GREMLIN Database
YJGM - Uncharacterized N-acetyltransferase YjgM
UniProt: P39337 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12532
Length: 167 (137)
Sequences: 16711 (13108)
Seq/√Len: 1119.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_R66_E3.4091.00
113_M144_F2.9091.00
106_K142_L2.7771.00
28_Q96_L2.7701.00
75_G112_A2.5771.00
106_K141_H2.3821.00
65_V104_L2.3581.00
63_W111_M2.2721.00
110_L142_L2.1921.00
115_Q119_M2.1701.00
67_Y99_I2.0741.00
72_V99_I2.0511.00
140_E146_H1.9981.00
12_R18_D1.9981.00
115_Q118_E1.9671.00
113_M124_C1.9551.00
111_M114_E1.8671.00
64_V71_V1.8311.00
126_L139_Y1.8111.00
67_Y72_V1.8101.00
109_A142_L1.7811.00
88_C116_A1.7411.00
73_G95_F1.7311.00
136_I140_E1.7301.00
67_Y102_K1.6921.00
146_H149_Y1.6391.00
21_A24_R1.5851.00
66_E71_V1.5711.00
61_A115_Q1.5201.00
79_P121_F1.5111.00
111_M115_Q1.5001.00
100_R134_E1.4931.00
62_Y76_G1.4801.00
24_R28_Q1.4611.00
106_K110_L1.4301.00
77_I112_A1.4051.00
99_I102_K1.4041.00
14_L22_I1.3961.00
86_D122_K1.3901.00
137_A140_E1.3871.00
70_E98_A1.3711.00
136_I146_H1.3491.00
88_C121_F1.3451.00
23_A27_R1.2961.00
70_E96_L1.2771.00
66_E69_G1.2561.00
14_L64_V1.2371.00
21_A71_V1.2281.00
87_I125_Y1.2091.00
44_A47_N1.1941.00
63_W115_Q1.1921.00
75_G108_L1.1821.00
77_I116_A1.1671.00
10_V66_E1.1641.00
114_E118_E1.1631.00
128_T132_L1.1591.00
24_R96_L1.1541.00
116_A124_C1.1431.00
103_G106_K1.1391.00
135_A139_Y1.1371.00
133_K137_A1.1151.00
87_I123_R1.1131.00
28_Q97_P1.1121.00
109_A139_Y1.0941.00
124_C144_F1.0901.00
61_A119_M1.0831.00
90_L109_A1.0801.00
133_K136_I1.0621.00
29_V94_Y1.0601.00
18_D66_E1.0571.00
28_Q98_A1.0521.00
67_Y70_E1.0381.00
128_T136_I1.0051.00
77_I115_Q1.0051.00
95_F104_L0.9991.00
13_R61_A0.9911.00
16_L52_Y0.9561.00
96_L99_I0.9411.00
13_R115_Q0.9261.00
110_L114_E0.9251.00
138_L142_L0.9231.00
25_V29_V0.9231.00
79_P119_M0.9171.00
11_M63_W0.9141.00
21_A70_E0.9051.00
132_L135_A0.8941.00
113_M117_R0.8911.00
41_Y45_D0.8721.00
19_N23_A0.8591.00
70_E99_I0.8581.00
78_A91_Q0.8571.00
109_A138_L0.8551.00
11_M111_M0.8441.00
65_V73_G0.8421.00
25_V71_V0.8391.00
107_K110_L0.8281.00
25_V96_L0.8281.00
93_M139_Y0.8251.00
101_G134_E0.8231.00
130_A149_Y0.8231.00
22_I74_G0.8201.00
26_I74_G0.8181.00
32_E97_P0.7991.00
93_M109_A0.7941.00
43_V47_N0.7871.00
20_P24_R0.7851.00
89_E125_Y0.7821.00
52_Y56_S0.7821.00
29_V33_Y0.7811.00
76_G91_Q0.7731.00
72_V104_L0.7711.00
43_V46_P0.7541.00
42_T46_P0.7541.00
11_M107_K0.7501.00
41_Y44_A0.7431.00
125_Y147_I0.7421.00
14_L62_Y0.7391.00
126_L135_A0.7351.00
44_A48_L0.7341.00
14_L19_N0.7341.00
15_T18_D0.7311.00
128_T135_A0.7271.00
57_Q60_H0.7261.00
113_M142_L0.7231.00
107_K111_M0.7211.00
27_R31_A0.7201.00
80_L89_E0.7161.00
104_L107_K0.7091.00
30_S94_Y0.7001.00
116_A121_F0.6971.00
74_G94_Y0.6961.00
75_G93_M0.6941.00
109_A144_F0.6921.00
75_G90_L0.6861.00
30_S34_G0.6841.00
81_T86_D0.6821.00
16_L19_N0.6821.00
110_L113_M0.6791.00
129_T132_L0.6771.00
88_C124_C0.6751.00
47_N50_E0.6751.00
24_R70_E0.6741.00
128_T139_Y0.6711.00
90_L126_L0.6691.00
21_A66_E0.6691.00
65_V108_L0.6641.00
111_M118_E0.6591.00
47_N51_L0.6511.00
50_E53_Q0.6441.00
21_A25_V0.6401.00
51_L54_V0.6361.00
51_L55_Y0.6271.00
13_R63_W0.6241.00
79_P88_C0.6231.00
46_P49_D0.6181.00
31_A35_L0.6171.00
106_K137_A0.6161.00
114_E117_R0.6151.00
33_Y36_T0.6151.00
105_A138_L0.6151.00
24_R27_R0.6101.00
101_G137_A0.6061.00
25_V94_Y0.6021.00
50_E54_V0.6011.00
26_I94_Y0.5981.00
65_V95_F0.5981.00
31_A34_G0.5971.00
26_I92_K0.5951.00
52_Y55_Y0.5921.00
20_P23_A0.5921.00
90_L112_A0.5841.00
45_D48_L0.5821.00
99_I104_L0.5791.00
132_L136_I0.5751.00
137_A141_H0.5741.00
65_V107_K0.5731.00
100_R135_A0.5711.00
109_A113_M0.5701.00
26_I30_S0.5641.00
89_E92_K0.5631.00
12_R15_T0.5601.00
90_L139_Y0.5601.00
74_G92_K0.5581.00
134_E137_A0.5531.00
21_A96_L0.5491.00
49_D53_Q0.5451.00
30_S36_T0.5351.00
62_Y66_E0.5351.00
126_L144_F0.5331.00
12_R64_V0.5291.00
61_A79_P0.5231.00
95_F108_L0.5221.00
14_L18_D0.5201.00
29_V34_G0.5191.00
48_L51_L0.5191.00
11_M108_L0.5151.00
42_T47_N0.5141.00
93_M126_L0.5121.00
61_A77_I0.5111.00
72_V98_A0.5101.00
93_M135_A0.5081.00
73_G108_L0.5071.00
101_G141_H0.5071.00
60_H76_G0.5051.00
42_T45_D0.5031.00
32_E36_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dr6A 2 0.9341 99.9 0.297 Contact Map
2j8mA 2 0.9341 99.9 0.306 Contact Map
2r7hA 2 0.9281 99.9 0.307 Contact Map
3d8pA 1 0.9281 99.9 0.314 Contact Map
2q7bA 2 0.9401 99.9 0.321 Contact Map
1gheA 1 0.9521 99.9 0.327 Contact Map
2ob0A 1 0.9042 99.9 0.33 Contact Map
2fiaA 1 0.9281 99.9 0.333 Contact Map
4kvxA 1 0.8743 99.9 0.333 Contact Map
4h89A 2 0.9461 99.9 0.335 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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