_E89_D0.5510.60
143_S192_R0.5510.60
110_G113_Y0.5500.60
103_R289_L0.5490.60
21_W151_Q0.5470.60
68_S315_E0.5460.59
295_G314_D0.5450.59
83_R113_Y0.5450.59
268_V272_I0.5440.59
298_A301_G0.5430.59
255_R277_L0.5420.59
149_V172_A0.5420.59
121_G142_K0.5410.59
125_G132_I0.5400.59
243_Y256_F0.5400.59
102_M291_G0.5390.58
141_P176_S0.5390.58
118_I142_K0.5380.58
149_V255_R0.5380.58
89_D172_A0.5370.58
74_Q322_L0.5360.58
131_T292_G0.5360.58
115_N140_T0.5350.58
164_I274_G0.5300.57
43_T47_Y0.5290.57
40_S185_P0.5290.57
218_F309_T0.5280.57
189_S193_L0.5280.57
210_L275_I0.5270.57
13_D21_W0.5260.57
115_N142_K0.5250.57
211_T241_Q0.5240.56
268_V289_L0.5240.56
48_L57_V0.5230.56
150_I193_L0.5230.56
187_V191_A0.5230.56
186_A251_V0.5220.56
51_A63_V0.5200.56
114_L171_I0.5190.56
267_D296_Y0.5190.56
41_R45_V0.5180.56
92_H101_L0.5170.55
107_S264_V0.5170.55
238_K245_D0.5160.55
186_A256_F0.5150.55
293_E316_G0.5150.55
303_L321_L0.5140.55
129_G272_I0.5130.55
18_H315_E0.5120.55
242_T266_A0.5110.55
192_R212_R0.5100.54
210_L254_G0.5090.54
127_A136_S0.5080.54
208_D238_K0.5080.54
310_D313_V0.5080.54
78_K262_M0.5060.54
77_D262_M0.5060.54
238_K241_Q0.5050.54
102_M314_D0.5040.54
70_D281_R0.5040.54
40_S64_N0.5020.53
290_A317_T0.5010.53
282_Q323_A0.5010.53
152_M275_I0.5000.53
226_E257_Y0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w48A 3 0.9451 100 0.388 Contact Map
4l5jA 4 0.9268 100 0.395 Contact Map
4l4yA 2 0.7256 100 0.461 Contact Map
3efbA 2 0.7561 100 0.468 Contact Map
2r5fA 1 0.6555 100 0.481 Contact Map
2o0mA 1 0.7409 100 0.482 Contact Map
3kv1A 2 0.7652 100 0.485 Contact Map
2gnpA 1 0.7957 100 0.486 Contact Map
4r9nA 1 0.753 100 0.488 Contact Map
4oqpA 2 0.7713 100 0.49 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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