GREMLIN Database
IDND - L-idonate 5-dehydrogenase (NAD(P)(+))
UniProt: P39346 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12541
Length: 343 (299)
Sequences: 52571 (36018)
Seq/√Len: 2083.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
322_D325_E3.1001.00
35_T146_E2.9981.00
35_T70_K2.8671.00
30_T137_C2.7191.00
11_A19_T2.6471.00
190_K216_D2.6391.00
172_R196_E2.5971.00
145_D148_V2.5801.00
84_T140_Y2.4821.00
83_Q139_P2.4751.00
80_H83_Q2.4381.00
67_V125_G2.3941.00
318_Y329_F2.3851.00
23_I129_Y2.2941.00
208_S212_E2.2741.00
33_Q129_Y2.2671.00
33_Q70_K2.2591.00
147_K317_E2.2081.00
196_E217_V2.1961.00
11_A17_A2.1581.00
301_S305_N2.1481.00
173_V189_V2.1461.00
78_E134_T2.1451.00
316_A329_F2.1201.00
73_H76_S2.1111.00
207_L211_K2.1071.00
178_V199_C2.1061.00
168_L171_K2.0821.00
9_V19_T2.0511.00
28_N75_D2.0431.00
26_N29_G2.0401.00
27_N74_S2.0321.00
186_V215_A2.0321.00
319_P322_D1.9941.00
84_T146_E1.9851.00
143_K304_A1.9781.00
27_N75_D1.9741.00
67_V87_I1.9661.00
68_I146_E1.9641.00
31_L131_M1.9131.00
208_S211_K1.9121.00
328_R332_D1.9051.00
171_K261_V1.8841.00
155_L184_L1.8561.00
174_F236_F1.8281.00
174_F200_A1.8251.00
325_E328_R1.8151.00
204_P208_S1.8141.00
318_Y326_A1.7731.00
48_Q331_G1.7731.00
198_V236_F1.7691.00
237_D257_R1.7381.00
191_T307_V1.7271.00
140_Y146_E1.7031.00
325_E329_F1.6771.00
256_T262_M1.6651.00
220_N223_N1.6651.00
204_P220_N1.6571.00
201_D207_L1.6401.00
176_S252_C1.6341.00
261_V285_S1.6331.00
228_H231_A1.6271.00
165_A238_V1.6261.00
79_L139_P1.6241.00
329_F334_T1.6201.00
207_L218_L1.6051.00
8_C323_L1.5641.00
256_T284_I1.5581.00
209_L212_E1.5581.00
196_E216_D1.5501.00
25_W131_M1.5431.00
6_Q20_E1.5381.00
31_L129_Y1.5361.00
29_G133_E1.5341.00
261_V287_R1.5281.00
79_L83_Q1.5111.00
126_F327_L1.5051.00
256_T260_G1.5001.00
140_Y149_M1.4981.00
204_P223_N1.4941.00
84_T142_A1.4911.00
25_W31_L1.4901.00
34_I67_V1.4731.00
6_Q128_R1.4441.00
70_K84_T1.4421.00
28_N133_E1.4121.00
29_G131_M1.3961.00
70_K146_E1.3961.00
71_V79_L1.3951.00
72_I81_E1.3921.00
239_S252_C1.3901.00
36_R147_K1.3881.00
186_V199_C1.3831.00
47_Y327_L1.3751.00
6_Q321_T1.3571.00
324_E328_R1.3551.00
239_S256_T1.3461.00
315_S329_F1.3451.00
30_T79_L1.3311.00
172_R198_V1.3141.00
163_H298_T1.3021.00
8_C18_V1.2921.00
202_V221_P1.2841.00
301_S304_A1.2781.00
185_I240_F1.2651.00
163_H295_E1.2621.00
176_S200_A1.2501.00
167_E194_A1.2331.00
191_T302_W1.2291.00
225_D228_H1.2281.00
7_S21_Q1.2221.00
35_T84_T1.1961.00
79_L137_C1.1911.00
23_I31_L1.1731.00
211_K218_L1.1621.00
207_L220_N1.1621.00
172_R237_D1.1541.00
25_W29_G1.1471.00
204_P207_L1.1451.00
187_S309_N1.1441.00
199_C215_A1.1361.00
34_I130_K1.1271.00
167_E171_K1.1201.00
28_N134_T1.1161.00
132_V137_C1.1071.00
32_V69_G1.1051.00
298_T301_S1.0941.00
8_C320_F1.0901.00
148_V309_N1.0861.00
36_R146_E1.0821.00
171_K237_D1.0811.00
39_I326_A1.0801.00
12_G15_T1.0791.00
232_E235_Y1.0711.00
47_Y331_G1.0631.00
164_Q285_S1.0581.00
165_A263_V1.0551.00
158_A188_A1.0481.00
302_W307_V1.0301.00
18_V321_T1.0281.00
35_T68_I1.0281.00
209_L336_A1.0261.00
32_V85_V1.0261.00
160_H295_E1.0241.00
297_N301_S1.0141.00
254_E278_T1.0101.00
40_C66_E1.0101.00
158_A185_I1.0101.00
243_S248_S1.0081.00
198_V217_V1.0061.00
37_G125_G1.0051.00
202_V207_L1.0051.00
211_K217_V1.0031.00
40_C65_H1.0031.00
323_L341_L1.0021.00
198_V219_V1.0021.00
72_I76_S0.9931.00
178_V201_D0.9811.00
126_F323_L0.9741.00
161_A265_V0.9741.00
144_A149_M0.9711.00
175_I185_I0.9621.00
9_V62_V0.9551.00
37_G126_F0.9471.00
61_M123_D0.9461.00
33_Q128_R0.9441.00
186_V197_I0.9411.00
155_L299_A0.9401.00
21_Q123_D0.9311.00
202_V222_Q0.9301.00
175_I189_V0.9291.00
329_F339_V0.9281.00
200_A221_P0.9271.00
44_L330_A0.9251.00
9_V21_Q0.9211.00
241_E244_G0.9191.00
126_F341_L0.9171.00
178_V210_G0.9171.00
76_S134_T0.9171.00
189_V194_A0.9151.00
224_D228_H0.9121.00
48_Q51_K0.9101.00
203_S206_S0.9041.00
188_A299_A0.8991.00
250_N254_E0.8991.00
328_R331_G0.8981.00
176_S239_S0.8971.00
159_I298_T0.8951.00
205_R208_S0.8931.00
36_R340_Q0.8911.00
178_V186_V0.8901.00
172_R236_F0.8901.00
80_H139_P0.8841.00
183_C209_L0.8831.00
38_G66_E0.8781.00
11_A15_T0.8781.00
278_T282_K0.8761.00
174_F255_V0.8761.00
310_P313_L0.8761.00
203_S220_N0.8701.00
151_F303_L0.8671.00
251_T254_E0.8671.00
67_V130_K0.8631.00
161_A240_F0.8621.00
7_S62_V0.8561.00
330_A339_V0.8541.00
142_A304_A0.8351.00
279_L286_L0.8331.00
199_C210_G0.8321.00
164_Q287_R0.8321.00
39_I330_A0.8281.00
210_G215_A0.8271.00
171_K238_V0.8251.00
206_S336_A0.8201.00
298_T302_W0.8171.00
318_Y322_D0.8141.00
162_A189_V0.8121.00
86_A300_V0.8111.00
259_R283_E0.8101.00
77_S134_T0.8031.00
40_C43_D0.7971.00
6_Q18_V0.7951.00
26_N131_M0.7921.00
188_A302_W0.7911.00
201_D218_L0.7911.00
158_A184_L0.7901.00
144_A303_L0.7891.00
158_A181_I0.7881.00
8_C16_V0.7861.00
28_N73_H0.7791.00
18_V320_F0.7791.00
227_D231_A0.7771.00
229_W236_F0.7751.00
85_V137_C0.7741.00
225_D251_T0.7731.00
161_A185_I0.7711.00
156_A295_E0.7701.00
39_I126_F0.7701.00
28_N74_S0.7661.00
8_C324_E0.7661.00
167_E238_V0.7641.00
239_S262_M0.7591.00
294_S298_T0.7561.00
252_C262_M0.7561.00
212_E309_N0.7551.00
173_V194_A0.7541.00
87_I132_V0.7531.00
30_T134_T0.7511.00
40_C153_E0.7481.00
145_D149_M0.7481.00
138_V297_N0.7471.00
176_S248_S0.7461.00
318_Y341_L0.7441.00
302_W305_N0.7441.00
302_W306_G0.7421.00
227_D254_E0.7401.00
21_Q62_V0.7391.00
329_F332_D0.7391.00
42_S65_H0.7361.00
275_P278_T0.7341.00
197_I216_D0.7301.00
68_I150_A0.7281.00
192_L298_T0.7271.00
294_S297_N0.7271.00
314_L317_E0.7271.00
264_Q286_L0.7201.00
316_A325_E0.7191.00
242_V265_V0.7181.00
236_F239_S0.7171.00
189_V197_I0.7151.00
227_D230_K0.7071.00
36_R317_E0.7061.00
86_A140_Y0.7061.00
66_E153_E0.7041.00
238_V263_V0.7031.00
160_H283_E0.7031.00
158_A162_A0.7001.00
159_I299_A0.6951.00
279_L284_I0.6951.00
194_A197_I0.6921.00
258_A282_K0.6891.00
250_N271_M0.6881.00
300_V304_A0.6871.00
10_V15_T0.6861.00
65_H153_E0.6861.00
14_K328_R0.6861.00
175_I199_C0.6861.00
83_Q142_A0.6861.00
188_A192_L0.6821.00
153_E157_V0.6821.00
138_V300_V0.6801.00
157_V181_I0.6791.00
84_T143_K0.6761.00
201_D221_P0.6741.00
198_V229_W0.6721.00
279_L288_G0.6721.00
86_A152_A0.6721.00
78_E139_P0.6701.00
194_A238_V0.6651.00
159_I302_W0.6641.00
125_G130_K0.6641.00
40_C154_P0.6631.00
201_D220_N0.6621.00
227_D251_T0.6611.00
154_P180_P0.6611.00
73_H81_E0.6591.00
141_P304_A0.6591.00
316_A339_V0.6581.00
166_G287_R0.6571.00
318_Y339_V0.6541.00
72_I80_H0.6531.00
166_G261_V0.6511.00
24_D131_M0.6511.00
68_I84_T0.6491.00
249_V262_M0.6491.00
30_T71_V0.6471.00
186_V213_M0.6461.00
78_E81_E0.6431.00
166_G285_S0.6431.00
68_I140_Y0.6421.00
209_L213_M0.6411.00
327_L331_G0.6401.00
207_L210_G0.6391.00
41_G45_H0.6381.00
36_R68_I0.6361.00
183_C313_L0.6331.00
32_V87_I0.6331.00
236_F255_V0.6321.00
138_V296_F0.6311.00
250_N273_E0.6301.00
207_L221_P0.6291.00
219_V224_D0.6271.00
24_D129_Y0.6261.00
190_K197_I0.6241.00
28_N135_S0.6231.00
25_W73_H0.6231.00
165_A261_V0.6231.00
250_N278_T0.6201.00
187_S213_M0.6201.00
229_W255_V0.6191.00
57_I61_M0.6171.00
163_H192_L0.6161.00
42_S46_Y0.6131.00
34_I37_G0.6121.00
241_E262_M0.6121.00
239_S255_V0.6111.00
215_A218_L0.6101.00
245_H248_S0.6091.00
185_I265_V0.6081.00
335_Q339_V0.6071.00
24_D31_L0.6071.00
200_A219_V0.6051.00
88_N138_V0.6041.00
209_L313_L0.6031.00
173_V238_V0.6021.00
157_V265_V0.6011.00
246_P250_N0.6011.00
230_K235_Y0.6011.00
25_W75_D0.6001.00
238_V261_V0.5991.00
241_E266_G0.5931.00
12_G17_A0.5931.00
263_V289_S0.5861.00
77_S80_H0.5861.00
60_P64_G0.5851.00
161_A289_S0.5811.00
41_G179_G0.5801.00
44_L331_G0.5761.00
146_E149_M0.5761.00
87_I137_C0.5741.00
223_N228_H0.5731.00
271_M275_P0.5711.00
154_P184_L0.5691.00
272_A275_P0.5681.00
32_V137_C0.5671.00
248_S252_C0.5621.00
329_F335_Q0.5611.00
42_S45_H0.5611.00
162_A188_A0.5611.00
64_G126_F0.5611.00
186_V210_G0.5601.00
58_K61_M0.5601.00
134_T137_C0.5571.00
296_F300_V0.5551.00
23_I131_M0.5551.00
226_M251_T0.5511.00
15_T324_E0.5511.00
25_W28_N0.5511.00
278_T281_G0.5501.00
303_L310_P0.5501.00
174_F239_S0.5501.00
169_Q193_G0.5491.00
34_I87_I0.5471.00
184_L188_A0.5471.00
70_K81_E0.5461.00
202_V210_G0.5451.00
220_N225_D0.5451.00
303_L308_I0.5431.00
18_V323_L0.5401.00
190_K215_A0.5391.00
202_V220_N0.5391.00
15_T47_Y0.5391.00
316_A336_A0.5361.00
306_G309_N0.5321.00
32_V67_V0.5321.00
295_E298_T0.5311.00
211_K215_A0.5301.00
44_L48_Q0.5301.00
159_I192_L0.5291.00
169_Q192_L0.5281.00
91_K136_Q0.5281.00
166_G171_K0.5281.00
68_I149_M0.5271.00
278_T284_I0.5271.00
318_Y325_E0.5231.00
177_G242_V0.5231.00
79_L134_T0.5231.00
172_R232_E0.5231.00
37_G341_L0.5221.00
145_D317_E0.5221.00
56_M59_A0.5221.00
271_M274_F0.5191.00
140_Y144_A0.5191.00
87_I125_G0.5181.00
210_G218_L0.5181.00
38_G150_A0.5151.00
178_V182_G0.5151.00
201_D210_G0.5141.00
28_N76_S0.5131.00
184_L308_I0.5131.00
16_V327_L0.5121.00
198_V232_E0.5121.00
87_I130_K0.5121.00
159_I295_E0.5111.00
24_D29_G0.5111.00
289_S292_F0.5101.00
243_S266_G0.5091.00
226_M229_W0.5091.00
62_V124_G0.5071.00
14_K47_Y0.5061.00
257_R260_G0.5051.00
175_I186_V0.5051.00
184_L187_S0.5051.00
183_C213_M0.5041.00
40_C338_K0.5011.00
133_E136_Q0.5011.00
163_H294_S0.5011.00
156_A291_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ilkA 2 0.9679 100 0.18 Contact Map
4ej6A 1 0.9679 100 0.184 Contact Map
1e3jA 4 0.9767 100 0.205 Contact Map
3m6iA 4 0.9825 100 0.206 Contact Map
2d8aA 3 0.9359 100 0.21 Contact Map
4uejA 2 0.9621 100 0.211 Contact Map
2dq4A 4 0.9621 100 0.213 Contact Map
1h2bA 4 0.9592 100 0.213 Contact Map
1pl8A 4 0.9854 100 0.214 Contact Map
4oh1A 4 0.9534 100 0.217 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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