GREMLIN Database
IDNT - Gnt-II system L-idonate transporter
UniProt: P39344 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12539
Length: 439 (417)
Sequences: 5618 (3775)
Seq/√Len: 184.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
294_D297_G3.7831.00
262_P266_L3.4621.00
332_T335_S3.2671.00
9_G312_F3.0621.00
12_L34_V3.0221.00
180_I184_P3.0201.00
228_A232_P2.8861.00
314_Q318_D2.8791.00
77_D291_I2.8491.00
87_T91_T2.8431.00
408_T411_E2.8181.00
284_T287_Q2.8011.00
323_H327_H2.7471.00
9_G35_V2.7131.00
196_L200_F2.6651.00
222_F226_I2.6561.00
338_L428_L2.6411.00
262_P265_A2.6291.00
231_I272_I2.5691.00
87_T222_F2.4881.00
232_P236_M2.4821.00
421_T425_I2.4301.00
49_S318_D2.3501.00
221_S224_N2.3181.00
77_D287_Q2.3131.00
11_A15_I2.3101.00
182_T185_T2.2761.00
15_I19_G2.2501.00
341_W424_S2.2501.00
87_T90_A2.2181.00
327_H330_T2.2081.00
183_I187_I2.1901.00
223_W227_F2.1861.00
429_L433_A2.1771.00
425_I429_L2.1531.00
48_H52_N2.1271.00
225_S228_A2.0761.00
188_V426_M2.0241.00
344_A361_T1.9981.00
197_L200_F1.9671.00
82_Q86_T1.9451.00
261_N266_L1.9381.00
229_A236_M1.9101.00
193_F197_L1.9081.00
52_N56_S1.8991.00
190_G193_F1.8821.00
197_L201_E1.8191.00
45_A48_H1.7861.00
201_E205_P1.7781.00
266_L269_A1.7711.00
167_F383_T1.7631.00
200_F204_P1.7451.00
42_D45_A1.7411.00
232_P240_A1.7371.00
266_L270_I1.6931.00
176_L180_I1.6791.00
193_F196_L1.6761.00
204_P207_G1.6641.00
414_R418_V1.6481.00
340_C383_T1.6461.00
73_K77_D1.6461.00
345_A389_I1.6441.00
235_L239_A1.6421.00
42_D46_V1.6331.00
256_F260_G1.6321.00
369_I379_M1.6211.00
190_G194_S1.6201.00
161_T164_A1.6151.00
324_Y328_L1.5981.00
12_L31_V1.5891.00
228_A236_M1.5851.00
163_I358_A1.5841.00
174_T380_V1.5631.00
257_E260_G1.5551.00
349_I390_A1.5481.00
175_L178_G1.5421.00
105_G108_V1.5361.00
396_P401_F1.5311.00
193_F200_F1.5311.00
199_R203_A1.5221.00
12_L16_L1.5221.00
224_N228_A1.5211.00
191_P194_S1.5181.00
198_T201_E1.5181.00
192_L195_K1.5151.00
113_F116_V1.5101.00
235_L268_I1.5101.00
110_L113_F1.5041.00
225_S232_P1.5021.00
373_H376_P1.4991.00
140_G405_F1.4851.00
193_F201_E1.4781.00
101_L104_T1.4671.00
152_C388_V1.4661.00
170_N173_T1.4601.00
83_R87_T1.4591.00
396_P400_L1.4511.00
264_V269_A1.4501.00
418_V422_L1.4391.00
236_M240_A1.4341.00
182_T186_V1.4311.00
397_G401_F1.4221.00
54_I62_A1.4211.00
94_K131_S1.4211.00
197_L204_P1.4201.00
5_I38_A1.4171.00
171_L176_L1.4171.00
99_W191_P1.4121.00
22_V27_A1.4001.00
13_L31_V1.3871.00
224_N227_F1.3831.00
261_N265_A1.3811.00
220_P225_S1.3791.00
262_P267_F1.3691.00
201_E204_P1.3671.00
389_I424_S1.3661.00
239_A243_E1.3631.00
176_L179_F1.3601.00
177_Y180_I1.3601.00
114_F117_G1.3591.00
116_V119_V1.3541.00
275_F280_R1.3461.00
290_D294_D1.3381.00
260_G265_A1.3361.00
180_I185_T1.3361.00
69_A292_I1.3331.00
115_E396_P1.3281.00
44_Q48_H1.3111.00
265_A269_A1.3081.00
53_G314_Q1.3071.00
200_F203_A1.3011.00
191_P195_K1.2871.00
261_N264_V1.2801.00
287_Q290_D1.2731.00
313_K317_V1.2731.00
166_I362_A1.2721.00
432_L435_N1.2711.00
229_A232_P1.2671.00
396_P399_W1.2591.00
223_W228_A1.2561.00
103_I107_V1.2511.00
237_A240_A1.2501.00
221_S225_S1.2491.00
50_I311_A1.2431.00
263_A267_F1.2261.00
49_S314_Q1.2171.00
178_G181_I1.2161.00
419_M423_I1.2091.00
45_A49_S1.2081.00
228_A244_I1.1931.00
179_F183_I1.1821.00
202_K205_P1.1781.00
78_T277_L1.1751.00
192_L196_L1.1711.00
133_G204_P1.1711.00
286_E290_D1.1641.00
171_L175_L1.1641.00
73_K291_I1.1631.00
77_D294_D1.1621.00
222_F225_S1.1561.00
204_P208_L1.1531.00
57_T310_G1.1531.00
410_G414_R1.1511.00
224_N232_P1.1511.00
115_E306_I1.1471.00
27_A31_V1.1401.00
130_A136_L1.1381.00
34_V38_A1.1331.00
184_P188_V1.1331.00
181_I184_P1.1331.00
31_V34_V1.1311.00
370_N376_P1.1281.00
385_A431_V1.1231.00
269_A273_A1.1211.00
81_A85_A1.1191.00
430_G434_I1.1191.00
222_F229_A1.1151.00
201_E208_L1.1151.00
237_A241_V1.1121.00
177_Y381_L1.1111.00
398_F402_K1.1051.00
274_I278_G1.1041.00
177_Y181_I1.1021.00
102_V105_G1.1011.00
103_I106_L1.0991.00
227_F231_I1.0971.00
353_S356_V1.0951.00
181_I434_I1.0891.00
175_L180_I1.0891.00
240_A244_I1.0881.00
341_W428_L1.0841.00
228_A231_I1.0821.00
278_G281_N1.0821.00
197_L203_A1.0791.00
409_V413_L1.0761.00
389_I421_T1.0731.00
101_L105_G1.0711.00
177_Y377_A1.0701.00
205_P208_L1.0681.00
306_I396_P1.0611.00
86_T131_S1.0611.00
349_I389_I1.0581.00
338_L432_L1.0501.00
223_W226_I1.0451.00
366_L370_N1.0411.00
71_L269_A1.0371.00
187_I192_L1.0371.00
101_L107_V1.0321.00
216_E220_P1.0271.00
145_A190_G1.0251.00
188_V192_L1.0211.00
48_H51_Q1.0191.00
190_G195_K1.0120.99
104_T107_V1.0110.99
71_L270_I1.0100.99
427_G431_V1.0090.99
196_L204_P1.0080.99
118_F404_Y1.0030.99
82_Q217_E1.0020.99
232_P237_A1.0010.99
6_I10_V0.9980.99
104_T108_V0.9970.99
426_M430_G0.9940.99
240_A243_E0.9930.99
173_T176_L0.9920.99
272_I276_T0.9910.99
277_L280_R0.9910.99
175_L179_F0.9840.99
264_V267_F0.9830.99
194_S198_T0.9820.99
84_I225_S0.9820.99
391_S395_D0.9810.99
265_A270_I0.9770.99
239_A244_I0.9750.99
262_P269_A0.9730.99
385_A427_G0.9720.99
86_T90_A0.9700.99
263_A266_L0.9670.99
194_S197_L0.9590.99
150_T157_H0.9570.99
196_L199_R0.9550.99
174_T377_A0.9520.99
261_N269_A0.9420.99
264_V268_I0.9420.99
114_F397_G0.9420.99
402_K412_T0.9400.99
261_N270_I0.9380.99
80_A225_S0.9370.99
74_L273_A0.9370.99
225_S244_I0.9370.99
271_V275_F0.9360.99
91_T95_K0.9350.99
354_A391_S0.9340.99
273_A277_L0.9340.99
218_E221_S0.9330.99
200_F208_L0.9300.99
417_T421_T0.9290.99
115_E118_F0.9280.99
101_L108_V0.9270.99
225_S229_A0.9240.99
241_V244_I0.9230.99
397_G402_K0.9200.99
160_P164_A0.9190.99
320_G323_H0.9160.99
9_G34_V0.9160.99
299_I303_V0.9150.99
241_V245_T0.9140.99
16_L27_A0.9120.99
169_A172_G0.9120.99
181_I185_T0.9120.99
39_E42_D0.9030.99
432_L436_A0.9020.99
150_T154_L0.8940.99
197_L422_L0.8880.99
195_K198_T0.8870.99
63_M67_F0.8850.99
420_E423_I0.8800.99
314_Q317_V0.8780.99
274_I292_I0.8780.99
16_L22_V0.8750.99
378_L434_I0.8730.98
178_G184_P0.8720.98
390_A417_T0.8700.98
229_A240_A0.8690.98
200_F205_P0.8670.98
411_E414_R0.8610.98
137_L203_A0.8610.98
174_T177_Y0.8600.98
391_S416_W0.8570.98
226_I230_V0.8540.98
332_T337_L0.8490.98
275_F279_R0.8490.98
243_E257_E0.8460.98
270_I274_I0.8440.98
184_P187_I0.8430.98
348_R395_D0.8390.98
39_E319_S0.8370.98
25_F304_F0.8330.98
115_E119_V0.8290.98
148_S420_E0.8230.98
169_A174_T0.8200.98
109_G113_F0.8180.98
35_V312_F0.8170.98
99_W103_I0.8160.98
64_I306_I0.8150.98
381_L431_V0.8150.98
273_A276_T0.8140.98
100_A108_V0.8130.98
193_F198_T0.8110.98
112_M119_V0.8110.98
277_L288_I0.8090.98
233_V237_A0.8090.98
141_V145_A0.8070.97
222_F232_P0.8070.97
228_A276_T0.8070.97
86_T219_M0.8030.97
102_V186_V0.8020.97
162_A166_I0.8010.97
224_N236_M0.7980.97
216_E219_M0.7960.97
227_F276_T0.7960.97
397_G400_L0.7940.97
198_T205_P0.7940.97
232_P235_L0.7920.97
378_L431_V0.7920.97
134_L138_Y0.7890.97
224_N280_R0.7880.97
256_F259_V0.7870.97
197_L205_P0.7840.97
7_A11_A0.7840.97
367_P372_T0.7810.97
366_L369_I0.7800.97
348_R354_A0.7800.97
377_A381_L0.7790.97
178_G185_T0.7780.97
223_W232_P0.7780.97
117_G147_L0.7770.97
41_M49_S0.7760.97
12_L15_I0.7750.97
402_K405_F0.7740.97
173_T377_A0.7740.97
416_W420_E0.7740.97
203_A207_G0.7730.97
344_A357_A0.7730.97
185_T430_G0.7720.97
93_G100_A0.7690.97
109_G114_F0.7660.97
382_A386_G0.7660.97
351_L360_T0.7640.97
239_A242_C0.7630.96
287_Q291_I0.7630.96
214_F217_E0.7620.96
52_N55_G0.7620.96
381_L385_A0.7620.96
357_A395_D0.7600.96
357_A361_T0.7570.96
192_L200_F0.7570.96
222_F227_F0.7560.96
198_T202_K0.7520.96
188_V422_L0.7510.96
181_I430_G0.7490.96
398_F401_F0.7480.96
68_G295_S0.7460.96
201_E206_E0.7420.96
231_I234_I0.7410.96
223_W245_T0.7410.96
197_L207_G0.7390.96
200_F207_G0.7380.96
174_T178_G0.7350.96
83_R225_S0.7340.96
8_A12_L0.7340.96
235_L242_C0.7320.96
196_L207_G0.7310.96
199_R202_K0.7300.95
354_A396_P0.7290.95
73_K294_D0.7280.95
222_F236_M0.7250.95
214_F218_E0.7250.95
345_A424_S0.7240.95
114_F118_F0.7230.95
340_C365_V0.7210.95
5_I31_V0.7200.95
30_L34_V0.7190.95
129_V139_V0.7180.95
399_W402_K0.7170.95
190_G197_L0.7170.95
274_I277_L0.7140.95
109_G117_G0.7140.95
236_M239_A0.7130.95
375_D378_L0.7130.95
133_G202_K0.7130.95
266_L273_A0.7100.95
329_M343_V0.7100.95
222_F230_V0.7100.95
181_I381_L0.7100.95
234_I238_I0.7070.95
166_I363_G0.7040.95
109_G112_M0.7030.94
100_A107_V0.7020.94
220_P224_N0.7020.94
332_T336_P0.6990.94
226_I232_P0.6990.94
73_K76_S0.6980.94
116_V159_G0.6980.94
185_T188_V0.6970.94
113_F117_G0.6970.94
52_N318_D0.6960.94
240_A245_T0.6960.94
196_L201_E0.6960.94
33_A264_V0.6940.94
428_L432_L0.6930.94
35_V315_V0.6920.94
146_A150_T0.6920.94
94_K132_S0.6910.94
112_M116_V0.6910.94
412_T416_W0.6910.94
23_N26_I0.6900.94
220_P228_A0.6900.94
345_A390_A0.6890.94
203_A206_E0.6870.94
417_T424_S0.6870.94
194_S200_F0.6840.94
238_I244_I0.6830.94
378_L435_N0.6810.93
193_F418_V0.6800.93
52_N314_Q0.6780.93
135_P201_E0.6780.93
260_G273_A0.6770.93
5_I39_E0.6760.93
404_Y407_L0.6720.93
238_I243_E0.6720.93
172_G176_L0.6710.93
203_A411_E0.6710.93
348_R387_S0.6680.93
175_L182_T0.6680.93
242_C245_T0.6680.93
113_F119_V0.6670.93
333_T337_L0.6670.93
213_L216_E0.6660.93
220_P232_P0.6660.93
12_L19_G0.6660.93
269_A272_I0.6650.93
275_F278_G0.6650.93
358_A387_S0.6640.93
222_F228_A0.6630.93
5_I9_G0.6620.93
148_S388_V0.6620.93
197_L208_L0.6590.92
215_S219_M0.6580.92
372_T376_P0.6570.92
129_V134_L0.6560.92
415_T418_V0.6540.92
16_L30_L0.6540.92
228_A235_L0.6530.92
348_R391_S0.6530.92
231_I235_L0.6510.92
178_G186_V0.6510.92
327_H331_G0.6500.92
367_P371_V0.6500.92
178_G182_T0.6490.92
236_M244_I0.6480.92
41_M46_V0.6480.92
162_A359_I0.6470.92
190_G196_L0.6440.91
190_G200_F0.6430.91
153_F427_G0.6400.91
400_L407_L0.6380.91
96_R99_W0.6360.91
140_G407_L0.6350.91
63_M66_G0.6340.91
228_A240_A0.6340.91
324_Y327_H0.6310.91
226_I229_A0.6310.91
354_A387_S0.6300.91
238_I242_C0.6290.90
196_L205_P0.6290.90
349_I417_T0.6270.90
172_G175_L0.6230.90
276_T280_R0.6230.90
151_H155_P0.6200.90
13_L350_A0.6200.90
348_R357_A0.6190.90
171_L178_G0.6170.90
344_A387_S0.6170.90
236_M242_C0.6170.90
265_A273_A0.6170.90
193_F422_L0.6160.90
99_W106_L0.6150.89
80_A83_R0.6140.89
233_V236_M0.6130.89
180_I186_V0.6120.89
225_S236_M0.6120.89
162_A167_F0.6110.89
410_G413_L0.6110.89
117_G157_H0.6100.89
153_F385_A0.6100.89
10_V13_L0.6100.89
403_G407_L0.6090.89
90_A199_R0.6070.89
266_L274_I0.6070.89
195_K199_R0.6060.89
264_V270_I0.6030.89
125_V129_V0.6020.88
26_I270_I0.6000.88
125_V143_M0.6000.88
391_S420_E0.5980.88
215_S331_G0.5970.88
358_A361_T0.5970.88
401_F407_L0.5950.88
184_P430_G0.5950.88
47_L51_Q0.5940.88
392_H420_E0.5910.88
223_W237_A0.5910.88
322_G326_S0.5910.88
183_I186_V0.5910.88
9_G39_E0.5900.87
262_P268_I0.5890.87
91_T94_K0.5890.87
193_F203_A0.5870.87
351_L356_V0.5860.87
221_S228_A0.5850.87
102_V106_L0.5850.87
407_L411_E0.5840.87
269_A279_R0.5830.87
35_V38_A0.5830.87
83_R222_F0.5820.87
210_N215_S0.5800.87
68_G85_A0.5800.87
265_A268_I0.5770.86
110_L115_E0.5760.86
111_A114_F0.5760.86
393_V413_L0.5760.86
403_G406_N0.5750.86
36_G46_V0.5730.86
305_I359_I0.5720.86
380_V423_I0.5720.86
164_A171_L0.5710.86
226_I236_M0.5710.86
145_A419_M0.5700.86
32_A36_G0.5670.85
171_L179_F0.5660.85
239_A245_T0.5660.85
95_K208_L0.5650.85
174_T180_I0.5650.85
102_V108_V0.5630.85
232_P245_T0.5630.85
106_L110_L0.5620.85
102_V107_V0.5620.85
218_E287_Q0.5620.85
222_F244_I0.5620.85
258_F261_N0.5620.85
122_L405_F0.5610.85
219_M223_W0.5590.85
335_S338_L0.5560.84
347_L351_L0.5550.84
398_F404_Y0.5550.84
5_I321_V0.5550.84
238_I245_T0.5540.84
211_P214_F0.5520.84
267_F270_I0.5520.84
96_R102_V0.5510.84
111_A116_V0.5500.84
210_N214_F0.5490.84
5_I34_V0.5480.83
100_A106_L0.5460.83
144_V399_W0.5460.83
400_L405_F0.5450.83
231_I236_M0.5440.83
33_A211_P0.5430.83
29_V67_F0.5430.83
229_A237_A0.5420.83
58_L307_A0.5410.83
149_V152_C0.5410.83
149_V182_T0.5400.83
176_L184_P0.5380.82
112_M117_G0.5380.82
230_V233_V0.5360.82
211_P215_S0.5330.82
361_T383_T0.5320.82
426_M429_L0.5310.81
25_F29_V0.5310.81
173_T179_F0.5310.81
113_F159_G0.5300.81
433_A436_A0.5300.81
32_A311_A0.5290.81
223_W234_I0.5270.81
37_F43_A0.5270.81
83_R219_M0.5260.81
143_M146_A0.5260.81
265_A276_T0.5260.81
423_I427_G0.5240.81
195_K203_A0.5230.80
141_V415_T0.5230.80
274_I288_I0.5230.80
220_P240_A0.5220.80
171_L180_I0.5220.80
97_V104_T0.5220.80
218_E222_F0.5210.80
345_A349_I0.5210.80
326_S329_M0.5210.80
308_G312_F0.5190.80
98_Q101_L0.5190.80
220_P244_I0.5180.80
109_G150_T0.5170.80
230_V237_A0.5150.79
198_T204_P0.5130.79
149_V420_E0.5130.79
315_V318_D0.5130.79
301_M305_I0.5130.79
272_I275_F0.5120.79
400_L403_G0.5100.79
152_C354_A0.5100.79
195_K200_F0.5090.79
185_T426_M0.5090.79
88_L92_F0.5090.79
221_S232_P0.5080.79
105_G121_L0.5070.78
269_A277_L0.5060.78
83_R221_S0.5060.78
232_P239_A0.5050.78
212_H215_S0.5050.78
354_A388_V0.5040.78
227_F234_I0.5030.78
232_P243_E0.5010.78
200_F206_E0.5000.77
356_V360_T0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.9772 100 0.55 Contact Map
4r0cA 3 0.9727 100 0.564 Contact Map
4f35D 2 0.8975 100 0.602 Contact Map
4pd6A 3 0.7654 90.8 0.931 Contact Map
4dx5A 3 0.3599 59.3 0.949 Contact Map
2cfqA 1 0.8178 54.9 0.951 Contact Map
3aqpA 1 0.3713 42.9 0.954 Contact Map
3qe7A 2 0.4465 34.1 0.956 Contact Map
2a65A 2 0.615 29.8 0.958 Contact Map
3giaA 1 0.4465 27.5 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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