GREMLIN Database
IDNR - HTH-type transcriptional regulator IdnR
UniProt: P39343 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12538
Length: 332 (321)
Sequences: 36465 (26301)
Seq/√Len: 1468.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_R204_D3.3761.00
180_V242_D3.1991.00
14_L46_E3.1081.00
265_A268_E3.0821.00
171_M273_A2.6421.00
122_G306_L2.6091.00
199_Y203_C2.5791.00
180_V271_S2.5561.00
277_G292_I2.4871.00
158_M309_K2.4691.00
169_F208_L2.3461.00
228_M261_E2.2631.00
34_K38_E2.2471.00
42_K46_E2.2181.00
88_V91_E2.2141.00
38_E42_K2.1771.00
88_V304_Q2.1491.00
232_R262_R2.1211.00
169_F204_D2.0721.00
301_M304_Q2.0651.00
173_C205_A2.0411.00
176_L209_H2.0331.00
169_F205_A2.0281.00
232_R258_L2.0281.00
166_Q170_D2.0161.00
25_Y40_I1.9711.00
89_T303_A1.9651.00
167_A275_F1.9131.00
165_R200_Q1.9081.00
37_G41_A1.9021.00
168_A172_V1.8881.00
84_G299_G1.8841.00
26_I44_M1.8801.00
227_G254_G1.8621.00
259_C270_I1.8601.00
175_M243_G1.8511.00
173_C177_E1.8491.00
88_V300_R1.8461.00
9_Q19_K1.8441.00
236_S262_R1.8221.00
168_A245_F1.8031.00
308_S313_N1.8031.00
172_V202_Y1.7741.00
292_I325_Q1.7651.00
87_S296_F1.7571.00
173_C209_H1.7191.00
15_A43_I1.6951.00
169_F173_C1.6871.00
14_L43_I1.6731.00
228_M258_L1.6681.00
294_P297_D1.6631.00
264_L269_Q1.6451.00
301_M320_V1.6381.00
170_D324_Y1.6271.00
185_L247_T1.6261.00
67_G120_I1.6261.00
184_I241_L1.6251.00
174_T178_K1.6231.00
231_M255_A1.6191.00
84_G296_F1.6171.00
88_V92_H1.5941.00
246_C255_A1.5891.00
265_A269_Q1.5821.00
258_L262_R1.5711.00
148_L302_A1.5531.00
41_A45_E1.5311.00
166_Q169_F1.5261.00
200_Q204_D1.5151.00
25_Y44_M1.5081.00
92_H307_L1.4961.00
260_R285_I1.4861.00
176_L205_A1.4841.00
297_D301_M1.4831.00
174_T177_E1.4791.00
277_G329_G1.4741.00
163_D166_Q1.4621.00
11_I43_I1.4531.00
258_L261_E1.4481.00
41_A44_M1.4451.00
64_Y121_D1.4151.00
273_A289_A1.4071.00
197_Q200_Q1.4001.00
182_H240_D1.3981.00
297_D300_R1.3951.00
88_V303_A1.3821.00
203_C207_M1.3611.00
228_M257_L1.3611.00
174_T328_H1.3581.00
259_C264_L1.3451.00
307_L311_K1.3301.00
172_V176_L1.3271.00
167_A324_Y1.3271.00
221_I226_L1.3201.00
172_V201_G1.3161.00
232_R261_E1.3121.00
184_I234_A1.3031.00
205_A208_L1.3011.00
231_M244_V1.3011.00
228_M232_R1.2981.00
9_Q13_T1.2931.00
218_P233_D1.2921.00
136_K140_S1.2911.00
172_V205_A1.2891.00
14_L47_I1.2841.00
66_L89_T1.2801.00
304_Q308_S1.2701.00
168_A201_G1.2691.00
34_K37_G1.2681.00
10_D13_T1.2671.00
201_G205_A1.2571.00
64_Y94_Y1.2561.00
231_M259_C1.2531.00
180_V243_G1.2481.00
39_R43_I1.2451.00
67_G115_L1.2441.00
33_A36_T1.2431.00
11_I15_A1.2381.00
232_R236_S1.2351.00
99_A111_S1.2331.00
124_I302_A1.2291.00
165_R169_F1.2271.00
24_R29_P1.2261.00
256_L272_I1.2221.00
182_H214_L1.2221.00
99_A115_L1.2191.00
43_I46_E1.2091.00
43_I47_I1.2021.00
170_D173_C1.1981.00
8_L19_K1.1921.00
85_I124_I1.1911.00
89_T96_T1.1911.00
173_C208_L1.1911.00
85_I303_A1.1901.00
182_H242_D1.1751.00
68_I85_I1.1711.00
165_R197_Q1.1701.00
233_D237_A1.1671.00
11_I47_I1.1621.00
36_T39_R1.1431.00
113_I137_F1.1411.00
186_Y255_A1.1311.00
296_F300_R1.1231.00
225_H229_Q1.1221.00
254_G258_L1.1221.00
202_Y206_M1.1171.00
65_T95_Q1.1171.00
92_H304_Q1.1051.00
249_D290_S1.1021.00
165_R201_G1.1011.00
204_D208_L1.0951.00
171_M245_F1.0931.00
299_G303_A1.0921.00
68_I96_T1.0901.00
42_K45_E1.0811.00
178_K328_H1.0811.00
38_E41_A1.0791.00
8_L22_V1.0781.00
86_E90_S1.0771.00
244_V255_A1.0751.00
185_L199_Y1.0691.00
183_K206_M1.0681.00
301_M305_M1.0621.00
181_R242_D1.0591.00
205_A209_H1.0591.00
230_L233_D1.0551.00
206_M211_L1.0541.00
223_S226_L1.0531.00
238_N241_L1.0521.00
65_T97_L1.0521.00
210_N213_P1.0491.00
249_D274_G1.0451.00
25_Y32_V1.0411.00
90_S107_S1.0411.00
28_S37_G1.0381.00
176_L211_L1.0271.00
52_N58_L1.0251.00
174_T289_A1.0211.00
227_G231_M1.0191.00
109_E113_I1.0161.00
200_Q203_C1.0111.00
54_A57_M1.0071.00
182_H239_P1.0061.00
300_R304_Q1.0011.00
246_C252_A1.0001.00
177_E209_H1.0001.00
305_M320_V0.9931.00
44_M47_I0.9931.00
306_L310_I0.9911.00
92_H311_K0.9911.00
229_Q233_D0.9901.00
94_Y307_L0.9881.00
202_Y245_F0.9841.00
246_C251_I0.9831.00
226_L229_Q0.9831.00
301_M322_L0.9811.00
107_S110_E0.9691.00
166_Q323_G0.9661.00
196_E200_Q0.9591.00
183_K243_G0.9561.00
178_K271_S0.9551.00
15_A22_V0.9521.00
203_C213_P0.9471.00
158_M305_M0.9471.00
256_L266_V0.9461.00
91_E300_R0.9341.00
224_I257_L0.9311.00
231_M235_L0.9251.00
256_L284_M0.9231.00
325_Q328_H0.9081.00
176_L181_R0.9041.00
24_R30_K0.9021.00
193_T197_Q0.9021.00
172_V206_M0.9011.00
83_A87_S0.9001.00
162_F294_P0.8991.00
87_S300_R0.8981.00
218_P230_L0.8961.00
171_M291_V0.8941.00
51_P56_G0.8931.00
206_M213_P0.8891.00
55_P58_L0.8851.00
124_I306_L0.8841.00
159_E319_T0.8821.00
181_R211_L0.8791.00
28_S41_A0.8771.00
85_I299_G0.8751.00
160_V305_M0.8701.00
52_N55_P0.8701.00
260_R287_S0.8671.00
82_L86_E0.8641.00
68_I82_L0.8641.00
294_P322_L0.8631.00
190_K219_R0.8621.00
188_G222_S0.8611.00
66_L124_I0.8601.00
191_D196_E0.8571.00
132_I136_K0.8541.00
249_D277_G0.8531.00
184_I244_V0.8501.00
229_Q232_R0.8461.00
166_Q324_Y0.8431.00
264_L270_I0.8421.00
244_V270_I0.8421.00
259_C272_I0.8411.00
220_A251_I0.8361.00
274_G290_S0.8321.00
25_Y41_A0.8311.00
235_L258_L0.8291.00
163_D321_D0.8291.00
104_D107_S0.8281.00
305_M308_S0.8271.00
163_D323_G0.8251.00
240_D264_L0.8211.00
81_I148_L0.8181.00
292_I327_Y0.8171.00
162_F324_Y0.8161.00
122_G310_I0.8141.00
161_G321_D0.8121.00
77_L295_R0.8101.00
158_M318_N0.8091.00
113_I117_S0.8061.00
187_L199_Y0.8051.00
204_D207_M0.8011.00
226_L230_L0.8001.00
35_E38_E0.7991.00
294_P325_Q0.7991.00
164_N198_R0.7971.00
53_R56_G0.7961.00
63_S121_D0.7921.00
65_T118_Y0.7901.00
211_L214_L0.7901.00
175_M273_A0.7881.00
162_F293_T0.7861.00
303_A307_L0.7851.00
85_I96_T0.7841.00
80_D296_F0.7841.00
87_S91_E0.7821.00
17_V40_I0.7811.00
197_Q201_G0.7801.00
137_F140_S0.7801.00
84_G300_R0.7791.00
21_T24_R0.7731.00
277_G327_Y0.7721.00
110_E113_I0.7691.00
185_L245_F0.7681.00
161_G319_T0.7651.00
231_M258_L0.7611.00
186_Y246_C0.7611.00
211_L215_R0.7571.00
84_G88_V0.7531.00
71_P78_F0.7521.00
35_E39_R0.7511.00
276_H293_T0.7491.00
20_M24_R0.7481.00
242_D271_S0.7441.00
235_L262_R0.7391.00
82_L98_I0.7381.00
170_D291_V0.7321.00
116_L141_A0.7281.00
231_M234_A0.7271.00
253_M284_M0.7241.00
277_G281_G0.7241.00
67_G123_I0.7221.00
136_K139_R0.7201.00
83_A86_E0.7181.00
97_L120_I0.7181.00
249_D252_A0.7121.00
62_Q121_D0.7121.00
257_L260_R0.7091.00
102_N107_S0.7091.00
24_R31_K0.7081.00
86_E96_T0.7081.00
50_I117_S0.7051.00
66_L303_A0.7051.00
174_T326_I0.7041.00
147_E152_Q0.6971.00
107_S111_S0.6971.00
237_A240_D0.6941.00
252_A274_G0.6941.00
245_F273_A0.6921.00
169_F201_G0.6911.00
259_C266_V0.6891.00
257_L287_S0.6881.00
183_K242_D0.6871.00
227_G230_L0.6871.00
122_G146_V0.6871.00
151_V319_T0.6861.00
237_A241_L0.6841.00
220_A226_L0.6821.00
233_D236_S0.6811.00
25_Y37_G0.6781.00
176_L206_M0.6781.00
38_E45_E0.6731.00
69_L111_S0.6731.00
139_R145_V0.6691.00
139_R156_L0.6681.00
138_L145_V0.6671.00
124_I148_L0.6611.00
216_M237_A0.6581.00
308_S312_N0.6571.00
62_Q311_K0.6541.00
106_D110_E0.6521.00
195_D222_S0.6481.00
86_E100_N0.6451.00
116_L143_I0.6421.00
312_N315_H0.6411.00
257_L261_E0.6401.00
112_V123_I0.6401.00
170_D174_T0.6391.00
248_N276_H0.6371.00
50_I113_I0.6361.00
185_L202_Y0.6331.00
287_S329_G0.6331.00
149_M194_R0.6291.00
97_L118_Y0.6291.00
231_M254_G0.6281.00
256_L260_R0.6271.00
182_H213_P0.6261.00
183_K202_Y0.6261.00
122_G302_A0.6251.00
146_V160_V0.6231.00
75_N250_D0.6221.00
146_V309_K0.6221.00
9_Q59_L0.6221.00
146_V306_L0.6211.00
308_S318_N0.6181.00
109_E134_T0.6161.00
80_D295_R0.6151.00
175_M245_F0.6141.00
17_V36_T0.6131.00
31_K36_T0.6121.00
45_E48_N0.6111.00
22_V25_Y0.6101.00
199_Y217_N0.6091.00
149_M164_N0.6071.00
11_I22_V0.6061.00
84_G295_R0.6041.00
218_P234_A0.6041.00
222_S247_T0.6031.00
169_F172_V0.6031.00
39_R42_K0.6001.00
134_T137_F0.5991.00
66_L122_G0.5951.00
224_I280_I0.5951.00
248_N251_I0.5951.00
202_Y213_P0.5951.00
81_I295_R0.5941.00
94_Y310_I0.5941.00
224_I254_G0.5901.00
253_M278_L0.5901.00
225_H228_M0.5881.00
83_A296_F0.5871.00
147_E157_D0.5871.00
218_P237_A0.5861.00
164_N197_Q0.5861.00
105_R109_E0.5851.00
296_F299_G0.5841.00
259_C262_R0.5841.00
216_M219_R0.5841.00
133_R136_K0.5831.00
94_Y121_D0.5831.00
245_F275_F0.5821.00
260_R265_A0.5791.00
77_L81_I0.5791.00
260_R286_P0.5781.00
182_H216_M0.5781.00
22_V44_M0.5771.00
257_L285_I0.5731.00
289_A326_I0.5701.00
99_A114_N0.5691.00
32_V37_G0.5681.00
188_G195_D0.5671.00
174_T273_A0.5651.00
63_S95_Q0.5651.00
24_R32_V0.5641.00
171_M243_G0.5641.00
123_I143_I0.5641.00
209_H212_S0.5631.00
66_L94_Y0.5631.00
253_M280_I0.5631.00
66_L310_I0.5571.00
145_V157_D0.5571.00
281_G288_L0.5561.00
139_R157_D0.5551.00
222_S251_I0.5511.00
195_D247_T0.5511.00
309_K312_N0.5501.00
230_L234_A0.5501.00
146_V302_A0.5481.00
151_V159_E0.5471.00
50_I54_A0.5461.00
305_M309_K0.5451.00
281_G290_S0.5451.00
65_T121_D0.5431.00
89_T307_L0.5431.00
246_C274_G0.5391.00
210_N214_L0.5381.00
275_F293_T0.5381.00
282_R287_S0.5341.00
76_Q250_D0.5341.00
28_S31_K0.5331.00
115_L120_I0.5331.00
266_V269_Q0.5321.00
178_K242_D0.5311.00
301_M308_S0.5291.00
146_V305_M0.5291.00
228_M231_M0.5281.00
89_T94_Y0.5271.00
22_V40_I0.5271.00
17_V22_V0.5261.00
182_H241_L0.5241.00
235_L259_C0.5231.00
291_V324_Y0.5231.00
113_I116_L0.5231.00
85_I89_T0.5231.00
321_D324_Y0.5211.00
241_L264_L0.5211.00
228_M254_G0.5201.00
162_F167_A0.5191.00
15_A25_Y0.5171.00
249_D278_L0.5161.00
241_L244_V0.5151.00
137_F141_A0.5141.00
15_A40_I0.5111.00
294_P298_I0.5111.00
160_V301_M0.5111.00
120_I123_I0.5111.00
101_Y108_E0.5111.00
264_L267_P0.5101.00
88_V307_L0.5091.00
147_E159_E0.5091.00
162_F275_F0.5081.00
75_N78_F0.5081.00
56_G60_N0.5081.00
255_A259_C0.5071.00
20_M29_P0.5061.00
224_I250_D0.5051.00
243_G271_S0.5041.00
186_Y230_L0.5041.00
298_I322_L0.5031.00
289_A328_H0.5021.00
10_D14_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o20A 2 0.8223 100 0.053 Contact Map
2hsgA 1 0.9789 100 0.063 Contact Map
3dbiA 2 0.8163 100 0.069 Contact Map
3bilA 2 0.762 100 0.071 Contact Map
4o5aA 2 0.7982 100 0.072 Contact Map
3e3mA 2 0.7952 100 0.072 Contact Map
1qpzA 2 0.9849 100 0.073 Contact Map
3kjxA 2 0.994 100 0.074 Contact Map
3h5oA 2 0.8042 100 0.076 Contact Map
3jvdA 2 0.7801 100 0.081 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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