GREMLIN Database
INTB - Putative prophage P4 integrase
UniProt: P39347 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12364
Length: 396 (327)
Sequences: 19221 (16217)
Seq/√Len: 896.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
323_C341_M4.7651.00
110_R119_D3.3101.00
222_W273_K3.1811.00
314_C317_G2.8651.00
116_K119_D2.8641.00
257_H342_S2.7821.00
214_S316_H2.7371.00
207_T315_G2.7211.00
252_K255_T2.6851.00
322_A340_Q2.5621.00
211_F322_A2.5141.00
202_W272_I2.4091.00
230_S266_L2.3981.00
320_T355_H2.3811.00
226_D229_A2.3581.00
127_V139_L2.3441.00
221_R280_D2.3011.00
42_R45_E2.2431.00
233_T258_L2.1801.00
77_A146_I2.0891.00
207_T217_L2.0761.00
74_K104_F2.0521.00
16_Q23_Q2.0331.00
96_L100_E2.0211.00
124_I140_Q2.0171.00
77_A99_L1.9801.00
322_A326_L1.9661.00
231_I258_L1.9501.00
36_L40_R1.9481.00
106_A126_A1.9051.00
76_V150_A1.8821.00
334_R350_R1.8771.00
327_V337_V1.8561.00
74_K78_I1.8501.00
78_I104_F1.8401.00
222_W282_I1.8321.00
260_P340_Q1.8151.00
149_Y153_S1.7901.00
76_V112_I1.7571.00
120_L161_A1.7491.00
134_E138_R1.7471.00
154_G158_Y1.7451.00
333_S336_A1.7411.00
111_N114_E1.7401.00
202_W271_Q1.7311.00
148_R162_Q1.7271.00
46_A49_L1.7171.00
212_I217_L1.6921.00
74_K109_E1.6881.00
266_L270_K1.6811.00
180_E183_R1.6701.00
209_L262_S1.6511.00
45_E49_L1.6301.00
18_R23_Q1.6221.00
81_H96_L1.6131.00
98_S142_R1.5901.00
327_V354_I1.5601.00
42_R46_A1.5501.00
35_T38_D1.5481.00
230_S263_T1.5241.00
76_V149_Y1.5181.00
91_H95_V1.5001.00
255_T344_M1.4971.00
224_E235_P1.4831.00
216_E257_H1.4791.00
263_T267_A1.4661.00
115_L147_M1.4641.00
348_S352_A1.4401.00
214_S218_R1.4381.00
184_I208_L1.4181.00
183_R186_E1.4111.00
85_K92_A1.4091.00
208_L318_F1.4081.00
48_K52_N1.3811.00
16_Q25_M1.3751.00
345_A348_S1.3731.00
140_Q144_T1.3611.00
201_R205_E1.3531.00
79_E83_T1.3521.00
223_S280_D1.3461.00
121_L153_S1.3441.00
263_T368_Q1.3431.00
345_A351_A1.3421.00
302_L306_G1.3401.00
221_R281_L1.3351.00
212_I234_I1.3341.00
220_A225_I1.3311.00
202_W268_I1.3281.00
323_C337_V1.3271.00
81_H92_A1.3031.00
72_T75_E1.3011.00
326_L332_W1.2991.00
203_A217_L1.2971.00
117_T152_Q1.2951.00
326_L337_V1.2951.00
179_L313_V1.2931.00
152_Q165_A1.2921.00
336_A366_M1.2871.00
184_I325_S1.2831.00
299_N303_R1.2821.00
335_D338_E1.2761.00
227_F270_K1.2681.00
179_L187_L1.2661.00
220_A232_W1.2661.00
261_L265_A1.2611.00
226_D231_I1.2601.00
146_I150_A1.2511.00
97_K101_D1.2491.00
92_A96_L1.2391.00
43_R47_R1.2221.00
192_D201_R1.2211.00
110_R114_E1.2191.00
121_L125_K1.2171.00
203_A298_V1.2171.00
99_L104_F1.2111.00
151_V156_I1.2011.00
224_E238_R1.1991.00
144_T148_R1.1981.00
78_I82_G1.1961.00
332_W369_W1.1941.00
261_L266_L1.1911.00
107_L123_P1.1881.00
206_L265_A1.1851.00
324_S354_I1.1701.00
186_E190_K1.1701.00
45_E48_K1.1671.00
44_D51_A1.1621.00
85_K96_L1.1621.00
179_L321_M1.1591.00
94_R97_K1.1551.00
343_H349_V1.1451.00
87_W95_V1.1431.00
152_Q163_E1.1391.00
148_R159_N1.1371.00
348_S351_A1.1361.00
321_M325_S1.1361.00
123_P139_L1.1311.00
185_P189_T1.1261.00
262_S265_A1.1191.00
88_S91_H1.1191.00
345_A349_V1.1131.00
338_E346_R1.1121.00
132_R135_V1.1111.00
332_W366_M1.1081.00
70_A113_A1.1031.00
272_I276_Y1.1011.00
181_L325_S1.0981.00
95_V142_R1.0851.00
349_V352_A1.0851.00
89_E93_H1.0811.00
12_Y27_A1.0791.00
76_V153_S1.0701.00
117_T154_G1.0611.00
188_L205_E1.0511.00
338_E350_R1.0421.00
84_N87_W1.0401.00
205_E268_I1.0391.00
328_E362_E1.0361.00
123_P127_V1.0351.00
100_E104_F1.0301.00
221_R224_E1.0291.00
14_R27_A1.0261.00
335_D339_R1.0181.00
118_R153_S1.0171.00
41_V45_E1.0161.00
206_L232_W1.0141.00
209_L265_A1.0131.00
70_A111_N1.0111.00
73_F146_I1.0081.00
264_Q267_A1.0071.00
40_R44_D1.0061.00
178_A321_M1.0031.00
37_A41_V1.0011.00
365_L369_W0.9951.00
324_S355_H0.9891.00
74_K108_G0.9871.00
214_S315_G0.9841.00
328_E359_H0.9841.00
49_L54_V0.9831.00
205_E264_Q0.9831.00
362_E365_L0.9741.00
223_S279_H0.9731.00
232_W236_P0.9711.00
147_M161_A0.9701.00
203_A283_F0.9611.00
301_A304_V0.9611.00
147_M156_I0.9561.00
206_L217_L0.9521.00
118_R122_A0.9491.00
127_V136_A0.9471.00
138_R141_Q0.9451.00
147_M160_P0.9451.00
303_R312_E0.9441.00
15_L42_R0.9431.00
78_I96_L0.9421.00
47_R51_A0.9421.00
325_S328_E0.9401.00
140_Q161_A0.9371.00
93_H97_K0.9331.00
181_L185_P0.9321.00
87_W92_A0.9271.00
44_D47_R0.9241.00
144_T162_Q0.9181.00
270_K273_K0.9131.00
224_E236_P0.9131.00
48_K51_A0.9121.00
37_A40_R0.9081.00
364_R368_Q0.9071.00
76_V146_I0.9021.00
151_V158_Y0.9011.00
200_T301_A0.8971.00
134_E137_A0.8871.00
151_V163_E0.8841.00
73_F77_A0.8831.00
120_L143_T0.8801.00
191_I204_I0.8791.00
41_V44_D0.8791.00
338_E351_A0.8781.00
41_V51_A0.8761.00
190_K309_T0.8761.00
209_L264_Q0.8751.00
112_I147_M0.8711.00
338_E349_V0.8711.00
8_N11_K0.8701.00
332_W336_A0.8691.00
323_C354_I0.8651.00
350_R354_I0.8641.00
220_A282_I0.8621.00
135_V139_L0.8611.00
38_D42_R0.8591.00
323_C327_V0.8591.00
322_A341_M0.8551.00
144_T161_A0.8551.00
222_W276_Y0.8551.00
329_S369_W0.8541.00
45_E52_N0.8531.00
13_W36_L0.8531.00
121_L124_I0.8511.00
339_R363_R0.8461.00
346_R351_A0.8431.00
71_R155_L0.8421.00
90_D93_H0.8391.00
89_E92_A0.8371.00
227_F266_L0.8361.00
219_F238_R0.8351.00
323_C350_R0.8331.00
192_D205_E0.8331.00
217_L315_G0.8291.00
71_R75_E0.8291.00
260_P363_R0.8281.00
94_R98_S0.8271.00
84_N145_A0.8261.00
122_A126_A0.8251.00
300_S304_V0.8241.00
215_S219_F0.8231.00
116_K154_G0.8221.00
265_A268_I0.8221.00
273_K276_Y0.8211.00
115_L120_L0.8201.00
116_K157_D0.8201.00
317_G320_T0.8181.00
73_F143_T0.8161.00
19_Y24_K0.8151.00
97_K100_E0.8151.00
49_L52_N0.8141.00
77_A81_H0.8121.00
359_H362_E0.8111.00
151_V159_N0.8101.00
147_M151_V0.8061.00
183_R311_V0.8051.00
112_I150_A0.8021.00
44_D48_K0.8001.00
222_W269_L0.8001.00
28_L42_R0.7991.00
187_L204_I0.7991.00
297_T300_S0.7981.00
214_S295_E0.7981.00
177_P183_R0.7971.00
273_K277_G0.7951.00
313_V317_G0.7941.00
204_I318_F0.7911.00
190_K308_D0.7891.00
159_N162_Q0.7881.00
38_D41_V0.7881.00
346_R350_R0.7871.00
106_A122_A0.7861.00
36_L39_A0.7781.00
340_Q363_R0.7781.00
73_F115_L0.7781.00
177_P311_V0.7711.00
320_T352_A0.7701.00
323_C349_V0.7681.00
191_I201_R0.7661.00
343_H350_R0.7661.00
90_D94_R0.7631.00
341_M350_R0.7581.00
80_W145_A0.7581.00
119_D122_A0.7571.00
71_R79_E0.7561.00
80_W84_N0.7541.00
118_R154_G0.7541.00
285_G291_K0.7531.00
206_L283_F0.7491.00
361_E364_R0.7481.00
333_S362_E0.7471.00
176_R314_C0.7461.00
103_L143_T0.7431.00
81_H85_K0.7371.00
327_V335_D0.7371.00
79_E155_L0.7361.00
53_G56_P0.7311.00
260_P364_R0.7291.00
208_L321_M0.7281.00
227_F261_L0.7261.00
137_A169_A0.7261.00
77_A104_F0.7251.00
12_Y30_V0.7231.00
34_I38_D0.7231.00
336_A362_E0.7211.00
361_E365_L0.7201.00
212_I216_E0.7191.00
124_I136_A0.7171.00
346_R349_V0.7161.00
106_A123_P0.7151.00
40_R43_R0.7151.00
41_V48_K0.7131.00
14_R25_M0.7111.00
80_W149_Y0.7111.00
323_C338_E0.7101.00
327_V334_R0.7081.00
213_R236_P0.7041.00
360_L363_R0.7021.00
198_P201_R0.7011.00
94_R138_R0.6991.00
39_A43_R0.6961.00
72_T111_N0.6951.00
267_A270_K0.6931.00
225_I269_L0.6911.00
179_L183_R0.6911.00
340_Q367_L0.6901.00
338_E348_S0.6881.00
212_I220_A0.6871.00
154_G163_E0.6851.00
306_G309_T0.6841.00
186_E189_T0.6811.00
12_Y34_I0.6801.00
124_I128_E0.6791.00
212_I232_W0.6791.00
225_I232_W0.6781.00
117_T163_E0.6771.00
221_R236_P0.6771.00
151_V162_Q0.6751.00
78_I100_E0.6741.00
345_A350_R0.6741.00
206_L210_I0.6741.00
101_D139_L0.6731.00
79_E153_S0.6691.00
87_W91_H0.6661.00
334_R338_E0.6661.00
75_E79_E0.6621.00
187_L302_L0.6611.00
218_R295_E0.6611.00
103_L108_G0.6581.00
281_L284_I0.6581.00
233_T256_T0.6561.00
210_I259_V0.6541.00
98_S139_L0.6541.00
297_T301_A0.6521.00
338_E341_M0.6521.00
206_L269_L0.6521.00
303_R307_Y0.6481.00
214_S299_N0.6471.00
107_L119_D0.6461.00
83_T125_K0.6461.00
150_A156_I0.6451.00
329_S332_W0.6451.00
366_M369_W0.6441.00
146_I149_Y0.6411.00
15_L46_A0.6401.00
147_M159_N0.6401.00
17_Y24_K0.6371.00
338_E345_A0.6361.00
128_E136_A0.6361.00
101_D105_A0.6361.00
178_A324_S0.6351.00
235_P256_T0.6341.00
365_L368_Q0.6341.00
125_K153_S0.6331.00
121_L152_Q0.6331.00
299_N315_G0.6321.00
76_V155_L0.6321.00
296_N300_S0.6311.00
79_E122_A0.6291.00
226_D230_S0.6291.00
117_T121_L0.6291.00
213_R316_H0.6241.00
137_A141_Q0.6241.00
140_Q164_M0.6231.00
335_D350_R0.6221.00
75_E78_I0.6201.00
188_L209_L0.6201.00
84_N95_V0.6191.00
211_F341_M0.6191.00
156_I160_P0.6191.00
328_E361_E0.6171.00
210_I262_S0.6171.00
128_E131_G0.6151.00
95_V98_S0.6151.00
326_L340_Q0.6141.00
335_D351_A0.6131.00
181_L329_S0.6131.00
360_L364_R0.6101.00
190_K305_M0.6091.00
55_D58_D0.6091.00
79_E82_G0.6091.00
15_L43_R0.6071.00
334_R351_A0.6071.00
287_H291_K0.6051.00
208_L325_S0.6041.00
79_E149_Y0.6021.00
145_A149_Y0.6011.00
71_R113_A0.6011.00
82_G85_K0.6001.00
327_V350_R0.5981.00
316_H341_M0.5981.00
104_F108_G0.5981.00
27_A30_V0.5971.00
184_I321_M0.5961.00
298_V315_G0.5951.00
227_F230_S0.5911.00
74_K99_L0.5901.00
232_W261_L0.5881.00
107_L115_L0.5871.00
268_I271_Q0.5861.00
210_I265_A0.5861.00
231_I364_R0.5851.00
15_L28_L0.5801.00
91_H94_R0.5731.00
221_R238_R0.5721.00
271_Q274_Q0.5711.00
99_L146_I0.5701.00
148_R152_Q0.5671.00
298_V302_L0.5671.00
296_N299_N0.5671.00
212_I259_V0.5641.00
188_L201_R0.5641.00
252_K256_T0.5621.00
123_P126_A0.5581.00
227_F232_W0.5571.00
301_A305_M0.5561.00
198_P271_Q0.5551.00
323_C343_H0.5551.00
50_L55_D0.5521.00
210_I217_L0.5521.00
332_W337_V0.5521.00
110_R115_L0.5511.00
181_L328_E0.5501.00
148_R151_V0.5451.00
26_L46_A0.5441.00
182_K185_P0.5431.00
204_I302_L0.5401.00
281_L292_P0.5381.00
198_P202_W0.5371.00
299_N302_L0.5361.00
177_P317_G0.5351.00
190_K193_S0.5341.00
99_L103_L0.5341.00
334_R346_R0.5301.00
117_T153_S0.5291.00
133_L137_A0.5281.00
260_P367_L0.5271.00
333_S366_M0.5271.00
302_L318_F0.5231.00
125_K128_E0.5211.00
363_R367_L0.5201.00
83_T149_Y0.5191.00
267_A271_Q0.5161.00
254_R344_M0.5161.00
253_M342_S0.5161.00
152_Q162_Q0.5161.00
47_R50_L0.5141.00
15_L50_L0.5111.00
228_E270_K0.5111.00
143_T161_A0.5111.00
103_L123_P0.5081.00
306_G312_E0.5041.00
173_R253_M0.5011.00
304_V308_D0.5011.00
121_L164_M0.5001.00
30_V35_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1bA 3 0.8359 100 0.297 Contact Map
1a0pA 1 0.6439 100 0.356 Contact Map
1z19A 3 0.6818 100 0.364 Contact Map
2a3vA 3 0.6944 100 0.366 Contact Map
4a8eA 2 0.6591 100 0.405 Contact Map
1xo0A 3 0.7197 100 0.408 Contact Map
3nkhA 2 0.5 100 0.51 Contact Map
1ae9A 4 0.404 100 0.585 Contact Map
1aihA 2 0.4293 99.9 0.608 Contact Map
4e0gA 2 0.6667 99.9 0.63 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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