GREMLIN Database
YJGN - Inner membrane protein YjgN
UniProt: P39338 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12533
Length: 398 (380)
Sequences: 108 (96)
Seq/√Len: 4.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_E64_R4.3230.93
69_I131_V3.8850.88
137_C205_F3.8160.87
44_P78_C3.6680.84
323_T326_G3.5960.83
43_L78_C3.5490.82
45_W213_G3.3270.78
54_L334_L3.2630.76
109_V273_M3.2480.76
28_C77_S3.1420.73
68_G127_S3.0250.70
48_M67_Y2.9360.68
41_I44_P2.8120.64
71_G129_N2.7060.61
18_H64_R2.6730.60
71_G78_C2.4830.54
79_L83_F2.4180.52
71_G75_F2.3750.51
15_F60_V2.3600.50
119_L150_P2.2250.46
29_V121_H2.2110.46
28_C54_L2.1960.45
27_I303_N2.1720.44
102_V165_T2.1590.44
386_S392_M2.1510.44
318_F360_N2.1500.44
212_F391_V2.1160.43
28_C334_L2.1100.42
49_K352_W2.0780.41
75_F78_C2.0240.40
44_P75_F1.9690.38
43_L74_V1.9440.37
26_L118_G1.9310.37
48_M217_F1.9150.36
18_H59_E1.9080.36
48_M356_W1.9060.36
32_V36_I1.8830.35
335_V363_L1.8600.35
60_V363_L1.8320.34
43_L75_F1.8090.33
48_M213_G1.7970.33
78_C129_N1.7970.33
77_S113_F1.7540.32
96_M104_T1.7470.32
334_L349_L1.7240.31
43_L71_G1.7130.31
100_G107_L1.7050.30
114_M341_T1.6910.30
299_V327_M1.6840.30
31_N46_A1.6830.30
238_L241_L1.6820.30
65_F356_W1.6650.29
109_V188_I1.6610.29
211_S344_L1.6460.29
68_G139_M1.6450.29
370_L389_R1.6380.29
123_A131_V1.6250.28
48_M65_F1.6240.28
19_G45_W1.6230.28
196_G227_I1.6180.28
132_R349_L1.6110.28
28_C330_R1.6000.28
45_W48_M1.5980.28
92_V318_F1.5910.27
60_V65_F1.5750.27
253_L332_C1.5540.26
34_L126_T1.5520.26
44_P71_G1.5470.26
302_R361_T1.5430.26
126_T326_G1.5240.26
133_F228_K1.5210.26
105_L109_V1.5170.26
44_P74_V1.5140.25
52_R79_L1.5100.25
185_I216_R1.5040.25
78_C386_S1.4960.25
125_M345_A1.4730.24
128_L392_M1.4700.24
148_F348_L1.4610.24
77_S334_L1.4590.24
206_L209_N1.4580.24
131_V352_W1.4450.24
306_M345_A1.4440.24
89_L196_G1.4430.24
64_R134_S1.4420.24
67_Y348_L1.4360.24
215_H222_D1.4230.23
213_G217_F1.4220.23
44_P391_V1.4210.23
47_L65_F1.4170.23
44_P386_S1.4110.23
303_N320_L1.3960.23
87_A318_F1.3910.23
69_I352_W1.3900.23
40_G45_W1.3710.22
245_G248_I1.3680.22
66_S117_K1.3420.22
159_T248_I1.3420.22
67_Y74_V1.3400.21
189_V250_D1.3370.21
21_G249_F1.3230.21
341_T346_Y1.3210.21
43_L47_L1.3130.21
147_F353_M1.3030.21
208_S365_G1.3010.21
60_V70_T1.2990.21
196_G233_A1.2940.20
76_V132_R1.2930.20
145_V155_I1.2920.20
67_Y283_Q1.2850.20
68_G355_D1.2730.20
125_M302_R1.2650.20
147_F185_I1.2590.20
318_F321_T1.2510.20
143_W226_C1.2470.20
75_F129_N1.2400.19
54_L351_I1.2350.19
67_Y217_F1.2310.19
133_F311_L1.2310.19
86_F104_T1.2310.19
80_F298_T1.2300.19
30_V53_Y1.2240.19
41_I45_W1.2230.19
65_F217_F1.2220.19
93_S281_I1.2210.19
54_L77_S1.2200.19
338_S346_Y1.2030.19
44_P230_A1.1970.19
36_I152_L1.1900.18
129_N143_W1.1890.18
169_P351_I1.1870.18
45_W311_L1.1830.18
119_L206_L1.1820.18
156_G299_V1.1760.18
29_V141_G1.1650.18
178_I245_G1.1600.18
243_V269_L1.1590.18
163_I270_Q1.1560.18
43_L386_S1.1530.18
178_I257_D1.1470.18
66_S75_F1.1450.18
65_F74_V1.1450.18
230_A391_V1.1410.17
107_L364_L1.1390.17
45_W67_Y1.1370.17
105_L329_Y1.1300.17
28_C143_W1.1290.17
21_G114_M1.1270.17
302_R345_A1.1240.17
67_Y392_M1.1200.17
193_I238_L1.1180.17
121_H295_S1.1130.17
330_R353_M1.1100.17
50_C121_H1.1090.17
21_G351_I1.1050.17
17_F38_T1.1030.17
57_N220_K1.1010.17
29_V255_A1.0950.17
27_I127_S1.0930.17
54_L120_R1.0920.17
22_E154_A1.0920.17
345_A370_L1.0910.17
16_V187_G1.0730.16
32_V284_L1.0720.16
119_L209_N1.0690.16
309_L360_N1.0690.16
113_F305_F1.0680.16
308_N329_Y1.0680.16
107_L164_S1.0640.16
245_G257_D1.0640.16
109_V277_R1.0630.16
129_N334_L1.0630.16
330_R334_L1.0610.16
19_G213_G1.0600.16
37_I384_L1.0580.16
285_I289_G1.0540.16
86_F159_T1.0520.16
109_V282_A1.0520.16
47_L128_L1.0470.16
301_L350_K1.0440.16
119_L353_M1.0430.16
40_G213_G1.0420.16
68_G320_L1.0370.16
161_F291_A1.0320.16
54_L129_N1.0270.15
229_Y239_P1.0260.15
48_M74_V1.0250.15
68_G125_M1.0220.15
43_L129_N1.0160.15
52_R125_M1.0120.15
116_A139_M1.0100.15
68_G356_W1.0070.15
83_F104_T1.0040.15
227_I355_D1.0020.15
194_F337_I0.9950.15
34_L46_A0.9950.15
31_N34_L0.9950.15
127_S206_L0.9950.15
72_G326_G0.9940.15
103_L357_Q0.9940.15
206_L309_L0.9930.15
110_L280_I0.9930.15
133_F217_F0.9920.15
83_F86_F0.9840.15
111_L288_F0.9820.15
47_L122_Q0.9780.15
41_I213_G0.9770.15
49_K356_W0.9760.15
29_V209_N0.9750.15
243_V276_Q0.9750.15
123_A345_A0.9710.15
65_F128_L0.9670.14
57_N232_L0.9580.14
27_I53_Y0.9560.14
56_A71_G0.9540.14
357_Q370_L0.9540.14
214_I382_G0.9520.14
71_G143_W0.9490.14
151_I234_F0.9480.14
352_W356_W0.9470.14
78_C128_L0.9430.14
20_T296_Y0.9420.14
251_Q299_V0.9370.14
181_V224_T0.9350.14
329_Y333_A0.9320.14
30_V57_N0.9280.14
107_L304_H0.9260.14
196_G311_L0.9260.14
58_M334_L0.9230.14
196_G302_R0.9230.14
188_I282_A0.9210.14
133_F232_L0.9170.14
28_C129_N0.9140.14
135_F300_S0.9140.14
178_I242_A0.9100.14
147_F322_L0.9060.14
35_T210_T0.9050.14
158_G257_D0.9040.13
230_A356_W0.9040.13
98_L182_L0.9030.13
25_F30_V0.9030.13
200_S288_F0.8990.13
306_M392_M0.8980.13
45_W65_F0.8960.13
185_I307_S0.8840.13
65_F345_A0.8830.13
302_R306_M0.8820.13
279_M284_L0.8810.13
293_S351_I0.8810.13
74_V81_F0.8800.13
284_L368_D0.8790.13
119_L135_F0.8750.13
43_L48_M0.8720.13
79_L106_L0.8700.13
33_L337_I0.8680.13
35_T227_I0.8670.13
61_N327_M0.8670.13
334_L351_I0.8670.13
182_L238_L0.8640.13
209_N349_L0.8640.13
208_S385_A0.8610.13
48_M348_L0.8610.13
56_A73_N0.8610.13
59_E134_S0.8580.13
78_C81_F0.8560.13
93_S383_F0.8530.13
106_L383_F0.8520.13
96_M294_T0.8510.13
16_V346_Y0.8500.13
70_T390_G0.8490.13
28_C346_Y0.8480.13
234_F278_K0.8460.13
66_S127_S0.8450.13
73_N97_P0.8440.13
133_F321_T0.8430.13
124_L377_E0.8430.13
289_G375_K0.8410.13
133_F358_A0.8400.13
363_L374_N0.8380.13
82_V163_I0.8360.13
36_I228_K0.8350.12
60_V287_Y0.8330.12
154_A342_G0.8310.12
346_Y350_K0.8300.12
91_T188_I0.8290.12
332_C336_V0.8280.12
231_I342_G0.8280.12
270_Q280_I0.8270.12
27_I125_M0.8260.12
66_S385_A0.8250.12
374_N379_P0.8210.12
97_P105_L0.8190.12
53_Y68_G0.8160.12
47_L73_N0.8150.12
28_C58_M0.8120.12
29_V80_F0.8080.12
124_L239_P0.8080.12
149_L201_L0.8060.12
44_P382_G0.8050.12
197_T205_F0.8050.12
207_W309_L0.8040.12
159_T271_Q0.8040.12
26_L89_L0.8030.12
288_F292_V0.8020.12
39_L342_G0.8010.12
65_F311_L0.7990.12
80_F130_G0.7980.12
106_L281_I0.7970.12
23_R28_C0.7970.12
117_K392_M0.7960.12
74_V333_A0.7960.12
302_R352_W0.7940.12
87_A322_L0.7910.12
214_I388_S0.7910.12
385_A391_V0.7900.12
17_F112_I0.7890.12
38_T112_I0.7890.12
44_P48_M0.7890.12
29_V195_N0.7880.12
165_T188_I0.7870.12
26_L47_L0.7840.12
22_E137_C0.7810.12
134_S149_L0.7760.12
20_T351_I0.7750.12
110_L299_V0.7720.12
372_L388_S0.7680.12
34_L334_L0.7670.12
151_I190_S0.7660.12
286_Y372_L0.7660.12
51_K302_R0.7620.12
74_V78_C0.7620.12
206_L349_L0.7600.11
387_I390_G0.7600.11
286_Y360_N0.7590.11
114_M234_F0.7590.11
86_F312_N0.7580.11
220_K368_D0.7580.11
118_G143_W0.7570.11
137_C211_S0.7560.11
132_R355_D0.7530.11
40_G52_R0.7500.11
102_V140_K0.7480.11
102_V250_D0.7480.11
105_L184_A0.7470.11
28_C351_I0.7470.11
214_I229_Y0.7460.11
151_I239_P0.7460.11
74_V386_S0.7450.11
148_F291_A0.7420.11
97_P303_N0.7420.11
309_L354_I0.7420.11
77_S143_W0.7400.11
42_Y344_L0.7400.11
37_I204_S0.7370.11
141_G224_T0.7370.11
77_S358_A0.7360.11
98_L163_I0.7340.11
372_L390_G0.7330.11
226_C393_P0.7320.11
117_K375_K0.7310.11
50_C66_S0.7290.11
32_V324_Y0.7280.11
65_F212_F0.7270.11
340_I354_I0.7270.11
338_S349_L0.7230.11
292_V367_L0.7230.11
42_Y131_V0.7200.11
42_Y143_W0.7200.11
133_F235_L0.7180.11
346_Y385_A0.7180.11
256_Y340_I0.7180.11
207_W305_F0.7160.11
99_V152_L0.7160.11
385_A388_S0.7130.11
51_K69_I0.7120.11
56_A97_P0.7100.11
197_T353_M0.7080.11
37_I238_L0.7030.11
77_S237_L0.7030.11
103_L273_M0.7030.11
44_P356_W0.7020.11
60_V314_G0.7010.11
71_G196_G0.7000.11
37_I145_V0.6990.11
77_S330_R0.6980.11
17_F40_G0.6970.11
107_L133_F0.6960.11
154_A238_L0.6950.11
191_I194_F0.6940.11
74_V348_L0.6930.11
17_F347_P0.6930.11
89_L118_G0.6930.11
38_T347_P0.6930.11
219_V361_T0.6930.11
102_V393_P0.6920.11
27_I57_N0.6920.11
50_C300_S0.6900.11
52_R152_L0.6850.11
209_N303_N0.6820.11
31_N38_T0.6800.10
17_F46_A0.6800.10
17_F31_N0.6800.10
38_T46_A0.6800.10
66_S126_T0.6770.10
20_T358_A0.6760.10
87_A102_V0.6760.10
292_V322_L0.6760.10
164_S269_L0.6710.10
45_W74_V0.6700.10
361_T367_L0.6690.10
282_A285_I0.6680.10
61_N295_S0.6660.10
67_Y356_W0.6630.10
46_A53_Y0.6630.10
33_L188_I0.6630.10
31_N53_Y0.6630.10
263_N280_I0.6620.10
66_S286_Y0.6620.10
44_P128_L0.6610.10
283_Q348_L0.6610.10
262_A284_L0.6610.10
15_F180_M0.6610.10
176_V186_V0.6580.10
302_R365_G0.6580.10
389_R393_P0.6560.10
44_P392_M0.6540.10
65_F133_F0.6510.10
57_N127_S0.6470.10
69_I204_S0.6430.10
367_L370_L0.6410.10
25_F49_K0.6400.10
377_E388_S0.6400.10
137_C300_S0.6370.10
345_A365_G0.6360.10
202_V224_T0.6350.10
53_Y143_W0.6350.10
169_P308_N0.6300.10
52_R236_A0.6280.10
44_P126_T0.6270.10
48_M320_L0.6260.10
26_L306_M0.6250.10
41_I111_L0.6250.10
21_G135_F0.6250.10
72_G147_F0.6210.10
68_G116_A0.6200.10
105_L110_L0.6200.10
245_G272_F0.6190.10
60_V367_L0.6180.10
120_R221_L0.6180.10
109_V175_S0.6160.10
19_G38_T0.6150.10
318_F347_P0.6120.10
331_M353_M0.6120.10
78_C213_G0.6100.10
61_N182_L0.6090.10
292_V316_I0.6080.10
101_C185_I0.6070.10
71_G81_F0.6040.10
192_G287_Y0.6040.10
262_A267_E0.6030.10
240_F321_T0.6030.10
384_L394_S0.6020.10
67_Y213_G0.6010.10
108_L381_K0.6010.10
121_H334_L0.6000.10
235_L240_F0.5980.10
151_I164_S0.5970.10
113_F141_G0.5960.10
48_M283_Q0.5950.09
105_L248_I0.5950.09
71_G303_N0.5940.09
63_Q91_T0.5910.09
44_P286_Y0.5900.09
54_L121_H0.5890.09
31_N126_T0.5880.09
46_A126_T0.5880.09
241_L288_F0.5870.09
141_G238_L0.5860.09
98_L161_F0.5860.09
64_R304_H0.5850.09
47_L81_F0.5830.09
154_A258_S0.5820.09
389_R392_M0.5820.09
287_Y395_L0.5820.09
209_N370_L0.5790.09
36_I238_L0.5770.09
121_H143_W0.5760.09
53_Y77_S0.5760.09
104_T270_Q0.5740.09
139_M198_L0.5710.09
299_V374_N0.5700.09
132_R384_L0.5690.09
122_Q128_L0.5690.09
61_N242_A0.5690.09
22_E286_Y0.5670.09
389_R394_S0.5670.09
385_A390_G0.5660.09
255_A387_I0.5650.09
47_L121_H0.5640.09
51_K210_T0.5630.09
74_V217_F0.5620.09
108_L333_A0.5620.09
49_K58_M0.5620.09
360_N393_P0.5610.09
108_L203_M0.5610.09
47_L386_S0.5600.09
167_M187_G0.5600.09
58_M349_L0.5590.09
358_A384_L0.5590.09
337_I340_I0.5580.09
246_Y359_K0.5580.09
216_R326_G0.5570.09
29_V135_F0.5570.09
112_I320_L0.5570.09
129_N330_R0.5570.09
168_L395_L0.5550.09
133_F360_N0.5530.09
48_M68_G0.5510.09
46_A213_G0.5500.09
31_N213_G0.5500.09
143_W385_A0.5500.09
328_L387_I0.5500.09
83_F166_K0.5500.09
43_L382_G0.5480.09
46_A132_R0.5480.09
31_N132_R0.5480.09
110_L249_F0.5440.09
98_L184_A0.5430.09
59_E132_R0.5400.09
179_S192_G0.5400.09
123_A338_S0.5400.09
213_G311_L0.5390.09
186_V262_A0.5390.09
49_K68_G0.5370.09
96_M359_K0.5370.09
129_N226_C0.5360.09
21_G187_G0.5350.09
350_K353_M0.5330.09
147_F231_I0.5320.09
292_V363_L0.5310.09
41_I358_A0.5310.09
333_A352_W0.5300.09
365_G370_L0.5290.09
188_I337_I0.5280.09
11_P200_S0.5250.09
352_W392_M0.5220.09
206_L210_T0.5210.09
327_M331_M0.5210.09
54_L330_R0.5190.09
65_F361_T0.5190.09
75_F95_D0.5170.09
138_S288_F0.5160.09
47_L129_N0.5140.09
332_C359_K0.5140.09
192_G328_L0.5140.09
231_I363_L0.5120.09
306_M361_T0.5120.09
275_M278_K0.5120.09
352_W386_S0.5120.09
69_I294_T0.5110.09
279_M323_T0.5110.09
378_Q383_F0.5100.09
125_M134_S0.5080.09
165_T242_A0.5070.09
207_W221_L0.5060.09
363_L366_D0.5030.09
108_L233_A0.5020.09
151_I245_G0.5020.09
165_T284_L0.5020.09
71_G128_L0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w9iA 3 0.4824 8.1 0.981 Contact Map
2llyA 1 0.1181 5.5 0.983 Contact Map
4aq5C 1 0.1332 4.9 0.983 Contact Map
1xcrA 1 0.1357 4.6 0.983 Contact Map
2wfpA 1 0.201 4.1 0.984 Contact Map
3dhxA 2 0.1281 3.8 0.984 Contact Map
3j1rA 5 0.0653 3.4 0.984 Contact Map
1vccA 1 0.0879 3 0.985 Contact Map
3nqhA 2 0.1709 2.9 0.985 Contact Map
3cedA 1 0.1256 2.7 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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