GREMLIN Database
YJHC - Uncharacterized oxidoreductase YjhC
UniProt: P39353 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12545
Length: 372 (312)
Sequences: 22140 (17620)
Seq/√Len: 997.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_D79_K3.4901.00
121_N179_D3.2881.00
78_I106_A3.1881.00
74_K102_D3.1541.00
191_T218_E3.0451.00
140_E245_T3.0111.00
34_P38_E2.9901.00
82_K106_A2.9581.00
128_Y131_K2.9071.00
3_N27_K2.8921.00
190_E220_P2.7181.00
130_R134_K2.6911.00
74_K99_D2.6861.00
5_G55_L2.6711.00
78_I102_D2.6641.00
78_I82_K2.6291.00
68_T76_P2.6281.00
86_H113_T2.5841.00
81_A112_V2.5151.00
131_K135_E2.4191.00
30_C49_M2.3921.00
51_S54_A2.3861.00
72_L76_P2.3791.00
105_K109_E2.2891.00
77_V89_C2.2331.00
74_K78_I2.1841.00
128_Y132_L2.1591.00
81_A107_C2.1321.00
101_V105_K2.1111.00
38_E42_R2.0911.00
106_A110_A2.0651.00
14_A43_E2.0591.00
68_T72_L2.0511.00
86_H112_V2.0161.00
75_E79_K2.0011.00
138_I244_G1.9821.00
82_K110_A1.9581.00
20_M65_I1.9571.00
4_Y63_C1.9051.00
56_V80_A1.8681.00
77_V103_M1.8621.00
64_V80_A1.8601.00
219_F225_A1.8541.00
5_G61_V1.8371.00
61_V85_K1.7931.00
50_S54_A1.7931.00
96_S99_D1.7701.00
132_L137_V1.7401.00
57_S83_N1.7101.00
129_A249_I1.7031.00
82_K109_E1.6971.00
39_N43_E1.6791.00
130_R183_H1.6441.00
142_L245_T1.6431.00
190_E218_E1.6421.00
49_M58_S1.6401.00
52_L79_K1.6261.00
34_P50_S1.6231.00
54_A57_S1.6131.00
95_L99_D1.5971.00
74_K103_M1.5671.00
106_A109_E1.5611.00
145_H241_I1.5071.00
185_L223_K1.5061.00
53_D57_S1.4841.00
49_M55_L1.4691.00
79_K82_K1.4621.00
97_Y101_V1.4591.00
94_A100_C1.4501.00
94_A103_M1.4461.00
195_I218_E1.4371.00
187_E220_P1.4281.00
3_N62_D1.4141.00
81_A110_A1.4101.00
9_V31_V1.3961.00
32_Y52_L1.3901.00
79_K83_N1.3851.00
241_I250_K1.3741.00
71_Y166_Q1.3691.00
3_N29_T1.3681.00
138_I247_G1.3571.00
189_P219_F1.3531.00
66_V77_V1.3521.00
4_Y26_A1.3491.00
48_N58_S1.3481.00
52_L76_P1.3421.00
182_Q219_F1.3371.00
54_A58_S1.3261.00
319_H323_C1.3231.00
93_I100_C1.3221.00
289_E293_A1.3191.00
141_I242_I1.3171.00
187_E221_S1.3141.00
32_Y55_L1.3111.00
102_D105_K1.3091.00
80_A87_V1.2871.00
66_V76_P1.2851.00
35_E38_E1.2821.00
39_N42_R1.2781.00
55_L61_V1.2691.00
145_H228_E1.2551.00
239_Y250_K1.2481.00
132_L135_E1.2381.00
84_K110_A1.2311.00
81_A106_A1.2241.00
292_G296_Y1.2141.00
193_T216_T1.2091.00
34_P37_G1.2041.00
286_M289_E1.2001.00
101_V311_I1.1931.00
167_S170_H1.1891.00
102_D106_A1.1861.00
52_L56_V1.1841.00
105_K108_K1.1801.00
144_C185_L1.1761.00
99_D102_D1.1751.00
163_M166_Q1.1741.00
59_K85_K1.1711.00
181_V225_A1.1711.00
78_I103_M1.1701.00
69_P72_L1.1691.00
35_E39_N1.1681.00
287_T291_D1.1581.00
30_C55_L1.1511.00
131_K134_K1.1501.00
126_V183_H1.1471.00
56_V83_N1.1381.00
7_V76_P1.1381.00
30_C61_V1.1371.00
60_L85_K1.1351.00
144_C225_A1.1351.00
33_D37_G1.1271.00
36_N39_N1.1271.00
94_A99_D1.1201.00
295_A299_P1.1171.00
88_F117_G1.1171.00
307_L310_L1.1161.00
89_C114_F1.1101.00
56_V79_K1.1031.00
189_P217_L1.1011.00
320_N324_G1.1011.00
104_V108_K1.0881.00
138_I249_I1.0841.00
293_A297_G1.0651.00
108_K308_A1.0641.00
141_I244_G1.0641.00
16_L65_I1.0641.00
58_S61_V1.0621.00
138_I141_I1.0551.00
93_I114_F1.0541.00
101_V104_V1.0501.00
98_E101_V1.0481.00
47_I58_S1.0421.00
285_N289_E1.0391.00
309_S312_R1.0351.00
195_I224_L1.0351.00
18_R22_M1.0301.00
76_P79_K1.0291.00
37_G41_A1.0291.00
103_M114_F1.0201.00
107_C110_A1.0071.00
77_V87_V1.0051.00
38_E41_A0.9981.00
49_M54_A0.9971.00
9_V33_D0.9971.00
66_V80_A0.9971.00
98_E102_D0.9941.00
37_G50_S0.9801.00
107_C114_F0.9731.00
4_Y20_M0.9691.00
74_K94_A0.9661.00
77_V81_A0.9651.00
81_A87_V0.9511.00
312_R316_L0.9461.00
214_F226_T0.9391.00
18_R43_E0.9361.00
291_D295_A0.9361.00
129_A251_I0.9281.00
70_N172_Y0.9271.00
81_A114_F0.9201.00
100_C104_V0.9141.00
141_I185_L0.9101.00
321_I325_A0.9011.00
107_C112_V0.9001.00
5_G30_C0.8961.00
315_T319_H0.8961.00
20_M26_A0.8911.00
288_S291_D0.8891.00
294_I298_H0.8861.00
292_G295_A0.8851.00
189_P220_P0.8781.00
13_G67_A0.8691.00
72_L75_E0.8691.00
12_F67_A0.8681.00
169_G210_D0.8661.00
89_C93_I0.8651.00
144_C242_I0.8631.00
25_N298_H0.8621.00
89_C103_M0.8621.00
3_N61_V0.8611.00
146_T240_V0.8601.00
318_L322_L0.8561.00
88_F115_M0.8531.00
134_K186_G0.8511.00
7_V52_L0.8501.00
258_G262_I0.8501.00
127_Q131_K0.8451.00
306_W309_S0.8401.00
6_V17_A0.8391.00
317_F321_I0.8371.00
2_I63_C0.8331.00
29_T60_L0.8321.00
40_I44_L0.8321.00
144_C181_V0.8311.00
147_K228_E0.8301.00
33_D36_N0.8291.00
17_A28_I0.8291.00
241_I248_S0.8271.00
293_A296_Y0.8251.00
308_A311_I0.8231.00
23_H26_A0.8211.00
12_F16_L0.8211.00
5_G32_Y0.8201.00
181_V219_F0.8201.00
282_R285_N0.8181.00
305_L309_S0.8131.00
147_K239_Y0.8131.00
239_Y252_D0.8131.00
306_W310_L0.8111.00
164_K208_N0.8101.00
322_L326_K0.8101.00
40_I43_E0.8101.00
146_T177_E0.8091.00
133_I244_G0.8071.00
194_M215_M0.8061.00
58_S85_K0.8041.00
93_I116_A0.7921.00
120_M123_F0.7901.00
139_G244_G0.7901.00
284_G287_T0.7881.00
140_E221_S0.7881.00
215_M321_I0.7881.00
145_H226_T0.7871.00
13_G18_R0.7861.00
63_C321_I0.7831.00
7_V68_T0.7811.00
14_A39_N0.7811.00
139_G247_G0.7801.00
118_H175_I0.7791.00
292_G304_P0.7731.00
29_T61_V0.7711.00
191_T195_I0.7701.00
174_H177_E0.7701.00
29_T58_S0.7651.00
217_L225_A0.7601.00
5_G64_V0.7601.00
31_V40_I0.7591.00
63_C293_A0.7541.00
27_K47_I0.7531.00
163_M208_N0.7531.00
307_L311_I0.7521.00
289_E294_I0.7481.00
176_H179_D0.7481.00
195_I216_T0.7451.00
179_D183_H0.7451.00
7_V32_Y0.7451.00
288_S292_G0.7441.00
12_F90_E0.7411.00
218_E224_L0.7391.00
126_V180_C0.7331.00
295_A301_K0.7331.00
22_M287_T0.7321.00
269_F273_E0.7301.00
216_T224_L0.7291.00
63_C86_H0.7271.00
140_E246_K0.7271.00
9_V37_G0.7261.00
89_C116_A0.7191.00
118_H179_D0.7181.00
52_L80_A0.7181.00
23_H291_D0.7131.00
282_R286_M0.7121.00
185_L219_F0.7121.00
295_A300_G0.7101.00
121_N183_H0.7091.00
174_H229_W0.7071.00
289_E292_G0.7041.00
215_M227_L0.7041.00
290_M293_A0.7001.00
323_C326_K0.6991.00
296_Y299_P0.6981.00
133_I242_I0.6961.00
78_I81_A0.6941.00
320_N323_C0.6931.00
285_N288_S0.6921.00
258_G263_G0.6911.00
85_K112_V0.6891.00
75_E102_D0.6871.00
84_K112_V0.6861.00
4_Y65_I0.6841.00
172_Y231_S0.6841.00
74_K106_A0.6831.00
243_N248_S0.6831.00
133_I184_L0.6831.00
143_S224_L0.6811.00
305_L308_A0.6781.00
26_A63_C0.6771.00
258_G261_R0.6741.00
219_F223_K0.6741.00
230_G233_F0.6741.00
308_A312_R0.6711.00
146_T181_V0.6711.00
97_Y319_H0.6701.00
95_L167_S0.6701.00
26_A294_I0.6681.00
81_A103_M0.6651.00
55_L58_S0.6641.00
3_N60_L0.6621.00
113_T300_G0.6591.00
197_G218_E0.6561.00
289_E296_Y0.6511.00
141_I223_K0.6481.00
184_L242_I0.6471.00
53_D75_E0.6471.00
77_V114_F0.6421.00
291_D294_I0.6411.00
130_R184_L0.6351.00
129_A184_L0.6351.00
73_H89_C0.6341.00
104_V107_C0.6321.00
10_G67_A0.6321.00
45_Q48_N0.6321.00
101_V316_L0.6311.00
64_V85_K0.6291.00
296_Y303_T0.6291.00
14_A18_R0.6291.00
281_R285_N0.6271.00
297_G300_G0.6261.00
283_K287_T0.6261.00
160_W163_M0.6251.00
196_G213_L0.6231.00
296_Y301_K0.6231.00
289_E297_G0.6231.00
217_L227_L0.6181.00
9_V40_I0.6161.00
262_I267_K0.6161.00
263_G267_K0.6151.00
91_K172_Y0.6151.00
120_M179_D0.6121.00
315_T318_L0.6081.00
193_T218_E0.6081.00
49_M59_K0.6071.00
48_N60_L0.6051.00
143_S226_T0.6041.00
194_M213_L0.6041.00
284_G288_S0.6031.00
65_I88_F0.6031.00
271_V274_T0.5991.00
213_L229_W0.5981.00
316_L319_H0.5981.00
25_N291_D0.5961.00
37_G48_N0.5961.00
82_K102_D0.5941.00
41_A48_N0.5931.00
143_S212_M0.5921.00
14_A44_L0.5911.00
75_E78_I0.5911.00
259_S262_I0.5901.00
29_T47_I0.5891.00
294_I297_G0.5891.00
57_S79_K0.5891.00
211_D232_A0.5891.00
116_A176_H0.5871.00
304_P308_A0.5861.00
119_I176_H0.5861.00
305_L310_L0.5841.00
67_A90_E0.5841.00
262_I265_Q0.5841.00
317_F322_L0.5831.00
14_A36_N0.5821.00
171_L213_L0.5801.00
7_V64_V0.5781.00
182_Q187_E0.5781.00
267_K272_H0.5771.00
303_T307_L0.5761.00
178_L317_F0.5751.00
161_K172_Y0.5741.00
32_Y49_M0.5741.00
212_M230_G0.5741.00
267_K270_L0.5701.00
16_L20_M0.5691.00
13_G17_A0.5691.00
14_A40_I0.5681.00
317_F324_G0.5661.00
285_N297_G0.5661.00
156_E159_S0.5661.00
263_G266_T0.5661.00
120_M253_M0.5661.00
216_T226_T0.5641.00
90_E117_G0.5621.00
77_V107_C0.5601.00
137_V140_E0.5591.00
321_I324_G0.5591.00
189_P225_A0.5591.00
18_R21_N0.5551.00
118_H121_N0.5541.00
265_Q269_F0.5531.00
295_A298_H0.5521.00
212_M228_E0.5521.00
118_H176_H0.5511.00
196_G210_D0.5491.00
270_L273_E0.5481.00
71_Y95_L0.5481.00
93_I103_M0.5461.00
286_M292_G0.5441.00
143_S228_E0.5441.00
259_S263_G0.5431.00
181_V227_L0.5431.00
11_Y15_E0.5421.00
178_L182_Q0.5391.00
13_G40_I0.5391.00
68_T73_H0.5381.00
143_S243_N0.5371.00
25_N326_K0.5351.00
107_C111_G0.5321.00
165_E208_N0.5301.00
114_F307_L0.5301.00
78_I110_A0.5291.00
182_Q309_S0.5291.00
293_A299_P0.5281.00
66_V73_H0.5261.00
170_H229_W0.5251.00
17_A40_I0.5251.00
292_G301_K0.5241.00
260_L265_Q0.5231.00
148_R151_W0.5231.00
143_S214_F0.5221.00
130_R186_G0.5221.00
152_E156_E0.5211.00
263_G269_F0.5201.00
260_L264_G0.5201.00
266_T270_L0.5161.00
303_T306_W0.5151.00
180_C184_L0.5151.00
302_K306_W0.5151.00
130_R133_I0.5141.00
267_K271_V0.5121.00
127_Q183_H0.5121.00
7_V66_V0.5101.00
185_L221_S0.5091.00
140_E223_K0.5091.00
10_G13_G0.5081.00
214_F224_L0.5081.00
15_E18_R0.5081.00
319_H322_L0.5081.00
91_K176_H0.5081.00
16_L67_A0.5071.00
17_A21_N0.5071.00
15_E19_F0.5061.00
6_V28_I0.5051.00
182_Q189_P0.5041.00
6_V65_I0.5031.00
253_M256_T0.5031.00
166_Q170_H0.5031.00
144_C240_V0.5021.00
136_G244_G0.5021.00
117_G289_E0.5011.00
73_H93_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dtyA 4 0.9167 100 0.27 Contact Map
3v5nA 4 0.8737 100 0.274 Contact Map
1h6dA 8 0.914 100 0.276 Contact Map
2nvwA 3 0.8898 100 0.278 Contact Map
1zh8A 2 0.8414 100 0.28 Contact Map
3db2A 2 0.9059 100 0.289 Contact Map
3i23A 2 0.922 100 0.29 Contact Map
3fhlA 2 0.8925 100 0.291 Contact Map
3btvA 2 0.9059 100 0.293 Contact Map
3oqbA 4 0.922 100 0.296 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.